| Indoleamine 2,3-dioxygenase 2 deficiency associates with autism-like behavior via dopaminergic neuronal dysfunction. | Indoleamine 2,3-dioxygenase 2 deficiency associates with autism-like behavior via dopaminergic neuronal dysfunction.
Ishikawa M, Yamamoto Y, Wulaer B, Kunisawa K, Fujigaki H, Ando T, Kimura H, Kushima I, Arioka Y, Torii Y, Mouri A, Ozaki N, Nabeshima T, Saito K. | 03/4/2024 |
| Absence of indoleamine 2,3dioxygenase 2 promotes liver regeneration after partial hepatectomy in mice. | Absence of indoleamine 2,3‑dioxygenase 2 promotes liver regeneration after partial hepatectomy in mice.
Ando T, Hoshi M, Tezuka H, Ito H, Nakamoto K, Yamamoto Y, Saito K., Free PMC Article | 12/17/2022 |
| The Immunomodulatory Enzyme IDO2 Mediates Autoimmune Arthritis through a Nonenzymatic Mechanism. | The Immunomodulatory Enzyme IDO2 Mediates Autoimmune Arthritis through a Nonenzymatic Mechanism.
Merlo LMF, Peng W, DuHadaway JB, Montgomery JD, Prendergast GC, Muller AJ, Mandik-Nayak L., Free PMC Article | 02/12/2022 |
| Differential Roles of IDO1 and IDO2 in T and B Cell Inflammatory Immune Responses. | Differential Roles of IDO1 and IDO2 in T and B Cell Inflammatory Immune Responses.
Merlo LMF, DuHadaway JB, Montgomery JD, Peng WD, Murray PJ, Prendergast GC, Caton AJ, Muller AJ, Mandik-Nayak L., Free PMC Article | 04/17/2021 |
| Data showed that Ido2 depletion in immune cells effectively reduces lung cancer burden, indicating that Ido2 plays an important role in tumor progression and an important immune regulator in the tumor microenvironment. | Indoleamine 2,3-dioxygenase 2 depletion suppresses tumor growth in a mouse model of Lewis lung carcinoma.
Yamasuge W, Yamamoto Y, Fujigaki H, Hoshi M, Nakamoto K, Kunisawa K, Mouri A, Nabeshima T, Saito K., Free PMC Article | 10/12/2019 |
| The current study shows that the Ido1 and Ido2 genes are imprinted and maternally expressed in mouse placentas. DNA methylation analysis demonstrates that nine CpG sites at the Ido1 promoter constitute a differentially methylated region that is highly methylated in sperm but unmethylated in oocytes | Identification of the novel Ido1 imprinted locus and its potential epigenetic role in pregnancy loss.
Spinelli P, Latchney SE, Reed JM, Fields A, Baier BS, Lu X, McCall MN, Murphy SP, Mak W, Susiarjo M., Free PMC Article | 06/22/2019 |
| IDO2-shRNA treatment also decreased the percentage of Tregs and T cell apoptosis in draining lymph nodes | [Knockdown of indoleamine 2, 3-dioxygenase 2 (IDO2)gene inhibits tumor growth and enhances immune function in mice bearing melanoma].
Liu Y, Liu H, Xiang Y, Chen X, Xu P, Min W. | 08/11/2018 |
| IDO is a critical regulator of acute pulmonary inflammation. | Inhibition of acute lethal pulmonary inflammation by the IDO-AhR pathway.
Lee SM, Park HY, Suh YS, Yoon EH, Kim J, Jang WH, Lee WS, Park SG, Choi IW, Choi I, Kang SW, Yun H, Teshima T, Kwon B, Seo SK., Free PMC Article | 05/26/2018 |
| Gene silencing of indoleamine 2,3-dioxygenase 2 in melanoma cells induces apoptosis through the suppression of NAD+ and inhibits in vivo tumor growth. | Gene silencing of indoleamine 2,3-dioxygenase 2 in melanoma cells induces apoptosis through the suppression of NAD+ and inhibits in vivo tumor growth.
Liu Y, Zhang Y, Zheng X, Zhang X, Wang H, Li Q, Yuan K, Zhou N, Yu Y, Song N, Fu J, Min W., Free PMC Article | 12/30/2017 |
| Findings suggest non-redundant neurophysiological roles for indoleamine 2,3-dioxygenase 1, indoleamine 2,3-dioxygenase 2 and tryptophan 2,3-dioxygenase in modulating brain activities and metabolism. | Deletion of TDO2, IDO-1 and IDO-2 differentially affects mouse behavior and cognitive function.
Too LK, Li KM, Suarna C, Maghzal GJ, Stocker R, McGregor IS, Hunt NH. | 12/23/2017 |
| The IDO2-deficient B cells lacked the ability to upregulate the costimulatory marker CD40, suggesting IDO2 acts at the T-B cell interface to modulate the potency of T cell help needed to promote autoantibody production. | IDO2 Modulates T Cell-Dependent Autoimmune Responses through a B Cell-Intrinsic Mechanism.
Merlo LM, DuHadaway JB, Grabler S, Prendergast GC, Muller AJ, Mandik-Nayak L., Free PMC Article | 09/30/2017 |
| Targeting IDO2 with a monoclonal antibody inhibits autoreactive B and T cell activation and alleviates joint inflammation in two well-characterized preclinical models of arthritis. | Therapeutic antibody targeting of indoleamine-2,3-dioxygenase (IDO2) inhibits autoimmune arthritis.
Merlo LMF, Grabler S, DuHadaway JB, Pigott E, Manley K, Prendergast GC, Laury-Kleintop LD, Mandik-Nayak L., Free PMC Article | 08/19/2017 |
| Indoleamine-2,3-dioxygenase (IDO) production by Plasmacytoid dendritic cells (pDCs)is necessary to confer suppressive function to T-Cells, Regulatory (Tregs) in experimental autoimmune encephalomyelitis (EAE). | IDO-orchestrated crosstalk between pDCs and Tregs inhibits autoimmunity.
Lippens C, Duraes FV, Dubrot J, Brighouse D, Lacroix M, Irla M, Aubry-Lachainaye JP, Reith W, Mandl JN, Hugues S., Free PMC Article | 06/3/2017 |
| Ido2 may be important for mouse embryo implantation and decidualization. | Differential expression and regulation of Ido2 in the mouse uterus during peri-implantation period.
Li DD, Liu XY, Guo CH, Yue L, Yang ZQ, Cao H, Guo B, Yue ZP. | 12/19/2015 |
| The data showed that there is not significant effect of IDO1 or TDO2 on mortality in pneumococcal meningitis. | The kynurenine pathway contributes to long-term neuropsychological changes in experimental pneumococcal meningitis.
Too LK, McQuillan JA, Ball HJ, Kanai M, Nakamura T, Funakoshi H, McGregor IS, Hunt NH. | 08/15/2015 |
| IDO2 is critical for IDO1-mediated T-cell regulation and exerts a non-redundant function in inflammation. | IDO2 is critical for IDO1-mediated T-cell regulation and exerts a non-redundant function in inflammation.
Metz R, Smith C, DuHadaway JB, Chandler P, Baban B, Merlo LM, Pigott E, Keough MP, Rust S, Mellor AL, Mandik-Nayak L, Muller AJ, Prendergast GC., Free PMC Article | 02/14/2015 |
| Deletion of Ido1 and reduced mRNA expression for Ido2 neither affected the concentration of the downstream metabolites of tryptophan nor mRNA expression for downstream genes on the kynurenine pathway in inguinal lymph nodes. | Investigation of the kynurenine pathway in Indoleamine 2, 3 dioxygenase deficient mice with inflammatory arthritis.
Kolodziej L., Free PMC Article | 04/26/2014 |
| results provide important insights into IDO2 function by defining its pathogenic contributions to autoantibody-mediated autoimmunity. | IDO2 is a critical mediator of autoantibody production and inflammatory pathogenesis in a mouse model of autoimmune arthritis.
Merlo LMF, Pigott E, DuHadaway JB, Grabler S, Metz R, Prendergast GC, Mandik-Nayak L., Free PMC Article | 04/19/2014 |
| Immunohistochemical analysis in Ido1(-/-) mouse epididymis showed that Ido2 protein was extensively upregulated due to the loss of Ido1 expression. | Studies on tissue and cellular distribution of indoleamine 2,3-dioxygenase 2: the absence of IDO1 upregulates IDO2 expression in the epididymis.
Fukunaga M, Yamamoto Y, Kawasoe M, Arioka Y, Murakami Y, Hoshi M, Saito K., Free PMC Article | 01/12/2013 |
| IDO-1 and IDO-2 play biologically important, contradictory roles during intracellular protozoal infection - facilitating (Toxoplasma gondii) or suppressing (Leishmania major) microbial clearance in a pathogen-specific manner. | Opposing biological functions of tryptophan catabolizing enzymes during intracellular infection.
Divanovic S, Sawtell NM, Trompette A, Warning JI, Dias A, Cooper AM, Yap GS, Arditi M, Shimada K, Duhadaway JB, Prendergast GC, Basaraba RJ, Mellor AL, Munn DH, Aliberti J, Karp CL., Free PMC Article | 02/18/2012 |
| Findings implicate novel IDO related enzyme IDO2 in cancer as a result of its preferential inhibition by the D racemer of 1-methyl-tryptophan, used widely in its racemic form (D,L-1MT) as an IDO inhibitor including as an anticancer agent | Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan.
Metz R, Duhadaway JB, Kamasani U, Laury-Kleintop L, Muller AJ, Prendergast GC. | 01/26/2010 |
| role in the inhibition of immune responses to tumours | Indoleamine 2,3-dioxygenase-2; a new enzyme in the kynurenine pathway.
Ball HJ, Yuasa HJ, Austin CJ, Weiser S, Hunt NH. | 01/21/2010 |
| A second tryptophan catabolic enzyme inducible by IFNg, implicated in transcriptional immune regulation (IFNg-driven negative feedback), may limit the pro-inflammatory and anti-proliferative functions(Review) | Indoleamine 2,3-dioxygenase in T-cell tolerance and tumoral immune escape.
Katz JB, Muller AJ, Prendergast GC. | 01/21/2010 |
| This article describes the evolutionary relationships between the INDO and INDOL1 genes. The INDOL1 protein has a distinct expression pattern compared to INDO and both have the ability to catabolise tryptophan. | Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice.
Ball HJ, Sanchez-Perez A, Weiser S, Austin CJ, Astelbauer F, Miu J, McQuillan JA, Stocker R, Jermiin LS, Hunt NH. | 06/13/2007 |