| Emerin mislocalization during chromatin bridge resolution can drive prostate cancer cell invasiveness in a collagen-rich microenvironment. | Emerin mislocalization during chromatin bridge resolution can drive prostate cancer cell invasiveness in a collagen-rich microenvironment.
Popęda M, Kowalski K, Wenta T, Beznoussenko GV, Rychłowski M, Mironov A, Lavagnino Z, Barozzi S, Richert J, Bertolio R, Myszczyński K, Szade J, Bieńkowski M, Miszewski K, Matuszewski M, Żaczek AJ, Braga L, Del Sal G, Bednarz-Knoll N, Maiuri P, Nastały P., Free PMC Article | 10/8/2024 |
| Acute downregulation of emerin alters actomyosin cytoskeleton connectivity and function. | Acute downregulation of emerin alters actomyosin cytoskeleton connectivity and function.
Jin Q, Pandey D, Thompson CB, Lewis S, Sung HW, Nguyen TD, Kuo S, Wilson KL, Gracias DH, Romer LH., Free PMC Article | 09/22/2023 |
| Emerin prevents BAF-mediated aggregation of lamin A on chromosomes in telophase to allow nuclear membrane expansion and nuclear lamina formation. | Emerin prevents BAF-mediated aggregation of lamin A on chromosomes in telophase to allow nuclear membrane expansion and nuclear lamina formation.
Snyers L, Löhnert R, Weipoltshammer K, Schöfer C., Free PMC Article | 11/26/2022 |
| ISGylation of EMD promotes its interaction with PDHA to inhibit aerobic oxidation in lung adenocarcinoma. | ISGylation of EMD promotes its interaction with PDHA to inhibit aerobic oxidation in lung adenocarcinoma.
Zhang C, Cui J, Cao L, Tian X, Miao Y, Wang Y, Qiu S, Guo W, Ma L, Xia J, Zhang X., Free PMC Article | 10/15/2022 |
| Emerin knockdown induces the migration and invasion of hepatocellular carcinoma cells by up-regulating the cytoplasmic p21. | Emerin knockdown induces the migration and invasion of hepatocellular carcinoma cells by up-regulating the cytoplasmic p21.
Wu KY, Xie H, Zhang ZL, Li ZX, Shi L, Zhou W, Zeng J, Tian Z, Zhang Y, Ding YB, Shen WG. | 02/19/2022 |
| Defects in Emerin-Nucleoskeleton Binding Disrupt Nuclear Structure and Promote Breast Cancer Cell Motility and Metastasis. | Defects in Emerin-Nucleoskeleton Binding Disrupt Nuclear Structure and Promote Breast Cancer Cell Motility and Metastasis.
Liddane AG, McNamara CA, Campbell MC, Mercier I, Holaska JM., Free PMC Article | 01/29/2022 |
| Immunohistochemical Expression of Emerin in Renal Cell Carcinomas: Does It Contribute to Histopathological Features and WHO/ISUP Grading in Predicting Prognosis? | Immunohistochemical Expression of Emerin in Renal Cell Carcinomas: Does It Contribute to Histopathological Features and WHO/ISUP Grading in Predicting Prognosis?
Argon A, Dal G, Salman T. | 04/13/2021 |
| Emerin Phosphorylation during the Early Phase of the Oxidative Stress Response Influences Emerin-BAF Interaction and BAF Nuclear Localization. | Emerin Phosphorylation during the Early Phase of the Oxidative Stress Response Influences Emerin-BAF Interaction and BAF Nuclear Localization.
Cenni V, Squarzoni S, Loi M, Mattioli E, Lattanzi G, Capanni C., Free PMC Article | 03/6/2021 |
| The Molecular Basis and Biologic Significance of the beta-Dystroglycan-Emerin Interaction. | The Molecular Basis and Biologic Significance of the β-Dystroglycan-Emerin Interaction.
Gómez-Monsivais WL, Monterrubio-Ledezma F, Huerta-Cantillo J, Mondragon-Gonzalez R, Alamillo-Iniesta A, García-Aguirre I, Azuara-Medina PM, Arguello-García R, Rivera-Monroy JE, Holaska JM, Hernández-Méndez JME, Garrido E, Magaña JJ, Winder SJ, Brancaccio A, Martínez-Vieyra I, Navarro-Garcia F, Cisneros B., Free PMC Article | 02/20/2021 |
| Taken together, these studies underscore a remarkable interplay between Lamin A/C and Emerin in modulating cytoskeletal organization of actin and NM1 that impinges on chromatin dynamics and function in the interphase nucleus. | Lamin A/C and Emerin depletion impacts chromatin organization and dynamics in the interphase nucleus.
Ranade D, Pradhan R, Jayakrishnan M, Hegde S, Sengupta K., Free PMC Article | 03/14/2020 |
| EmeryDreifuss muscular dystrophy type 1 phenotype may be strengthened by the toxicity of truncated emerin expressed in patients with certain nonsense mutations in EMD. | Emerin Is Required for Proper Nucleus Reassembly after Mitosis: Implications for New Pathogenetic Mechanisms for Laminopathies Detected in EDMD1 Patients.
Dubińska-Magiera M, Kozioł K, Machowska M, Piekarowicz K, Filipczak D, Rzepecki R., Free PMC Article | 12/7/2019 |
| emerin is a mediator of nuclear shape stability in cancer; destabilization of emerin can promote metastasis | Emerin Deregulation Links Nuclear Shape Instability to Metastatic Potential.
Reis-Sobreiro M, Chen JF, Novitskaya T, You S, Morley S, Steadman K, Gill NK, Eskaros A, Rotinen M, Chu CY, Chung LWK, Tanaka H, Yang W, Knudsen BS, Tseng HR, Rowat AC, Posadas EM, Zijlstra A, Di Vizio D, Freeman MR. | 10/12/2019 |
| Dimerization of barrier to autointegration factor 1 protein (BAF) is essential for both lamin A/C and emerin binding. | Structural analysis of the ternary complex between lamin A/C, BAF and emerin identifies an interface disrupted in autosomal recessive progeroid diseases.
Samson C, Petitalot A, Celli F, Herrada I, Ropars V, Le Du MH, Nhiri N, Jacquet E, Arteni AA, Buendia B, Zinn-Justin S., Free PMC Article | 07/13/2019 |
| Hop stabilises emerin and that loss of Hop alters nuclear structure via emerin degradation. | Hop/STIP1 depletion alters nuclear structure via depletion of nuclear structural protein emerin.
Kituyi SN, Edkins AL. | 05/18/2019 |
| Study data revealed that low expression of emerin contributes not only to the oval shape of nuclei, but also to the enlargement in nuclear size in lung adenocarcinoma pathological specimens. | Image analysis of the nuclear characteristics of emerin protein and the correlation with nuclear grooves and intranuclear cytoplasmic inclusions in lung adenocarcinoma.
Kobayashi S, Saio M, Fukuda T, Kimura K, Hirato J, Oyama T., Free PMC Article | 02/2/2019 |
| Emerin plays a crucial role in nuclear invagination and in the nuclear calcium transient in Emery-Dreifuss muscular dystrophy. | Emerin plays a crucial role in nuclear invagination and in the nuclear calcium transient.
Shimojima M, Yuasa S, Motoda C, Yozu G, Nagai T, Ito S, Lachmann M, Kashimura S, Takei M, Kusumoto D, Kunitomi A, Hayashiji N, Seki T, Tohyama S, Hashimoto H, Kodaira M, Egashira T, Hayashi K, Nakanishi C, Sakata K, Yamagishi M, Fukuda K., Free PMC Article | 11/10/2018 |
| evaluation of the diagnostic value of emerin and CD56 in papillary thyroid carcinoma, using immunohistochemistry | Evaluation of the diagnostic value of emerin and CD56 in papillary thyroid carcinoma - an immunohistochemical study.
Abdou AG, Abdelwahed M, Said A, Taie DM, Fahmy S. | 10/27/2018 |
| the mobility of YFP-Emerin was higher in Samp1 knock out cells and lower in cells overexpressing Samp1, suggesting that Samp1 significantly attenuates the mobility of Emerin in the nuclear envelope. The mobility of Emerin depends on RanGTP. The affinity between Samp1 and Emerin is decreased in the presence of Ran, suggesting that Ran attenuates the interaction between Samp1 and Emerin. | RanGTPase regulates the interaction between the inner nuclear membrane proteins, Samp1 and Emerin.
Vijayaraghavan B, Figueroa RA, Bergqvist C, Gupta AJ, Sousa P, Hallberg E. | 08/18/2018 |
| Epstein-Barr virus early lytic protein BFRF1 alters emerin distribution and post-translational modifications. | EBV early lytic protein BFRF1 alters emerin distribution and post-translational modification.
Yadav S, Libotte F, Buono E, Valia S, Farina GA, Faggioni A, Farina A. | 12/23/2017 |
| results indicate that emerin negatively regulates Notch signaling by promoting the retention of the NICD at the nuclear membrane | Emerin suppresses Notch signaling by restricting the Notch intracellular domain to the nuclear membrane.
Lee B, Lee TH, Shim J. | 06/24/2017 |
| It has been concluded that the LEM domain, responsible for binding to the chromatin protein BAF, undergoes a conformational change during self-assembly of emerin N-terminal region. | Emerin self-assembly mechanism: role of the LEM domain.
Samson C, Celli F, Hendriks K, Zinke M, Essawy N, Herrada I, Arteni AA, Theillet FX, Alpha-Bazin B, Armengaud J, Coirault C, Lange A, Zinn-Justin S. | 06/24/2017 |
| X-linked Emery-Dreifuss muscular dystrophy may occur along with dilative cardiomyopathy. | Dilated, arrhythmogenic cardiomyopathy in emery-dreifuss muscular dystrophy due to the emerin splice-site mutation c.449 + 1G>A.
Finsterer J, Stöllberger C, Sehnal E, Rehder H, Laccone F. | 10/3/2015 |
| Association of emerin with nuclear BAF in cells required the LEM domain (residues 1-47). | The molecular basis of emerin-emerin and emerin-BAF interactions.
Berk JM, Simon DN, Jenkins-Houk CR, Westerbeck JW, Grønning-Wang LM, Carlson CR, Wilson KL., Free PMC Article | 06/27/2015 |
| These data suggest a new role of EMD as an enhancer of autophagosome formation in the C16-ceramide autophagy pathway in colon cancer cells. | New role for EMD (emerin), a key inner nuclear membrane protein, as an enhancer of autophagosome formation in the C16-ceramide autophagy pathway.
Deroyer C, Rénert AF, Merville MP, Fillet M., Free PMC Article | 02/28/2015 |
| Results highlight the interactions at the nuclear envelope where mutations in the EMD and TMPO gene in combination with mutations in SUN1 have an impact on several components of the network. | Contribution of SUN1 mutations to the pathomechanism in muscular dystrophies.
Li P, Meinke P, Huong le TT, Wehnert M, Noegel AA. | 01/31/2015 |