| ASM is a therapeutic target in dermatomyositis by regulating the differentiation of naive CD4 + T cells into Th17 and Treg subsets. | ASM is a therapeutic target in dermatomyositis by regulating the differentiation of naive CD4 + T cells into Th17 and Treg subsets.
Chen Y, Liu H, Luo Z, Zhang J, Dong M, Yin G, Xie Q., Free PMC Article | 08/8/2024 |
| Podocyte-specific silencing of acid sphingomyelinase gene to abrogate hyperhomocysteinemia-induced NLRP3 inflammasome activation and glomerular inflammation. | Podocyte-specific silencing of acid sphingomyelinase gene to abrogate hyperhomocysteinemia-induced NLRP3 inflammasome activation and glomerular inflammation.
Huang D, Kidd JM, Zou Y, Wu X, Li N, Gehr TWB, Li PL, Li G., | 06/7/2024 |
| Neurons regulate the esterification of bioactive lipid mediators in the brain of acid sphingomyelinase deficient mice. | Neurons regulate the esterification of bioactive lipid mediators in the brain of acid sphingomyelinase deficient mice.
Taha AY, Gaudioso Á, Moran-Garrido M, Camunas-Alberca SM, Bachiller-Hernández J, Sáiz J, Ledesma MD, Barbas C. | 12/27/2023 |
| Factor VIIa releases phosphatidylserine-enriched extracellular vesicles from endothelial cells by activating acid sphingomyelinase. | Factor VIIa releases phosphatidylserine-enriched extracellular vesicles from endothelial cells by activating acid sphingomyelinase.
Das K, Keshava S, Mukherjee T, Wang J, Magisetty J, Kolesnick R, Pendurthi UR, Rao LVM. | 11/30/2023 |
| Regulation of NLRP3 Inflammasome Activation and Inflammatory Exosome Release in Podocytes by Acid Sphingomyelinase During Obesity. | Regulation of NLRP3 Inflammasome Activation and Inflammatory Exosome Release in Podocytes by Acid Sphingomyelinase During Obesity.
Huang D, Kidd JM, Zou Y, Wu X, Gehr TWB, Li PL, Li G., Free PMC Article | 10/26/2023 |
| Modulation of Dietary Choline Uptake in a Mouse Model of Acid Sphingomyelinase Deficiency. | Modulation of Dietary Choline Uptake in a Mouse Model of Acid Sphingomyelinase Deficiency.
Gaudioso Á, Moreno-Huguet P, Casas J, Schuchman EH, Ledesma MD., Free PMC Article | 06/15/2023 |
| Caspase-7 activates ASM to repair gasdermin and perforin pores. | Caspase-7 activates ASM to repair gasdermin and perforin pores.
Nozaki K, Maltez VI, Rayamajhi M, Tubbs AL, Mitchell JE, Lacey CA, Harvest CK, Li L, Nash WT, Larson HN, McGlaughon BD, Moorman NJ, Brown MG, Whitmire JK, Miao EA., Free PMC Article | 07/9/2022 |
| Targeting the ASMase/S1P pathway protects from sortilin-evoked vascular damage in hypertension. | Targeting the ASMase/S1P pathway protects from sortilin-evoked vascular damage in hypertension.
Di Pietro P, Carrizzo A, Sommella E, Oliveti M, Iacoviello L, Di Castelnuovo A, Acernese F, Damato A, De Lucia M, Merciai F, Iesu P, Venturini E, Izzo R, Trimarco V, Ciccarelli M, Giugliano G, Carnevale R, Cammisotto V, Migliarino S, Virtuoso N, Strianese A, Izzo V, Campiglia P, Ciaglia E, Levkau B, Puca AA, Vecchione C., Free PMC Article | 04/2/2022 |
| Acid Sphingomyelinase Controls Early Phases of Skeletal Muscle Regeneration by Shaping the Macrophage Phenotype. | Acid Sphingomyelinase Controls Early Phases of Skeletal Muscle Regeneration by Shaping the Macrophage Phenotype.
Roux-Biejat P, Coazzoli M, Marrazzo P, Zecchini S, Di Renzo I, Prata C, Napoli A, Moscheni C, Giovarelli M, Barbalace MC, Catalani E, Bassi MT, De Palma C, Cervia D, Malaguti M, Hrelia S, Clementi E, Perrotta C., Free PMC Article | 12/25/2021 |
| Functional inhibition or genetic deletion of acid sphingomyelinase bacteriostatically inhibits Anaplasma phagocytophilum infection in vivo. | Functional inhibition or genetic deletion of acid sphingomyelinase bacteriostatically inhibits Anaplasma phagocytophilum infection in vivo.
Naimi WA, Gumpf JJ, Cockburn CL, Camus S, Chalfant CE, Li PL, Carlyon JA., Free PMC Article | 12/25/2021 |
| Homozygous Smpd1 deficiency aggravates brain ischemia/ reperfusion injury by mechanisms involving polymorphonuclear neutrophils, whereas heterozygous Smpd1 deficiency protects against mild focal cerebral ischemia. | Homozygous Smpd1 deficiency aggravates brain ischemia/ reperfusion injury by mechanisms involving polymorphonuclear neutrophils, whereas heterozygous Smpd1 deficiency protects against mild focal cerebral ischemia.
Hagemann N, Mohamud Yusuf A, Martiny C, Zhang X, Kleinschnitz C, Gunzer M, Kolesnick R, Gulbins E, Hermann DM., Free PMC Article | 10/23/2021 |
| Altered Macrophage Function Associated with Crystalline Lung Inflammation in Acid Sphingomyelinase Deficiency. | Altered Macrophage Function Associated with Crystalline Lung Inflammation in Acid Sphingomyelinase Deficiency.
Poczobutt JM, Mikosz AM, Poirier C, Beatman EL, Serban KA, Gally F, Cao D, McCubbrey AL, Cornell CF, Schweitzer KS, Berdyshev EV, Bronova IA, Paris F, Petrache I., Free PMC Article | 07/31/2021 |
| Reevaluation of Lung Injury in TNF-Induced Shock: The Role of the Acid Sphingomyelinase. | Reevaluation of Lung Injury in TNF-Induced Shock: The Role of the Acid Sphingomyelinase.
Reiss LK, Raffetseder U, Gibbert L, Drescher HK, Streetz KL, Schwarz A, Martin C, Uhlig S, Adam D., Free PMC Article | 07/10/2021 |
| mRNA Expression of SMPD1 Encoding Acid Sphingomyelinase Decreases upon Antidepressant Treatment. | mRNA Expression of SMPD1 Encoding Acid Sphingomyelinase Decreases upon Antidepressant Treatment.
Rhein C, Zoicas I, Marx LM, Zeitler S, Hepp T, von Zimmermann C, Mühle C, Richter-Schmidinger T, Lenz B, Erim Y, Reichel M, Gulbins E, Kornhuber J., Free PMC Article | 06/26/2021 |
| Acid Sphingomyelinase Contributes to the Control of Mycobacterial Infection via a Signaling Cascade Leading from Reactive Oxygen Species to Cathepsin D. | Acid Sphingomyelinase Contributes to the Control of Mycobacterial Infection via a Signaling Cascade Leading from Reactive Oxygen Species to Cathepsin D.
Wu Y, Li C, Peng H, Swaidan A, Riehle A, Pollmeier B, Zhang Y, Gulbins E, Grassmé H., Free PMC Article | 06/19/2021 |
| Acid Sphingomyelinase Downregulation Enhances Mitochondrial Fusion and Promotes Oxidative Metabolism in a Mouse Model of Melanoma. | Acid Sphingomyelinase Downregulation Enhances Mitochondrial Fusion and Promotes Oxidative Metabolism in a Mouse Model of Melanoma.
Coazzoli M, Napoli A, Roux-Biejat P, Palma C, Moscheni C, Catalani E, Zecchini S, Conte V, Giovarelli M, Caccia S, Procacci P, Cervia D, Clementi E, Perrotta C., Free PMC Article | 02/27/2021 |
| The Forebrain-Specific Overexpression of Acid Sphingomyelinase Induces Depressive-Like Symptoms in Mice. | The Forebrain-Specific Overexpression of Acid Sphingomyelinase Induces Depressive-Like Symptoms in Mice.
Zoicas I, Schumacher F, Kleuser B, Reichel M, Gulbins E, Fejtova A, Kornhuber J, Rhein C., Free PMC Article | 02/27/2021 |
| Secretion of Acid Sphingomyelinase and Ceramide by Endothelial Cells Contributes to Radiation-Induced Intestinal Toxicity. | Secretion of Acid Sphingomyelinase and Ceramide by Endothelial Cells Contributes to Radiation-Induced Intestinal Toxicity.
Leonetti D, Estéphan H, Ripoche N, Dubois N, Aguesse A, Gouard S, Brossard L, Chiavassa S, Corre I, Pecqueur C, Neunlist M, Hadchity E, Gaugler MH, Mahé MM, Paris F. | 11/21/2020 |
| Acid sphingomyelinase deficiency protects mitochondria and improves function recovery after brain injury | Acid sphingomyelinase deficiency protects mitochondria and improves function recovery after brain injury.
Novgorodov SA, Voltin JR, Wang W, Tomlinson S, Riley CL, Gudz TI., Free PMC Article | 06/20/2020 |
| acid sphingomyelinase could be a potential new therapeutic target for Farber disease to reduce disease manifestations and prolong survival. | Acid Sphingomyelinase Deficiency Ameliorates Farber Disease.
Beckmann N, Becker KA, Kadow S, Schumacher F, Kramer M, Kühn C, Schulz-Schaeffer WJ, Edwards MJ, Kleuser B, Gulbins E, Carpinteiro A., Free PMC Article | 04/25/2020 |
| Acid sphingomyelinase (aSMase) plays an important role in endothelial dysfunction. These results suggest that inhibition of aSMase/ceramide pathway improves endothelium-dependent vasodilation in diabetic animals. | Inhibition of acid sphingomyelinase activity ameliorates endothelial dysfunction in db/db mice.
Jiang M, Huang S, Duan W, Liu Q, Lei M., Free PMC Article | 04/18/2020 |
| These data indicate that lipopolysaccharide - or cytokine-induced TF procoagulant activity requires the decryption of newly synthesized TF protein by ASMase-mediated hydrolysis of sphingomyelin. | Acid sphingomyelinase plays a critical role in LPS- and cytokine-induced tissue factor procoagulant activity.
Wang J, Pendurthi UR, Rao LVM., Free PMC Article | 01/25/2020 |
| This first demonstration of a p62/SQSTM1-dependent myofibroblast-like phenotypic transition in Smpd1(-/-) SMCs suggests that ASM-mediated autophagy pathway contributes to maintaining the arterial smooth muscle homeostasis in situation of vascular remodeling during atherosclerosis. | Contribution of p62/SQSTM1 to PDGF-BB-induced myofibroblast-like phenotypic transition in vascular smooth muscle cells lacking Smpd1 gene.
Zhang P, Guan Y, Chen J, Li X, McConnell BK, Zhou W, Boini KM, Zhang Y., Free PMC Article | 12/14/2019 |
| immunoregulatory role of acid sphingomyelinase in allergic asthma | Immunoregulatory role of acid sphingomyelinase in allergic asthma.
Sopel N, Kölle J, Dumendiak S, Koch S, Reichel M, Rhein C, Kornhuber J, Finotto S., Free PMC Article | 09/21/2019 |
| Nitric Oxide Generated by Tumor-Associated Macrophages Is Responsible for Cancer Resistance to Cisplatin and Correlated With Syntaxin 4 and Acid Sphingomyelinase Inhibition. | Nitric Oxide Generated by Tumor-Associated Macrophages Is Responsible for Cancer Resistance to Cisplatin and Correlated With Syntaxin 4 and Acid Sphingomyelinase Inhibition.
Perrotta C, Cervia D, Di Renzo I, Moscheni C, Bassi MT, Campana L, Martelli C, Catalani E, Giovarelli M, Zecchini S, Coazzoli M, Capobianco A, Ottobrini L, Lucignani G, Rosa P, Rovere-Querini P, De Palma C, Clementi E., Free PMC Article | 08/17/2019 |