| Germline- and Somatic-Inactivating FLCN Variants in Parathyroid Cancer and Atypical Parathyroid Tumors. | Germline- and Somatic-Inactivating FLCN Variants in Parathyroid Cancer and Atypical Parathyroid Tumors.
Jha S, Welch J, Tora R, Lack J, Warner A, Del Rivero J, Sadowski SM, Nilubol N, Schmidt LS, Linehan WM, Weinstein LS, Simonds WF, Agarwal SK., Free PMC Article | 09/20/2023 |
| Progress in Adrenal Cortical Neoplasms: From Predictive Histomorphology to FLCN-Driven Germline Pathogenesis and the Prognostic Performance of Multiparameter Scoring Systems in Pediatric Adrenal Cortical Neoplasms. | Progress in Adrenal Cortical Neoplasms: From Predictive Histomorphology to FLCN-Driven Germline Pathogenesis and the Prognostic Performance of Multiparameter Scoring Systems in Pediatric Adrenal Cortical Neoplasms.
Mete O, Juhlin CC. | 06/22/2023 |
| Role of FLCN Phosphorylation in Insulin-Mediated mTORC1 Activation and Tumorigenesis. | Role of FLCN Phosphorylation in Insulin-Mediated mTORC1 Activation and Tumorigenesis.
Wang G, Chen L, Lei X, Qin S, Geng H, Zheng Y, Xia C, Yao J, Meng T, Deng L., Free PMC Article | 06/15/2023 |
| Folliculin Prevents Lysosomal Degradation of Human Papillomavirus To Support Infectious Cell Entry. | Folliculin Prevents Lysosomal Degradation of Human Papillomavirus To Support Infectious Cell Entry.
Ishii Y, Yamaji T, Sekizuka T, Homma Y, Mori S, Takeuchi T, Kukimoto I., Free PMC Article | 06/2/2023 |
| Exons 1-3 deletion in FLCN is associated with increased risk of pneumothorax in Chinese patients with Birt-Hogg-Dube syndrome. | Exons 1-3 deletion in FLCN is associated with increased risk of pneumothorax in Chinese patients with Birt-Hogg-Dubé syndrome.
Wang Y, Cai M, Jiang X, Lv G, Hu D, Zhang G, Liu J, Wei W, Xiao J, Shen B, Ryu JH, Hu X., Free PMC Article | 05/15/2023 |
| PRDM10 directs FLCN expression in a novel disorder overlapping with Birt-Hogg-Dube syndrome and familial lipomatosis. | PRDM10 directs FLCN expression in a novel disorder overlapping with Birt-Hogg-Dubé syndrome and familial lipomatosis.
van de Beek I, Glykofridis IE, Oosterwijk JC, van den Akker PC, Diercks GFH, Bolling MC, Waisfisz Q, Mensenkamp AR, Balk JA, Zwart R, Postma AV, Meijers-Heijboer HEJ, van Moorselaar RJA, Wolthuis RMF, Houweling AC., Free PMC Article | 03/24/2023 |
| Combined germline pathogenic variants in FLCN and TP53 are associated with early onset renal cell carcinoma and brain tumors. | Combined germline pathogenic variants in FLCN and TP53 are associated with early onset renal cell carcinoma and brain tumors.
van de Beek I, Glykofridis IE, Wagner A, den Toom DT, Bongers EMHF, van Leenders GJLH, Johannesma PC, Meijers-Heijboer HEJ, Wolthuis RMF, van Steensel MAM, Dubbink HJ, Houweling AC., Free PMC Article | 02/27/2023 |
| Phosphoproteomic Analysis of FLCN Inactivation Highlights Differential Kinase Pathways and Regulatory TFEB Phosphoserines. | Phosphoproteomic Analysis of FLCN Inactivation Highlights Differential Kinase Pathways and Regulatory TFEB Phosphoserines.
Glykofridis IE, Henneman AA, Balk JA, Goeij-de Haas R, Westland D, Piersma SR, Knol JC, Pham TV, Boekhout M, Zwartkruis FJT, Wolthuis RMF, Jimenez CR., Free PMC Article | 10/8/2022 |
| Frequency of truncating FLCN variants and Birt-Hogg-Dube-associated phenotypes in a health care system population. | Frequency of truncating FLCN variants and Birt-Hogg-Dubé-associated phenotypes in a health care system population.
Savatt JM, Shimelis H, Moreno-De-Luca A, Strande NT, Oetjens MT, Ledbetter DH, Martin CL, Myers SM, Finucane BM., Free PMC Article | 09/17/2022 |
| A systematic review assessing the existence of pneumothorax-only variants of FLCN. Implications for lifelong surveillance of renal tumours. | A systematic review assessing the existence of pneumothorax-only variants of FLCN. Implications for lifelong surveillance of renal tumours.
Matsumoto K, Lim D, Pharoah PD, Maher ER, Marciniak SJ., Free PMC Article | 05/14/2022 |
| Genetic insight into Birt-Hogg-Dube syndrome in Indian patients reveals novel mutations at FLCN. | Genetic insight into Birt-Hogg-Dubé syndrome in Indian patients reveals novel mutations at FLCN.
Ray A, Chattopadhyay E, Singh R, Ghosh S, Bera A, Sarma M, Munot M, Desai U, Rajan S, Prabhudesai P, Prakash AK, Roy Chowdhury S, Bhowmick N, Dhar R, Udwadia ZF, Dey A, Mitra S, Joshi JM, Maitra A, Roy B., Free PMC Article | 05/14/2022 |
| A retrospective two centre study of Birt-Hogg-Dube syndrome reveals a pathogenic founder mutation in FLCN in the Swedish population. | A retrospective two centre study of Birt-Hogg-Dubé syndrome reveals a pathogenic founder mutation in FLCN in the Swedish population.
Lagerstedt-Robinson K, Baranowska Körberg I, Tsiaprazis S, Björck E, Tham E, Poluha A, Hellström Pigg M, Paulsson-Karlsson Y, Nordenskjöld M, Johansson-Soller M, Aravidis C., Free PMC Article | 04/30/2022 |
| Loss of FLCN-FNIP1/2 induces a non-canonical interferon response in human renal tubular epithelial cells. | Loss of FLCN-FNIP1/2 induces a non-canonical interferon response in human renal tubular epithelial cells.
Glykofridis IE, Knol JC, Balk JA, Westland D, Pham TV, Piersma SR, Lougheed SM, Derakhshan S, Veen P, Rooimans MA, van Mil SE, Böttger F, Poddighe PJ, van de Beek I, Drost J, Zwartkruis FJ, de Menezes RX, Meijers-Heijboer HE, Houweling AC, Jimenez CR, Wolthuis RM., Free PMC Article | 02/5/2022 |
| The tumor suppressor Folliculin also known as FLCN, functions as an intracellular uncompetitive inhibitor of Lactate Dehydrogenase-A and a regulator of the Warburg effect. | The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect.
Woodford MR, Baker-Williams AJ, Sager RA, Backe SJ, Blanden AR, Hashmi F, Kancherla P, Gori A, Loiselle DR, Castelli M, Serapian SA, Colombo G, Haystead TA, Jensen SM, Stetler-Stevenson WG, Loh SN, Schmidt LS, Linehan WM, Bah A, Bourboulia D, Bratslavsky G, Mollapour M., Free PMC Article | 12/29/2021 |
| Folliculin impairs breast tumor growth by repressing TFE3-dependent induction of the Warburg effect and angiogenesis. | Folliculin impairs breast tumor growth by repressing TFE3-dependent induction of the Warburg effect and angiogenesis.
El-Houjeiri L, Biondini M, Paquette M, Kuasne H, Pacis A, Park M, Siegel PM, Pause A., Free PMC Article | 12/18/2021 |
| Folliculin haploinsufficiency causes cellular dysfunction of pleural mesothelial cells. | Folliculin haploinsufficiency causes cellular dysfunction of pleural mesothelial cells.
Okamoto S, Ebana H, Kurihara M, Mitani K, Kobayashi E, Hayashi T, Sekimoto Y, Nishino K, Otsuji M, Kumasaka T, Takahashi K, Seyama K., Free PMC Article | 11/6/2021 |
| Quantitative genetic screening reveals a Ragulator-FLCN feedback loop that regulates the mTORC1 pathway. | Quantitative genetic screening reveals a Ragulator-FLCN feedback loop that regulates the mTORC1 pathway.
De Zan E, van Stiphout R, Gapp BV, Blomen VA, Brummelkamp TR, Nijman SMB. | 10/30/2021 |
| Intratumoral heterogeneity of FLCN somatic mutations in gastric and colorectal cancers. | Intratumoral heterogeneity of FLCN somatic mutations in gastric and colorectal cancers.
Son HJ, Choi EJ, Yoo NJ, Lee SH. | 10/9/2021 |
| Novel folliculin gene mutations in Polish patients with Birt-Hogg-Dube syndrome. | Novel folliculin gene mutations in Polish patients with Birt-Hogg-Dubé syndrome.
Radzikowska E, Lechowicz U, Winek J, Opoka L., Free PMC Article | 09/18/2021 |
| FLCN regulates transferrin receptor 1 transport and iron homeostasis. | FLCN regulates transferrin receptor 1 transport and iron homeostasis.
Wang X, Wu H, Zhao L, Liu Z, Qi M, Jin Y, Liu W., Free PMC Article | 08/28/2021 |
| Ciliary localization of folliculin mediated via a kinesin-2-binding motif is required for its functions in mTOR regulation and tumor suppression. | Ciliary localization of folliculin mediated via a kinesin-2-binding motif is required for its functions in mTOR regulation and tumor suppression.
Zhang Y, Liu Y, Dai Y, Ren Y, Bao G, Ai B, Jiang Y., Free PMC Article | 07/10/2021 |
| New Developments in the Pathogenesis of Pulmonary Cysts in Birt-Hogg-Dube Syndrome. | New Developments in the Pathogenesis of Pulmonary Cysts in Birt-Hogg-Dubé Syndrome.
Kennedy JC, Khabibullin D, Boku Y, Shi W, Henske EP. | 07/10/2021 |
| Blood and lymphatic systems are segregated by the FLCN tumor suppressor. | Blood and lymphatic systems are segregated by the FLCN tumor suppressor.
Tai-Nagara I, Hasumi Y, Kusumoto D, Hasumi H, Okabe K, Ando T, Matsuzaki F, Itoh F, Saya H, Liu C, Li W, Mukouyama YS, Marston Linehan W, Liu X, Hirashima M, Suzuki Y, Funasaki S, Satou Y, Furuya M, Baba M, Kubota Y., Free PMC Article | 01/9/2021 |
| Folliculin variants linked to Birt-Hogg-Dube syndrome are targeted for proteasomal degradation. | Folliculin variants linked to Birt-Hogg-Dubé syndrome are targeted for proteasomal degradation.
Clausen L, Stein A, Grønbæk-Thygesen M, Nygaard L, Søltoft CL, Nielsen SV, Lisby M, Ravid T, Lindorff-Larsen K, Hartmann-Petersen R., Free PMC Article | 01/9/2021 |
| FLCN alteration drives metabolic reprogramming towards nucleotide synthesis and cyst formation in salivary gland. | FLCN alteration drives metabolic reprogramming towards nucleotide synthesis and cyst formation in salivary gland.
Isono Y, Furuya M, Kuwahara T, Sano D, Suzuki K, Jikuya R, Mitome T, Otake S, Kawahara T, Ito Y, Muraoka K, Nakaigawa N, Kimura Y, Baba M, Nagahama K, Takahata H, Saito I, Schmidt LS, Linehan WM, Kodama T, Yao M, Oridate N, Hasumi H., Free PMC Article | 09/5/2020 |