| Male meiotic spindle poles are stabilized by TACC3 and cKAP5/chTOG differently from female meiotic or somatic mitotic spindles in mice. | Male meiotic spindle poles are stabilized by TACC3 and cKAP5/chTOG differently from female meiotic or somatic mitotic spindles in mice.
Simerly C, Robertson E, Harrison C, Ward S, George C, Deleon J, Hartnett C, Schatten G., Free PMC Article | 02/29/2024 |
| Aurora kinase A is essential for meiosis in mouse oocytes. | Aurora kinase A is essential for meiosis in mouse oocytes.
Blengini CS, Ibrahimian P, Vaskovicova M, Drutovic D, Solc P, Schindler K., Free PMC Article | 08/28/2021 |
| Satellite cell expansion is mediated by P-eIF2alpha-dependent Tacc3 translation. | Satellite cell expansion is mediated by P-eIF2α-dependent Tacc3 translation.
Fujita R, Jamet S, Lean G, Cheng HCM, Hébert S, Kleinman CL, Crist C. | 04/24/2021 |
| Tacc3 is required for the proper mitosis of Apc-deficient ISCs, and its disruption significantly attenuated the expansion of the crypt domain. In vivo analysis of corresponding mutant mice demonstrated that Tacc3 disruption led to a significant decrease in tumor number and prolonged survival. | Suppression of intestinal tumors by targeting the mitotic spindle of intestinal stem cells.
Yao R, Oyanagi J, Natsume Y, Kusama D, Kato Y, Nagayama S, Noda T. | 09/9/2017 |
| Aurora-A kinase does not regulate TACC3-chTOG complex formation, indicating that Aurora-A solely functions as a recruitment factor for the TACC3-chTOG complex to centrosomes and proximal mitotic spindles. | The centrosomal adaptor TACC3 and the microtubule polymerase chTOG interact via defined C-terminal subdomains in an Aurora-A kinase-independent manner.
Thakur HC, Singh M, Nagel-Steger L, Kremer J, Prumbaum D, Fansa EK, Ezzahoini H, Nouri K, Gremer L, Abts A, Schmitt L, Raunser S, Ahmadian MR, Piekorz RP., Free PMC Article | 03/22/2014 |
| The TACC3 and clathrin were interdependent for spindle recruitment, having to interact in order for either to be recruited to the spindle. | Coordination of adjacent domains mediates TACC3-ch-TOG-clathrin assembly and mitotic spindle binding.
Hood FE, Williams SJ, Burgess SG, Richards MW, Roth D, Straube A, Pfuhl M, Bayliss R, Royle SJ., Free PMC Article | 11/30/2013 |
| DOCK7 interaction with TACC3 controls interkinetic nuclear migration and the genesis of neurons from radial glial progenitor cells during cortical development | DOCK7 interacts with TACC3 to regulate interkinetic nuclear migration and cortical neurogenesis.
Yang YT, Wang CL, Van Aelst L., Free PMC Article | 11/17/2012 |
| results show that Tacc3 is a vulnerable component of the spindle assembly in lymphoma cells and is a promising cancer chemotherapy target | Disruption of Tacc3 function leads to in vivo tumor regression.
Yao R, Natsume Y, Saiki Y, Shioya H, Takeuchi K, Yamori T, Toki H, Aoki I, Saga T, Noda T. | 03/3/2012 |
| Tacc3 is a negative regulator of the Notch signaling pathway. | Transforming acidic coiled-coil protein-3 (Tacc3) acts as a negative regulator of Notch signaling through binding to CDC10/Ankyrin repeats.
Bargo S, Raafat A, McCurdy D, Amirjazil I, Shu Y, Traicoff J, Plant J, Vonderhaar BK, Callahan R., Free PMC Article | 11/27/2010 |
| in addition to spindle assembly, Tacc3 has critical roles in chromosome separation and cytokinesis, and is essential for the mitosis of sclerotome mesenchymal cells during axial formation in mammals. | TACC3 is required for the proper mitosis of sclerotome mesenchymal cells during formation of the axial skeleton.
Yao R, Natsume Y, Noda T., Free PMC Article | 01/21/2010 |
| role in hematopoietic stem cell function and interface with p53-regulated apoptosis | The centrosomal protein TACC3 is essential for hematopoietic stem cell function and genetically interfaces with p53-regulated apoptosis.
Piekorz RP, Hoffmeyer A, Duntsch CD, McKay C, Nakajima H, Sexl V, Snyder L, Rehg J, Ihle JN., Free PMC Article | 01/21/2010 |
| a role in control the transition between expansion of multipotential progenitor cell populations and final stages of erythroid maturation. | Transforming acidic coiled-coil protein 3 (TACC3) controls friend of GATA-1 (FOG-1) subcellular localization and regulates the association between GATA-1 and FOG-1 during hematopoiesis.
Garriga-Canut M, Orkin SH. | 01/21/2010 |
| REVIEW: genetics, expression, gene expression regulation, and function studies | AINT/ERIC/TACC: an expanding family of proteins with C-terminal coiled coil domains.
Lappin TR, Mullan RN, Stewart JP, Morgan NA, Thompson A, Maxwell AP. | 01/21/2010 |
| the alpha-helix of FOG-ZF3 recognizes a C-terminal portion of the TACC3 coiled-coil. | A classic zinc finger from friend of GATA mediates an interaction with the coiled-coil of transforming acidic coiled-coil 3.
Simpson RJ, Yi Lee SH, Bartle N, Sum EY, Visvader JE, Matthews JM, Mackay JP, Crossley M. | 01/21/2010 |