| Microglial SIX2 suppresses lipopolysaccharide (LPS)-induced neuroinflammation by up-regulating FXYD2 expression. | Microglial SIX2 suppresses lipopolysaccharide (LPS)-induced neuroinflammation by up-regulating FXYD2 expression.
Cao XY, Liu Y, Kan JS, Huang XX, Kambey PA, Zhang CT, Gao J. | 06/7/2024 |
| Tet2- and Tet3- Mediated Cytosine Hydroxymethylation in Six2 Progenitor Cells in Mice Is Critical for Nephron Progenitor Differentiation and Nephron Endowment. | Tet2- and Tet3- Mediated Cytosine Hydroxymethylation in Six2 Progenitor Cells in Mice Is Critical for Nephron Progenitor Differentiation and Nephron Endowment.
Liang X, Aranyi T, Zhou J, Guan Y, Hu H, Liu H, Susztak K., Free PMC Article | 04/5/2023 |
| Chromatin Remodelers Interact with Eya1 and Six2 to Target Enhancers to Control Nephron Progenitor Cell Maintenance. | Chromatin Remodelers Interact with Eya1 and Six2 to Target Enhancers to Control Nephron Progenitor Cell Maintenance.
Li J, Xu J, Jiang H, Zhang T, Ramakrishnan A, Shen L, Xu PX., Free PMC Article | 12/18/2021 |
| Generation and characterization of Six2 conditional mice. | Generation and characterization of Six2 conditional mice.
Li C, Liu H, Hu YC, Lan Y, Jiang R., Free PMC Article | 02/6/2021 |
| identified a lncRNA, Gm29418, in nephron progenitor cells that has an enhancer-like function on a key regulatory gene, Six2. | Comprehensive analysis of chromatin signature and transcriptome uncovers functional lncRNAs expressed in nephron progenitor cells.
Nishikawa M, Yuri S, Kimura H, Yanagawa N, Hamon M, Hauser P, Zhao L, Jo OD, Yanagawa N. | 08/17/2019 |
| Six2 expression is regulated by Gulo in the metanephric mesenchyme cells. | Gulo regulates the proliferation, apoptosis and mesenchymal-to-epithelial transformation of metanephric mesenchyme cells via inhibiting Six2.
He Q, Chen L, Liu Y, Wu Y, Ni D, Liu J, Hu Y, Gu Y, Xie Y, Zhou Q, Li Q. | 06/1/2019 |
| Reveal a unique dose response of nephron progenitors to the level of SIX2 protein in which the role of SIX2 in progenitor proliferation versus self-renewal is separable. | Haploinsufficiency for the Six2 gene increases nephron progenitor proliferation promoting branching and nephron number.
Combes AN, Wilson S, Phipson B, Binnie BB, Ju A, Lawlor KT, Cebrian C, Walton SL, Smyth IM, Moritz KM, Kopan R, Oshlack A, Little MH., Free PMC Article | 12/22/2018 |
| Embryonic day 18.5 Six2Frs2alphaKO kidneys were hypoplastic and not cystic, postnatal day (P) 7 mutants had proximal tubular-derived cysts that nearly replaced the renal parenchyma by P21. Mutants had high proximal tubular proliferation rates and interstitial fibrosis, similar to known polycystic kidney disease models. | Six2creFrs2α knockout mice are a novel model of renal cystogenesis.
Puri P, Bushnell D, Schaefer CM, Bates CM., Free PMC Article | 07/7/2018 |
| GATA1 may be a potential regulator of Six2-maintained population of nephron progenitor cells. | Six2 is involved in GATA1-mediated cell apoptosis in mouse embryonic kidney-derived cell lines.
Xia H, Yan X, Liu Y, Ju P, Liu J, Ni D, Gu Y, Zhou Q, Xie Y. | 06/9/2018 |
| Six2 mediates the protective effects of GDNF on damaged DA neurons by regulating Smurf1 expression. | Transcription factor Six2 mediates the protection of GDNF on 6-OHDA lesioned dopaminergic neurons by regulating Smurf1 expression.
Gao J, Kang XY, Sun S, Li L, Zhang BL, Li YQ, Gao DS., Free PMC Article | 11/4/2017 |
| Differentiation of nephron progenitors requires downregulation of Six2, a transcription factor required for progenitor maintenance, and that Notch signaling is necessary and sufficient for Six2 downregulation. | Notch signaling promotes nephrogenesis by downregulating Six2.
Chung E, Deacon P, Marable S, Shin J, Park JS., Free PMC Article | 09/16/2017 |
| Zeb1 promotes proliferation and apoptosis and inhibits the migration of metanephric mesenchyme cells, in association with Six2. | Zeb1 Is a Potential Regulator of Six2 in the Proliferation, Apoptosis and Migration of Metanephric Mesenchyme Cells.
Gu Y, Zhao Y, Zhou Y, Xie Y, Ju P, Long Y, Liu J, Ni D, Cao F, Lyu Z, Mao Z, Hao J, Li Y, Wan Q, Kanyomse Q, Liu Y, Ren D, Ning Y, Li X, Zhou Q, Li B., Free PMC Article | 03/25/2017 |
| In Six2-positive nephrogenic progenitors, GLI3 repressor decreased progenitor cell proliferation reducing the number of nephrogenic precursor structures in the Pallister-Hall syndrome mouse model. | Urogenital development in Pallister-Hall syndrome is disrupted in a cell-lineage-specific manner by constitutive expression of GLI3 repressor.
Blake J, Hu D, Cain JE, Rosenblum ND., Free PMC Article | 12/17/2016 |
| These data suggest differential SIX-factor regulation might have contributed to species differences in nephron progenitor programs such as the duration of nephrogenesis and the final nephron count | Differential regulation of mouse and human nephron progenitors by the Six family of transcriptional regulators.
O'Brien LL, Guo Q, Lee Y, Tran T, Benazet JD, Whitney PH, Valouev A, McMahon AP., Free PMC Article | 07/16/2016 |
| Mechanistically, LIF activates STAT, which binds to a Stat consensus sequence in the Six2 proximal promoter and sustains SIX2 levels. | Preferential Propagation of Competent SIX2+ Nephronic Progenitors by LIF/ROCKi Treatment of the Metanephric Mesenchyme.
Tanigawa S, Sharma N, Hall MD, Nishinakamura R, Perantoni AO., Free PMC Article | 06/11/2016 |
| Dicer ablation in the early metanephric mesenchyme results in severe renal dysgenesis despite normal initial specification of nephron progenitors and ureteric bud outgrowth. | Dicer function is required in the metanephric mesenchyme for early kidney development.
Chu JY, Sims-Lucas S, Bushnell DS, Bodnar AJ, Kreidberg JA, Ho J., Free PMC Article | 09/22/2015 |
| miR181c downregulates the expression of Six2, restrain the proliferation and promote the apoptosis that even makes the nephron progenitor phenotype lose MM cells, suggesting a potential role of miR181c during the kidney development. | miR181c promotes apoptosis and suppresses proliferation of metanephric mesenchyme cells by targeting Six2 in vitro.
Lv X, Mao Z, Lyu Z, Zhang P, Zhan A, Wang J, Yang H, Li M, Wang H, Wan Q, Wei H, Wang M, Wang N, Li X, Liu Y, Zhao H, Zhou Q. | 07/25/2015 |
| results reveal a functional link between Eya1, Six2, and Myc in driving the expansion and maintenance of the multipotent progenitors during nephrogenesis | Eya1 interacts with Six2 and Myc to regulate expansion of the nephron progenitor pool during nephrogenesis.
Xu J, Wong EY, Cheng C, Li J, Sharkar MT, Xu CY, Chen B, Sun J, Jing D, Xu PX., Free PMC Article | 02/14/2015 |
| Our findings establish Six2 as a regulator of metastasis in human breast cancers and demonstrate an epigenetic function for SIX family transcription factors in metastatic progression through the regulation of E-cadherin. | Homeoprotein Six2 promotes breast cancer metastasis via transcriptional and epigenetic control of E-cadherin expression.
Wang CA, Drasin D, Pham C, Jedlicka P, Zaberezhnyy V, Guney M, Li H, Nemenoff R, Costello JC, Tan AC, Ford HL., Free PMC Article | 02/14/2015 |
| These results implied that inhibition of Nf1 may delay metanephros development via down-regulation of Six2. | Down-regulated Six2 by knockdown of neurofibromin results in apoptosis of metanephric mesenchyme cells in vitro.
Zhou P, Chen T, Fang Y, Wang H, Li M, Ma P, He L, Li Q, Liu T, Yang X, Nie F, Wang X, Yuan Y, Zhou L, Peng R, Liu Z, Zhou Q. | 12/6/2014 |
| Osr1 plays crucial roles in Six2-dependent maintenance of nephron progenitors during mammalian nephrogenesis. | Osr1 acts downstream of and interacts synergistically with Six2 to maintain nephron progenitor cells during kidney organogenesis.
Xu J, Liu H, Park JS, Lan Y, Jiang R., Free PMC Article | 05/17/2014 |
| this study concluded that by targeting the transcription factor gene Six2, miR-181b inhibits the proliferation of metanephric mesenchymal cells in vitro and might play an important role in the formation of nephrons. | MiR-181b targets Six2 and inhibits the proliferation of metanephric mesenchymal cells in vitro.
lyu Z, Mao Z, Wang H, Fang Y, Chen T, Wan Q, Wang M, Wang N, Xiao J, Wei H, Li X, Liu Y, Zhou Q. | 02/15/2014 |
| Six1 and Six2 are complementarily but asymmetrically expressed in the peri-cloacal mesenchymal progenitors and are critical for correct genitor-urinary and digestive organs body patterning. | Embryonic origin and remodeling of the urinary and digestive outlets.
Wang C, Wang J, Borer JG, Li X., Free PMC Article | 07/20/2013 |
| Wnt and BMP signaling cooperate with Hox in the control of Six2 expression in limb tendon precursor. | Wnt and BMP signaling cooperate with Hox in the control of Six2 expression in limb tendon precursor.
Yamamoto-Shiraishi Y, Kuroiwa A. | 06/29/2013 |
| The Six2 and Lef/Tcf factors form a regulatory complex that promotes progenitor maintenance while entry of beta-catenin into this complex promotes nephrogenesis. | Six2 and Wnt regulate self-renewal and commitment of nephron progenitors through shared gene regulatory networks.
Park JS, Ma W, O'Brien LL, Chung E, Guo JJ, Cheng JG, Valerius MT, McMahon JA, Wong WH, McMahon AP., Free PMC Article | 01/12/2013 |