| Regulation of hepatic inclusions and fibrinogen biogenesis by SEL1L-HRD1 ERAD. | Regulation of hepatic inclusions and fibrinogen biogenesis by SEL1L-HRD1 ERAD.
Song Z, Thepsuwan P, Hur WS, Torres M, Wu SA, Wei X, Tushi NJ, Wei J, Ferraresso F, Paton AW, Paton JC, Zheng Z, Zhang K, Fang D, Kastrup CJ, Jaiman S, Flick MJ, Sun S., Free PMC Article | 10/31/2024 |
| ER-associated degradation adapter Sel1L is required for CD8[+] T cell function and memory formation following acute viral infection. | ER-associated degradation adapter Sel1L is required for CD8(+) T cell function and memory formation following acute viral infection.
Correa-Medero LO, Jankowski SE, Hong HS, Armas ND, Vijendra AI, Reynolds MB, Fogo GM, Awad D, Dils AT, Inoki KA, Williams RG, Ye AM, Svezhova N, Gomez-Rivera F, Collins KL, O'Riordan MX, Sanderson TH, Lyssiotis CA, Carty SA., Free PMC Article | 06/14/2024 |
| SEL1L-HRD1 interaction is required to form a functional HRD1 ERAD complex. | SEL1L-HRD1 interaction is required to form a functional HRD1 ERAD complex.
Lin LL, Wang HH, Pederson B, Wei X, Torres M, Lu Y, Li ZJ, Liu X, Mao H, Wang H, Zhou LE, Zhao Z, Sun S, Qi L., Free PMC Article | 03/1/2024 |
| SEL1L preserves CD8[+] T-cell survival and homeostasis by fine-tuning PERK signaling and the IL-15 receptor-mediated mTORC1 axis. | SEL1L preserves CD8(+) T-cell survival and homeostasis by fine-tuning PERK signaling and the IL-15 receptor-mediated mTORC1 axis.
Gao Y, Li W, Wang Z, Zhang C, He Y, Liu X, Tang K, Zhang W, Long Q, Liu Y, Zhang J, Zhang B, Zhang L., Free PMC Article | 10/10/2023 |
| Sel1L-Hrd1 ER-associated degradation maintains beta cell identity via TGF-beta signaling. | Sel1L-Hrd1 ER-associated degradation maintains β cell identity via TGF-β signaling.
Shrestha N, Liu T, Ji Y, Reinert RB, Torres M, Li X, Zhang M, Tang CA, Hu CA, Liu C, Naji A, Liu M, Lin JD, Kersten S, Arvan P, Qi L., Free PMC Article | 02/6/2021 |
| This study not only establishes the importance of Sel1L-Hrd1 ERAD in the liver in the regulation of systemic energy metabolism, but also reveals a novel hepatic "ERAD-Crebh-Fgf21" axis directly linking ER protein turnover to gene transcription and systemic metabolic regulation. | Hepatic Sel1L-Hrd1 ER-associated degradation (ERAD) manages FGF21 levels and systemic metabolism via CREBH.
Bhattacharya A, Sun S, Wang H, Liu M, Long Q, Yin L, Kersten S, Zhang K, Qi L., Free PMC Article | 10/5/2019 |
| he drastic phenotypic characteristics exhibited in mSEL-1L null mice can, in part, be explained by the negative influence it plays on Notch1 signaling pathway. | mSEL-1L deficiency affects vasculogenesis and neural stem cell lineage commitment.
Cardano M, Diaferia GR, Conti L, Baronchelli S, Sessa A, Broccoli V, Barbieri A, De Blasio P, Biunno I. | 12/22/2018 |
| This study implicates Endoplasmic reticulum (ER)-associated degradation mediated by Sel1L-Hrd1 as a key regulator of B cell development. | The Sel1L-Hrd1 Endoplasmic Reticulum-Associated Degradation Complex Manages a Key Checkpoint in B Cell Development.
Ji Y, Kim H, Yang L, Sha H, Roman CA, Long Q, Qi L., Free PMC Article | 11/25/2017 |
| Mice deficient for ERAD machinery component Sel1L develop central diabetes insipidus | Mice deficient for ERAD machinery component Sel1L develop central diabetes insipidus.
Bichet DG, Lussier Y., Free PMC Article | 10/28/2017 |
| significant determinant of serum bile acid concentration | Genome-wide association study in mice identifies loci affecting liver-related phenotypes including Sel1l influencing serum bile acids.
Wu W, Patel A, Kyöstilä K, Lohi H, Mladkova N, Kiryluk K, Sun X, Lefkowitch JH, Worman HJ, Gharavi AG. | 07/22/2017 |
| The authors propose that certain Sel1-Like Repeat motifs of SEL1L play a unique role in membrane bound ERAD machinery. | Crystal structure of SEL1L: Insight into the roles of SLR motifs in ERAD pathway.
Jeong H, Sim HJ, Song EK, Lee H, Ha SC, Jun Y, Park TJ, Lee C., Free PMC Article | 03/4/2017 |
| Sel1L-Hrd1 plays a constitutive role in endoplasmic reticulum associated degradation in epithelial cell biology and the pathogenesis of intestinal inflammation in Crohn's disease. | Epithelial Sel1L is required for the maintenance of intestinal homeostasis.
Sun S, Lourie R, Cohen SB, Ji Y, Goodrich JK, Poole AC, Ley RE, Denkers EY, McGuckin MA, Long Q, Duhamel GE, Simpson KW, Qi L., Free PMC Article | 10/29/2016 |
| Data show that inositol requiring enzyme 1alpha (IRE1alpha), the sensor of the unfolded protein response (UPR), is a bona fide substrate of the Sel1L proten-Hrd1 protein endoplasmic reticulum (ER)-associated degradation (ERAD) complex. | IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation.
Sun S, Shi G, Sha H, Ji Y, Han X, Shu X, Ma H, Inoue T, Gao B, Kim H, Bu P, Guber RD, Shen X, Lee AH, Iwawaki T, Paton AW, Paton JC, Fang D, Tsai B, Yates JR 3rd, Wu H, Kersten S, Long Q, Duhamel GE, Simpson KW, Qi L., Free PMC Article | 04/2/2016 |
| Adipocyte-specific Sel1L-deficient (AKO) mice are resistant to diet-induced obesity. Sel1L stabilizes and prevents LPL dimers from aggregation in the endoplasmic reticulum. | The ER-associated degradation adaptor protein Sel1L regulates LPL secretion and lipid metabolism.
Sha H, Sun S, Francisco AB, Ehrhardt N, Xue Z, Liu L, Lawrence P, Mattijssen F, Guber RD, Panhwar MS, Brenna JT, Shi H, Xue B, Kersten S, Bensadoun A, Péterfy M, Long Q, Qi L., Free PMC Article | 05/23/2015 |
| Data revealed close interaction of these two proteins in regulating the cross-talk between extracellular matrix and insulin signalling to create a favourable micro-environment for ss-cell development and function. | SEL1L regulates adhesion, proliferation and secretion of insulin by affecting integrin signaling.
Diaferia GR, Cirulli V, Biunno I., Free PMC Article | 08/9/2014 |
| Sel1L is an indispensable component of the mammalian Hrd1 endoplasmic reticulum-associated degradation and endoplasmic reticulum homeostasis. | Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival.
Sun S, Shi G, Han X, Francisco AB, Ji Y, Mendonça N, Liu X, Locasale JW, Simpson KW, Duhamel GE, Kersten S, Yates JR 3rd, Long Q, Qi L., Free PMC Article | 04/5/2014 |
| a critical and previously unknown function for SEL1L in regulating adult beta-cell function and growth | Haploid insufficiency of suppressor enhancer Lin12 1-like (SEL1L) protein predisposes mice to high fat diet-induced hyperglycemia.
Francisco AB, Singh R, Sha H, Yan X, Qi L, Lei X, Long Q., Free PMC Article | 09/3/2011 |
| mSEL-1L as a primitive marker with a possible involvement in the regulation of neural progenitor stemness maintenance and lineage determination. | mSEL-1L (Suppressor/enhancer Lin12-like) protein levels influence murine neural stem cell self-renewal and lineage commitment.
Cardano M, Diaferia GR, Cattaneo M, Dessì SS, Long Q, Conti L, Deblasio P, Cattaneo E, Biunno I., Free PMC Article | 07/30/2011 |
| an essential role for SEL1L in protein quality control during mouse embryonic development. | Deficiency of suppressor enhancer Lin12 1 like (SEL1L) in mice leads to systemic endoplasmic reticulum stress and embryonic lethality.
Francisco AB, Singh R, Li S, Vani AK, Yang L, Munroe RJ, Diaferia G, Cardano M, Biunno I, Qi L, Schimenti JC, Long Q., Free PMC Article | 05/31/2010 |
| Data suggest that Sel1l is essential for the growth and differentiation of endoderm-derived pancreatic epithelial cells during mouse embryonic development. | SEL1L deficiency impairs growth and differentiation of pancreatic epithelial cells.
Li S, Francisco AB, Munroe RJ, Schimenti JC, Long Q., Free PMC Article | 05/31/2010 |