| E3 ubiquitin ligase CBLB regulates innate immune responses and bacterial dissemination during nontuberculous mycobacteria infection. | E3 ubiquitin ligase CBLB regulates innate immune responses and bacterial dissemination during nontuberculous mycobacteria infection.
Sharma J, Mudalagiriyappa S, Abdelaal HFM, Kelly TC, Choi W, Ponnuraj N, Vieson MD, Talaat AM, Nanjappa SG., Free PMC Article | 09/19/2024 |
| Exploring the role of CBLB in acute myocardial infarction: transcriptomic, microbiomic, and metabolomic analyses. | Exploring the role of CBLB in acute myocardial infarction: transcriptomic, microbiomic, and metabolomic analyses.
You H, Chang F, Chen H, Wang Y, Han W., Free PMC Article | 08/12/2024 |
| Deficiency of CBL and CBLB ubiquitin ligases leads to hyper T follicular helper cell responses and lupus by reducing BCL6 degradation. | Deficiency of CBL and CBLB ubiquitin ligases leads to hyper T follicular helper cell responses and lupus by reducing BCL6 degradation.
Li X, Sun W, Huang M, Gong L, Zhang X, Zhong L, Calderon V, Bian Z, He Y, Suh WK, Li Y, Song T, Zou Y, Lian ZX, Gu H. | 08/6/2024 |
| T cell specific deletion of Casitas B lineage lymphoma-b reduces atherosclerosis, but increases plaque T cell infiltration and systemic T cell activation. | T cell specific deletion of Casitas B lineage lymphoma-b reduces atherosclerosis, but increases plaque T cell infiltration and systemic T cell activation.
Vos WG, van Os BW, den Toom M, Beckers L, van Roomen CPAA, van Tiel CM, Mohapatra BC, Band H, Nitz K, Weber C, Atzler D, de Winther MPJ, Bosmans LA, Lutgens E, Seijkens TTP., Free PMC Article | 03/22/2024 |
| The ubiquitin ligases Cbl and Cbl-b regulate macrophage growth by controlling CSF-1R import into macropinosomes. | The ubiquitin ligases Cbl and Cbl-b regulate macrophage growth by controlling CSF-1R import into macropinosomes.
Huang L, Thiex NW, Lou J, Ahmad G, An W, Low-Nam ST, Kerkvliet JG, Band H, Hoppe AD., Free PMC Article | 02/5/2024 |
| Involvement of the E3 ubiquitin ligase Cblb in host defense and evaluation of transcriptome during Trueperella pyogenes infection. | Involvement of the E3 ubiquitin ligase Cblb in host defense and evaluation of transcriptome during Trueperella pyogenes infection.
Huang T, Lv Z, Cui K, Wang X, Zhang X, Yue B, Chu Y, Zhao K. | 06/7/2023 |
| IFT80 negatively regulates osteoclast differentiation via association with Cbl-b to disrupt TRAF6 stabilization and activation. | IFT80 negatively regulates osteoclast differentiation via association with Cbl-b to disrupt TRAF6 stabilization and activation.
Deepak V, Yang ST, Li Z, Li X, Ng A, Xu D, Li YP, Oursler MJ, Yang S., Free PMC Article | 07/2/2022 |
| Cbl-b modulated TrkA ubiquitination and function in the dorsal root ganglion of mice. | Cbl-b modulated TrkA ubiquitination and function in the dorsal root ganglion of mice.
Chen HK, Li YZ, Ge AN, Zhu YB, Wu SJ, Bai X, Bai HH, Liu YN. | 04/16/2022 |
| Overproduction of IFNgamma by Cbl-b-Deficient CD8+ T Cells Provides Resistance against Regulatory T Cells and Induces Potent Antitumor Immunity. | Overproduction of IFNγ by Cbl-b-Deficient CD8+ T Cells Provides Resistance against Regulatory T Cells and Induces Potent Antitumor Immunity.
Han S, Liu ZQ, Chung DC, Paul MS, Garcia-Batres CR, Sayad A, Elford AR, Gold MJ, Grimshaw N, Ohashi PS., Free PMC Article | 04/9/2022 |
| Ubiquitin Ligases CBL and CBL-B Maintain the Homeostasis and Immune Quiescence of Dendritic Cells. | Ubiquitin Ligases CBL and CBL-B Maintain the Homeostasis and Immune Quiescence of Dendritic Cells.
Tong H, Li X, Zhang J, Gong L, Sun W, Calderon V, Zhang X, Li Y, Gadzinski A, Langdon WY, Reizis B, Zou Y, Gu H., Free PMC Article | 03/19/2022 |
| BDNF modulated KCC2 ubiquitylation in spinal cord dorsal horn of mice. | BDNF modulated KCC2 ubiquitylation in spinal cord dorsal horn of mice.
Ma JJ, Zhang TY, Diao XT, Yao L, Li YX, Suo ZW, Yang X, Hu XD, Liu YN. | 12/18/2021 |
| Deletion of Cbl-b inhibits CD8(+) T-cell exhaustion and promotes CAR T-cell function. | Deletion of Cbl-b inhibits CD8(+) T-cell exhaustion and promotes CAR T-cell function.
Kumar J, Kumar R, Kumar Singh A, Tsakem EL, Kathania M, Riese MJ, Theiss AL, Davila ML, Venuprasad K., Free PMC Article | 12/18/2021 |
| Ubiquitination and functional modification of GluN2B subunit-containing NMDA receptors by Cbl-b in the spinal cord dorsal horn. | Ubiquitination and functional modification of GluN2B subunit-containing NMDA receptors by Cbl-b in the spinal cord dorsal horn.
Zhang ZY, Bai HH, Guo Z, Li HL, Diao XT, Zhang TY, Yao L, Ma JJ, Cao Z, Li YX, Bai X, Chen HK, Suo ZW, Yang X, Hu XD. | 11/6/2021 |
| Cbl-b deficiency prevents functional but not phenotypic T cell anergy. | Cbl-b deficiency prevents functional but not phenotypic T cell anergy.
Nguyen TTT, Wang ZE, Shen L, Schroeder A, Eckalbar W, Weiss A., Free PMC Article | 10/16/2021 |
| Cbl and Cbl-b control the germinal center reaction by facilitating naive B cell antigen processing. | Cbl and Cbl-b control the germinal center reaction by facilitating naive B cell antigen processing.
Li X, Gong L, Meli AP, Karo-Atar D, Sun W, Zou Y, King IL, Gu H., Free PMC Article | 03/6/2021 |
| Sequential ubiquitination of NLRP3 by RNF125 and Cbl-b limits inflammasome activation and endotoxemia. | Sequential ubiquitination of NLRP3 by RNF125 and Cbl-b limits inflammasome activation and endotoxemia.
Tang J, Tu S, Lin G, Guo H, Yan C, Liu Q, Huang L, Tang N, Xiao Y, Pope RM, Rajaram MVS, Amer AO, Ahmer BM, Gunn JS, Wozniak DJ, Tao L, Coppola V, Zhang L, Langdon WY, Torrelles JB, Lipkowitz S, Zhang J., Free PMC Article | 11/21/2020 |
| Deficiency of Cbl-b resulted in differential expression of genes involved in apoptosis evasion, tumor suppression and cell survival in UV-exposed skin. After UVB, Cbl-b(-/-) mice upregulated gene expression pattern associated with regulation of epidermal cell proliferation linked to Wnt signaling mediators and enzymes that relate to cell removal and tissue remodeling like MMP12. | Cbl-b deficiency provides protection against UVB-induced skin damage by modulating inflammatory gene signature.
Singh TP, Vieyra-Garcia PA, Wagner K, Penninger J, Wolf P., Free PMC Article | 11/16/2019 |
| study suggests that Cbl-b limits autoimmunity by preventing the pathogenic effects of GM-CSF overproduction in T cells | Regulation of Lymphatic GM-CSF Expression by the E3 Ubiquitin Ligase Cbl-b.
Peer S, Cappellano G, Hermann-Kleiter N, Albrecht-Schgoer K, Hinterleitner R, Baier G, Gruber T., Free PMC Article | 09/28/2019 |
| CBLB impedes the effector CD8(+) T cell responses in a cell-intrinsic manner. | CBLB Constrains Inactivated Vaccine-Induced CD8(+) T Cell Responses and Immunity against Lethal Fungal Pneumonia.
Nanjappa SG, Mudalagiriyappa S, Fites JS, Suresh M, Klein BS., Free PMC Article | 07/6/2019 |
| The establishment of a new model of concurrent tissue-selective CBL/CBL-B deletion should allow a clear assessment of the tumor-intrinsic roles of CBL/CBL-B in non-myeloid malignancies and help test the potential for CBL/CBL-B inactivation in immunotherapy of tumors. | A novel CBL-Bflox/flox mouse model allows tissue-selective fully conditional CBL/CBL-B double-knockout: CD4-Cre mediated CBL/CBL-B deletion occurs in both T-cells and hematopoietic stem cells.
Goetz B, An W, Mohapatra B, Zutshi N, Iseka F, Storck MD, Meza J, Sheinin Y, Band V, Band H., Free PMC Article | 02/10/2018 |
| GSK3 catalyzes two previously unreported phosphorylation events at Ser(476) and Ser(480) of Cbl-b. Constitutive activation of PKB in vivo results in a loss of tolerance that is mediated through the downregulation of Cbl-b. The PI3K-PKB-GSK-3 pathway is a novel regulatory axis that is important for controlling the decision between T cell activation and tolerance via Cbl-b. | Glycogen Synthase Kinase-3 Modulates Cbl-b and Constrains T Cell Activation.
Tran CW, Saibil SD, Le Bihan T, Hamilton SR, Lang KS, You H, Lin AE, Garza KM, Elford AR, Tai K, Parsons ME, Wigmore K, Vainberg MG, Penninger JM, Woodgett JR, Mak TW, Ohashi PS. | 12/30/2017 |
| These studies reveal a novel, cell-autonomous requirement of CBL and CBL-B in epithelial stem cell maintenance during organ development and remodeling through modulation of mTOR signaling. | An essential role of CBL and CBL-B ubiquitin ligases in mammary stem cell maintenance.
Mohapatra B, Zutshi N, An W, Goetz B, Arya P, Bielecki TA, Mushtaq I, Storck MD, Meza JL, Band V, Band H., Free PMC Article | 09/16/2017 |
| CBLB controls proximal C-type lectin receptor signaling in macrophages and dendritic cells. CBLB associates with SYK and ubiquitinates SYK, dectin-1, and dectin-2 after fungal recognition. CBLB deficiency results in increased inflammasome activation, enhanced reactive oxygen species production, and increased fungal killing. | Inhibition of CBLB protects from lethal Candida albicans sepsis.
Wirnsberger G, Zwolanek F, Asaoka T, Kozieradzki I, Tortola L, Wimmer RA, Kavirayani A, Fresser F, Baier G, Langdon WY, Ikeda F, Kuchler K, Penninger JM., Free PMC Article | 08/12/2017 |
| CBLB directs polyubiquitination of dectin-1 and dectin-2, two key pattern-recognition receptors for sensing Candida albicans, and their downstream kinase SYK, thus inhibiting dectin-1- and dectin-2-mediated innate immune responses. | Targeting CBLB as a potential therapeutic approach for disseminated candidiasis.
Xiao Y, Tang J, Guo H, Zhao Y, Tang R, Ouyang S, Zeng Q, Rappleye CA, Rajaram MV, Schlesinger LS, Tao L, Brown GD, Langdon WY, Li BT, Zhang J., Free PMC Article | 08/12/2017 |
| study indicates that Cbl-b negatively regulates CLR-mediated antifungal innate immunity | E3 ubiquitin ligase Cbl-b negatively regulates C-type lectin receptor-mediated antifungal innate immunity.
Zhu LL, Luo TM, Xu X, Guo YH, Zhao XQ, Wang TT, Tang B, Jiang YY, Xu JF, Lin X, Jia XM., Free PMC Article | 07/29/2017 |