| Accumulation of beta-aminoisobutyric acid mediates hyperalgesia in ovariectomized mice through Mas-related G protein-coupled receptor D signaling. | Accumulation of β-aminoisobutyric acid mediates hyperalgesia in ovariectomized mice through Mas-related G protein-coupled receptor D signaling.
Tu C, Chen YB, Lai SQ, Yu YP, Huang ZW, Li HZ, Ao RF, Han D, Gao JW, Zhu GZ, Wu DZ, Huang YS, Zhao K, Meng TT, Zhong ZM. | 07/1/2024 |
| The Mas-related G protein-coupled receptor d (Mrgprd) mediates pain hypersensitivity in painful diabetic neuropathy. | The Mas-related G protein-coupled receptor d (Mrgprd) mediates pain hypersensitivity in painful diabetic neuropathy.
George DS, Jayaraj ND, Pacifico P, Ren D, Sriram N, Miller RE, Malfait AM, Miller RJ, Menichella DM., Free PMC Article | 04/29/2024 |
| Brown adipose tissue transcriptome unveils an important role of the Beta-alanine/alamandine receptor, MrgD, in metabolism. | Brown adipose tissue transcriptome unveils an important role of the Beta-alanine/alamandine receptor, MrgD, in metabolism.
Cerri GC, Santos SHS, Bader M, Santos RAS. | 03/9/2023 |
| Impact of genetic deletion of MrgD or Mas receptors in depressive-like behaviour in mice. | Impact of genetic deletion of MrgD or Mas receptors in depressive-like behaviour in mice.
Becari L, Fonseca MLA, Gonçalves SCA, Bader M, Santos RAS, Campagnole-Santos MJ, Kangussu LM. | 02/13/2023 |
| Identification of MrgprD expression in mouse enteric neurons. | Identification of MrgprD expression in mouse enteric neurons.
Xu M, Zhang Z, Lan L. | 05/7/2022 |
| Mas-related G protein-coupled receptor D participates in inflammatory pain by promoting NF-kappaB activation through interaction with TAK1 and IKK complex. | Mas-related G protein-coupled receptor D participates in inflammatory pain by promoting NF-κB activation through interaction with TAK1 and IKK complex.
Lan L, Xu M, Li J, Liu L, Xu M, Zhou C, Shen L, Tang Z, Wan F. | 12/4/2021 |
| Expression and Function of Mas-Related G Protein-Coupled Receptor D and Its Ligand Alamandine in Retina. | Expression and Function of Mas-Related G Protein-Coupled Receptor D and Its Ligand Alamandine in Retina.
Zhu P, Verma A, Prasad T, Li Q. | 10/10/2020 |
| This study shows, for the first time, the expression and localization of MrgprD in the intestinal tract and in macrophages and T lymphocytes, indicating the potential roles of MrgprD in intestinal mobility and immunity. | Expression and localization of MrgprD in mouse intestinal tract.
Zhou C, Li J, Liu L, Tang Z, Wan F, Lan L., Free PMC Article | 12/21/2019 |
| MrgD-deficient mice presented a pronounced dilated cardiomyopathy with a marked decrease in systolic function. | Genetic deletion of the alamandine receptor MRGD leads to dilated cardiomyopathy in mice.
Oliveira AC, Melo MB, Motta-Santos D, Peluso AA, Souza-Neto F, da Silva RF, Almeida JFQ, Canta G, Reis AM, Goncalves G, Cerri G, Coutinho D, Guedes de Jesus IC, Guatimosim S, Linhares ND, Alenina N, Bader M, Campagnole-Santos MJ, Santos RAS. | 11/16/2019 |
| MrgprD is essential in cold allodynia in CCI-induced neuropathic pain through the PKA-TRP-A1 pathway | Facilitation of MrgprD by TRP-A1 promotes neuropathic pain.
Wang C, Gu L, Ruan Y, Geng X, Xu M, Yang N, Yu L, Jiang Y, Zhu C, Yang Y, Zhou Y, Guan X, Luo W, Liu Q, Dong X, Yu G, Lan L, Tang Z., Free PMC Article | 09/21/2019 |
| showed that both MRGPRA3+ and MRGPRD+ neurons from hapten-challenged mice displayed a significantly more depolarized resting membrane potential, decreased rheobase, and greater number of action potentials at twice rheobase compared with neurons | Enhanced excitability of MRGPRA3- and MRGPRD-positive nociceptors in a model of inflammatory itch and pain.
Qu L, Fan N, Ma C, Wang T, Han L, Fu K, Wang Y, Shimada SG, Dong X, LaMotte RH., Free PMC Article | 05/24/2014 |
| An itching response is mediated in mice by Mrgprd expressed in primary sensory neurons. | Mechanisms of itch evoked by β-alanine.
Liu Q, Sikand P, Ma C, Tang Z, Han L, Li Z, Sun S, LaMotte RH, Dong X., Free PMC Article | 01/5/2013 |
| This study demonstrated that Mrgprd influences the excitability of polymodal nonpeptidergic nociceptors to mechanical and thermal stimuli. | Mrgprd enhances excitability in specific populations of cutaneous murine polymodal nociceptors.
Rau KK, McIlwrath SL, Wang H, Lawson JJ, Jankowski MP, Zylka MJ, Anderson DJ, Koerber HR., Free PMC Article | 01/21/2010 |
| Mrgprd+ neurons are nociceptors in the outer epidermis and may respond indirectly to external stimuli by detecting ATP release in the skin | Cutaneous sensory neurons expressing the Mrgprd receptor sense extracellular ATP and are putative nociceptors.
Dussor G, Zylka MJ, Anderson DJ, McCleskey EW., Free PMC Article | 01/21/2010 |