| CrbpI chaperones retinol and retinal in the cell, protecting them from nonspecific oxidation and delivering them to biosynthesis enzymes where the bound (holo-) and unbound (apo-) forms of CrbpI exert distinct biological functions. Using nanoelectrospray, a native MS assay was developed for probing apo- and holo-CrbpI abundance to facilitate exploring their biological functions in in retinoid metabolism and signaling. | Quantitation of the Noncovalent Cellular Retinol-Binding Protein, Type 1 Complex Through Native Mass Spectrometry.
Li W, Yu J, Kane MA., Free PMC Article | 06/29/2019 |
| genetic deletion of RBP1 and RBP2 did not impair synapse ultrastructure of ribbon-type synapses formed between rod bipolar cells (RBCs) and amacrine type-2 (AII) cells in the mouse retina but dramatically reduced the density of presynaptic Ca(2+) channels, decreased and desynchronized evoked neurotransmitter release | Efficient stimulus-secretion coupling at ribbon synapses requires RIM-binding protein tethering of L-type Ca(2+) channels.
Luo F, Liu X, Südhof TC, Acuna C., Free PMC Article | 06/9/2018 |
| RBPs perform unexpectedly broad roles at the active zone that together with those of RIMs are essential for all active zone functions. | How to Make an Active Zone: Unexpected Universal Functional Redundancy between RIMs and RIM-BPs.
Acuna C, Liu X, Südhof TC. | 07/15/2017 |
| RBP1 expression was reduced in tissue and endometrial stromal cells derived from endometritis lesions versus eutopic endometruim in humans and mice. | Retinoic acid biosynthesis is impaired in human and murine endometriosis.
Pierzchalski K, Taylor RN, Nezhat C, Jones JW, Napoli JL, Yang G, Kane MA, Sidell N., Free PMC Article | 06/20/2015 |
| CrbpI loss disrupts all-trans retinoic acid homeostasis in mammary tissue, resulting in microenvironmental defects similar to those observed at the early stages of tumorigenesis. | CrbpI regulates mammary retinoic acid homeostasis and the mammary microenvironment.
Pierzchalski K, Yu J, Norman V, Kane MA. | 07/6/2013 |
| glucose homeostasis and energy metabolism rely on Rbp1 expression and its moderation of pancreas retinol and of the autacoid 9-cis-retinoic acid. | CrbpI modulates glucose homeostasis and pancreas 9-cis-retinoic acid concentrations.
Kane MA, Folias AE, Pingitore A, Perri M, Krois CR, Ryu JY, Cione E, Napoli JL., Free PMC Article | 11/12/2011 |
| As such, the effects of RBP1 on these processes are mediated through both regulation of Runx2 expression and transcriptional activity. | Retinoblastoma binding protein-1 (RBP1) is a Runx2 coactivator and promotes osteoblastic differentiation.
Monroe DG, Hawse JR, Subramaniam M, Spelsberg TC., Free PMC Article | 07/26/2010 |
| CRBP-I is a cytosolic protein specifically expressed in preadipocytes that regulates adipocyte differentiation in part by affecting PPAR gamma activity. | Cellular retinol-binding protein type I (CRBP-I) regulates adipogenesis.
Zizola CF, Frey SK, Jitngarmkusol S, Kadereit B, Yan N, Vogel S., Free PMC Article | 07/19/2010 |
| This murine RBP-null model may have relevance to fetal development in human populations with inadequate retinoid intake. | Increased fibronectin deposition in embryonic hearts of retinol-binding protein-null mice.
Wendler CC, Schmoldt A, Flentke GR, Case LC, Quadro L, Blaner WS, Lough J, Smith SM., Free PMC Article | 01/21/2010 |
| Data show that while vitamin A-replete retinol binding protein (rbp)-cryptochrome(cry) 1- and 2-knockout mice are light responsive, vitamin A-depleted knockout mice lose most behavioral and molecular responses to light. | Effect of vitamin A depletion on nonvisual phototransduction pathways in cryptochromeless mice.
Thompson CL, Selby CP, Van Gelder RN, Blaner WS, Lee J, Quadro L, Lai K, Gottesman ME, Sancar A. | 01/21/2010 |
| Epigenetic silencing of cellular CRBPI is associated with nasopharyngeal carcinoma | Epigenetic silencing of cellular retinol-binding proteins in nasopharyngeal carcinoma.
Kwong J, Lo KW, Chow LS, To KF, Choy KW, Chan FL, Mok SC, Huang DP., Free PMC Article | 01/21/2010 |
| Crbp1-/- mice also exhibited increased metabolism of a dose of retinol into retinoic acid, and this increased metabolism was not observed in Crbp1-/-/Adh1-/- mice | Opposing actions of cellular retinol-binding protein and alcohol dehydrogenase control the balance between retinol storage and degradation.
Molotkov A, Ghyselinck NB, Chambon P, Duester G., Free PMC Article | 01/21/2010 |