| Mapping Cell Types and Efferent Pathways in the Ascending Relaxin-3 System of the Nucleus Incertus. | Mapping Cell Types and Efferent Pathways in the Ascending Relaxin-3 System of the Nucleus Incertus.
Nasirova N, Quina LA, Morton G, Walker A, Turner EE., Free PMC Article | 07/3/2021 |
| Results indicate endogenous RLN3/RXFP3 signaling can modulate hippocampal-dependent spatial reference and working memory via effects on somatostatin interneurons, and further our knowledge of hippocampal cognitive processing | Relaxin-3 inputs target hippocampal interneurons and deletion of hilar relaxin-3 receptors in "floxed-RXFP3" mice impairs spatial memory.
Haidar M, Guèvremont G, Zhang C, Bathgate RAD, Timofeeva E, Smith CM, Gundlach AL. | 04/29/2017 |
| That endogenous relaxin-3-RXFP3 signalling is a powerful mediator of salt appetite in mice. | Involvement of central relaxin-3 signalling in sodium (salt) appetite.
Smith CM, Walker LL, Chua BE, McKinley MJ, Gundlach AL, Denton DA, Lawrence AJ. | 06/4/2016 |
| Relaxin-3 knockout mice exhibit mild anxiolytic characteristics relative to wild-type mice, suggesting that this peptide is involved in anxiety-related behavior. | Behavioral analysis of relaxin-3 deficient mice.
Tanaka M, Furube E, Aoki M, Watanabe Y. | 05/3/2014 |
| Central injection of the RXFP3 agonists R3/I5 or H3 relaxin (0.5 nmol, icv) did not alter chow consumption in satiated mice relative to vehicle controls, during the 60 min after treatment. | Pharmacological activation of RXFP3 is not orexigenic in C57BL/6J mice.
Smith CM, Hosken IT, Downer NL, Chua BE, Hossain MA, Wade JD, Gundlach AL. | 05/3/2014 |
| These preliminary studies suggest an interaction between relaxin-3 and ventrolateral preoptic galanin neurons that may contribute to the arousal-promoting action of relaxin-3. | Potential hypothalamic targets of relaxin-3 innervation: a perspective.
Smith CM, Chua BE, Walker AW, Gundlach AL. | 05/3/2014 |
| These findings are consistent with an earlier report of increased activity scores in rats acutely injected centrally with R3/I5, and further suggest a role for relaxin-3/RXFP3 signalling in promoting behavioural arousal. | Viral-mediated delivery of an RXFP3 agonist into brain promotes arousal in mice.
Smith CM, Blasiak A, Ganella DE, Chua BE, Layfield SL, Bathgate RA, Gundlach AL. | 05/3/2014 |
| The present study compared the ability of relaxin-3 deficient (null mutation) and C57BL/6J wildtype littermate mice to entrain daily running wheel activity to timed food availability. | Consequences of relaxin-3 null mutation in mice on food-entrainable arousal.
Hosken IT, Smith CM, Chua BE, Gundlach AL. | 05/3/2014 |
| These studies support a role for relaxin-3 signaling in the control of arousal and sleep/wakefulness, and identify the relaxin-3 KO mouse as a useful model to study this role further. | Relaxin-3 null mutation mice display a circadian hypoactivity phenotype.
Smith CM, Hosken IT, Sutton SW, Lawrence AJ, Gundlach AL. | 06/2/2012 |
| Data provide evidence for the conserved nature of RLN3/RXFP3 systems in mammalian brain and the ability of RLN3/RXFP3 signaling to modulate "behavioral state" and an array of circuits involved in arousal, stress, affect, and cognition. | Distribution of relaxin-3 and RXFP3 within arousal, stress, affective, and cognitive circuits of mouse brain.
Smith CM, Shen PJ, Banerjee A, Bonaventure P, Ma S, Bathgate RA, Sutton SW, Gundlach AL. | 12/11/2010 |
| The findings support the hypothesis that relaxin-3 signaling contributes to the central control of arousal, exploratory behavior and stress responses. | Behavioral phenotyping of mixed background (129S5:B6) relaxin-3 knockout mice.
Smith CM, Lawrence AJ, Sutton SW, Gundlach AL. | 01/21/2010 |
| results indicate that relaxin 3 transcription is activated via the cAMP-PKA pathway in the downstream of CRF-R1 | Regulation of relaxin 3 gene expression via cAMP-PKA in a neuroblastoma cell line.
Tanaka M, Watanabe Y, Yoshimoto K. | 01/21/2010 |