| PGC-1alpha and MEF2 Regulate the Transcription of the Carnitine Transporter OCTN2 Gene in C2C12 Cells and in Mouse Skeletal Muscle. | PGC-1α and MEF2 Regulate the Transcription of the Carnitine Transporter OCTN2 Gene in C2C12 Cells and in Mouse Skeletal Muscle.
Novakova K, Török M, Panajatovic M, Bouitbir J, Duong FHT, Handschin C, Krähenbühl S., Free PMC Article | 11/5/2022 |
| Slc22a5 haploinsufficiency does not aggravate the phenotype of the long-chain acyl-CoA dehydrogenase KO mouse. | Slc22a5 haploinsufficiency does not aggravate the phenotype of the long-chain acyl-CoA dehydrogenase KO mouse.
Ranea-Robles P, Yu C, van Vlies N, Vaz FM, Houten SM., Free PMC Article | 08/28/2021 |
| Dystrophin deficiency likely disrupts Octn2 expression decreasing muscle carnitine uptake thus contributing to membranotoxic long-chain acyl-CoAs with sarcolemmal and organellar membrane oxidative injury | Expression of the organic cation/carnitine transporter family (Octn1,-2 and-3) in mdx muscle and heart: Implications for early carnitine therapy in Duchenne muscular dystrophy to improve cellular carnitine homeostasis.
Lamhonwah AM, Tein I. | 04/18/2020 |
| l-carnitine deficiency due to a defect in the carnitine transporter OCTN2 (SLC22A5) in a mouse model leads to embryonic lethality. Placental levels of l-carnitine are reduced to <10% of normal and deficiency of l-carnitine is associated with markedly reduced expression of several growth factors and transforming growth factor beta (TGF-beta) genes. | Embryonic lethality in mice due to carnitine transporter OCTN2 defect and placental carnitine deficiency.
Shekhawat PS, Sonne S, Matern D, Ganapathy V. | 09/14/2019 |
| Acute and chronic administration of clozapine to mice resulted in 2-3-fold greater renal excretion of L-carnitine (L-Car) than in the vehicle group. Concomitantly, mRNA and protein levels of mOctn2 in the kidney were markedly down regulated. These results indicate that clozapine-induced reduction of L-Car reabsorption via inhibition/down-regulation of renal Octn2 contributes to liver lipid metabolic disorder. | Clozapine-induced reduction of l-carnitine reabsorption via inhibition/down-regulation of renal carnitine/organic cation transporter 2 contributes to liver lipid metabolic disorder in mice.
Wang W, Bai M, Jiang T, Li C, Li P, Zhou H, Wang Z, Li L, Jiang H. | 07/20/2019 |
| Both mRNA and protein levels of OCTN2 were detected in kidney after exercise and during recovery, suggesting renal transport mechanisms were stimulated. These changes were accompanied with a reciprocal increase in PPARalpha protein expression. | Acute Exercise Stimulates Carnitine Biosynthesis and OCTN2 Expression in Mouse Kidney.
Broderick TL, Cusimano FA, Carlson C, Tamura LK. | 06/30/2018 |
| There was increased apoptosis in gut samples from OCTN2(-/-) mice. | Carnitine deficiency in OCTN2-/- newborn mice leads to a severe gut and immune phenotype with widespread atrophy, apoptosis and a pro-inflammatory response.
Sonne S, Shekhawat PS, Matern D, Ganapathy V, Ignatowicz L., Free PMC Article | 04/27/2013 |
| Colon OCTN2 gene expression is up-regulated by peroxisome proliferator-activated receptor gamma in humans and mice and contributes to local and systemic carnitine homeostasis. | Colon OCTN2 gene expression is up-regulated by peroxisome proliferator-activated receptor gamma in humans and mice and contributes to local and systemic carnitine homeostasis.
D'Argenio G, Petillo O, Margarucci S, Torpedine A, Calarco A, Koverech A, Boccia A, Paolella G, Peluso G., Free PMC Article | 09/20/2010 |
| OCTN2, a transporter that is thought to be responsible for the accumulation of L-carnitine in the epididymal lumen, is regulated in response to changes in tonicity. | Organic cation/carnitine transporter, OCTN2, transcriptional activity is regulated by osmotic stress in epididymal cells.
Cotton LM, Rodriguez CM, Suzuki K, Orgebin-Crist MC, Hinton BT. | 03/8/2010 |
| Mouse OCTN2 is a direct target gene of PPARalpha and transcriptional upregulation of OCTN2 by PPARalpha is likely mediated via PPRE1 in its first intron. | Mouse OCTN2 is directly regulated by peroxisome proliferator-activated receptor alpha (PPARalpha) via a PPRE located in the first intron.
Wen G, Ringseis R, Eder K. | 03/1/2010 |
| Octn1, -2, and -3 are expressed in many regions of murine heart | Organic cation/carnitine transporter family expression patterns in adult murine heart.
Lamhonwah AM, Wong J, Tam C, Mai L, Tein I. | 01/21/2010 |
| PDZK1 regulates two intestinal transporters, Slc15a1 and Slc22a5, as an adaptor protein for these transporters and affects oral absorption of their substrates. | PDZK1 regulates two intestinal solute carriers (Slc15a1 and Slc22a5) in mice.
Sugiura T, Kato Y, Wakayama T, Silver DL, Kubo Y, Iseki S, Tsuji A. | 01/21/2010 |
| OCTN2 is functionally expressed on the plasma membrane of muscle cells and is involved in distribution of carnitine to the heart. | Involvement of carnitine/organic cation transporter OCTN2 (SLC22A5) in distribution of its substrate carnitine to the heart.
Iwata D, Kato Y, Wakayama T, Sai Y, Kubo Y, Iseki S, Tsuji A. | 01/21/2010 |
| shows that transcriptional upregulation of OCTN2 and OCTN3 in tissues and of enzymes involved in hepatic carnitine biosynthesis are mediated by PPAR alpha | PPAR alpha mediates transcriptional upregulation of novel organic cation transporters-2 and -3 and enzymes involved in hepatic carnitine synthesis.
Koch A, König B, Stangl GI, Eder K. | 01/21/2010 |
| This distribution may play a role in the pattern of neurological injury that occurs in hOCTN2 deficiency during catabolic episodes of hypoglycemic, hypoketotic encephalopathy and which may manifest with cognitive impairment, hypotonia and seizures. | Expression patterns of the organic cation/carnitine transporter family in adult murine brain.
Lamhonwah AM, Hawkins CE, Tam C, Wong J, Mai L, Tein I. | 01/21/2010 |
| PPARalpha up-regulates the expression of Slc22a5 in small intestine. | PPARalpha agonists positively and negatively regulate the expression of several nutrient/drug transporters in mouse small intestine.
Hirai T, Fukui Y, Motojima K. | 01/21/2010 |
| PPAR alpha-activation results in enhanced carnitine biosynthesis and OCTN2-mediated hepatic carnitine accumulation | PPAR alpha-activation results in enhanced carnitine biosynthesis and OCTN2-mediated hepatic carnitine accumulation.
van Vlies N, Ferdinandusse S, Turkenburg M, Wanders RJ, Vaz FM. | 01/21/2010 |
| Novel OCTN2 in mouse pancreas. | Expression of novel organic cation/carnitine transporter (OCTN2) in the mouse pancreas.
Kai S, Yakushiji K, Yamauchi M, Ito C, Kuwajima M, Osada Y, Toshimori K. | 01/21/2010 |
| acetyl-L-carnitine is transported from blood to brain extracellular fluid by OCTN2 | Acetyl-L-carnitine permeability across the blood-brain barrier and involvement of carnitine transporter OCTN2.
Inano A, Sai Y, Nikaido H, Hasimoto N, Asano M, Tsuji A, Tamai I. | 01/21/2010 |
| placental OCTN2 is obligatory for accumulation of carnitine in placenta & fetus, fatty acid beta-oxidation enzymes are expressed in placenta & reduced carnitine levels upregulate expression of short-chain L-3-hydroxyacyl CoA dehydrogenase in placenta | Carnitine content and expression of mitochondrial beta-oxidation enzymes in placentas of wild-type (OCTN2(+/+)) and OCTN2 Null (OCTN2(-/-)) Mice.
Shekhawat PS, Yang HS, Bennett MJ, Carter AL, Matern D, Tamai I, Ganapathy V. | 01/21/2010 |
| OCTN2 functions as a carnitine transporter between the epithelium and the lumen in distal corpus and cauda epididymides and provides a clue as to why obstructive azoospermia is induced in distal parts of epididymis. | Expression and distribution of OCTN2 in mouse epididymis and its association with obstructive azoospermia in juvenile visceral steatosis mice.
Yakushiji K, Kai S, Yamauchi M, Kuwajima M, Osada Y, Toshimori K. | 01/21/2010 |
| These findings indicate that OCTN2 is predominantly responsible for the uptake of carnitine from the apical surface of mouse small intestinal epithelial cells. | Organic cation/carnitine transporter OCTN2 (Slc22a5) is responsible for carnitine transport across apical membranes of small intestinal epithelial cells in mouse.
Kato Y, Sugiura M, Sugiura T, Wakayama T, Kubo Y, Kobayashi D, Sai Y, Tamai I, Iseki S, Tsuji A. | 01/21/2010 |