| Rab3a, a small GTP-binding protein, is required for the stabilization of the murine leukaemia virus Gag protein. | Rab3a, a small GTP-binding protein, is required for the stabilization of the murine leukaemia virus Gag protein.
Izumida M, Kakoki K, Hayashi H, Matsuyama T, Kubo Y., Free PMC Article | 12/3/2022 |
| TET3-mediated accumulation of DNA hydroxymethylation contributes to the activity-dependent gene expression of Rab3a in post-mitotic neurons. | TET3-mediated accumulation of DNA hydroxymethylation contributes to the activity-dependent gene expression of Rab3a in post-mitotic neurons.
Luo K, Wang L, Shen Y, She S, Cui Y, Liu K. | 02/5/2022 |
| Rab3A might function as a marker of cortical granules and participates in cortical granule exocytosis in mouse eggs. | Rab3A, a possible marker of cortical granules, participates in cortical granule exocytosis in mouse eggs.
Bello OD, Cappa AI, de Paola M, Zanetti MN, Fukuda M, Fissore RA, Mayorga LS, Michaut MA., Free PMC Article | 05/20/2017 |
| Rab3a accelerates cell proliferation by increasing cyclin D1 expression, enhances anti-cancer drug resistance, and increases tumorigenicity and self-renewal of glioma cells. | Rab3a promotes brain tumor initiation and progression.
Kim JK, Lee SY, Park CW, Park SH, Yin J, Kim J, Park JB, Lee JY, Kim H, Kim SC. | 12/12/2015 |
| Rab3a deficiency promotes constitutive secretion and underlies selective impairment of Ca(2)-dependent release of alpha-MSH | Rab3a is critical for trapping alpha-MSH granules in the high Ca²⁺-affinity pool by preventing constitutive exocytosis.
Sedej S, Klemen MS, Schlüter OM, Rupnik MS., Free PMC Article | 08/9/2014 |
| Rab3a deletion restores excitatory/inhibitory imbalance in synapsin II(-) hippocampal slices. | Synapsin II and Rab3a cooperate in the regulation of epileptic and synaptic activity in the CA1 region of the hippocampus.
Feliciano P, Andrade R, Bykhovskaia M., Free PMC Article | 01/11/2014 |
| betaARs couple to a cAMP/Epac/PLC/Munc13-1/Rab3a/RIM1a-dependent pathway to enhance glutamate release at cerebrocortical nerve terminals. | β-Adrenergic receptors activate exchange protein directly activated by cAMP (Epac), translocate Munc13-1, and enhance the Rab3A-RIM1α interaction to potentiate glutamate release at cerebrocortical nerve terminals.
Ferrero JJ, Alvarez AM, Ramírez-Franco J, Godino MC, Bartolomé-Martín D, Aguado C, Torres M, Luján R, Ciruela F, Sánchez-Prieto J., Free PMC Article | 01/4/2014 |
| key role of Rab3a proteins control the balance between secretory vesicle biogenesis and degradation, and suggest that the ablation of this protein probably changes the nature of the reservoir of secretory vesicles available for regulated exocytosis. | Rab3a ablation related changes in morphology of secretory vesicles in major endocrine pancreatic cells, pituitary melanotroph cells and adrenal gland chromaffin cells in mice.
Lipovšek S, Janžekovič F, Leitinger G, Rupnik MS. | 09/21/2013 |
| alpha-Synuclein membrane association is regulated by the Rab3a recycling machinery and presynaptic activity | α-Synuclein membrane association is regulated by the Rab3a recycling machinery and presynaptic activity.
Chen RHC, Wislet-Gendebien S, Samuel F, Visanji NP, Zhang G, Marsilio D, Langman T, Fraser PE, Tandon A., Free PMC Article | 05/18/2013 |
| Data show diminished actin plasticity in the cell processes of Rab3A knockout (KO) podocytes. | Proteinuria and glomerular damage in Rab3A knockout mice chronically fed a high-glucose diet.
Armelloni S, Calvaresi N, Ikehata M, Corbelli A, Mattinzoli D, Giardino LA, Li M, Messa P, Rastaldi MP. | 09/29/2012 |
| these findings suggest a crucial role of Rab3A in delivering vesicles to Ca2+ -dependent release sites at ribbon synapses. | Rab3A mediates vesicle delivery at photoreceptor ribbon synapses.
Tian M, Xu CS, Montpetit R, Kramer RH., Free PMC Article | 07/28/2012 |
| Myo5a and Rab3A are direct binding partners and interact on synaptic vesicles and the Myo5a/Rab3A complex is involved in transport of neuronal vesicles | Myosin5a tail associates directly with Rab3A-containing compartments in neurons.
Wöllert T, Patel A, Lee YL, Provance DW Jr, Vought VE, Cosgrove MS, Mercer JA, Langford GM., Free PMC Article | 07/2/2011 |
| We conclude that Rab3A is involved in a novel presynaptic mechanism to homeostatically regulate the amount of transmitter in a quantum. | Impaired activity-dependent plasticity of quantal amplitude at the neuromuscular junction of Rab3A deletion and Rab3A earlybird mutant mice.
Wang X, Wang Q, Yang S, Bucan M, Rich MM, Engisch KL., Free PMC Article | 05/14/2011 |
| roles in maintaining the total store of synaptic vesicles and cooperate in promoting the latest steps of neuronal secretion. | Cooperative regulation of neurotransmitter release by Rab3a and synapsin II.
Coleman WL, Bykhovskaia M., Free PMC Article | 08/9/2010 |
| We suggest that Rab3A may regulate SNAP-29-mediated membrane fusion during myelination | The SNARE protein SNAP-29 interacts with the GTPase Rab3A: Implications for membrane trafficking in myelinating glia.
Schardt A, Brinkmann BG, Mitkovski M, Sereda MW, Werner HB, Nave KA. | 02/8/2010 |
| Data show that Rab3A is highly and specifically expressed in brain regions. | Motifs and cis-regulatory modules mediating the expression of genes co-expressed in presynaptic neurons.
Liu R, Hannenhalli S, Bucan M., Free PMC Article | 01/21/2010 |
| Results support the hypothesis that Rab3a maintains the pool of fusion competent vesicles tightly coupled to Ca2+ channels. | Rab3a-mediated vesicle recruitment regulates short-term plasticity at the mouse diaphragm synapse.
Coleman WL, Bykhovskaia M. | 01/21/2010 |
| We found that small amplitude pre-spike feet with abnormally long durations were increased in Rab3A(-/-) cells. | Regulation of quantal shape by Rab3A: evidence for a fusion pore-dependent mechanism.
Wang X, Thiagarajan R, Wang Q, Tewolde T, Rich MM, Engisch KL., Free PMC Article | 01/21/2010 |
| Rab3GEP has a role as the non-redundant guanine nucleotide exchange factor for Rab27a in melanocytes | Rab3GEP is the non-redundant guanine nucleotide exchange factor for Rab27a in melanocytes.
Figueiredo AC, Wasmeier C, Tarafder AK, Ramalho JS, Baron RA, Seabra MC., Free PMC Article | 01/21/2010 |
| Rab3a positively regulates docking and basal quantal release at the mouse neuromuscular junction. This result is consistent with the proposed role of rab3a in trafficking and targeting vesicles to the active zones. | Rab3a deletion reduces vesicle docking and transmitter release at the mouse diaphragm synapse.
Coleman WL, Bill CA, Bykhovskaia M. | 01/21/2010 |
| The monomeric GTP binding protein, rab3a, is associated with the acrosome in mouse sperm. | The monomeric GTP binding protein, rab3a, is associated with the acrosome in mouse sperm.
Ward CR, Faundes D, Foster JA. | 01/21/2010 |
| a possible role in glomerulopathies | Glomerular podocytes possess the synaptic vesicle molecule Rab3A and its specific effector rabphilin-3a.
Rastaldi MP, Armelloni S, Berra S, Li M, Pesaresi M, Poczewski H, Langer B, Kerjaschki D, Henger A, Blattner SM, Kretzler M, Wanke R, D'Amico G., Free PMC Article | 01/21/2010 |
| role in regulatory mechanism of neurotransmitter release | [Regulatory mechanism of neurotransmitter release by low-molecular-weight G protein, Rab3A and the regulatory proteins].
Nakanishi H, Takai Y. | 01/21/2010 |
| In p130-deficient mice the GTP-bound form of Rab3A accumulated in the brain. | Rab3 GTPase-activating protein regulates synaptic transmission and plasticity through the inactivation of Rab3.
Sakane A, Manabe S, Ishizaki H, Tanaka-Okamoto M, Kiyokage E, Toida K, Yoshida T, Miyoshi J, Kamiya H, Takai Y, Sasaki T., Free PMC Article | 01/21/2010 |
| Phenotypic assessment of earlybird mice and a null allele of Rab3a revealed anomalies in circadian period and sleep homeostasis, providing evidence that Rab3a-mediated synaptic transmission is involved in these behaviors | Mutations in Rab3a alter circadian period and homeostatic response to sleep loss in the mouse.
Kapfhamer D, Valladares O, Sun Y, Nolan PM, Rux JJ, Arnold SE, Veasey SC, Bućan M. | 01/21/2010 |