| Biological Significance of EphB4 Expression in Cancer. | Biological Significance of EphB4 Expression in Cancer.
Ullah A, Razzaq A, Zhou C, Ullah N, Shehzadi S, Aziz T, Alfaifi MY, Elbehairi SEI, Iqbal H. | 04/23/2024 |
| SAM domain variants of EPHB4 associated with aberrant signaling are linked to lymphatic-related fetal hydrops and facial dysmorphology. | SAM domain variants of EPHB4 associated with aberrant signaling are linked to lymphatic-related fetal hydrops and facial dysmorphology.
Vanden Broek K, Ryu JR, Perrier R, Tyndall AV, Childs SJ, Au PYB. | 03/7/2024 |
| Discovery and Characterization of Ephrin B2 and EphB4 Dysregulation and Novel Mutations in Cerebral Cavernous Malformations: In Vitro and Patient-Derived Evidence of Ephrin-Mediated Endothelial Cell Pathophysiology. | Discovery and Characterization of Ephrin B2 and EphB4 Dysregulation and Novel Mutations in Cerebral Cavernous Malformations: In Vitro and Patient-Derived Evidence of Ephrin-Mediated Endothelial Cell Pathophysiology.
Sesen J, Ghalali A, Driscoll J, Martinez T, Lupieri A, Zurakowski D, Alexandrescu S, Smith ER, Fehnel KP. | 01/11/2024 |
| Diverse p120RasGAP interactions with doubly phosphorylated partners EphB4, p190RhoGAP, and Dok1. | Diverse p120RasGAP interactions with doubly phosphorylated partners EphB4, p190RhoGAP, and Dok1.
Vish KJ, Stiegler AL, Boggon TJ., Free PMC Article | 11/1/2023 |
| Seven cases of hereditary haemorrhagic telangiectasia-like hepatic vascular abnormalities associated with EPHB4 pathogenic variants. | Seven cases of hereditary haemorrhagic telangiectasia-like hepatic vascular abnormalities associated with EPHB4 pathogenic variants.
Guilhem A, Dupuis-Girod S, Espitia O, Rivière S, Seguier J, Kerjouan M, Lavigne C, Maillard H, Magro P, Alric L, Lipsker D, Parrot A, Leguy V, Vanlemmens C, Guibaud L, Vikkula M, Eyries M, Valette PJ, Giraud S. | 08/23/2023 |
| Assessing the association of common genetic variants in EPHB4 and RASA1 with phenotype severity in familial cerebral cavernous malformation. | Assessing the association of common genetic variants in EPHB4 and RASA1 with phenotype severity in familial cerebral cavernous malformation.
Choksi F, Weinsheimer S, Nelson J, Pawlikowska L, Fox CK, Zafar A, Mabray MC, Zabramski J, Akers A, Hart BL, Morrison L, McCulloch CE, Kim H., Free PMC Article | 03/26/2022 |
| Mutations in EPHB4 cause human venous valve aplasia. | Mutations in EPHB4 cause human venous valve aplasia.
Lyons O, Walker J, Seet C, Ikram M, Kuchta A, Arnold A, Hernández-Vásquez M, Frye M, Vizcay-Barrena G, Fleck RA, Patel AS, Padayachee S, Mortimer P, Jeffery S, Berland S, Mansour S, Ostergaard P, Makinen T, Modarai B, Saha P, Smith A., Free PMC Article | 03/19/2022 |
| EphrinB2-EphB4 Signaling in Neurooncological Disease. | EphrinB2-EphB4 Signaling in Neurooncological Disease.
Piffko A, Uhl C, Vajkoczy P, Czabanka M, Broggini T., Free PMC Article | 03/12/2022 |
| EPHB4 mutation causes adult and adolescent-onset primary lymphedema. | EPHB4 mutation causes adult and adolescent-onset primary lymphedema.
Greene AK, Brouillard P, Sudduth CL, Smits PJ, Konczyk DJ, Vikkula M. | 03/5/2022 |
| Transcriptional and Post-Translational Control Mechanisms for EphB4 Expression in Physiology and Cancer Disease. | Transcriptional and Post-Translational Control Mechanisms for EphB4 Expression in Physiology and Cancer Disease.
Scalia P, Maurancy J, Giordano A, Williams SJ. | 02/19/2022 |
| Low Expression of EphB2, EphB3, and EphB4 in Bladder Cancer: Novel Potential Indicators of Muscular Invasion. | Low Expression of EphB2, EphB3, and EphB4 in Bladder Cancer: Novel Potential Indicators of Muscular Invasion.
Lee TH, Heo JH, Jeong JY, Lee GH, Park DS, Kim TH., Free PMC Article | 09/18/2021 |
| EphB4 as a Novel Target for the EGFR-Independent Suppressive Effects of Osimertinib on Cell Cycle Progression in Non-Small Cell Lung Cancer. | EphB4 as a Novel Target for the EGFR-Independent Suppressive Effects of Osimertinib on Cell Cycle Progression in Non-Small Cell Lung Cancer.
Nanamiya R, Saito-Koyama R, Miki Y, Inoue C, Asavasupreechar T, Abe J, Sato I, Sasano H., Free PMC Article | 09/18/2021 |
| Dysregulation of the EphrinB2-EphB4 ratio in pediatric cerebral arteriovenous malformations is associated with endothelial cell dysfunction in vitro and functions as a novel noninvasive biomarker in patients. | Dysregulation of the EphrinB2-EphB4 ratio in pediatric cerebral arteriovenous malformations is associated with endothelial cell dysfunction in vitro and functions as a novel noninvasive biomarker in patients.
Fehnel KP, Penn DL, Duggins-Warf M, Gruber M, Pineda S, Sesen J, Moses-Gardner A, Shah N, Driscoll J, Zurakowski D, Orbach DB, Smith ER., Free PMC Article | 08/7/2021 |
| The differential expression of EPHB4 and ephrin B2 in cutaneous squamous cell carcinoma according to the grade of tumor differentiation: a clinicopathological study. | The differential expression of EPHB4 and ephrin B2 in cutaneous squamous cell carcinoma according to the grade of tumor differentiation: a clinicopathological study.
Oh ST, Yang KJ, Bae JM, Park HJ, Yoo DS, Park YM. | 07/3/2021 |
| Cantharidin treatment inhibits hepatocellular carcinoma development by regulating the JAK2/STAT3 and PI3K/Akt pathways in an EphB4-dependent manner. | Cantharidin treatment inhibits hepatocellular carcinoma development by regulating the JAK2/STAT3 and PI3K/Akt pathways in an EphB4-dependent manner.
Zhu M, Shi X, Gong Z, Su Q, Yu R, Wang B, Yang T, Dai B, Zhan Y, Zhang D, Zhang Y. | 06/5/2021 |
| Ephrin/Eph receptor interaction facilitates macrophage recognition of differentiating human erythroblasts. | Ephrin/Eph receptor interaction facilitates macrophage recognition of differentiating human erythroblasts.
Hampton-O'Neil LA, Severn CE, Cross SJ, Gurung S, Nobes CD, Toye AM., Free PMC Article | 05/8/2021 |
| Kinome multigenic panel identified novel druggable EPHB4-V871I somatic variant in high-risk neuroblastoma. | Kinome multigenic panel identified novel druggable EPHB4-V871I somatic variant in high-risk neuroblastoma.
Andolfo I, Lasorsa VA, Manna F, Rosato BE, Formicola D, Iolascon A, Capasso M., Free PMC Article | 05/1/2021 |
| The Pyrazolo[3,4-d]pyrimidine-Based Kinase Inhibitor NVP-BHG712: Effects of Regioisomers on Tumor Growth, Perfusion, and Hypoxia in EphB4-Positive A375 Melanoma Xenografts. | The Pyrazolo[3,4-d]pyrimidine-Based Kinase Inhibitor NVP-BHG712: Effects of Regioisomers on Tumor Growth, Perfusion, and Hypoxia in EphB4-Positive A375 Melanoma Xenografts.
Neuber C, Tröster A, Löser R, Belter B, Schwalbe H, Pietzsch J., Free PMC Article | 04/3/2021 |
| Hsa_circ_0081534 increases the proliferation and invasion of nasopharyngeal carcinoma cells through regulating the miR-508-5p/FN1 axis. | Hsa_circ_0081534 increases the proliferation and invasion of nasopharyngeal carcinoma cells through regulating the miR-508-5p/FN1 axis.
Li S, Wang Q., Free PMC Article | 04/3/2021 |
| Inhibition of the erythropoietin-producing receptor EPHB4 antagonizes androgen receptor overexpression and reduces enzalutamide resistance. | Inhibition of the erythropoietin-producing receptor EPHB4 antagonizes androgen receptor overexpression and reduces enzalutamide resistance.
Li C, Lanman NA, Kong Y, He D, Mao F, Farah E, Zhang Y, Liu J, Wang C, Wei Q, Liu X., Free PMC Article | 12/19/2020 |
| The effects of ephrinB2 signaling on proliferation and invasion in glioblastoma multiforme. | The effects of ephrinB2 signaling on proliferation and invasion in glioblastoma multiforme.
Bhatia S, Bukkapatnam S, Van Court B, Phan A, Oweida A, Gadwa J, Mueller AC, Piper M, Darragh L, Nguyen D, Gilani A, Knitz M, Bickett T, Green A, Venkataraman S, Vibhakar R, Cittelly D, Karam SD., Free PMC Article | 11/21/2020 |
| EPHB4 inhibition activates ER stress to promote immunogenic cell death of prostate cancer cells. | EPHB4 inhibition activates ER stress to promote immunogenic cell death of prostate cancer cells.
Sagar V, Vatapalli R, Lysy B, Pamarthy S, Anker JF, Rodriguez Y, Han H, Unno K, Stadler WM, Catalona WJ, Hussain M, Gill PS, Abdulkadir SA., Free PMC Article | 09/12/2020 |
| EphrinB2/EphB4 signaling regulates the capacity of dental pulp stem cells to induce sprouting angiogenesis | EphrinB2/EphB4 Signaling Regulates DPSCs to Induce Sprouting Angiogenesis of Endothelial Cells.
Gong T, Xu J, Heng B, Qiu S, Yi B, Han Y, Lo ECM, Zhang C. | 07/18/2020 |
| MicroRNA-652-3p promotes the proliferation and invasion of the trophoblast HTR-8/SVneo cell line by targeting homeobox A9 to modulate the expression of ephrin receptor B4 | MicroRNA-652-3p promotes the proliferation and invasion of the trophoblast HTR-8/SVneo cell line by targeting homeobox A9 to modulate the expression of ephrin receptor B4.
Shi Z, Liu B, Li Y, Liu F, Yuan X, Wang Y. | 07/4/2020 |
| Results show that EPHB4 was the most prominently phosphorylated protein on VE-PTP inhibition among those VE-PTP targets. Further analysis revealed that EPHB4 forms a ternary complex with VE-PTP and TIE2 in endothelial cells. | Vascular Endothelial Receptor Tyrosine Phosphatase: Identification of Novel Substrates Related to Junctions and a Ternary Complex with EPHB4 and TIE2.
Drexler HCA, Vockel M, Polaschegg C, Frye M, Peters K, Vestweber D., Free PMC Article | 06/13/2020 |