| Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of alpha-synuclein in vivo. | Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of α-synuclein in vivo.
Lackie RE, de Miranda AS, Lim MP, Novikov V, Madrer N, Karunatilleke NC, Rutledge BS, Tullo S, Brickenden A, Maitland MER, Greenberg D, Gallino D, Luo W, Attaran A, Shlaifer I, Del Cid Pellitero E, Schild-Poulter C, Durcan TM, Fon EA, Duennwald M, Beraldo FH, Chakravarty MM, Bussey TJ, Saksida LM, Soreq H, Choy WY, Prado VF, Prado MAM., Free PMC Article | 10/15/2022 |
| Hsp90 and its co-chaperone Sti1 control TDP-43 misfolding and toxicity. | Hsp90 and its co-chaperone Sti1 control TDP-43 misfolding and toxicity.
Lin LT, Razzaq A, Di Gregorio SE, Hong S, Charles B, Lopes MH, Beraldo F, Prado VF, Prado MAM, Duennwald ML. | 07/24/2021 |
| Modulation of hippocampal neuronal resilience during aging by the Hsp70/Hsp90 co-chaperone STI1. | Modulation of hippocampal neuronal resilience during aging by the Hsp70/Hsp90 co-chaperone STI1.
Lackie RE, Razzaq AR, Farhan SMK, Qiu LR, Moshitzky G, Beraldo FH, Lopes MH, Maciejewski A, Gros R, Fan J, Choy WY, Greenberg DS, Martins VR, Duennwald ML, Lerch JP, Soreq H, Prado VF, Prado MAM. | 11/21/2020 |
| Role of FOXC1 in regulating APSCs self-renewal via STI-1/PrP(C) signaling. | Role of FOXC1 in regulating APSCs self-renewal via STI-1/PrP(C) signaling.
Lee YH, Lee HT, Chen CL, Chang CH, Hsu CY, Shyu WC., Free PMC Article | 10/24/2020 |
| Our experiments reveal that STI1 activates multiple signaling pathways that cooperate to increase neuronal resilience in neurons subjected to ischemic insult. | Mechanisms of neuroprotection against ischemic insult by stress-inducible phosphoprotein-1/prion protein complex.
Beraldo FH, Ostapchenko VG, Xu JZ, Di Guglielmo GM, Fan J, Nicholls PJ, Caron MG, Prado VF, Prado MAM., Free PMC Article | 05/18/2019 |
| These results indicate that PrPC mutations impair cellular functions mediated by the wild-type protein in conjunction with STI1 in neural cells, supporting the hypothesis of a PrPC loss-of-function mechanism linked to prion disease. | Loss of STI1-mediated neuronal survival and differentiation in disease-associated mutations of prion protein.
Landemberger MC, de Oliveira GP, Machado CF, Gollob KJ, Martins VR. | 05/11/2019 |
| In conclusion, STIP1 is upregulated in HCC and associated with poor clinical prognosis. Blocking STIP1 activity suppresses HCC cell growth, providing the rationale for STIP1 as a potential therapeutic target in HCC. | Autocrine STIP1 signaling promotes tumor growth and is associated with disease outcome in hepatocellular carcinoma.
Chen Z, Xu L, Su T, Ke Z, Peng Z, Zhang N, Peng S, Zhang Q, Liu G, Wei G, Guo Y, He M, Kuang M. | 10/21/2017 |
| Domains of STIP1 responsible for regulating PrPC-dependent amyloid-beta oligomer toxicity | Domains of STIP1 responsible for regulating PrPC-dependent amyloid-β oligomer toxicity.
Maciejewski A, Ostapchenko VG, Beraldo FH, Prado VF, Prado MA, Choy WY. | 05/20/2017 |
| Reduced STIP1 levels can contribute to phenotypes related to hyperactivity and attention deficits. | Hyperactivity and attention deficits in mice with decreased levels of stress-inducible phosphoprotein 1 (STIP1).
Beraldo FH, Thomas A, Kolisnyk B, Hirata PH, De Jaeger X, Martyn AC, Fan J, Goncalves DF, Cowan MF, Masood T, Martins VR, Gros R, Prado VF, Prado MA., Free PMC Article | 08/27/2016 |
| We correlate the expression of STI1 and glioma progression, and suggest that STI1 expression in microglia/macrophages and infiltrating lymphocytes is modulated by the brain tumor microenvironment. | Increased expression of stress inducible protein 1 in glioma-associated microglia/macrophages.
Carvalho da Fonseca AC, Wang H, Fan H, Chen X, Zhang I, Zhang L, Lima FR, Badie B., Free PMC Article | 11/22/2014 |
| Knockdown of PIAS1 in astrocytes impairs the accumulation of nuclear STI1 in response to irradiation. Moreover, a PIAS1 mutant lacking the STI1 binding site is unable to increase STI1 nuclear retention. | Regulation of stress-inducible phosphoprotein 1 nuclear retention by protein inhibitor of activated STAT PIAS1.
Soares IN, Caetano FA, Pinder J, Rodrigues BR, Beraldo FH, Ostapchenko VG, Durette C, Pereira GS, Lopes MH, Queiroz-Hazarbassanov N, Cunha IW, Sanematsu PI, Suzuki S, Bleggi-Torres LF, Schild-Poulter C, Thibault P, Dellaire G, Martins VR, Prado VF, Prado MA., Free PMC Article | 06/7/2014 |
| stress-inducible protein-1 has a role in recruitment of bone marrow derived cells into the ischemic brains | Role of stress-inducible protein-1 in recruitment of bone marrow derived cells into the ischemic brains.
Lee SD, Lai TW, Lin SZ, Lin CH, Hsu YH, Li CY, Wang HJ, Lee W, Su CY, Yu YL, Shyu WC., Free PMC Article | 12/28/2013 |
| Our findings reveal a previously unrecognized role of the PrP(C) ligand STI1 in protecting neurons in Alzheimer disease and suggest a novel pathway that may help to offset AbetaO-induced toxicity. | The prion protein ligand, stress-inducible phosphoprotein 1, regulates amyloid-β oligomer toxicity.
Ostapchenko VG, Beraldo FH, Mohammad AH, Xie YF, Hirata PH, Magalhaes AC, Lamour G, Li H, Maciejewski A, Belrose JC, Teixeira BL, Fahnestock M, Ferreira ST, Cashman NR, Hajj GN, Jackson MF, Choy WY, MacDonald JF, Martins VR, Prado VF, Prado MA., Free PMC Article | 12/14/2013 |
| Stress-inducible phosphoprotein 1 has unique cochaperone activity during development and regulates cellular response to ischemia via the prion protein. | Stress-inducible phosphoprotein 1 has unique cochaperone activity during development and regulates cellular response to ischemia via the prion protein.
Beraldo FH, Soares IN, Goncalves DF, Fan J, Thomas AA, Santos TG, Mohammad AH, Roffé M, Calder MD, Nikolova S, Hajj GN, Guimaraes AL, Massensini AR, Welch I, Betts DH, Gros R, Drangova M, Watson AJ, Bartha R, Prado VF, Martins VR, Prado MA. | 11/16/2013 |
| STI1 and laminin-gamma1 promote robust axonogenesis in wild-type dorsal root ganglia neurons; STI1 promotes extracellular calcium influx. | Laminin-γ1 chain and stress inducible protein 1 synergistically mediate PrPC-dependent axonal growth via Ca2+ mobilization in dorsal root ganglia neurons.
Santos TG, Beraldo FH, Hajj GN, Lopes MH, Roffe M, Lupinacci FC, Ostapchenko VG, Prado VF, Prado MA, Martins VR. | 03/9/2013 |
| Neuroprotection and neuritogenesis mediated by PrP(C)-STI1 engagement are dependent upon the increased protein synthesis mediated by PI3K-mTOR signaling. | Prion protein interaction with stress-inducible protein 1 enhances neuronal protein synthesis via mTOR.
Roffé M, Beraldo FH, Bester R, Nunziante M, Bach C, Mancini G, Gilch S, Vorberg I, Castilho BA, Martins VR, Hajj GN., Free PMC Article | 09/6/2010 |
| evaluated the temporal expression pattern of STI1 and Vn and their colocalization with their ligand PrPC, demonstrated that PrPC, STI1, and Vn are coexpressed in most of the embryonic tissues evaluated. | Developmental expression of prion protein and its ligands stress-inducible protein 1 and vitronectin.
Hajj GN, Santos TG, Cook ZS, Martins VR. | 01/21/2010 |
| our data show that PrP(C) and STI1 are essential to astrocyte development and act through distinct signaling pathways. | Prion protein and its ligand stress inducible protein 1 regulate astrocyte development.
Arantes C, Nomizo R, Lopes MH, Hajj GN, Lima FR, Martins VR. | 01/21/2010 |
| Hop facilitates the phosphorylation and nuclear translocation of Stat3, implying a role for the Hsp70/Hsp90 chaperone heterocomplex machinery in pluripotency signalling. | Knockdown of the co-chaperone Hop promotes extranuclear accumulation of Stat3 in mouse embryonic stem cells.
Longshaw VM, Baxter M, Prewitz M, Blatch GL. | 01/21/2010 |
| These results show that PrP(C) endocytosis is a necessary step to modulate STI1-dependent ERK1/2 signaling involved in neuritogenesis. | Endocytosis of prion protein is required for ERK1/2 signaling induced by stress-inducible protein 1.
Caetano FA, Lopes MH, Hajj GN, Machado CF, Pinto Arantes C, Magalhães AC, Vieira Mde P, Américo TA, Massensini AR, Priola SA, Vorberg I, Gomez MV, Linden R, Prado VF, Martins VR, Prado MA., Free PMC Article | 01/21/2010 |
| Hop/STI1 can modulate both proliferation and cell death in the developing retina independent of PrP(C). | Hop/STI1 modulates retinal proliferation and cell death independent of PrPC.
Arruda-Carvalho M, Njaine B, Silveira MS, Linden R, Chiarini LB. | 01/21/2010 |
| Stress-inducible protein 1 is a cell surface ligand for cellular prion that triggers neuroprotection. The interaction sites were mapped to amino acids 113-128 from PrP(c) and 230-245 from STI1. Both proteins are associated in vivo. | Stress-inducible protein 1 is a cell surface ligand for cellular prion that triggers neuroprotection.
Zanata SM, Lopes MH, Mercadante AF, Hajj GN, Chiarini LB, Nomizo R, Freitas AR, Cabral AL, Lee KS, Juliano MA, de Oliveira E, Jachieri SG, Burlingame A, Huang L, Linden R, Brentani RR, Martins VR., Free PMC Article | 01/21/2010 |
| mSTI1 has a specific tetratricopeptide repeat motif that enables it to bind to HSC70 | Tetratricopeptide repeat motif-mediated Hsc70-mSTI1 interaction. Molecular characterization of the critical contacts for successful binding and specificity.
Odunuga OO, Hornby JA, Bies C, Zimmermann R, Pugh DJ, Blatch GL. | 01/21/2010 |
| These data are consistent with results established with a model where OR and N-terminal half of the HR mediate the action of STI1 upon cell survival and upregulation of SOD activity. | PrP cooperates with STI1 to regulate SOD activity in PrP-deficient neuronal cell line.
Sakudo A, Lee DC, Li S, Nakamura T, Matsumoto Y, Saeki K, Itohara S, Ikuta K, Onodera T. | 01/21/2010 |
| This suggests an important role for Stip1 in the ability of germ cells to survive in stress conditions including high temperatures. | Expression of stress inducible protein 1 (Stip1) in the mouse testis.
Mizrak SC, Bogerd J, Lopez-Casas PP, Párraga M, Del Mazo J, de Rooij DG. | 01/21/2010 |