| Upregulation of Metrnl improves diabetic kidney disease by inhibiting the TGF-beta1/Smads signaling pathway: A potential therapeutic target. | Upregulation of Metrnl improves diabetic kidney disease by inhibiting the TGF-β1/Smads signaling pathway: A potential therapeutic target.
Lin L, Huang S, Lin X, Liu X, Xu X, Li C, Chen P., Free PMC Article | 09/4/2024 |
| Metrnl inhibits choroidal neovascularization by attenuating the choroidal inflammation via inactivating the UCHL-1/NF-kappaB signaling pathway. | Metrnl inhibits choroidal neovascularization by attenuating the choroidal inflammation via inactivating the UCHL-1/NF-κB signaling pathway.
Zhang L, Li Y, Wu Z, Shen Q, Zeng C, Liu H, Zhang X, Yang J, Liu Q, Tang D, Ou K, Fang Y., Free PMC Article | 07/8/2024 |
| Meteorin-like/Meteorin-beta protects LPS-induced acute lung injury by activating SIRT1-P53-SLC7A11 mediated ferroptosis pathway. | Meteorin-like/Meteorin-β protects LPS-induced acute lung injury by activating SIRT1-P53-SLC7A11 mediated ferroptosis pathway.
Chen Z, Li J, Peng H, Zhang M, Wu X, Gui F, Li W, Ai F, Yu B, Liu Y., Free PMC Article | 11/14/2023 |
| Metrnl ameliorates diabetic cardiomyopathy via inactivation of cGAS/STING signaling dependent on LKB1/AMPK/ULK1-mediated autophagy. | Metrnl ameliorates diabetic cardiomyopathy via inactivation of cGAS/STING signaling dependent on LKB1/AMPK/ULK1-mediated autophagy.
Lu QB, Ding Y, Liu Y, Wang ZC, Wu YJ, Niu KM, Li KX, Zhang JR, Sun HJ., Free PMC Article | 09/15/2023 |
| Protective role of the novel cytokine Metrnl/ interleukin-41 in host immunity defense during sepsis by promoting macrophage recruitment and modulating Treg/Th17 immune cell balance. | Protective role of the novel cytokine Metrnl/ interleukin-41 in host immunity defense during sepsis by promoting macrophage recruitment and modulating Treg/Th17 immune cell balance.
Chen X, Chen X, Yang Y, Luo N, Yang J, Zhong L, Guo T, Yuan Z, Wei Q, Wang C. | 08/16/2023 |
| Metrnl Alleviates Lipid Accumulation by Modulating Mitochondrial Homeostasis in Diabetic Nephropathy. | Metrnl Alleviates Lipid Accumulation by Modulating Mitochondrial Homeostasis in Diabetic Nephropathy.
Zhou Y, Liu L, Jin B, Wu Y, Xu L, Chang X, Hu L, Wang G, Huang Y, Song L, Zhang T, Wang Y, Xiao Y, Zhang F, Shi M, Liu L, Wang T, Yan R, Guo B., Free PMC Article | 05/8/2023 |
| Metrnl regulates cognitive dysfunction and hippocampal BDNF levels in D-galactose-induced aging mice. | Metrnl regulates cognitive dysfunction and hippocampal BDNF levels in D-galactose-induced aging mice.
Hong C, Wang Z, Zheng SL, Hu WJ, Wang SN, Zhao Y, Miao CY., Free PMC Article | 04/7/2023 |
| The role of Meteorin-like in skeletal development and bone fracture healing. | The role of Meteorin-like in skeletal development and bone fracture healing.
Huang R, Balu AR, Molitoris KH, White JP, Robling AG, Ayturk UM, Baht GS., Free PMC Article | 10/22/2022 |
| Meteorin links the bone marrow hypoxic state to hematopoietic stem/progenitor cell mobilization. | Meteorin links the bone marrow hypoxic state to hematopoietic stem/progenitor cell mobilization.
Dai YW, Ma JK, Jiang R, Zhan XL, Chen SY, Feng LL, Zhang Q, Liang TB, Lv K, Yang GJ, Lu JF, Chen J, Lu XJ. | 10/1/2022 |
| Meteorin-like promotes heart repair through endothelial KIT receptor tyrosine kinase. | Meteorin-like promotes heart repair through endothelial KIT receptor tyrosine kinase.
Reboll MR, Klede S, Taft MH, Cai CL, Field LJ, Lavine KJ, Koenig AL, Fleischauer J, Meyer J, Schambach A, Niessen HW, Kosanke M, van den Heuvel J, Pich A, Bauersachs J, Wu X, Zheng L, Wang Y, Korf-Klingebiel M, Polten F, Wollert KC., Free PMC Article | 06/25/2022 |
| Exercise Inhibits NLRP3 Inflammasome Activation in Obese Mice via the Anti-Inflammatory Effect of Meteorin-like. | Exercise Inhibits NLRP3 Inflammasome Activation in Obese Mice via the Anti-Inflammatory Effect of Meteorin-like.
Javaid HMA, Sahar NE, ZhuGe DL, Huh JY., Free PMC Article | 01/22/2022 |
| Meteorin-like/Meteorin-beta protects heart against cardiac dysfunction. | Meteorin-like/Meteorin-β protects heart against cardiac dysfunction.
Rupérez C, Ferrer-Curriu G, Cervera-Barea A, Florit L, Guitart-Mampel M, Garrabou G, Zamora M, Crispi F, Fernandez-Solà J, Lupón J, Bayes-Genis A, Villarroya F, Planavila A., Free PMC Article | 10/9/2021 |
| The myokine meteorin-like (metrnl) improves glucose tolerance in both skeletal muscle cells and mice by targeting AMPKalpha2. | The myokine meteorin-like (metrnl) improves glucose tolerance in both skeletal muscle cells and mice by targeting AMPKα2.
Lee JO, Byun WS, Kang MJ, Han JA, Moon J, Shin MJ, Lee HJ, Chung JH, Lee JS, Son CG, Song KH, Kim TW, Lee ES, Kim HM, Chung CH, Ngoei KRW, Ling NXY, Oakhill JS, Galic S, Murray-Segal L, Kemp BE, Kim KM, Lim S, Kim HS., Free PMC Article | 04/24/2021 |
| Aggravated ulcerative colitis caused by intestinal Metrnl deficiency is associated with reduced autophagy in epithelial cells. | Aggravated ulcerative colitis caused by intestinal Metrnl deficiency is associated with reduced autophagy in epithelial cells.
Zhang SL, Li ZY, Wang DS, Xu TY, Fan MB, Cheng MH, Miao CY., Free PMC Article | 03/13/2021 |
| Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism. | Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism.
Baht GS, Bareja A, Lee DE, Rao RR, Huang R, Huebner JL, Bartlett DB, Hart CR, Gibson JR, Lanza IR, Kraus VB, Gregory SG, Spiegelman BM, White JP., Free PMC Article | 01/9/2021 |
| these observations indicate that Metrnl encodes a novel immunoregulatory cytokine associated with inflammatory responses | Meteorin-like/Meteorin-β Is a Novel Immunoregulatory Cytokine Associated with Inflammation.
Ushach I, Arrevillaga-Boni G, Heller GN, Pone E, Hernandez-Ruiz M, Catalan-Dibene J, Hevezi P, Zlotnik A., Free PMC Article | 08/3/2019 |
| METRNL alleviates inflammation and insulin resistance and induces fatty acid oxidation through AMPK or PPARdelta-dependent signaling in skeletal muscle. | METRNL attenuates lipid-induced inflammation and insulin resistance via AMPK or PPARδ-dependent pathways in skeletal muscle of mice.
Jung TW, Lee SH, Kim HC, Bang JS, Abd El-Aty AM, Hacımüftüoğlu A, Shin YK, Jeong JH., Free PMC Article | 05/18/2019 |
| Exercise-induced muscle Metrnl effectively reduces fat accumulation. | Aerobic Exercise Increases Meteorin-Like Protein in Muscle and Adipose Tissue of Chronic High-Fat Diet-Induced Obese Mice.
Bae JY., Free PMC Article | 10/6/2018 |
| The results of this study suggest that regular exercise is indispensable to reduce body weight and fat mass through upregulation of the muscle energy-sensing network and Metrnl protein levels, and retraining with dietary change is necessary to obtain the retraining effects more quickly. | Effects of detraining and retraining on muscle energy-sensing network and meteorin-like levels in obese mice.
Bae JY, Woo J, Kang S, Shin KO., Free PMC Article | 09/29/2018 |
| Data (including data from studies in transgenic/knockout mice and 3T3-L1 cells) suggest expression of Metrnl in white adipocytes controls insulin sensitivity via activation of PPARg (peroxisome proliferator activated receptor gamma) signaling pathway. | Adipocyte Metrnl Antagonizes Insulin Resistance Through PPARγ Signaling.
Li ZY, Song J, Zheng SL, Fan MB, Guan YF, Qu Y, Xu J, Wang P, Miao CY. | 03/19/2016 |
| Metrnl represents a novel cytokine, which is likely involved in both innate and acquired immune responses. | METEORIN-LIKE is a cytokine associated with barrier tissues and alternatively activated macrophages.
Ushach I, Burkhardt AM, Martinez C, Hevezi PA, Gerber PA, Buhren BA, Schrumpf H, Valle-Rios R, Vazquez MI, Homey B, Zlotnik A., Free PMC Article | 05/2/2015 |
| Results show that Subfatin is a novel adipokine regulated by adipogenesis and obesity, with tissue distribution different from its homologue Meteorin | Subfatin is a novel adipokine and unlike Meteorin in adipose and brain expression.
Li ZY, Zheng SL, Wang P, Xu TY, Guan YF, Zhang YJ, Miao CY., Free PMC Article | 12/20/2014 |
| Study reports the identification of meteorin-like (Metrnl), a circulating factor that is induced in muscle after exercise and in adipose tissue upon cold exposure; increasing circulating levels of Metrnl stimulates energy expenditure and improves glucose tolerance and the expression of genes associated with beige fat thermogenesis and anti-inflammatory cytokines. | Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis.
Rao RR, Long JZ, White JP, Svensson KJ, Lou J, Lokurkar I, Jedrychowski MP, Ruas JL, Wrann CD, Lo JC, Camera DM, Lachey J, Gygi S, Seehra J, Hawley JA, Spiegelman BM., Free PMC Article | 08/9/2014 |
| Cometin is a novel neurotrophic factor(meteorin protein family) that promotes neurite outgrowth and neuroblast migration in vitro and supports survival of spiral ganglion neurons in vivo. | Cometin is a novel neurotrophic factor that promotes neurite outgrowth and neuroblast migration in vitro and supports survival of spiral ganglion neurons in vivo.
Jørgensen JR, Fransson A, Fjord-Larsen L, Thompson LH, Houchins JP, Andrade N, Torp M, Kalkkinen N, Andersson E, Lindvall O, Ulfendahl M, Brunak S, Johansen TE, Wahlberg LU. | 06/12/2012 |