| Cardiac function is regulated by the sodium-dependent inhibition of the sodium-calcium exchanger NCX1. | Cardiac function is regulated by the sodium-dependent inhibition of the sodium-calcium exchanger NCX1.
Scranton K, John S, Angelini M, Steccanella F, Umar S, Zhang R, Goldhaber JI, Olcese R, Ottolia M., Free PMC Article | 05/28/2024 |
| Silencing mouse circular RNA circSlc8a1 by circular antisense cA-circSlc8a1 induces cardiac hepatopathy. | Silencing mouse circular RNA circSlc8a1 by circular antisense cA-circSlc8a1 induces cardiac hepatopathy.
Wu N, Li F, Yang W, Du WW, Awan FM, Zhang C, Lyu J, Misir S, Zeng K, Eshaghi E, Yang BB., Free PMC Article | 06/14/2023 |
| Higher Na(+)-Ca(2+) Exchanger Function and Triggered Activity Contribute to Male Predisposition to Atrial Fibrillation. | Higher Na(+)-Ca(2+) Exchanger Function and Triggered Activity Contribute to Male Predisposition to Atrial Fibrillation.
Thibault S, Long V, Fiset C., Free PMC Article | 10/15/2022 |
| IN BRAIN POST-ISCHEMIC PLASTICITY, Na(+)/Ca(2+) EXCHANGER 1 AND Ascl1 INTERVENE IN MICROGLIA-DEPENDENT CONVERSION OF ASTROCYTES INTO NEURONAL LINEAGE. | IN BRAIN POST-ISCHEMIC PLASTICITY, Na(+)/Ca(2+) EXCHANGER 1 AND Ascl1 INTERVENE IN MICROGLIA-DEPENDENT CONVERSION OF ASTROCYTES INTO NEURONAL LINEAGE.
Casamassa A, Cuomo O, Pannaccione A, Cepparulo P, Laudati G, Valsecchi V, Annunziato L, Pignataro G. | 07/30/2022 |
| Na(+)/Ca(2+) exchanger isoform 1 (NCX1) and canonical transient receptor potential channel 6 (TRPC6) are recruited by STIM1 to mediate Store-Operated Calcium Entry in primary cortical neurons. | Na(+)/Ca(2+) exchanger isoform 1 (NCX1) and canonical transient receptor potential channel 6 (TRPC6) are recruited by STIM1 to mediate Store-Operated Calcium Entry in primary cortical neurons.
Tedeschi V, Sisalli MJ, Pannaccione A, Piccialli I, Molinaro P, Annunziato L, Secondo A. | 02/5/2022 |
| Acute Genetic Ablation of Cardiac Sodium/Calcium Exchange in Adult Mice: Implications for Cardiomyocyte Calcium Regulation, Cardioprotection, and Arrhythmia. | Acute Genetic Ablation of Cardiac Sodium/Calcium Exchange in Adult Mice: Implications for Cardiomyocyte Calcium Regulation, Cardioprotection, and Arrhythmia.
Lotteau S, Zhang R, Hazan A, Grabar C, Gonzalez D, Aynaszyan S, Philipson KD, Ottolia M, Goldhaber JI., Free PMC Article | 01/8/2022 |
| Genetic knockout and pharmacologic inhibition of NCX1 attenuate hypoxia-induced pulmonary arterial hypertension. | Genetic knockout and pharmacologic inhibition of NCX1 attenuate hypoxia-induced pulmonary arterial hypertension.
Nagata A, Tagashira H, Kita S, Kita T, Nakajima N, Abe K, Iwasaki A, Iwamoto T. | 02/13/2021 |
| Genetic Up-Regulation or Pharmacological Activation of the Na(+)/Ca(2+) Exchanger 1 (NCX1) Enhances Hippocampal-Dependent Contextual and Spatial Learning and Memory. | Genetic Up-Regulation or Pharmacological Activation of the Na(+)/Ca(2+) Exchanger 1 (NCX1) Enhances Hippocampal-Dependent Contextual and Spatial Learning and Memory.
Natale S, Anzilotti S, Petrozziello T, Ciccone R, Serani A, Calabrese L, Severino B, Frecentese F, Secondo A, Pannaccione A, Fiorino F, Cuomo O, Vinciguerra A, D'Esposito L, Sadile AG, Cabib S, Di Renzo G, Annunziato L, Molinaro P. | 02/6/2021 |
| NO-induced vasodilation correlates directly with BP in smooth muscle-Na/Ca exchanger-1-engineered mice: elevated BP does not attenuate endothelial function. | NO-induced vasodilation correlates directly with BP in smooth muscle-Na/Ca exchanger-1-engineered mice: elevated BP does not attenuate endothelial function.
Wang Y, Zhang J, Wier WG, Chen L, Blaustein MP., Free PMC Article | 02/6/2021 |
| NCX1 is able to sense Na+ and is required for amplifying inflammatory and antimicrobial macrophage responses upon high salt exposure. | NCX1 represents an ionic Na+ sensing mechanism in macrophages.
Neubert P, Homann A, Wendelborn D, Bär AL, Krampert L, Trum M, Schröder A, Ebner S, Weichselbaum A, Schatz V, Linz P, Veelken R, Schulte-Schrepping J, Aschenbrenner AC, Quast T, Kurts C, Geisberger S, Kunzelmann K, Hammer K, Binger KJ, Titze J, Müller DN, Kolanus W, Schultze JL, Wagner S, Jantsch J., Free PMC Article | 08/1/2020 |
| PKD2L1 deficiency increased p300-mediated acetylation of histone 3 lysine 27 on the promoter of sodium/calcium exchange 1 (NCX1) by repressing AMP-activated protein kinase (AMPK) activity, resulting in NCX1 overexpression and mitochondrial Ca(2+) overload. | Deficiency of PKD2L1 (TRPP3) Exacerbates Pathological Cardiac Hypertrophy by Augmenting NCX1-Mediated Mitochondrial Calcium Overload.
Lu Z, Cui Y, Wei X, Gao P, Zhang H, Wei X, Li Q, Sun F, Yan Z, Zheng H, Yang G, Liu D, Zhu Z. | 02/1/2020 |
| Smooth muscle Na+/Ca2+ exchanger-1 transgene overexpression increases femoral artery basal cytosolic Ca2+ concentration and tone in vivo and raises blood pressure. | Na(+)/Ca(2+) exchanger overexpression in smooth muscle augments cytosolic Ca(2+) in femoral arteries of living mice.
Zhang J, Wang Y, Chen L, Wier WG, Blaustein MP., Free PMC Article | 12/28/2019 |
| NCX1 was exclusively co-expressed in IBA-1-positive microglial cells in the striatum, whereas NCX3 was solely co-expressed in tyrosine hydroxylase-positive neurons in substantia nigra. | NCX1 and NCX3 as potential factors contributing to neurodegeneration and neuroinflammation in the A53T transgenic mouse model of Parkinson's Disease.
Sirabella R, Sisalli MJ, Costa G, Omura K, Ianniello G, Pinna A, Morelli M, Di Renzo GM, Annunziato L, Scorziello A., Free PMC Article | 11/9/2019 |
| These findings reveal a novel regulatory pathway that comprises circular transcript of NCX1, miR-133a-3p and CDIP1, that is involved in cardiomyocyte apoptosis during ischemic cardiac disease. | A circular transcript of ncx1 gene mediates ischemic myocardial injury by targeting miR-133a-3p.
Li M, Ding W, Tariq MA, Chang W, Zhang X, Xu W, Hou L, Wang Y, Wang J., Free PMC Article | 09/7/2019 |
| the increased CaMKII activity and consequent c-Fos expression likely account for the dysregulation of amygdala-dependent cued fear memory in NCX1(+/-) mice. | Aberrant Amygdala-Dependent Cued Fear Memory in Na(+)/Ca(2+) Exchanger 1 Heterozygous Mice.
Moriguchi S, Kita S, Inagaki R, Yabuki Y, Sasaki Y, Ishikawa S, Sakagami H, Iwamoto T, Fukunaga K. | 08/31/2019 |
| These findings indicate that NCX1 may play a role in maintaining patent DA not only by preventing DA functional closure through reducing cytosolic Ca(2+) level in DASMC but also by delaying the anatomical closure process. | The Role of Na+/Ca2+ Exchanger 1 in Maintaining Ductus Arteriosus Patency.
Li M, Jiang C, Ye L, Wang S, Zhang H, Liu J, Hong H., Free PMC Article | 04/27/2019 |
| present study highlights the significant role of NCX in the evolution of neonatal brain injury and in the learning and memory processes that are impaired in mice injured in the neonatal period | Acute and long-term NCX activation reduces brain injury and restores behavioral functions in mice subjected to neonatal brain ischemia.
Cerullo P, Brancaccio P, Anzilotti S, Vinciguerra A, Cuomo O, Fiorino F, Severino B, Di Vaio P, Di Renzo G, Annunziato L, Pignataro G. | 02/9/2019 |
| Pin1 serves as a modulator of SERCA2a and Na(2+)/Ca(2+) exchanger 1 Ca(2+) handling proteins, with loss of function resulting in impaired cardiomyocyte relaxation | Peptidyl-Prolyl Isomerase 1 Regulates Ca(2+) Handling by Modulating Sarco(Endo)Plasmic Reticulum Calcium ATPase and Na(2+)/Ca(2+) Exchanger 1 Protein Levels and Function.
Sacchi V, Wang BJ, Kubli D, Martinez AS, Jin JK, Alvarez R Jr, Hariharan N, Glembotski C, Uchida T, Malter JS, Yang Y, Gross P, Zhang C, Houser S, Rota M, Sussman MA., Free PMC Article | 06/9/2018 |
| NCX1 (and NCX2) are expressed in neurons that regulate the motility of the gastric fundus. | Na(+) /Ca(2+) exchanger-heterozygote knockout mice display increased relaxation in gastric fundus and accelerated gastric transit in vivo.
Azuma YT, Hayashi S, Nishiyama K, Kita S, Mukai K, Nakajima H, Iwamoto T, Takeuchi T. | 02/10/2018 |
| Induced overexpression of NCX1 attenuated pressure overload-induced pathological cardiac remodelling | Induced NCX1 overexpression attenuates pressure overload-induced pathological cardiac remodelling.
Ujihara Y, Iwasaki K, Takatsu S, Hashimoto K, Naruse K, Mohri S, Katanosaka Y. | 09/30/2017 |
| The heterogeneous expression of multiple types of Na(+)/Ca(2+) exchangers and the quantitative differences found in calcium concentration, together with other risk factors specific to dopaminergic neurons such as dopamine oxidation resulting in oxidative stress, may drive these cells to undergo selective degeneration. | Calcium regulation in mouse mesencephalic neurons-Differential roles of Na(+)/Ca(2+) exchanger, mitochondria and endoplasmic reticulum.
Wu PC, Kao LS. | 09/30/2017 |
| NCX1 is dispensable for osteoclast differentiation. | Increased bone resorption by osteoclast-specific deletion of the sodium/calcium exchanger isoform 1 (NCX1).
Albano G, Dolder S, Siegrist M, Mercier-Zuber A, Auberson M, Stoudmann C, Hofstetter W, Bonny O, Fuster DG. | 08/26/2017 |
| the functional role of NCX on gastrointestinal motility | Na(+)/Ca(2+) exchanger contributes to stool transport in mice with experimental diarrhea.
Nishiyama K, Tanioka K, Azuma YT, Hayashi S, Fujimoto Y, Yoshida N, Kita S, Suzuki S, Nakajima H, Iwamoto T, Takeuchi T., Free PMC Article | 08/12/2017 |
| These results suggested that NCX1 may play an important role in the proper spatial distribution of LTCC and JP2 in T-tubules in the context of pressure-overloading. | Effects of induced Na(+)/Ca(2+) exchanger overexpression on the spatial distribution of L-type Ca(2+) channels and junctophilin-2 in pressure-overloaded hearts.
Ujihara Y, Mohri S, Katanosaka Y. | 06/3/2017 |
| In this study, authors demonstrate that NCX1 regulates gastric fundus motility. | Overexpression of Na(+)/Ca(2+) exchanger 1 display enhanced relaxation in the gastric fundus.
Fujimoto Y, Hayashi S, Azuma YT, Mukai K, Nishiyama K, Kita S, Morioka A, Nakajima H, Iwamoto T, Takeuchi T. | 04/15/2017 |