| The tumor-intrinsic role of the m[6]A reader YTHDF2 in regulating immune evasion. | The tumor-intrinsic role of the m(6)A reader YTHDF2 in regulating immune evasion.
Xiao S, Ma S, Sun B, Pu W, Duan S, Han J, Hong Y, Zhang J, Peng Y, He C, Yi P, Caligiuri MA, Yu J. | 09/30/2024 |
| lncRNA JPX Promotes Tumor Progression by Interacting with and Destabilizing YTHDF2 in Cutaneous Melanoma. | lncRNA JPX Promotes Tumor Progression by Interacting with and Destabilizing YTHDF2 in Cutaneous Melanoma.
Luo D, Tang H, Tan L, Zhang L, Wang L, Cheng Q, Lei X, Wu J. | 09/3/2024 |
| Smooth Muscle Ythdf2 Abrogation Ameliorates Pulmonary Vascular Remodeling by Regulating Myadm Transcript Stability. | Smooth Muscle Ythdf2 Abrogation Ameliorates Pulmonary Vascular Remodeling by Regulating Myadm Transcript Stability.
Wang J, Shen Y, Zhang Y, Lin D, Wang Q, Sun X, Wei D, Shen B, Chen J, Ji Y, Fulton D, Yu Y, Chen F, Hu L. | 08/16/2024 |
| Foot-and-mouth disease virus VP1 degrades YTHDF2 through autophagy to regulate IRF3 activity for viral replication. | Foot-and-mouth disease virus VP1 degrades YTHDF2 through autophagy to regulate IRF3 activity for viral replication.
Liu H, Xue Q, Yang F, Cao W, Liu P, Liu X, Zhu Z, Zheng H., Free PMC Article | 06/30/2024 |
| METTL3/YTHDF2 m6A axis mediates the progression of diabetic nephropathy through epigenetically suppressing PINK1 and mitophagy. | METTL3/YTHDF2 m6A axis mediates the progression of diabetic nephropathy through epigenetically suppressing PINK1 and mitophagy.
Wang F, Bai J, Zhang X, Wang D, Zhang X, Xue J, Chen H, Wang S, Chi B, Li J, Ma X., Free PMC Article | 03/13/2024 |
| YTHDF2 alleviates microglia activation via promoting circHIPK2 degradation. | YTHDF2 alleviates microglia activation via promoting circHIPK2 degradation.
Huang R, Sun M, Wang W, Yu X, Liu F. | 02/20/2024 |
| YTHDF2 promotes DNA damage repair by positively regulating the histone methyltransferase SETDB1 in spermatogoniadagger. | YTHDF2 promotes DNA damage repair by positively regulating the histone methyltransferase SETDB1 in spermatogonia†.
Guo M, Li X, Li T, Liu R, Pang W, Luo J, Zeng W, Zheng Y. | 01/26/2024 |
| Epitranscriptional regulation of TGF-beta pseudoreceptor BAMBI by m6A/YTHDF2 drives extrinsic radioresistance. | Epitranscriptional regulation of TGF-β pseudoreceptor BAMBI by m6A/YTHDF2 drives extrinsic radioresistance.
Wang L, Si W, Yu X, Piffko A, Dou X, Ding X, Bugno J, Yang K, Wen C, Zhang L, Chen D, Huang X, Wang J, Arina A, Pitroda S, Chmura SJ, He C, Liang HL, Weichselbaum R., Free PMC Article | 12/20/2023 |
| FTO-Nrf2 axis regulates bisphenol F-induced leydig cell toxicity in an m6A-YTHDF2-dependent manner. | FTO-Nrf2 axis regulates bisphenol F-induced leydig cell toxicity in an m6A-YTHDF2-dependent manner.
Zhou SM, Li JZ, Chen HQ, Zeng Y, Yuan WB, Shi Y, Wang N, Fan J, Zhang Z, Xu Y, Cao J, Liu WB. | 08/11/2023 |
| YTHDF2 inhibition potentiates radiotherapy antitumor efficacy. | YTHDF2 inhibition potentiates radiotherapy antitumor efficacy.
Wang L, Dou X, Chen S, Yu X, Huang X, Zhang L, Chen Y, Wang J, Yang K, Bugno J, Pitroda S, Ding X, Piffko A, Si W, Chen C, Jiang H, Zhou B, Chmura SJ, Luo C, Liang HL, He C, Weichselbaum RR., Free PMC Article | 07/19/2023 |
| YTHDF2 in dentate gyrus is the m[6]A reader mediating m[6]A modification in hippocampus-dependent learning and memory. | YTHDF2 in dentate gyrus is the m(6)A reader mediating m(6)A modification in hippocampus-dependent learning and memory.
Zhuang M, Geng X, Han P, Che P, Liang F, Liu C, Yang L, Yu J, Zhang Z, Dong W, Ji SJ. | 05/30/2023 |
| YTHDF2 controls hexavalent chromium-induced mitophagy through modulating Hif1alpha and Bnip3 decay via the m[6]A/mRNA pathway in spermatogonial stem cells/progenitors. | YTHDF2 controls hexavalent chromium-induced mitophagy through modulating Hif1α and Bnip3 decay via the m(6)A/mRNA pathway in spermatogonial stem cells/progenitors.
Li T, Zheng Y, Wu Z, Guo M, Liu R, Zeng W, Lv Y. | 03/19/2023 |
| Ythdf2 promotes pulmonary hypertension by suppressing Hmox1-dependent anti-inflammatory and antioxidant function in alveolar macrophages. | Ythdf2 promotes pulmonary hypertension by suppressing Hmox1-dependent anti-inflammatory and antioxidant function in alveolar macrophages.
Hu L, Yu Y, Shen Y, Huang H, Lin D, Wang K, Yu Y, Li K, Cao Y, Wang Q, Sun X, Qiu Z, Wei D, Shen B, Chen J, Fulton D, Ji Y, Wang J, Chen F., Free PMC Article | 03/15/2023 |
| Suppression of YTHDF2 attenuates autoimmune hepatitis by expansion of myeloid-derived suppressor cells. | Suppression of YTHDF2 attenuates autoimmune hepatitis by expansion of myeloid-derived suppressor cells.
Lyu Z, Huang B, Zhang J, Qian Q, Pu X, Cui N, Ou Y, Li B, You Z, Lian M, Tang R, Chen W, Zhao Z, Hou J, Gershwin ME, Zhang H, Xia Q, Ma X. | 03/1/2023 |
| YTHDF2 is essential for spermatogenesis and fertility by mediating a wave of transcriptional transition in spermatogenic cells. | YTHDF2 is essential for spermatogenesis and fertility by mediating a wave of transcriptional transition in spermatogenic cells.
Zhao X, Lin Z, Fan Y, Li W, Zhang Y, Li F, Hong T, Feng H, Tong M, Wang N, Kuang Y, Lyu Q. | 03/19/2022 |
| The m(6) A Readers YTHDF1 and YTHDF2 Synergistically Control Cerebellar Parallel Fiber Growth by Regulating Local Translation of the Key Wnt5a Signaling Components in Axons. | The m(6) A Readers YTHDF1 and YTHDF2 Synergistically Control Cerebellar Parallel Fiber Growth by Regulating Local Translation of the Key Wnt5a Signaling Components in Axons.
Yu J, She Y, Yang L, Zhuang M, Han P, Liu J, Lin X, Wang N, Chen M, Jiang C, Zhang Y, Yuan Y, Ji SJ., Free PMC Article | 03/12/2022 |
| m(6) A reader protein YTHDF2 regulates spermatogenesis by timely clearance of phase-specific transcripts. | m(6) A reader protein YTHDF2 regulates spermatogenesis by timely clearance of phase-specific transcripts.
Qi M, Sun H, Guo Y, Zhou Y, Gu X, Jin J, Chen X, Wang F, Ma H, Guo X, Chen H, Shen B., Free PMC Article | 01/29/2022 |
| The RNA m6A reader YTHDF2 controls NK cell antitumor and antiviral immunity. | The RNA m6A reader YTHDF2 controls NK cell antitumor and antiviral immunity.
Ma S, Yan J, Barr T, Zhang J, Chen Z, Wang LS, Sun JC, Chen J, Caligiuri MA, Yu J., Free PMC Article | 11/6/2021 |
| The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function. | The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function.
Mapperley C, van de Lagemaat LN, Lawson H, Tavosanis A, Paris J, Campos J, Wotherspoon D, Durko J, Sarapuu A, Choe J, Ivanova I, Krause DS, von Kriegsheim A, Much C, Morgan M, Gregory RI, Mead AJ, O'Carroll D, Kranc KR., Free PMC Article | 09/18/2021 |
| Fusarium infection alters the m(6)A-modified transcript landscape in the cornea. | Fusarium infection alters the m(6)A-modified transcript landscape in the cornea.
Hu J, Lin Y. | 03/6/2021 |
| YTHDF2 promotes spermagonial adhesion through modulating MMPs decay via m(6)A/mRNA pathway. | YTHDF2 promotes spermagonial adhesion through modulating MMPs decay via m(6)A/mRNA pathway.
Huang T, Liu Z, Zheng Y, Feng T, Gao Q, Zeng W., Free PMC Article | 01/16/2021 |
| FTO regulates ocular angiogenesis via m(6)A-YTHDF2-dependent mechanism. | FTO regulates ocular angiogenesis via m(6)A-YTHDF2-dependent mechanism.
Shan K, Zhou RM, Xiang J, Sun YN, Liu C, Lv MW, Xu JJ. | 01/16/2021 |
| Binding to m(6)A RNA promotes YTHDF2-mediated phase separation. | Binding to m(6)A RNA promotes YTHDF2-mediated phase separation.
Wang J, Wang L, Diao J, Shi YG, Shi Y, Ma H, Shen H., Free PMC Article | 01/2/2021 |
| Targeting the RNA m(6)A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia. | Targeting the RNA m(6)A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia.
Paris J, Morgan M, Campos J, Spencer GJ, Shmakova A, Ivanova I, Mapperley C, Lawson H, Wotherspoon DA, Sepulveda C, Vukovic M, Allen L, Sarapuu A, Tavosanis A, Guitart AV, Villacreces A, Much C, Choe J, Azar A, van de Lagemaat LN, Vernimmen D, Nehme A, Mazurier F, Somervaille TCP, Gregory RI, O'Carroll D, Kranc KR., Free PMC Article | 08/22/2020 |
| The study provides the first demonstration of the function of YTHDF2 in adult stem cell maintenance and identifies its important role in regulating HSC ex vivo expansion by regulating the stability of multiple mRNAs critical for HSC self-renewal, thus identifying potential for future clinical applications. | Suppression of m(6)A reader Ythdf2 promotes hematopoietic stem cell expansion.
Li Z, Qian P, Shao W, Shi H, He XC, Gogol M, Yu Z, Wang Y, Qi M, Zhu Y, Perry JM, Zhang K, Tao F, Zhou K, Hu D, Han Y, Zhao C, Alexander R, Xu H, Chen S, Peak A, Hall K, Peterson M, Perera A, Haug JS, Parmely T, Li H, Shen B, Zeitlinger J, He C, Li L., Free PMC Article | 09/28/2019 |