| The Transcription Factor Mohawk Facilitates Skeletal Muscle Repair via Modulation of the Inflammatory Environment. | The Transcription Factor Mohawk Facilitates Skeletal Muscle Repair via Modulation of the Inflammatory Environment.
Lynch CA, Acosta SA, Anderson DM, Rogers GE, Wilson-Rawls J, Rawls A., Free PMC Article | 06/7/2024 |
| Mohawk impedes angiofibrosis by preventing the differentiation of tendon stem/progenitor cells into myofibroblasts. | Mohawk impedes angiofibrosis by preventing the differentiation of tendon stem/progenitor cells into myofibroblasts.
Mechakra A, Lin J, Yang Y, Du X, Zhang J, Ewetse PM, Zhou F, Alakpa E., Free PMC Article | 12/3/2022 |
| Involvement of homeobox transcription factor Mohawk in palatogenesis. | Involvement of homeobox transcription factor Mohawk in palatogenesis.
Adachi Y, Higuchi A, Wakai E, Shiromizu T, Koiwa J, Nishimura Y. | 01/22/2022 |
| Mkx-Deficient Mice Exhibit Hedgehog Signaling-Dependent Ectopic Ossification in the Achilles Tendons. | Mkx-Deficient Mice Exhibit Hedgehog Signaling-Dependent Ectopic Ossification in the Achilles Tendons.
Liu H, Xu J, Jiang R., Free PMC Article | 06/27/2020 |
| Data show that homeobox protein Mohawk (Mkx) is mainly expressed in the outer annulus fibrosus (OAF) of humans and mice. | Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs.
Nakamichi R, Ito Y, Inui M, Onizuka N, Kayama T, Kataoka K, Suzuki H, Mori M, Inagawa M, Ichinose S, Lotz MK, Sakai D, Masuda K, Ozaki T, Asahara H., Free PMC Article | 09/8/2018 |
| accelerates tendon differentiation and prevents chondrogenic/osteogenic differentiation | Gene targeting of the transcription factor Mohawk in rats causes heterotopic ossification of Achilles tendon via failed tenogenesis.
Suzuki H, Ito Y, Shinohara M, Yamashita S, Ichinose S, Kishida A, Oyaizu T, Kayama T, Nakamichi R, Koda N, Yagishita K, Lotz MK, Okawa A, Asahara H., Free PMC Article | 12/2/2017 |
| Mkx prevents periodontal ligament degeneration by regulating osteogenesis. | The transcription factor mohawk homeobox regulates homeostasis of the periodontal ligament.
Koda N, Sato T, Shinohara M, Ichinose S, Ito Y, Nakamichi R, Kayama T, Kataoka K, Suzuki H, Moriyama K, Asahara H., Free PMC Article | 09/30/2017 |
| Gtf2ird1 is essential for Mkx transcription, while also linking mechanical forces to Mkx-mediated tendon homeostasis and regeneration. | Gtf2ird1-Dependent Mohawk Expression Regulates Mechanosensing Properties of the Tendon.
Kayama T, Mori M, Ito Y, Matsushima T, Nakamichi R, Suzuki H, Ichinose S, Saito M, Marumo K, Asahara H., Free PMC Article | 09/17/2016 |
| these data shed light on previously unrecognized roles of Mkx in tendinopathy, tenogenesis, and tendon repair as well as in regulating the TGFbeta pathway. | Mohawk promotes the tenogenesis of mesenchymal stem cells through activation of the TGFβ signaling pathway.
Liu H, Zhang C, Zhu S, Lu P, Zhu T, Gong X, Zhang Z, Hu J, Yin Z, Heng BC, Chen X, Ouyang HW. | 09/26/2015 |
| Mkx is an important regulator of the differentiation of VPs and pulleys, as well as of tendon differentiation. | The Mohawk homeobox transcription factor regulates the differentiation of tendons and volar plates.
Onizuka N, Ito Y, Inagawa M, Nakahara H, Takada S, Lotz M, Toyama Y, Asahara H., Free PMC Article | 10/18/2014 |
| Smad3 binds Scleraxis and Mohawk and regulates tendon matrix organization. | Smad3 binds Scleraxis and Mohawk and regulates tendon matrix organization.
Berthet E, Chen C, Butcher K, Schneider RA, Alliston T, Amirtharajah M., Free PMC Article | 09/28/2013 |
| these data identify the unique DNA-recognition properties of MKX and reveal a novel role for Mkx in promoting slow fiber type specification during skeletal muscle differentiation. | Characterization of the DNA-binding properties of the Mohawk homeobox transcription factor.
Anderson DM, George R, Noyes MB, Rowton M, Liu W, Jiang R, Wolfe SA, Wilson-Rawls J, Rawls A., Free PMC Article | 01/5/2013 |
| These results suggest that Irxl1 is required for the tendon differentiation but dispensable for the patterning of the musculoskeletal system in development. | Irxl1 mutant mice show reduced tendon differentiation and no patterning defects in musculoskeletal system development.
Kimura W, Machii M, Xue X, Sultana N, Hikosaka K, Sharkar MT, Uezato T, Matsuda M, Koseki H, Miura N. | 04/16/2011 |
| Mkx mRNA was strongly expressed in differentiating tendon cells during embryogenesis and in the tendon sheath cells in postnatal stages. In addition to defects in tendon collagen fibrillogenesis, Mkx(-/-) mice exhibited abnormal tendon sheaths. | The atypical homeodomain transcription factor Mohawk controls tendon morphogenesis.
Liu W, Watson SS, Lan Y, Keene DR, Ovitt CE, Liu H, Schweitzer R, Jiang R., Free PMC Article | 10/30/2010 |
| observed small collagen fibril diameters and a down-regulation of type I collagen in Mkx(-/-) tendons. | The Mohawk homeobox gene is a critical regulator of tendon differentiation.
Ito Y, Toriuchi N, Yoshitaka T, Ueno-Kudoh H, Sato T, Yokoyama S, Nishida K, Akimoto T, Takahashi M, Miyaki S, Asahara H., Free PMC Article | 07/26/2010 |
| Mohawk can repress transcription through recruitment of the Sin3A/HDAC co-repressor complex | The homeobox gene Mohawk represses transcription by recruiting the sin3A/HDAC co-repressor complex.
Anderson DM, Beres BJ, Wilson-Rawls J, Rawls A. | 01/21/2010 |
| Irxl1 is a newly identified highly divergent member of the Irx gene family with specific expression patterns in embryogenesis. | Irxl1, a divergent Iroquois homeobox family transcription factor gene.
Takeuchi JK, Bruneau BG. | 01/21/2010 |
| The developmental expression pattern indicates that Irxl1 is a good candidate gene for the Twirler gene. | Identification and developmental expression analysis of a novel homeobox gene closely linked to the mouse Twirler mutation.
Liu H, Liu W, Maltby KM, Lan Y, Jiang R., Free PMC Article | 01/21/2010 |
| Mohawk is an important regulator of vertebrate development. | Mohawk is a novel homeobox gene expressed in the developing mouse embryo.
Anderson DM, Arredondo J, Hahn K, Valente G, Martin JF, Wilson-Rawls J, Rawls A. | 01/21/2010 |