| Dysregulation of the WNK4-SPAK/OSR1 pathway has a minor effect on baseline NKCC2 phosphorylation. | Dysregulation of the WNK4-SPAK/OSR1 pathway has a minor effect on baseline NKCC2 phosphorylation.
Maeoka Y, Nguyen LT, Sharma A, Cornelius RJ, Su XT, Gutierrez MR, Carbajal-Contreras H, Castañeda-Bueno M, Gamba G, McCormick JA. | 12/28/2023 |
| Tubular-specific CDK12 knockout causes a defect in urine concentration due to premature cleavage of the slc12a1 gene. | Tubular-specific CDK12 knockout causes a defect in urine concentration due to premature cleavage of the slc12a1 gene.
Wang B, Wang Y, Wen Y, Zhang YL, Ni WJ, Tang TT, Cao JY, Yin Q, Jiang W, Yin D, Li ZL, Lv LL, Liu BC., Free PMC Article | 10/15/2022 |
| Renal NKCC2 Is Dual Regulated by the Synergy of 20-HETE and High-Fat Diet in CYP4F2 Transgenic Mice. | Renal NKCC2 Is Dual Regulated by the Synergy of 20-HETE and High-Fat Diet in CYP4F2 Transgenic Mice.
Wu J, Lai G, Chen F, Zhang B, Zhao Y. | 02/12/2022 |
| Upregulation of renal Na-K-2Cl cotransporter 2 in obese diabetes mellitus via a vasopressin receptor 2-dependent pathway. | Upregulation of renal Na-K-2Cl cotransporter 2 in obese diabetes mellitus via a vasopressin receptor 2-dependent pathway.
Sakai K, Yamazaki O, Ishizawa K, Tamura Y, Wang Q, Ueno M, Hayama Y, Fujigaki Y, Shibata S. | 10/24/2020 |
| Collectively, these findings demonstrate that downregulation of renal TNF-alpha production in response to low-salt conditions contributes to the regulation of NaCl reabsorption via an NKCC2B-dependent mechanism. | Regulation of NKCC2B by TNF-α in response to salt restriction.
Hao S, Salzo J, Hao M, Ferreri NR., Free PMC Article | 05/9/2020 |
| that WNK4 increases the abundance of phosphorylated NKCC2 | With no lysine kinase 4 modulates sodium potassium 2 chloride cotransporter activity in vivo.
Terker AS, Castañeda-Bueno M, Ferdaus MZ, Cornelius RJ, Erspamer KJ, Su XT, Miller LN, McCormick JA, Wang WH, Gamba G, Yang CL, Ellison DH., Free PMC Article | 09/7/2019 |
| Moesin regulates the internalization of NKCC2. | Internalization of NKCC2 is impaired in thick ascending limb of Henle in moesin knockout mice.
Kawaguchi K, Hatano R, Matsubara M, Asano S. | 08/31/2019 |
| the decrease in urine volume and NaCl excretion induced by renal TNF silencing was abolished when NKCC2A was concurrently silenced, suggesting that this isoform contributes to the transition from a salt-resistant to salt-sensitive phenotype. | Renal-Specific Silencing of TNF (Tumor Necrosis Factor) Unmasks Salt-Dependent Increases in Blood Pressure via an NKCC2A (Na(+)-K(+)-2Cl(-) Cotransporter Isoform A)-Dependent Mechanism.
Hao S, Hao M, Ferreri NR., Free PMC Article | 03/2/2019 |
| The differential regulation of ROMK, large-conductance Ca(2+)-activated K(+) (BK) channel, BK-alpha and NKCC2 between female and male mice, at least, were partly mediated via WNK1 pathway, which may contribute to the sexual dimorphism of plasma K(+) and blood pressure control. | Involvement of WNK1-mediated potassium channels in the sexual dimorphism of blood pressure.
Yu G, Cheng M, Wang W, Zhao R, Liu Z. | 06/24/2017 |
| VAMP3 is required for normal NKCC2 expression, renal function, and blood pressure. | Vesicle-associated Membrane Protein 3 (VAMP3) Mediates Constitutive Trafficking of the Renal Co-transporter NKCC2 in Thick Ascending Limbs: ROLE IN RENAL FUNCTION AND BLOOD PRESSURE.
Caceres PS, Mendez M, Haque MZ, Ortiz PA., Free PMC Article | 05/27/2017 |
| IL-1 receptor (IL-1R1) deficiency or blockade limits blood pressure elevation in this model by mitigating sodium reabsorption via the NKCC2 co-transporter in the nephron. | Interleukin-1 Receptor Activation Potentiates Salt Reabsorption in Angiotensin II-Induced Hypertension via the NKCC2 Co-transporter in the Nephron.
Zhang J, Rudemiller NP, Patel MB, Karlovich NS, Wu M, McDonough AA, Griffiths R, Sparks MA, Jeffs AD, Crowley SD., Free PMC Article | 11/5/2016 |
| Data suggest renal cell lines exhibit an OS9- (osteosarcoma amplified 9 protein-)mediated ERAD (endoplasmic reticulum-associated degradation) pathway that degrades Nkcc2/Slc12a1 prior to glycosylation/processing. | OS9 Protein Interacts with Na-K-2Cl Co-transporter (NKCC2) and Targets Its Immature Form for the Endoplasmic Reticulum-associated Degradation Pathway.
Seaayfan E, Defontaine N, Demaretz S, Zaarour N, Laghmani K., Free PMC Article | 08/6/2016 |
| The findings demonstrated a substantial role of mitochondrial dysfunction in mediating the downregulation of NKCC2 and ENaCalpha in obstructive kidney disease, possibly via iNOS-derived nitric oxide and BNP. | Inhibition of Mitochondrial Complex-1 Prevents the Downregulation of NKCC2 and ENaCα in Obstructive Kidney Disease.
Zhang Y, Sun Y, Ding G, Huang S, Zhang A, Jia Z., Free PMC Article | 05/28/2016 |
| our results suggest that NKCCs are involved in insulin secretion and that a single Slc12a2 allele may protect beta-cells from failure due to increased homeostatic expression of Slc12a1. | Increased Slc12a1 expression in β-cells and improved glucose disposal in Slc12a2 heterozygous mice.
Alshahrani S, Almutairi MM, Kursan S, Dias-Junior E, Almiahuob MM, Aguilar-Bryan L, Di Fulvio M., Free PMC Article | 02/6/2016 |
| Vasopressin plays an important role in the colonic epithelia by stimulating NKCC2 trafficking to the apical membrane and inducing NKCC2-mediated ion transport. | Localization and vasopressin regulation of the Na⁺-K⁺-2Cl⁻ cotransporter in the distal colonic epithelium.
Xue H, Zhang ZJ, Li XS, Sun HM, Kang Q, Wu B, Wang YX, Zou WJ, Zhou DS., Free PMC Article | 04/18/2015 |
| In this systemic analysis no clear primary effects of the Slc12a1I299F mutation appeared for the organs other than the kidneys where Slc12a1 expression has been described. | Standardized, systemic phenotypic analysis of Slc12a1I299F mutant mice.
Kemter E, Rathkolb B, Becker L, Bolle I, Busch DH, Dalke C, Elvert R, Favor J, Graw J, Hans W, Ivandic B, Kalaydjiev S, Klopstock T, Rácz I, Rozman J, Schrewe A, Schulz H, Zimmer A, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Wolf E, Aigner B., Free PMC Article | 04/4/2015 |
| increased phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter in obesity and identifies a new role for AMP-activated protein kinase in regulating the activity of oxidative stress responsive 1 kinase-related proline-alanine-rich protein kinase | Novel mechanisms of Na+ retention in obesity: phosphorylation of NKCC2 and regulation of SPAK/OSR1 by AMPK.
Davies M, Fraser SA, Galic S, Choy SW, Katerelos M, Gleich K, Kemp BE, Mount PF, Power DA. | 09/27/2014 |
| Differential splicing of NKCC2 contributes to the adaptive capacity of the kidney to cope with changes in reabsorptive needs. | Dietary salt intake modulates differential splicing of the Na-K-2Cl cotransporter NKCC2.
Schiessl IM, Rosenauer A, Kattler V, Minuth WW, Oppermann M, Castrop H. | 12/14/2013 |
| NKCC2A-dependent activation of NFAT5 is part of a pathway by which the medullary thick ascending limb produces TNF in response to hypertonic NaCl intake. | NKCC2A and NFAT5 regulate renal TNF production induced by hypertonic NaCl intake.
Hao S, Bellner L, Ferreri NR., Free PMC Article | 05/18/2013 |
| Abnormal anterograde trafficking as a common mechanism associated with mutations depriving NKCC2. | Multiple evolutionarily conserved Di-leucine like motifs in the carboxyl terminus control the anterograde trafficking of NKCC2.
Zaarour N, Demaretz S, Defontaine N, Zhu Y, Laghmani K., Free PMC Article | 02/16/2013 |
| NKCC1 and NKCC2 were expressed in the gastric mucosa of rat, mouse and human. | Cellular distribution of NKCC2 in the gastric mucosa and its response to short-term osmotic shock.
Ji T, Liu S, Zheng LF, Wang Q, Dou ZF, Zhang Y, Zhu JX. | 08/11/2012 |
| In the kidneys, NKCC2 but not NCC is the main target of OSR1 and the reduced p-NKCC2 in KSP-OSR1(-/-) mice may lead to a Bartter-like syndrome. | Impaired phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome.
Lin SH, Yu IS, Jiang ST, Lin SW, Chu P, Chen A, Sytwu HK, Sohara E, Uchida S, Sasaki S, Yang SS., Free PMC Article | 12/31/2011 |
| a permissive role for THP in the modulation of NKCC2-dependent TAL salt reabsorptive function. | Activation of the bumetanide-sensitive Na+,K+,2Cl- cotransporter (NKCC2) is facilitated by Tamm-Horsfall protein in a chloride-sensitive manner.
Mutig K, Kahl T, Saritas T, Godes M, Persson P, Bates J, Raffi H, Rampoldi L, Uchida S, Hille C, Dosche C, Kumar S, Castañeda-Bueno M, Gamba G, Bachmann S., Free PMC Article | 10/22/2011 |
| these findings suggest that TNF plays a role as an endogenous inhibitor of NKCC2 expression and function | Tumor necrosis factor-alpha is an endogenous inhibitor of Na+-K+-2Cl- cotransporter (NKCC2) isoform A in the thick ascending limb.
Battula S, Hao S, Pedraza PL, Stier CT, Ferreri NR., Free PMC Article | 09/10/2011 |
| These findings suggest that NKCC2A and NKCC2F exhibit differential effects on NFAT5 expression and transcriptional activity in response to hypertonicity produced by high NaCl concentration. | Differential regulation of NFAT5 by NKCC2 isoforms in medullary thick ascending limb (mTAL) cells.
Hao S, Zhao H, Darzynkiewicz Z, Battula S, Ferreri NR., Free PMC Article | 07/2/2011 |