| Role and mechanism of REG2 depletion in insulin secretion augmented by glutathione peroxidase-1 overproduction. | Role and mechanism of REG2 depletion in insulin secretion augmented by glutathione peroxidase-1 overproduction.
Yan X, Zhao Z, Weaver J, Sun T, Yun JW, Roneker CA, Hu F, Doliba NM, McCormick CCW, Vatamaniuk MZ, Lei XG., Free PMC Article | 10/8/2022 |
| Normal expression of Reg2 gene is required for appropriate compensations in pancreatic islet proliferation and expansion in response to obesity and aging. | Reg2 Expression Is Required for Pancreatic Islet Compensation in Response to Aging and High-Fat Diet-Induced Obesity.
Li Q, Li B, Miao X, Ramgattie C, Gao ZH, Liu JL. | 09/9/2017 |
| mReg2 inhibits AIF-mediated apoptosis by promoting the nuclear presence of Scythe and inducing hsp70. | mReg2 inhibits nuclear entry of apoptosis-inducing factor in mouse insulinoma cells.
Liu L, Chowdhury S, Uppal S, Fang X, Liu JL, Srikant CB. | 11/28/2015 |
| Reg2 induces glucose-regulated peptide 78 (GRP78) expression via the Akt-mTORC1 axis. | Attenuation of unfolded protein response and apoptosis by mReg2 induced GRP78 in mouse insulinoma cells.
Liu L, Chowdhury S, Fang X, Liu JL, Srikant CB. | 07/12/2014 |
| Direct stimulation of Reg2 and Reg3beta genes by glucocorticoids. | Transcriptional activation of Reg2 and Reg3β genes by glucocorticoids and interleukin-6 in pancreatic acinar and islet cells.
Luo C, Li B, Liu L, Yin HP, Wang M, Liu JL. | 06/22/2013 |
| Reg2, Reg3alpha, and Reg3beta were abundantly expressed in most acinar cells of the pancreas with clear age-dependent and isoform-specific patterns. | Coordinated age-dependent and pancreatic-specific expression of mouse Reg2Reg3α, and Reg3β genes.
Wang Y, Jacovetti C, Li B, Siddique T, Xiong X, Yin H, Wang M, Zhao H, Liu JL. | 10/1/2011 |
| Reg2 protects MIN6 cells from streptozotocin-induced apoptosis by attenuating streptozotocin's ability to disrupt mitochondrial membrane integrity, activate caspase-3 and promote poly-ADP ribose polymerase cleavage, and induce apoptosis. | Reg2 protects mouse insulinoma cells from streptozotocin-induced mitochondrial disruption and apoptosis.
Liu L, Liu JL, Srikant CB. | 02/5/2011 |
| adjuvant immunotherapy regulates type 1 diabetes in diabetic mice and induces Reg2-mediated regeneration of beta cells | Adjuvant immunotherapy increases beta cell regenerative factor Reg2 in the pancreas of diabetic mice.
Huszarik K, Wright B, Keller C, Nikoopour E, Krougly O, Lee-Chan E, Qin HY, Cameron MJ, Gurr WK, Hill DJ, Sherwin RS, Kelvin DJ, Singh B. | 11/13/2010 |
| Overexpression of Reg2 gene offered no protection against streptozotocin-induced beta-cell damage and diabetes and did not protect acinar cells against caerulein-induced acute pancreatitis. | Pancreatic acinar-specific overexpression of Reg2 gene offered no protection against either experimental diabetes or pancreatitis in mice.
Li B, Wang X, Liu JL. | 09/6/2010 |
| RegII is a novel beta-cell-derived autoantigen in NOD mice. The autoimmune response against this protein may convert a regenerative into an islet-destructive process accelerating development of type 1 diabetes. [regII protein] | RegII is a beta-cell protein and autoantigen in diabetes of NOD mice.
Gurr W, Shaw M, Li Y, Sherwin R. | 01/21/2010 |
| Reg-II is a likely mouse exocrine pancreas cytoprotective candidate protein whose expression is regulated by keratin filament organization and phosphorylation | Reg-II is an exocrine pancreas injury-response product that is up-regulated by keratin absence or mutation.
Zhong B, Strnad P, Toivola DM, Tao GZ, Ji X, Greenberg HB, Omary MB., Free PMC Article | 01/21/2010 |
| Reg2 deficiency enhanced liver sensitivity to Fas-induced oxidative stress and delayed liver regeneration with persistent TNF-alpha/IL6/STAT3 signaling. | Reg2 inactivation increases sensitivity to Fas hepatotoxicity and delays liver regeneration post-hepatectomy in mice.
Lieu HT, Simon MT, Nguyen-Khoa T, Kebede M, Cortes A, Tebar L, Smith AJ, Bayne R, Hunt SP, Bréchot C, Christa L. | 01/21/2010 |