| Study shows that Sox1 is a master cell identity factor: the induction of its endogenous gene copy restores the neuronal differentiation potential of glial progenitor cells. Moreover, chromatin features, in particular, DNA methylation at its promoter, tightly control the capability of Sox1 to be trans-activated. | Targeted removal of epigenetic barriers during transcriptional reprogramming.
Baumann V, Wiesbeck M, Breunig CT, Braun JM, Köferle A, Ninkovic J, Götz M, Stricker SH., Free PMC Article | 06/15/2019 |
| Optimal SOXB1 levels are critical for each pluripotent state and for cell fate decisions during exit from naive pluripotency. | Distinct SoxB1 networks are required for naïve and primed pluripotency.
Corsinotti A, Wong FC, Tatar T, Szczerbinska I, Halbritter F, Colby D, Gogolok S, Pantier R, Liggat K, Mirfazeli ES, Hall-Ponsele E, Mullin NP, Wilson V, Chambers I., Free PMC Article | 08/25/2018 |
| These results demonstrate a novel role for SOX2 in glial process outgrowth and adhesion, and provide new insights into the essential role Muller glia play in the development of retinal cytoarchitecture. | Sox2-Deficient Müller Glia Disrupt the Structural and Functional Maturation of the Mammalian Retina.
Bachleda AR, Pevny LH, Weiss ER., Free PMC Article | 07/30/2016 |
| Sox10 overexpression causes mammary cells to undergo a mesenchymal transition. | Sox10 Regulates Stem/Progenitor and Mesenchymal Cell States in Mammary Epithelial Cells.
Dravis C, Spike BT, Harrell JC, Johns C, Trejo CL, Southard-Smith EM, Perou CM, Wahl GM., Free PMC Article | 07/16/2016 |
| Sox1 lineage labels activated neural stem/progenitor cells in the adult mouse hippocampus. | Sox1 marks an activated neural stem/progenitor cell in the hippocampus.
Venere M, Han YG, Bell R, Song JS, Alvarez-Buylla A, Blelloch R, Venere M, Han YG, Bell R, Song JS, Alvarez-Buylla A, Blelloch R., Free PMC Articles: PMC3472585, PMC3472585 | 04/8/2016 |
| Data show that a neural crest cells (NCCs) population that is not derived from Sox1(+) dorsal neuroepithelial cells but are derived from Sox1(-) cells differentiate into a significant population of melanocytes in the skin. | Dual origin of melanocytes defined by Sox1 expression and their region-specific distribution in mammalian skin.
Yoshimura N, Motohashi T, Aoki H, Tezuka K, Watanabe N, Wakaoka T, Era T, Kunisada T. | 07/27/2013 |
| genes induced in a SoxB1-dependent manner appear to constitute repressive gene regulatory networks that are directly interlinked. | SoxB1-driven transcriptional network underlies neural-specific interpretation of morphogen signals.
Oosterveen T, Kurdija S, Ensterö M, Uhde CW, Bergsland M, Sandberg M, Sandberg R, Muhr J, Ericson J., Free PMC Article | 06/29/2013 |
| Sox1, a member of the SoxB1 family of transcription factors, is expressed in a subset of radial astrocytes | Sox1 marks an activated neural stem/progenitor cell in the hippocampus.
Venere M, Han YG, Bell R, Song JS, Alvarez-Buylla A, Blelloch R, Venere M, Han YG, Bell R, Song JS, Alvarez-Buylla A, Blelloch R., Free PMC Articles: PMC3472585, PMC3472585 | 12/22/2012 |
| Sox1 regulates the size of the cortical neural progenitor pool via suppression of neurogenic cell divisions. | Sox1 maintains the undifferentiated state of cortical neural progenitor cells via the suppression of Prox1-mediated cell cycle exit and neurogenesis.
Elkouris M, Balaskas N, Poulou M, Politis PK, Panayiotou E, Malas S, Thomaidou D, Remboutsika E. | 05/7/2011 |
| Genetic fate mapping and loss-of-function analysis show that transcription factor Sox1 is expressed in, and required for, a third type of p2-derived interneuron, which has been named V2c. | Sox1 is required for the specification of a novel p2-derived interneuron subtype in the mouse ventral spinal cord.
Panayi H, Panayiotou E, Orford M, Genethliou N, Mean R, Lapathitis G, Li S, Xiang M, Kessaris N, Richardson WD, Malas S., Free PMC Article | 10/30/2010 |
| Our results show that the Bergmann glia population expresses Sox1 during cerebellar development, and that these cells can be isolated and show stem cell characteristics in vitro, suggesting that they could hold a broader potential than previously thought. | Dynamic distribution and stem cell characteristics of Sox1-expressing cells in the cerebellar cortex.
Alcock J, Sottile V. | 03/1/2010 |
| These data integrate functional roles of neural patterning factors, Notch signalling and SOX1 during gliogenesis. | SOX1 links the function of neural patterning and Notch signalling in the ventral spinal cord during the neuron-glial fate switch.
Genethliou N, Panayiotou E, Panayi H, Orford M, Mean R, Lapathitis G, Gill H, Raoof S, De Gasperi R, Elder G, Kessaris N, Richardson WD, Malas S. | 01/21/2010 |
| Sox1 enhances neuroectodermal commitment and maintenance but blocks further differentiation. In contrast, Pax6 is involved in the progression of neuroectoderm toward radial glia. | A Sox1 to Pax6 switch drives neuroectoderm to radial glia progression during differentiation of mouse embryonic stem cells.
Suter DM, Tirefort D, Julien S, Krause KH. | 01/21/2010 |
| expression of shRNA against GPM6A markedly reduced the expression of neuroectodermal-associated genes (OTX1, Lmx1b, En1, Pax2, Pax5, Sox1, Sox2, and Wnt1), and also the number of neural stem cells (NSC) derived from D3mshM6A cells | Inhibition of mouse GPM6A expression leads to decreased differentiation of neurons derived from mouse embryonic stem cells.
Michibata H, Okuno T, Konishi N, Wakimoto K, Kyono K, Aoki K, Kondo Y, Takata K, Kitamura Y, Taniguchi T. | 01/21/2010 |
| Sox1 expression by early embryonic progenitor cells initially helps to maintain the cells in cell cycle, but that continued expression subsequently promotes neuronal lineage commitment | Dual function of Sox1 in telencephalic progenitor cells.
Kan L, Jalali A, Zhao LR, Zhou X, McGuire T, Kazanis I, Episkopou V, Bassuk AG, Kessler JA., Free PMC Article | 01/21/2010 |
| SOX1 is essential for ventral telencephalic development | Sox1-deficient mice suffer from epilepsy associated with abnormal ventral forebrain development and olfactory cortex hyperexcitability.
Malas S, Postlethwaite M, Ekonomou A, Whalley B, Nishiguchi S, Wood H, Meldrum B, Constanti A, Episkopou V. | 01/21/2010 |
| newly identified enhancer with Sox elements activates the alphaB-crystallin promoter in the lens, although they are separated by the entire HSPB2 gene | Distal Sox binding elements of the alphaB-crystallin gene show lens enhancer activity in transgenic mouse embryos.
Ijichi N, Tsujimoto N, Iwaki T, Fukumaki Y, Iwaki A. | 01/21/2010 |
| Ventral striatum precursors and their early neuronal differentiation are unaffected in the absence of SOX1, but the prospective neurons fail to migrate to their appropriate position. | Neuronal migration and ventral subtype identity in the telencephalon depend on SOX1.
Ekonomou A, Kazanis I, Malas S, Wood H, Alifragis P, Denaxa M, Karagogeos D, Constanti A, Lovell-Badge R, Episkopou V., Free PMC Article | 01/21/2010 |