| Influence of proteolytic cleavage of ENaC's gamma subunit upon Na[+] and K[+] handling. | Influence of proteolytic cleavage of ENaC's γ subunit upon Na(+) and K(+) handling.
Ray EC, Nickerson A, Sheng S, Carrisoza-Gaytan R, Lam T, Marciszyn A, Zhang L, Jordahl A, Bi C, Winfrey A, Kou Z, Gingras S, Kirabo A, Satlin LM, Kleyman TR., | 06/7/2024 |
| Deletion of the Gamma Subunit of ENaC in Endothelial Cells Does Not Protect against Renal Ischemia Reperfusion Injury. | Deletion of the Gamma Subunit of ENaC in Endothelial Cells Does Not Protect against Renal Ischemia Reperfusion Injury.
Mutchler SM, Hasan M, Kohan DE, Kleyman TR, Tan RJ., Free PMC Article | 12/18/2021 |
| Salt sensitivity of volume and blood pressure in a mouse with globally reduced ENaC gamma-subunit expression. | Salt sensitivity of volume and blood pressure in a mouse with globally reduced ENaC γ-subunit expression.
Ray EC, Pitzer A, Lam T, Jordahl A, Patel R, Ao M, Marciszyn A, Winfrey A, Barak Y, Sheng S, Kirabo A, Kleyman TR., Free PMC Article | 12/11/2021 |
| Endothelial epithelial sodium channel involves in high-fat diet-induced atherosclerosis in low-density lipoprotein receptor-deficient mice. | Endothelial epithelial sodium channel involves in high-fat diet-induced atherosclerosis in low-density lipoprotein receptor-deficient mice.
Niu N, Yang X, Zhang BL, Liang C, Zhu D, Wang QS, Cai YX, Yang YC, Ao X, Wu MM, Zhang ZR. | 04/17/2021 |
| Interaction between Epithelial Sodium Channel gamma-Subunit and Claudin-8 Modulates Paracellular Sodium Permeability in Renal Collecting Duct. | Interaction between Epithelial Sodium Channel γ-Subunit and Claudin-8 Modulates Paracellular Sodium Permeability in Renal Collecting Duct.
Sassi A, Wang Y, Chassot A, Komarynets O, Roth I, Olivier V, Crambert G, Dizin E, Boscardin E, Hummler E, Feraille E., Free PMC Article | 01/2/2021 |
| Apical fluid shear stress specifically downregulates beta-ENaC and gamma-ENaC subunits at the transcriptional level through an unidentified heat-insensitive paracrine basolateral factor in collecting duct principal cells. | Uninephrectomy and apical fluid shear stress decrease ENaC abundance in collecting duct principal cells.
Ernandez T, Udwan K, Chassot A, Martin PY, Feraille E. | 09/7/2019 |
| the results of the present study demonstrated that insulin protected the lung epithelium and attenuated pulmonary edema through the upregulation of ENaC via the PI3K/SGK1 pathway in LPSinduced lung injury. | Insulin ameliorates pulmonary edema through the upregulation of epithelial sodium channel via the PI3K/SGK1 pathway in mice with lipopolysaccharide‑induced lung injury.
Deng W, Li CY, Tong J, He J, Zhao Y, Wang DX., Free PMC Article | 05/25/2019 |
| Casein kinase 2 phosphorylation is an important regulator of ENaC activity and sodium handling by the aldosterone sensitive distal nephron. | Physiological regulation of the epithelial Na(+) channel by casein kinase II.
Berman JM, Mironova E, Stockand JD., Free PMC Article | 05/4/2019 |
| N-linked glycans on each subunit are required for proper folding, maturation, surface expression, and function of the epithelial sodium channel. | N-linked glycans are required on epithelial Na(+) channel subunits for maturation and surface expression.
Kashlan OB, Kinlough CL, Myerburg MM, Shi S, Chen J, Blobner BM, Buck TM, Brodsky JL, Hughey RP, Kleyman TR., Free PMC Article | 05/4/2019 |
| The derlin-1 pathway therefore may represent a significant early checkpoint in the recognition and degradation of ENaC in mammalian cells. | Derlin-1 promotes ubiquitylation and degradation of the epithelial Na(+) channel, ENaC.
You H, Ge Y, Zhang J, Cao Y, Xing J, Su D, Huang Y, Li M, Qu S, Sun F, Liang X. | 08/12/2017 |
| ENaC and ROMK channel activity in kidney tubules are inhibited in TgWnk4(pseudoaldosteronism type II) mice. Wnk4(PHAII)-induced inhibition of ENaC and ROMK may contribute to the suppression of K(+) secretion in the tubules. | ENaC and ROMK activity are inhibited in the DCT2/CNT of TgWnk4(PHAII) mice.
Zhang C, Wang L, Su XT, Zhang J, Lin DH, Wang WH., Free PMC Article | 07/15/2017 |
| Mouse cells conditionally overexpressing gamma ENAC had enhanced apical Na(+) entry increased the basolateral cell surface expression of Na,K-ATPase by inhibiting p38 kinase-mediated endocytosis of Na,K-ATPase. | Sodium transport is modulated by p38 kinase-dependent cross-talk between ENaC and Na,K-ATPase in collecting duct principal cells.
Wang YB, Leroy V, Maunsbach AB, Doucet A, Hasler U, Dizin E, Ernandez T, de Seigneux S, Martin PY, Féraille E., Free PMC Article | 04/19/2014 |
| Data indicate that insulin receptor (InsR) is important for epithelial sodium channel (ENaC) activity. | Regulation of ENaC in mice lacking renal insulin receptors in the collecting duct.
Pavlov TS, Ilatovskaya DV, Levchenko V, Li L, Ecelbarger CM, Staruschenko A., Free PMC Article | 09/21/2013 |
| These data suggest that adenylyl cyclase VI mediates vasopressin-stimulated ENaC activity in the kidney. | Adenylyl cyclase VI mediates vasopressin-stimulated ENaC activity.
Roos KP, Bugaj V, Mironova E, Stockand JD, Ramkumar N, Rees S, Kohan DE., Free PMC Article | 03/30/2013 |
| Cys substitutions at sites in the wrist domains of the beta and gamma subunits alter the Na+ self-inhibition response. | Role of the wrist domain in the response of the epithelial sodium channel to external stimuli.
Shi S, Carattino MD, Kleyman TR., Free PMC Article | 03/30/2013 |
| ENaC is not a passive passenger in regulated epithelial vesicle trafficking, but plays a role in establishing and maintaining the pool of vesicles that respond to cAMP stimulation. | The epithelial sodium channel (ENaC) establishes a trafficking vesicle pool responsible for its regulation.
Edinger RS, Bertrand CA, Rondandino C, Apodaca GA, Johnson JP, Butterworth MB., Free PMC Article | 02/23/2013 |
| The reactive intermediates formed during and after exposure to chlorine activated ERK1/2 in alveolar epithelial cells, leading to decreased ENaC concentrations and activity. | Regulation of alveolar epithelial Na+ channels by ERK1/2 in chlorine-breathing mice.
Lazrak A, Chen L, Jurkuvenaite A, Doran SF, Liu G, Li Q, Lancaster JR Jr, Matalon S., Free PMC Article | 04/28/2012 |
| TMPRSS4 primarily activates ENaC by cleaving basic residues within the tract gammaK173-K186 distal to the furin cleavage site, thereby releasing a previously defined key inhibitory tract encompassing gammaR158-F168 from the gamma-subunit. | TMPRSS4-dependent activation of the epithelial sodium channel requires cleavage of the γ-subunit distal to the furin cleavage site.
Passero CJ, Mueller GM, Myerburg MM, Carattino MD, Hughey RP, Kleyman TR., Free PMC Article | 02/11/2012 |
| estrogen regulates expression and function of epithelial sodium channel gamma in osteoblasts | Estrogen regulates the expression and activity of epithelial sodium channel in mouse osteoblasts.
Yang GZ, Nie HG, Lu L, Chen J, Lu XY, Ji HL, Li QN., Free PMC Article | 08/27/2011 |
| Il-6 activates ENaC-gamma channels in cortical collecting duct cells. | Interleukin-6 stimulates epithelial sodium channels in mouse cortical collecting duct cells.
Li K, Guo D, Zhu H, Hering-Smith KS, Hamm LL, Ouyang J, Dong Y., Free PMC Article | 09/13/2010 |
| Dot1a and AF9 downregulate Na(+) transport, most likely by regulating ENaC mRNA and subsequent protein expression and ENaC activity. | Dot1a contains three nuclear localization signals and regulates the epithelial Na+ channel (ENaC) at multiple levels.
Reisenauer MR, Wang SW, Xia Y, Zhang W., Free PMC Article | 07/19/2010 |
| Report regulation of ENaC-mediated sodium transport by glucocorticoids in Reissner's membrane epithelium. | Regulation of ENaC-mediated sodium transport by glucocorticoids in Reissner's membrane epithelium.
Kim SH, Kim KX, Raveendran NN, Wu T, Pondugula SR, Marcus DC., Free PMC Article | 01/21/2010 |
| Plasmin activates epithelial Na+ channels by cleaving the gamma subunit | Plasmin activates epithelial Na+ channels by cleaving the gamma subunit.
Passero CJ, Mueller GM, Rondon-Berrios H, Tofovic SP, Hughey RP, Kleyman TR., Free PMC Article | 01/21/2010 |
| P2Y2 receptor activation by nucleotides thus provides physiologically important regulation of ENaC and electrolyte handling in mammalian kidney | Paracrine regulation of the epithelial Na+ channel in the mammalian collecting duct by purinergic P2Y2 receptor tone.
Pochynyuk O, Bugaj V, Rieg T, Insel PA, Mironova E, Vallon V, Stockand JD., Free PMC Article | 01/21/2010 |
| SGK1 is essential for optimal processing of ENaC but is not required for activation of the channel by aldosterone | Epithelial Na+ channel activation and processing in mice lacking SGK1.
Fejes-Tóth G, Frindt G, Náray-Fejes-Tóth A, Palmer LG. | 01/21/2010 |