| The results showed that Among designated developmental stages, RDX has highest fold difference in early embryonic and postnatal stages. | Deciphering brain-specific transcriptomic expression of Ezr, Rad and Msn genes in the development of Mus musculus.
Ali SA, Baig DN. | 08/10/2019 |
| LRBA deficiency is associated with a reduced abundance of radixin and Nherf2, two adaptor proteins, which are important for the mechanical stability of the basal taper region of stereocilia. | The BEACH protein LRBA is required for hair bundle maintenance in cochlear hair cells and for hearing.
Vogl C, Butola T, Haag N, Hausrat TJ, Leitner MG, Moutschen M, Lefèbvre PP, Speckmann C, Garrett L, Becker L, Fuchs H, Hrabe de Angelis M, Nietzsche S, Kessels MM, Oliver D, Kneussel M, Kilimann MW, Strenzke N., Free PMC Article | 07/21/2018 |
| Inactivation of SHIP2 leads to increased microvilli formation and solute reabsorption by the renal proximal tubule and was associated with hyperactivated ezrin/radixin/moesin proteins and increased Rho-GTP. | The lipid 5-phoshatase SHIP2 controls renal brush border ultrastructure and function by regulating the activation of ERM proteins.
Sayyed SG, Jouret F, Vermeersch M, Pérez-Morga D, Schurmans S. | 04/7/2018 |
| identification of radixin as a PRG-2 interaction partner and showing that radixin accumulation in growth cones and its LPA-dependent phosphorylation depend on its binding to specific regions within the C-terminal region of PRG-2 | Precise Somatotopic Thalamocortical Axon Guidance Depends on LPA-Mediated PRG-2/Radixin Signaling.
Cheng J, Sahani S, Hausrat TJ, Yang JW, Ji H, Schmarowski N, Endle H, Liu X, Li Y, Böttche R, Radyushkin K, Maric HM, Hoerder-Suabedissen A, Molnár Z, Prouvot PH, Trimbuch T, Ninnemann O, Huai J, Fan W, Visentin B, Sabbadini R, Strømgaard K, Stroh A, Luhmann HJ, Kneussel M, Nitsch R, Vogt J., Free PMC Article | 10/7/2017 |
| This study describes a novel mechanism that regulates plasma receptor pools in the control of synaptic receptor density. | Radixin regulates synaptic GABAA receptor density and is essential for reversal learning and short-term memory.
Hausrat TJ, Muhia M, Gerrow K, Thomas P, Hirdes W, Tsukita S, Heisler FF, Herich L, Dubroqua S, Breiden P, Feldon J, Schwarz JR, Yee BK, Smart TG, Triller A, Kneussel M., Free PMC Article | 03/5/2016 |
| These results indicate that radixin plays an important role in regulating P-glycoprotein localization and P-glycoprotein functional activity at the intestinal membrane. | Contribution of radixin to P-glycoprotein expression and transport activity in mouse small intestine in vivo.
Yano K, Tomono T, Sakai R, Kano T, Morimoto K, Kato Y, Ogihara T. | 03/8/2014 |
| The specific location of radixin-positive cells in the peri-infarct region and in microglia suggests a role for radixin in microglial activation after stroke. | Radixin expression in microglia after cortical stroke lesion.
Persson Å, Osman A, Bolouri H, Mallard C, Kuhn HG. | 12/21/2013 |
| A Pak1-PP2A-ERM signaling axis mediates F-actin rearrangement and degranulation in mast cells. | A Pak1-PP2A-ERM signaling axis mediates F-actin rearrangement and degranulation in mast cells.
Staser K, Shew MA, Michels EG, Mwanthi MM, Yang FC, Clapp DW, Park SJ., Free PMC Article | 03/30/2013 |
| the extracellular matrix molecule VN and its neuronal receptor TLCN play a pivotal role in the phosphorylation of ezrin/radixin/moesin proteins and the formation of phagocytic cup-like structures on neuronal dendrites | Vitronectin induces phosphorylation of ezrin/radixin/moesin actin-binding proteins through binding to its novel neuronal receptor telencephalin.
Furutani Y, Kawasaki M, Matsuno H, Mitsui S, Mori K, Yoshihara Y., Free PMC Article | 02/2/2013 |
| Ezrin/radixin/moesin are required for the purinergic P2X7 receptor (P2X7R)-dependent processing of the amyloid precursor protein. | Ezrin/radixin/moesin are required for the purinergic P2X7 receptor (P2X7R)-dependent processing of the amyloid precursor protein.
Darmellah A, Rayah A, Auger R, Cuif MH, Prigent M, Arpin M, Alcover A, Delarasse C, Kanellopoulos JM., Free PMC Article | 01/5/2013 |
| The ERM (ezrin, radixin, moesin) proteins are novel scaffolds at the level of SOS activity control, which is relevant for both normal Ras function and dysfunction known to occur in several human cancers. | Activation of Ras requires the ERM-dependent link of actin to the plasma membrane.
Sperka T, Geissler KJ, Merkel U, Scholl I, Rubio I, Herrlich P, Morrison HL., Free PMC Article | 04/7/2012 |
| Ezrin-radixin-moesin (ERM) proteins are induced in activated microglia/macrophages, whereas ERM molecules are only marginally expressed in quiescent microglia in the normal brain. | Induction of ezrin-radixin-moesin molecules after cryogenic traumatic brain injury of the mouse cortex.
Moon Y, Kim JY, Choi SY, Kim K, Kim H, Sun W. | 03/10/2012 |
| Ezrin, radixin, and moesin are phosphorylated in response to 2-methoxyestradiol and modulate endothelial hyperpermeability. | Ezrin, radixin, and moesin are phosphorylated in response to 2-methoxyestradiol and modulate endothelial hyperpermeability.
Bogatcheva NV, Zemskova MA, Gorshkov BA, Kim KM, Daglis GA, Poirier C, Verin AD., Free PMC Article | 02/4/2012 |
| Results show that while CD43 binding to ezrin-radixin-moesin proteins is crucial for S76 phosphorylation, CD43 movement and regulation of T-cell migration can occur through an ERM-independent, phosphorylation-dependent mechanism. | CD43 interaction with ezrin-radixin-moesin (ERM) proteins regulates T-cell trafficking and CD43 phosphorylation.
Cannon JL, Mody PD, Blaine KM, Chen EJ, Nelson AD, Sayles LJ, Moore TV, Clay BS, Dulin NO, Shilling RA, Burkhardt JK, Sperling AI., Free PMC Article | 12/10/2011 |
| Radixin inactivation causes hyperbilirubinemia (likely due to a defect in the localization Multidrug resistance protein 2 in the bile canalicular membranes) and deafness due to progressive degeneration of cochlear stereocilia. (Review) | Emerging role for ERM proteins in cell adhesion and migration.
Arpin M, Chirivino D, Naba A, Zwaenepoel I., Free PMC Article | 08/13/2011 |
| Data suggest that myosin-II and ERM proteins modulate mechanical properties in oocytes, contributing to cell polarity and to completion of meiosis. | Cortical mechanics and meiosis II completion in mammalian oocytes are mediated by myosin-II and Ezrin-Radixin-Moesin (ERM) proteins.
Larson SM, Lee HJ, Hung PH, Matthews LM, Robinson DN, Evans JP., Free PMC Article | 02/26/2011 |
| The expression pattern demonstrated here suggests a role for radixin in neuronal migration and differentiation in the adult RMS. | Expression of ezrin radixin moesin proteins in the adult subventricular zone and the rostral migratory stream.
Persson A, Lindwall C, Curtis MA, Kuhn HG. | 06/28/2010 |
| argue for ezrin-radixin-moesin proteins being both targets and modulators of parvovirus infection | Ezrin-radixin-moesin family proteins are involved in parvovirus replication and spreading.
Nüesch JP, Bär S, Lachmann S, Rommelaere J., Free PMC Article | 01/21/2010 |
| These studies identify a new ERM kinase of importance in lymphocytes and confirm the role of ezrin-radixin-moesin phosphorylation in regulating cell shape and motility. | LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylation.
Belkina NV, Liu Y, Hao JJ, Karasuyama H, Shaw S., Free PMC Article | 01/21/2010 |
| These data identify the ERM proteins, which cross-link the plasma membrane and actin, as major and stable cytoskeletal-associated proteins in lens fibers, and indicate a potential role(s) for the ERMs in fiber cell actin cytoskeletal organization. | Characterization of lens fiber cell triton insoluble fraction reveals ERM (ezrin, radixin, moesin) proteins as major cytoskeletal-associated proteins.
Rao PV, Ho T, Skiba NP, Maddala R., Free PMC Article | 01/21/2010 |
| Ezrin/radixin/moesin proteins are activated by osmotic shrinkage in a PtdIns(4,5)-P(2)-dependent manner. | Osmotic cell shrinkage activates ezrin/radixin/moesin (ERM) proteins: activation mechanisms and physiological implications.
Rasmussen M, Alexander RT, Darborg BV, Møbjerg N, Hoffmann EK, Kapus A, Pedersen SF. | 01/21/2010 |
| Radixin knockout increases Mrp3 expression. | Effects of genetic backgrounds on hyperbilirubinemia in radixin-deficient mice due to different expression levels of Mrp3.
Fukumoto K, Kikuchi S, Itoh N, Tamura A, Hata M, Yamagishi H, Tsukita S, Tsukita S. | 01/21/2010 |
| cross talk between the blastocyst and uterus involving the ezrin/radixin/moesin (ERM) proteins and ERM-associated cytoskeletal cross-linker proteins CD43, CD44, ICAM-1, and ICAM-2 | Differential expression of ezrin/radixin/moesin (ERM) and ERM-associated adhesion molecules in the blastocyst and uterus suggests their functions during implantation.
Matsumoto H, Daikoku T, Wang H, Sato E, Dey SK. | 01/21/2010 |
| radixin has a role in preventing progressive degeneration of cochlear stereocilia and deafness | Radixin deficiency causes deafness associated with progressive degeneration of cochlear stereocilia.
Kitajiri S, Fukumoto K, Hata M, Sasaki H, Katsuno T, Nakagawa T, Ito J, Tsukita S, Tsukita S., Free PMC Article | 01/21/2010 |
| radixin via its C-terminal domain mediates gene transcription through activation of Rac1 and CaMKII | Radixin stimulates Rac1 and Ca2+/calmodulin-dependent kinase, CaMKII: cross-talk with Galpha13 signaling.
Liu G, Voyno-Yasenetskaya TA. | 01/21/2010 |