| Epidermal RORalpha Maintains Barrier Integrity and Prevents Allergic Inflammation by Regulating Late Differentiation and Lipid Metabolism. | Epidermal RORα Maintains Barrier Integrity and Prevents Allergic Inflammation by Regulating Late Differentiation and Lipid Metabolism.
Hua X, Ficaro MK, Wallace NL, Dai J., Free PMC Article | 10/23/2024 |
| RORalpha-GABP-TFAM axis alleviates myosteatosis with fatty atrophy through reinforcement of mitochondrial capacity. | RORα-GABP-TFAM axis alleviates myosteatosis with fatty atrophy through reinforcement of mitochondrial capacity.
Kim HJ, Lee SH, Jeong C, Han YH, Lee MO., Free PMC Article | 04/11/2024 |
| RORalpha is required for expansion and memory maintenance of ILC1s via a lymph node-liver axis. | RORα is required for expansion and memory maintenance of ILC1s via a lymph node-liver axis.
Cheng M, Li J, Song J, Song H, Chen Y, Tang H, Wei H, Sun R, Tian Z, Wang X, Peng H. | 03/5/2024 |
| Mechanism of lncRNA HOTAIR in attenuating cardiomyocyte pyroptosis in mice with heart failure via the miR-17-5p/RORA axis. | Mechanism of lncRNA HOTAIR in attenuating cardiomyocyte pyroptosis in mice with heart failure via the miR-17-5p/RORA axis.
He L, Lu F, Zhang F, Fan S, Xu J. | 12/26/2023 |
| RORalpha overexpression reduced interleukin-33 expression and prevented mast cell degranulation and inflammation by inducing autophagy in allergic rhinitis. | RORα overexpression reduced interleukin-33 expression and prevented mast cell degranulation and inflammation by inducing autophagy in allergic rhinitis.
Yu W, Du J, Peng L, Zhang T., Free PMC Article | 11/1/2023 |
| MicroRNA-155 suppressed cholesterol-induced matrix degradation, pyroptosis and apoptosis by targeting RORalpha in nucleus pulposus cells. | MicroRNA-155 suppressed cholesterol-induced matrix degradation, pyroptosis and apoptosis by targeting RORα in nucleus pulposus cells.
Qin T, Yan J, Li S, Lin X, Wu J, Huang Z, Zhang C, Zhang Y, Deng Z, Xiao D, Jin S, Xiao Y, Xu K, Ye W. | 05/17/2023 |
| Maternal diabetes-mediated RORA suppression contributes to gastrointestinal symptoms in autism-like mouse offspring. | Maternal diabetes-mediated RORA suppression contributes to gastrointestinal symptoms in autism-like mouse offspring.
Xiao L, Wang M, Zhang W, Song Y, Zeng J, Li H, Yu H, Li L, Gao P, Yao P., Free PMC Article | 05/14/2022 |
| RORalpha is critical for mTORC1 activity in T cell-mediated colitis. | RORα is critical for mTORC1 activity in T cell-mediated colitis.
Chi X, Jin W, Bai X, Zhao X, Shao J, Li J, Sun Q, Su B, Wang X, Yang XO, Dong C. | 02/19/2022 |
| The nuclear receptor RORalpha preserves cardiomyocyte mitochondrial function by regulating caveolin-3-mediated mitophagy. | The nuclear receptor RORα preserves cardiomyocyte mitochondrial function by regulating caveolin-3-mediated mitophagy.
Beak JY, Kang HS, Huang W, Deshmukh R, Hong SJ, Kadakia N, Aghajanian A, Gerrish K, Jetten A, Jensen B., Free PMC Article | 02/19/2022 |
| RORalpha contributes to the maintenance of genome ploidy in the liver of mice with diet-induced nonalcoholic steatohepatitis. | RORα contributes to the maintenance of genome ploidy in the liver of mice with diet-induced nonalcoholic steatohepatitis.
Kim JY, Yang IS, Kim HJ, Yoon JY, Han YH, Seong JK, Lee MO. | 02/12/2022 |
| Inhibition of nuclear receptor RORalpha attenuates cartilage damage in osteoarthritis by modulating IL-6/STAT3 pathway. | Inhibition of nuclear receptor RORα attenuates cartilage damage in osteoarthritis by modulating IL-6/STAT3 pathway.
Liang T, Chen T, Qiu J, Gao W, Qiu X, Zhu Y, Wang X, Chen Y, Zhou H, Deng Z, Li P, Xu C, Peng Y, Liang A, Su P, Gao B, Huang D., Free PMC Article | 02/5/2022 |
| Functions for Retinoic Acid-Related Orphan Receptor Alpha (RORalpha) in the Activation of Macrophages During Lipopolysaccharide-Induced Septic Shock. | Functions for Retinoic Acid-Related Orphan Receptor Alpha (RORα) in the Activation of Macrophages During Lipopolysaccharide-Induced Septic Shock.
Hams E, Roberts J, Bermingham R, Fallon PG., Free PMC Article | 10/9/2021 |
| Loss of retinoic acid receptor-related receptor alpha (Roralpha) promotes the progression of UV-induced cSCC. | Loss of retinoic acid receptor-related receptor alpha (Rorα) promotes the progression of UV-induced cSCC.
Zhang G, Yan G, Fu Z, Wu Y, Wu F, Zheng Z, Fang S, Gao Y, Bao X, Liu Y, Wang X, Zhu S., Free PMC Article | 09/18/2021 |
| RORalpha regulates hepatic lipolysis by inducing transcriptional expression of PNPLA3 in mice. | RORα regulates hepatic lipolysis by inducing transcriptional expression of PNPLA3 in mice.
Han YH, Kim HJ, Lee MO. | 08/14/2021 |
| Role for Retinoic Acid-Related Orphan Receptor Alpha (RORalpha) Expressing Macrophages in Diet-Induced Obesity. | Role for Retinoic Acid-Related Orphan Receptor Alpha (RORα) Expressing Macrophages in Diet-Induced Obesity.
Hams E, Roberts J, Bermingham R, Hogan AE, O'Shea D, O'Neill L, Fallon PG., Free PMC Article | 05/1/2021 |
| RORalpha is a critical checkpoint for T cell and ILC2 commitment in the embryonic thymus. | RORα is a critical checkpoint for T cell and ILC2 commitment in the embryonic thymus.
Ferreira ACF, Szeto ACH, Heycock MWD, Clark PA, Walker JA, Crisp A, Barlow JL, Kitching S, Lim A, Gogoi M, Berks R, Daly M, Jolin HE, McKenzie ANJ., Free PMC Article | 04/13/2021 |
| Deletion of the nuclear receptor RORalpha in macrophages does not modify the development of obesity, insulin resistance and NASH. | Deletion of the nuclear receptor RORα in macrophages does not modify the development of obesity, insulin resistance and NASH.
L'homme L, Sermikli BP, Molendi-Coste O, Fleury S, Quemener S, Le Maître M, Joseph ML, Pineau L, Duhem C, Gross B, Vallez E, Tailleux A, Staels B, Dombrowicz D., Free PMC Article | 03/20/2021 |
| Pharmacological modulation of RORalpha controls fat browning, adaptive thermogenesis, and body weight in mice. | Pharmacological modulation of RORα controls fat browning, adaptive thermogenesis, and body weight in mice.
Auclair M, Roblot N, Capel E, Fève B, Antoine B., Free PMC Article | 03/6/2021 |
| Genetic and pharmacological inhibition of the nuclear receptor RORalpha regulates TH17 driven inflammatory disorders. | Genetic and pharmacological inhibition of the nuclear receptor RORα regulates T(H)17 driven inflammatory disorders.
Wang R, Campbell S, Amir M, Mosure SA, Bassette MA, Eliason A, Sundrud MS, Kamenecka TM, Solt LA., Free PMC Article | 01/16/2021 |
| Retinoic Acid Receptor-Related Receptor Alpha Ameliorates Autoimmune Arthritis via Inhibiting of Th17 Cells and Osteoclastogenesis. | Retinoic Acid Receptor-Related Receptor Alpha Ameliorates Autoimmune Arthritis via Inhibiting of Th17 Cells and Osteoclastogenesis.
Park JS, Moon SJ, Lim MA, Byun JK, Hwang SH, Yang S, Kim EK, Lee H, Kim SM, Lee J, Kwok SK, Min JK, Lee MO, Shin DY, Park SH, Cho ML., Free PMC Article | 11/21/2020 |
| Single-cell analysis of RORalpha tracer mouse lung reveals ILC progenitors and effector ILC2 subsets. | Single-cell analysis of RORα tracer mouse lung reveals ILC progenitors and effector ILC2 subsets.
Ghaedi M, Shen ZY, Orangi M, Martinez-Gonzalez I, Wei L, Lu X, Das A, Heravi-Moussavi A, Marra MA, Bhandoola A, Takei F., Free PMC Article | 10/31/2020 |
| RORalpha suppresses interleukin-6-mediated hepatic acute phase response. | RORα suppresses interleukin-6-mediated hepatic acute phase response.
Kim JY, Han YH, Nam MW, Kim HJ, Lee MO., Free PMC Article | 10/24/2020 |
| Loss of RAR-related orphan receptor alpha (RORalpha) selectively lowers docosahexaenoic acid in developing cerebellum. | Loss of RAR-related orphan receptor alpha (RORα) selectively lowers docosahexaenoic acid in developing cerebellum.
Chen CT, Schultz JA, Haven SE, Wilhite B, Liu CH, Chen J, Hibbeln JR., Free PMC Article | 10/3/2020 |
| RORalpha autoregulates its transcription via MLL4-associated enhancer remodeling in the liver. | RORα autoregulates its transcription via MLL4-associated enhancer remodeling in the liver.
Han YH, Kim HJ, Choi H, Lee S, Lee MO. | 09/5/2020 |
| essential regulator of both qualitative and quantitative testicular structure | Retinoid-related orphan nuclear receptor alpha (RORα)-deficient mice display morphological testicular defects.
Sayed RKA, Mokhtar DM, Fernández-Ortiz M, Escames G, Acuña-Castroviejo D. | 07/4/2020 |