| Exocytosis in mouse vestibular Type II hair cells shows a high-order Ca(2+) dependence that is independent of synaptotagmin-4. | Exocytosis in mouse vestibular Type II hair cells shows a high-order Ca(2+) dependence that is independent of synaptotagmin-4.
Spaiardi P, Marcotti W, Masetto S, Johnson SL., Free PMC Article | 07/10/2021 |
| Synaptotagmin-4 promotes dendrite extension and melanogenesis in alpaca melanocytes by regulating Ca(2+) influx via TRPM1 channels. | Synaptotagmin-4 promotes dendrite extension and melanogenesis in alpaca melanocytes by regulating Ca(2+) influx via TRPM1 channels.
Jia Q, Hu S, Jiao D, Li X, Qi S, Fan R., Free PMC Article | 02/2/2021 |
| Syt4 Overexpression Represses Basal Insulin Secretion and Impairs Islet Morphogenesis. | Synaptotagmin 4 Regulates Pancreatic β Cell Maturation by Modulating the Ca(2+) Sensitivity of Insulin Secretion Vesicles.
Huang C, Walker EM, Dadi PK, Hu R, Xu Y, Zhang W, Sanavia T, Mun J, Liu J, Nair GG, Tan HYA, Wang S, Magnuson MA, Stoeckert CJ Jr, Hebrok M, Gannon M, Han W, Stein R, Jacobson DA, Gu G., Free PMC Article | 06/2/2018 |
| BDNF secretion mediated by syt-IV is subject to extensive temporal and spatial control to modulate the spatial pattern of synaptic efficacy in networks of neurons | Distinct subsets of Syt-IV/BDNF vesicles are sorted to axons versus dendrites and recruited to synapses by activity.
Dean C, Liu H, Staudt T, Stahlberg MA, Vingill S, Bückers J, Kamin D, Engelhardt J, Jackson MB, Hell SW, Chapman ER., Free PMC Article | 06/16/2012 |
| Somatodendritic dopamine release requires synaptotagmin 4 and 7 and the participation of voltage-gated calcium channels. | Somatodendritic dopamine release requires synaptotagmin 4 and 7 and the participation of voltage-gated calcium channels.
Mendez JA, Bourque MJ, Fasano C, Kortleven C, Trudeau LE., Free PMC Article | 09/10/2011 |
| these data suggest that syt IV plays a role both in the Golgi and in the maintenance of normal numbers of synaptic vesicles in presynaptic terminals | Loss of synaptotagmin IV results in a reduction in synaptic vesicles and a distortion of the Golgi structure in cultured hippocampal neurons.
Arthur CP, Dean C, Pagratis M, Chapman ER, Stowell MH., Free PMC Article | 06/28/2010 |
| From the results of this study the author proposed that the differential expression of synaptotagmins determines the characteristic Ca2+ sensitivity of vesicle fusion at hair cell synapses. | Synaptotagmin IV determines the linear Ca2+ dependence of vesicle fusion at auditory ribbon synapses.
Johnson SL, Franz C, Kuhn S, Furness DN, Rüttiger L, Münkner S, Rivolta MN, Seward EP, Herschman HR, Engel J, Knipper M, Marcotti W., Free PMC Article | 01/21/2010 |
| Thus, regulation of BDNF secretion by syt-IV emerges as a mechanism for maintaining synaptic strength in a useful range during LTP. | Synaptotagmin-IV modulates synaptic function and long-term potentiation by regulating BDNF release.
Dean C, Liu H, Dunning FM, Chang PY, Jackson MB, Chapman ER., Free PMC Article | 01/21/2010 |
| Given the neuroendocrine functions of the posterior pituitary, changes in Syt IV levels could be involved in endocrine transitions involving alterations in the release of the neuropeptides oxytocin and vasopressin | Synaptotagmin IV: a multifunctional regulator of peptidergic nerve terminals.
Zhang Z, Bhalla A, Dean C, Chapman ER, Jackson MB., Free PMC Article | 01/21/2010 |
| propose that Syt IV is essential for the regulated release of glutamate from astrocytes and is a candidate Ca2+ sensor for gliotransmission by these nonneuronal cells | Synaptotagmin IV regulates glial glutamate release.
Zhang Q, Fukuda M, Van Bockstaele E, Pascual O, Haydon PG., Free PMC Article | 01/21/2010 |
| Syt IV plays a role in rodent mood-related behavior by regulating synaptic function in the neuronal networks that modulate these behaviors. | Reduced anxiety and depression-like behavior in synaptotagmin IV (-/-) mice.
Ferguson GD, Herschman HR, Storm DR. | 01/21/2010 |
| Syt IV is a presynaptic negative regulator of short-term plasticity in area CA1 of the hippocampus and is required for some, but not all, forms of hippocampus-dependent memory. | Altered hippocampal short-term plasticity and associative memory in synaptotagmin IV (-/-) mice.
Ferguson GD, Wang H, Herschman HR, Storm DR. | 01/21/2010 |