| Deficiency of Pdk1 drives heart failure by impairing taurine homeostasis through Slc6a6. | Deficiency of Pdk1 drives heart failure by impairing taurine homeostasis through Slc6a6.
Li C, Zhou Y, Niu Y, He W, Wang X, Zhang X, Wu Y, Zhang W, Zhao L, Zheng H, Song W, Gao H. | 08/11/2023 |
| Characterization of Bone Tissue and Bone Morphology in Taurine Transporter Knockout Mice. | Characterization of Bone Tissue and Bone Morphology in Taurine Transporter Knockout Mice.
Kato T, Ma N, Ito T, Nishimura A, Sudo A, Yamashita T. | 07/30/2022 |
| Significance of taurine transporter (TauT) in homeostasis and its layers of regulation (Review). | Significance of taurine transporter (TauT) in homeostasis and its layers of regulation (Review).
Baliou S, Kyriakopoulos AM, Goulielmaki M, Panayiotidis MI, Spandidos DA, Zoumpourlis V., Free PMC Article | 04/24/2021 |
| Evaluation of the neuroprotective effect of taurine in Alzheimer's disease using functional molecular imaging. | Evaluation of the neuroprotective effect of taurine in Alzheimer's disease using functional molecular imaging.
Oh SJ, Lee HJ, Jeong YJ, Nam KR, Kang KJ, Han SJ, Lee KC, Lee YJ, Choi JY., Free PMC Article | 12/19/2020 |
| Circulating levels of GDF15 were elevated in old slc6a6 knockout mice | Induction of Growth Differentiation Factor 15 in Skeletal Muscle of Old Taurine Transporter Knockout Mouse.
Ito T, Nakanishi Y, Yamaji N, Murakami S, Schaffer SW. | 09/1/2018 |
| These findings suggest that TauT protein expression is relatively insensitive to changes in muscle taurine content in WT and mdx mice, and that taurine and beta-alanine supplementation may be viable therapeutic strategies to improve fatigue resistance of dystrophic skeletal muscle. | The effect of taurine and β-alanine supplementation on taurine transporter protein and fatigue resistance in skeletal muscle from mdx mice.
Horvath DM, Murphy RM, Mollica JP, Hayes A, Goodman CA. | 12/9/2017 |
| This study evaluated the role of taurine and its transporter on pancreatic islet cells and insulin secretion. | Protein malnutrition blunts the increment of taurine transporter expression by a high-fat diet and impairs taurine reestablishment of insulin secretion.
Branco RCS, Camargo RL, Batista TM, Vettorazzi JF, Borck PC, Dos Santos-Silva JCR, Boschero AC, Zoppi CC, Carneiro EM. | 10/14/2017 |
| both homozygous and heterozygous TauT gene deletion predispose C57BL/6 mice to develop end-stage diabetic kidney disease | Knockout of the TauT gene predisposes C57BL/6 mice to streptozotocin-induced diabetic nephropathy.
Han X, Patters AB, Ito T, Azuma J, Schaffer SW, Chesney RW., Free PMC Article | 02/6/2016 |
| This study demonistrated that intracellular taurine deficits lead in particular to a hyposensitivity of nociceptive sensory neurons sensitive to noxious chemical stimulation. | Congenital taurine deficiency in mice is associated with reduced sensitivity to nociceptive chemical stimulation.
Lötsch J, Hummel T, Warskulat U, Coste O, Häussinger D, Geisslinger G, Tegeder I. | 09/13/2014 |
| Studied protective effect of taurine associated with the upregulation of TAUT expression in acute myocardial ischemia. Data showed that taurine reversed the apoptosis induced by hypoxia and AMI, thereby, effectively protecting the myocardium. | Low-dose taurine upregulates taurine transporter expression in acute myocardial ischemia.
Zhang Y, Yang L, Yang YJ, Liu XY, Jia JG, Qian JY, Wang KQ, Zuo J, Ge JB. | 04/26/2014 |
| Acute exposure to ROS reduces taurine uptake as a result of modulated TauT transport kinetics. | Downregulation of the taurine transporter TauT during hypo-osmotic stress in NIH3T3 mouse fibroblasts.
Hansen DB, Friis MB, Hoffmann EK, Lambert IH., Free PMC Article | 08/4/2012 |
| Effective T-cell recall responses require the taurine transporter Taut. | Effective T-cell recall responses require the taurine transporter Taut.
Kaesler S, Sobiesiak M, Kneilling M, Volz T, Kempf WE, Lang PA, Lang KS, Wieder T, Heller-Stilb B, Warskulat U, Häussinger D, Lang F, Biedermann T. | 06/23/2012 |
| study represents the first characterization of TauT in neural precursor cells | Functional expression and subcellular localization of the taurine transporter TauT in murine neural precursors.
Hernández-Benítez R, Pasantes-Morales H, Pinzón-Estrada E, Ramos-Mandujano G. | 03/26/2011 |
| data suggest TauT plays a critical role in renal function; expression of TauT is negatively regulated by p53 and positively regulated by c-Jun; outcome level of TauT may determine the fate of renal cells during stress-induced acute kidney injury | Stress-responsive gene TauT and acute kidney injury.
Han X, Chesney RW., Free PMC Article | 02/5/2011 |
| All taut-/- mice succumb to infections during crisis, while about 90% of the control taut(+/+) mice survive. | Loss of ability to self-heal malaria upon taurine transporter deletion.
Delic D, Warskulat U, Borsch E, Al-Qahtani S, Al-Quraishi S, Häussinger D, Wunderlich F., Free PMC Article | 04/19/2010 |
| critical role in protecting against cisplatin-induced nephrotoxicity, possibly by attenuating a p53-dependent pathway | Functional TauT protects against acute kidney injury.
Han X, Yue J, Chesney RW., Free PMC Article | 01/21/2010 |
| Multiple actions of taurine, including osmoregulation, regulation of mitochondrial protein expression and inhibition of apoptosis, collectively ensure proper maintenance of cardiac and skeletal muscular structure and function. | Taurine depletion caused by knocking out the taurine transporter gene leads to cardiomyopathy with cardiac atrophy.
Ito T, Kimura Y, Uozumi Y, Takai M, Muraoka S, Matsuda T, Ueki K, Yoshiyama M, Ikawa M, Okabe M, Schaffer SW, Fujio Y, Azuma J. | 01/21/2010 |
| Lack of taurine leads to reduced sensitivity of synaptic and extrasynaptic GABAA receptors and consequently to disinhibition in Taut knockout mice | GABAA-receptor modification in taurine transporter knockout mice causes striatal disinhibition.
Sergeeva OA, Fleischer W, Chepkova AN, Warskulat U, Häussinger D, Siebler M, Haas HL., Free PMC Article | 01/21/2010 |
| In a TAUT-deficient model, lack of taurine in the skin was found to cause a significantly higher sensitivity to ultraviolet B-induced immunosuppression. | The osmolyte taurine protects against ultraviolet B radiation-induced immunosuppression.
Rockel N, Esser C, Grether-Beck S, Warskulat U, Flögel U, Schwarz A, Schwarz T, Yarosh D, Häussinger D, Krutmann J. | 01/21/2010 |
| Knockout of the taurine transporter identifies taurine transport as a crucial factor for the maintenance of skeletal muscle function and total exercise capacity, while cardiac muscle apparently can compensate for the loss of taurine. | Taurine transporter knockout depletes muscle taurine levels and results in severe skeletal muscle impairment but leaves cardiac function uncompromised.
Warskulat U, Flögel U, Jacoby C, Hartwig HG, Thewissen M, Merx MW, Molojavyi A, Heller-Stilb B, Schrader J, Häussinger D. | 01/21/2010 |
| Results describe the gene expressions of taurine transporter and taurine biosynthetic enzyme during mouse and chicken embryonic development. | Gene expressions of taurine transporter and taurine biosynthetic enzyme during mouse and chicken embryonic development.
Kim HW, Yoon SH, Park T, Kim BK, Park KK, Lee DH. | 01/21/2010 |
| Apoptotic liver damage develops as a consequence of taurine deficiency due to taurine transporter knockout mutation. | Chronic liver disease is triggered by taurine transporter knockout in the mouse.
Warskulat U, Borsch E, Reinehr R, Heller-Stilb B, Mönnighoff I, Buchczyk D, Donner M, Flögel U, Kappert G, Soboll S, Beer S, Pfeffer K, Marschall HU, Gabrielsen M, Amiry-Moghaddam M, Ottersen OP, Dienes HP, Häussinger D. | 01/21/2010 |
| decreased sensitivity of mature erythrocytes from taut-/- mice to osmotic shock and oxidative stress, rendering them more resistant to apoptosis | Blunted apoptosis of erythrocytes from taurine transporter deficient mice.
Lang PA, Warskulat U, Heller-Stilb B, Huang DY, Grenz A, Myssina S, Duszenko M, Lang F, Häussinger D, Vallon V, Wieder T. | 01/21/2010 |
| TAUT is responsible for taurine uptake in mouse cerebrocortical neurons, and that the expression of TAUT is increased with developing cerebrocortical neurons | Functional expression of taurine transporter and its up-regulation in developing neurons from mouse cerebral cortex.
Fujita T, Shimada A, Wada M, Miyakawa S, Yamamoto A. | 01/21/2010 |
| Furthermore, taut-/- and taut+/- mice develop moderate unspecific hepatitis and liver fibrosis beyond 1 year of age where hepatocyte apoptosis and activation of the CD95 system are pronounced. | Taurine deficiency and apoptosis: findings from the taurine transporter knockout mouse.
Warskulat U, Borsch E, Reinehr R, Heller-Stilb B, Roth C, Witt M, Häussinger D. | 01/21/2010 |