| miR-540-3p partially recovers the locomotor function of spinal cord injury mice by targeting SIX4/Yap1 and inactivation of astrocytes. | miR-540-3p partially recovers the locomotor function of spinal cord injury mice by targeting SIX4/Yap1 and inactivation of astrocytes.
Wang Y, Zhao T, Chen WC, Zheng Y, Xu W, Huang S. | 08/26/2024 |
| Reciprocal regulation of pancreatic ductal adenocarcinoma growth and molecular subtype by HNF4alpha and SIX1/4. | Reciprocal regulation of pancreatic ductal adenocarcinoma growth and molecular subtype by HNF4α and SIX1/4.
Camolotto SA, Belova VK, Torre-Healy L, Vahrenkamp JM, Berrett KC, Conway H, Shea J, Stubben C, Moffitt R, Gertz J, Snyder EL., Free PMC Article | 12/4/2021 |
| Time-dependent Pax3-mediated chromatin remodeling and cooperation with Six4 and Tead2 specify the skeletal myogenic lineage in developing mouse mesoderm. | Time-dependent Pax3-mediated chromatin remodeling and cooperation with Six4 and Tead2 specify the skeletal myogenic lineage in developing mesoderm.
Magli A, Baik J, Mills LJ, Kwak IY, Dillon BS, Mondragon Gonzalez R, Stafford DA, Swanson SA, Stewart R, Thomson JA, Garry DJ, Dynlacht BD, Perlingeiro RCR., Free PMC Article | 11/30/2019 |
| Six4 and Six5 are required for growth and morphological change of the primary abdominal wall. | Mice doubly deficient in Six4 and Six5 show ventral body wall defects reproducing human omphalocele.
Takahashi M, Tamura M, Sato S, Kawakami K., Free PMC Article | 06/1/2019 |
| significant co-localization of binding sites for MyoD and Six proteins on over a thousand mouse genomic DNA regions, were found. | MyoD reprogramming requires Six1 and Six4 homeoproteins: genome-wide cis-regulatory module analysis.
Santolini M, Sakakibara I, Gauthier M, Ribas-Aulinas F, Takahashi H, Sawasaki T, Mouly V, Concordet JP, Defossez PA, Hakim V, Maire P., Free PMC Article | 06/10/2017 |
| The results indicated that low Six4 and Six5 gene dosage improved dystrophic phenotypes of Dmd(mdx) /Y mice by enhancing muscle regeneration, and suggested that SIX4 and SIX5 are potentially useful de novo targets in therapeutic applications against muscle disorders, including DMD. | Low Six4 and Six5 gene dosage improves dystrophic phenotype and prolongs life span of mdx mice.
Yajima H, Kawakami K. | 02/18/2017 |
| data support a model where Eya-Six may form a complex to regulate nephron progenitor cell development before metanephric specification and are critical mesenchymal factors for inducing nephric duct development. | Eya-six are necessary for survival of nephrogenic cord progenitors and inducing nephric duct development before ureteric bud formation.
Xu J, Xu PX., Free PMC Article | 03/19/2016 |
| results reveal a role for Six4 during adult muscle regeneration and suggest a widespread mechanism of cooperation between Six4 and MyoD. | Genome-wide association between Six4, MyoD, and the histone demethylase Utx during myogenesis.
Chakroun I, Yang D, Girgis J, Gunasekharan A, Phenix H, Kærn M, Blais A. | 02/13/2016 |
| the transcription factors Six1 and Six4 are required for male gonadal differentiation. | Homeoproteins Six1 and Six4 regulate male sex determination and mouse gonadal development.
Fujimoto Y, Tanaka SS, Yamaguchi YL, Kobayashi H, Kuroki S, Tachibana M, Shinomura M, Kanai Y, Morohashi K, Kawakami K, Nishinakamura R. | 11/30/2013 |
| Direct molecular regulation of the myogenic determination gene Myf5 by Pax3, with modulation by Six1/4 factors, is exemplified by the -111 kb-Myf5 enhancer | Direct molecular regulation of the myogenic determination gene Myf5 by Pax3, with modulation by Six1/4 factors, is exemplified by the -111 kb-Myf5 enhancer.
Daubas P, Buckingham ME. | 05/18/2013 |
| Data show that absence of Six1 and Six4 leads to the development of dorsal myofibers lacking expression of fast-type muscle genes, and mainly expressing a slow-type muscle program. | Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression.
Richard AF, Demignon J, Sakakibara I, Pujol J, Favier M, Strochlic L, Le Grand F, Sgarioto N, Guernec A, Schmitt A, Cagnard N, Huang R, Legay C, Guillet-Deniau I, Maire P. | 01/28/2012 |
| These results suggest that Six1 and Six4 genes are expressed in the taste bud cells, in newly formed or surviving type-II cells. | Expression of Six1 and Six4 in mouse taste buds.
Suzuki Y, Ikeda K, Kawakami K. | 01/8/2011 |
| Six4 and Six5 repressed, while Six1 activated myogenin expression, suggesting that the differential regulation of myogenin expression is responsible for the differential effects of Six genes | Six family genes control the proliferation and differentiation of muscle satellite cells.
Yajima H, Motohashi N, Ono Y, Sato S, Ikeda K, Masuda S, Yada E, Kanesaki H, Miyagoe-Suzuki Y, Takeda S, Kawakami K. | 11/13/2010 |
| Six1 and Six4 expression is required to specifically activate fast-type muscle genes | Six1 and Six4 gene expression is necessary to activate the fast-type muscle gene program in the mouse primary myotome.
Niro C, Demignon J, Vincent S, Liu Y, Giordani J, Sgarioto N, Favier M, Guillet-Deniau I, Blais A, Maire P. | 04/12/2010 |
| The threshold of Six1/4 may be crucial for the expression of olfactory specific genes and Six1 and Six4 may act synergistically to mediate olfactory placode specification and patterning through Fgf and Bmp signaling pathways. | Initiation of olfactory placode development and neurogenesis is blocked in mice lacking both Six1 and Six4.
Chen B, Kim EH, Xu PX., Free PMC Article | 01/21/2010 |
| Six1 and Six4 have collaborative functions in the metanephros but not in the mesonephros. | Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric-tubule defects.
Kobayashi H, Kawakami K, Asashima M, Nishinakamura R. | 01/21/2010 |
| Six4 is involved in myogenic regulatory gene Myf5 expression in the developing limb. | Six proteins regulate the activation of Myf5 expression in embryonic mouse limbs.
Giordani J, Bajard L, Demignon J, Daubas P, Buckingham M, Maire P., Free PMC Article | 01/21/2010 |
| Early syndetomal expression of scleraxis is reduced in the Six1Six4 embryo | Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo.
Grifone R, Demignon J, Houbron C, Souil E, Niro C, Seller MJ, Hamard G, Maire P. | 01/21/2010 |
| essential role for Eya1 and Six genes in patterning the third pouch into organ-specific primordia | Patterning of the third pharyngeal pouch into thymus/parathyroid by Six and Eya1.
Zou D, Silvius D, Davenport J, Grifone R, Maire P, Xu PX., Free PMC Article | 01/21/2010 |
| Data show that Six4 is transcriptional regulatory element X (TrexBF) in skeletal myocytes and transactivates the muscle creatine kinase enhancer. | Quantitative proteomic identification of six4 as the trex-binding factor in the muscle creatine kinase enhancer.
Himeda CL, Ranish JA, Angello JC, Maire P, Aebersold R, Hauschka SD., Free PMC Article | 01/21/2010 |
| Six1 and Six4 regulate Slc12a2, the promoter region of Slc12a2 contains multiple Six1-binding sites and one common binding site of Six1 and Six4 | Slc12a2 is a direct target of two closely related homeobox proteins, Six1 and Six4.
Ando Z, Sato S, Ikeda K, Kawakami K. | 01/21/2010 |