| Semaphorin 3F signaling actively retains neutrophils at sites of inflammation. | Semaphorin 3F signaling actively retains neutrophils at sites of inflammation.
Plant T, Eamsamarng S, Sanchez-Garcia MA, Reyes L, Renshaw SA, Coelho P, Mirchandani AS, Morgan JM, Ellett FE, Morrison T, Humphries D, Watts ER, Murphy F, Raffo-Iraolagoitia XL, Zhang A, Cash JL, Loynes C, Elks PM, Van Eeden F, Carlin LM, Furley AJ, Whyte MK, Walmsley SR., Free PMC Article | 02/6/2021 |
| Results define a developmental function for NrCAM in Sema3F receptor signaling that limits dendritic spine density on cortical pyramidal neurons during adolescence. | Temporal Regulation of Dendritic Spines Through NrCAM-Semaphorin3F Receptor Signaling in Developing Cortical Pyramidal Neurons.
Mohan V, Sullivan CS, Guo J, Wade SD, Majumder S, Agarwal A, Anton ES, Temple BS, Maness PF., Free PMC Article | 05/16/2020 |
| Studies of interneuron cell-specific knockout of Sema 3F signaling suggest that deficient Sema 3F signaling may lead to neuroinflammation and oxidative stress. | Deletion of Semaphorin 3F in Interneurons Is Associated with Decreased GABAergic Neurons, Autism-like Behavior, and Increased Oxidative Stress Cascades.
Li Z, Jagadapillai R, Gozal E, Barnes G., Free PMC Article | 12/14/2019 |
| data suggest that Sema3f and Nrp2 are dispensable for the exclusion of vessels from the cap mesenchyme during kidney development. | Refuting the hypothesis that semaphorin-3f/neuropilin-2 exclude blood vessels from the cap mesenchyme in the developing kidney.
Munro DAD, Hohenstein P, Coate TM, Davies JA., Free PMC Article | 07/14/2018 |
| Sema3f is suppressed in outer nuclear layer in very low-density lipid-receptor deficient retina. | Sema3f Protects Against Subretinal Neovascularization In Vivo.
Sun Y, Liegl R, Gong Y, Bühler A, Cakir B, Meng SS, Burnim SB, Liu CH, Reuer T, Zhang P, Walz JM, Ludwig F, Lange C, Agostini H, Böhringer D, Schlunck G, Smith LEH, Stahl A., Free PMC Article | 01/20/2018 |
| Sema3F functions as an unconventional Sema3 that promotes extraembryonic angiogenesis by inhibiting the Myc-regulated synthesis of Thbs1 in visceral yolk sac epithelial cells. | Sema3F (Semaphorin 3F) Selectively Drives an Extraembryonic Proangiogenic Program.
Regano D, Visintin A, Clapero F, Bussolino F, Valdembri D, Maione F, Serini G, Giraudo E., Free PMC Article | 09/9/2017 |
| Nrp2 deficiency increased blood vessel permeability and decreased lymphatic vessel drainage during inflammation, highlighting the importance of the NRP2/SEMA3F pathway in the modulation of tissue swelling and resolution of postinflammatory edema. | Inflammation and Lymphedema Are Exacerbated and Prolonged by Neuropilin 2 Deficiency.
Mucka P, Levonyak N, Geretti E, Zwaans BMM, Li X, Adini I, Klagsbrun M, Adam RM, Bielenberg DR., Free PMC Article | 08/19/2017 |
| Sema3F plays important roles in the development of neuronal circuitry underlying the regulation of some aspects of anxiety and fear responses. | Comprehensive behavioral phenotyping of a new Semaphorin 3 F mutant mouse.
Matsuda I, Shoji H, Yamasaki N, Miyakawa T, Aiba A., Free PMC Article | 10/22/2016 |
| The authors demonstrate that expression of Semaphorin-3F in the outer hair cell region inhibits type I spiral ganglion neuron process extension by activating Neuropilin-2 receptors expressed on spiral ganglion neurons. | Neuropilin-2/Semaphorin-3F-mediated repulsion promotes inner hair cell innervation by spiral ganglion neurons.
Coate TM, Spita NA, Zhang KD, Isgrig KT, Kelley MW., Free PMC Article | 06/11/2016 |
| the embryonically developed wiring deficits in Sema3F mutants persist until adulthood | A critical period for postnatal adaptive plasticity in a model of motor axon miswiring.
Helmbrecht MS, Soellner H, Castiblanco-Urbina MA, Winzeck S, Sundermeier J, Theis FJ, Fouad K, Huber AB., Free PMC Article | 01/30/2016 |
| Sema4A promotes Th1 and Th17 differentiation and increases adhesive activation of T cells to endothelial cells, even in the presence of IFN-beta. | Sema4A inhibits the therapeutic effect of IFN-β in EAE.
Koda T, Okuno T, Takata K, Honorat JA, Kinoshita M, Tada S, Moriya M, Sakoda S, Mochizuki H, Kumanogoh A, Nakatsuji Y. | 05/3/2014 |
| In a growth cone collapse assay, mouse embryonic stem cell-derived spinal motor neurons respond to ephrin-A5, semaphorin(Sema)3f, and Sema3a in a concentration-dependent manner. | Concentration-dependent requirement for local protein synthesis in motor neuron subtype-specific response to axon guidance cues.
Nédelec S, Peljto M, Shi P, Amoroso MW, Kam LC, Wichterle H., Free PMC Article | 03/17/2012 |
| Sema3F is secreted by early-arriving axons of olfactory sensory neurons and is deposited at the anterodorsal olfactory bulb to repel Nrp2-positive axons that arrive later. | Sequential arrival and graded secretion of Sema3F by olfactory neuron axons specify map topography at the bulb.
Takeuchi H, Inokuchi K, Aoki M, Suto F, Tsuboi A, Matsuda I, Suzuki M, Aiba A, Serizawa S, Yoshihara Y, Fujisawa H, Sakano H. | 06/28/2010 |
| These data suggest that Sema3F plays a relatively restricted, if any, role in its receptor expression and postnatal development of the somatosensory cortex, the cerebellum, and the main olfactory system. | Development of the somatosensory cortex, the cerebellum, and the main olfactory system in Semaphorin 3F knockout mice.
Matsuda I, Fukaya M, Nakao H, Nakao K, Matsumoto H, Mori K, Watanabe M, Aiba A. | 06/14/2010 |
| Data demonstrate that methyl-CpG binding protein 2 deficiency disrupts the establishment of neural connections before synaptogenesis by altering semaphorin 3F function. | MeCP2 deficiency disrupts axonal guidance, fasciculation, and targeting by altering Semaphorin 3F function.
Degano AL, Pasterkamp RJ, Ronnett GV., Free PMC Article | 01/21/2010 |
| Soluble neuropilin-2Fc did not inhibit repulsion but increased the repellent effect of semaphorin 3F. | Soluble neuropilin-2, a nerve repellent receptor, is increased in rheumatoid arthritis synovium and aggravates sympathetic fiber repulsion and arthritis.
Fassold A, Falk W, Anders S, Hirsch T, Mirsky VM, Straub RH. | 01/21/2010 |
| Semaphorin3F induces significant growth cone collapse of temporal, but not nasal, RGCs expressing high levels of Neuropilin-2. | Implication of neuropilin 2/semaphorin 3F in retinocollicular map formation.
Claudepierre T, Koncina E, Pfrieger FW, Bagnard D, Aunis D, Reber M. | 01/21/2010 |
| Sema 3D and Sema 3F genes are overlappingly and distinctly expressed in the developing parathyroid and thymus, respectively, and they might play roles in the interactions between these organs and surrounding tissues | Expression of the semaphorins Sema 3D and Sema 3F in the developing parathyroid and thymus.
Takahashi K, Ishida M, Hirokawa K, Takahashi H. | 01/21/2010 |
| An important regulator of the ventral tangential cell migration stream, confining the migrating neurons on the telencephalon surface by repelling from the deeper domain. | Semaphorin 3F confines ventral tangential migration of lateral olfactory tract neurons onto the telencephalon surface.
Ito K, Kawasaki T, Takashima S, Matsuda I, Aiba A, Hirata T., Free PMC Article | 01/21/2010 |
| Genetic evidence for a Nrp2-Sema3f interaction as a determinant of the wiring of axons of gucy2d+ neurons into the unusual configuration of necklace glomeruli. | Axonal wiring of guanylate cyclase-D-expressing olfactory neurons is dependent on neuropilin 2 and semaphorin 3F.
Walz A, Feinstein P, Khan M, Mombaerts P. | 01/21/2010 |
| Sema3F is the principal ligand for Npn-2-mediated axon guidance events in vivo and is a critical determinant of limbic and peripheral nervous system circuitry | Semaphorin 3F is critical for development of limbic system circuitry and is required in neurons for selective CNS axon guidance events.
Sahay A, Molliver ME, Ginty DD, Kolodkin AL., Free PMC Article | 01/21/2010 |
| We describe a related signaling pathway involving secreted class 3 semaphorins, neuropilins, and a plexin receptor, PlexinD1, expressed by endothelial cells | PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development.
Gitler AD, Lu MM, Epstein JA. | 01/21/2010 |
| Sema 3A and 3F, but not Sema 3C or 3E, induce chemorepulsion of septal axons. | Role of class 3 semaphorins in the development and maturation of the septohippocampal pathway.
Pascual M, Pozas E, Soriano E. | 01/21/2010 |
| Using sema3F-/- mice, we show that Sema3F is critical for vomeronasal sensory neuron axonal fasciculation and for segregation of these sensory afferents from the main olfactory system and lamina-specific targeting of olfactory sensory axons | Differential requirements for semaphorin 3F and Slit-1 in axonal targeting, fasciculation, and segregation of olfactory sensory neuron projections.
Cloutier JF, Sahay A, Chang EC, Tessier-Lavigne M, Dulac C, Kolodkin AL, Ginty DD., Free PMC Article | 01/21/2010 |
| Npn2/Sema3f signaling guides neural crest migration through the somite. | Guidance of trunk neural crest migration requires neuropilin 2/semaphorin 3F signaling.
Gammill LS, Gonzalez C, Gu C, Bronner-Fraser M. | 01/21/2010 |