| This is the first study to recognize the potential implication of maspin in the pathophysiology of asthma | Increased extracellular maspin levels after mechanical compression in vitro or allergen challenge in vivo.
Kim SH, Mitchel JA, McGill M, Cremona TP, Baek JW, Kasahara DI, Anathy V, Israel E, Park JA., Free PMC Article | 06/20/2020 |
| model of apoptosis in which maspin binds to cardiolipin, displaces cytochrome c from the membrane, and facilitates its release to the cytoplasm. | Maspin binds to cardiolipin in mitochondria and triggers apoptosis.
Mahajan N, Hoover B, Rajendram M, Shi HY, Kawasaki K, Weibel DB, Zhang M., Free PMC Article | 05/16/2020 |
| maspin is a powerful context-dependent tumor suppressor. | An Essential Role of Maspin in Embryogenesis and Tumor Suppression.
Dzinic SH, Bernardo MM, Li X, Fernandez-Valdivia R, Ho YS, Mi QS, Bandyopadhyay S, Lonardo F, Vranic S, Oliveira DS, Bonfil RD, Dyson G, Chen K, Omerovic A, Sheng X, Han X, Wu D, Bi X, Cabaravdic D, Jakupovic U, Wahba M, Pang A, Harajli D, Sakr WA, Sheng S., Free PMC Article | 08/12/2017 |
| these data indicate that SerpinB5 expression and phosphorylation are developmentally regulated. In vitro analyses indicate that SerpinB5 phosphorylation is regulated by EGFR ligands, but EGF appears to be the only able to induce SerpinB5 nuclear localization. | EGFR Signaling Regulates Maspin/SerpinB5 Phosphorylation and Nuclear Localization in Mammary Epithelial Cells.
Tamazato Longhi M, Magalhães M, Reina J, Morais Freitas V, Cella N., Free PMC Article | 07/29/2017 |
| perturbation of genes near maspin may in fact explain poor survival in certain patient cohorts with low maspin expression | Maspin is not required for embryonic development or tumour suppression.
Teoh SS, Vieusseux J, Prakash M, Berkowicz S, Luu J, Bird CH, Law RH, Rosado C, Price JT, Whisstock JC, Bird PI., Free PMC Article | 03/12/2016 |
| evidence demonstrates that D(346) is a critical cis-element in maspin sequence that determines the molecular context and subcellular localization of maspin. | Identification of an intrinsic determinant critical for maspin subcellular localization and function.
Dzinic SH, Kaplun A, Li X, Bernardo M, Meng Y, Dean I, Krass D, Stemmer P, Shin N, Lonardo F, Sheng S., Free PMC Article | 09/20/2014 |
| a novel mechanism by which maspin utilizes its cysteine thiols to inhibit oxidative stress and cell growth. | Tumor-suppressive maspin functions as a reactive oxygen species scavenger: importance of cysteine residues.
Mahajan N, Shi HY, Lukas TJ, Zhang M., Free PMC Article | 06/15/2013 |
| results suggest that maspin, a tumor suppressor, may play an important role in embryo implantation | Expression of maspin in the early pregnant mouse endometrium and its role during embryonic implantation.
Huang Y, Cai LW, Yang R., Free PMC Article | 11/17/2012 |
| The nuclear localization of maspin is required for its tumor and metastasis suppressor functions in vivo. | Nuclear localization of maspin is essential for its inhibition of tumor growth and metastasis.
Goulet B, Kennette W, Ablack A, Postenka CO, Hague MN, Mymryk JS, Tuck AB, Giguère V, Chambers AF, Lewis JD. | 09/24/2011 |
| SERPINB5 and AKAP12 may have a role in increased metastasis in pancreatic ductal adenocarcinoma | SERPINB5 and AKAP12 - expression and promoter methylation of metastasis suppressor genes in pancreatic ductal adenocarcinoma.
Mardin WA, Petrov KO, Enns A, Senninger N, Haier J, Mees ST., Free PMC Article | 03/26/2011 |
| PAR-1 negatively regulates the expression of the Maspin tumor-suppressor gene in the acquisition of the metastatic melanoma phenotype | Protease activated receptor-1 inhibits the Maspin tumor-suppressor gene to determine the melanoma metastatic phenotype.
Villares GJ, Zigler M, Dobroff AS, Wang H, Song R, Melnikova VO, Huang L, Braeuer RR, Bar-Eli M., Free PMC Article | 02/26/2011 |
| Results describe a mechanism by which maspin exerts its effect on endothelial cell adhesion and migration through an integrin signal transduction pathway. | Maspin regulates endothelial cell adhesion and migration through an integrin signaling pathway.
Qin L, Zhang M., Free PMC Article | 12/11/2010 |
| A partial loss of maspin caused an early developmental defect of the prostate and prostate hyperplastic lesions in mouse. | Haploinsufficiency of the maspin tumor suppressor gene leads to hyperplastic lesions in prostate.
Shao LJ, Shi HY, Ayala G, Rowley D, Zhang M., Free PMC Article | 01/21/2010 |
| Results show that deletion of maspin affects visceral endoderm function by reducing cell proliferation and adhesion, thereby controlling early embryonic development. | Maspin plays an essential role in early embryonic development.
Gao F, Shi HY, Daughty C, Cella N, Zhang M. | 01/21/2010 |
| We propose that tumour-infiltrating RANKL-expressing cells lead to nuclear IKKalpha activation and inhibition of Maspin transcription, thereby promoting the metastatic phenotype | Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin.
Luo JL, Tan W, Ricono JM, Korchynskyi O, Zhang M, Gonias SL, Cheresh DA, Karin M. | 01/21/2010 |
| we believe that maspin is a tumour suppressor in malignant melanoma. | Loss of maspin expression contributes to a more invasive potential in malignant melanoma.
Denk AE, Bettstetter M, Wild PJ, Hoek K, Bataille F, Dietmaier W, Bosserhoff AK. | 01/21/2010 |
| Maspin overexpression modulates tumor cell apoptosis through the regulation of Bcl2 family proteins | Maspin overexpression modulates tumor cell apoptosis through the regulation of Bcl-2 family proteins.
Zhang W, Shi HY, Zhang M., Free PMC Article | 01/21/2010 |
| maspin exerts its tumor suppressive role, at least in part, by blocking the pericellular uPA system | Maspin expression inhibits osteolysis, tumor growth, and angiogenesis in a model of prostate cancer bone metastasis.
Cher ML, Biliran HR Jr, Bhagat S, Meng Y, Che M, Lockett J, Abrams J, Fridman R, Zachareas M, Sheng S., Free PMC Article | 01/21/2010 |