| Tbr1 Misexpression Alters Neuronal Development in the Cerebral Cortex. | Tbr1 Misexpression Alters Neuronal Development in the Cerebral Cortex.
Crespo I, Pignatelli J, Kinare V, Méndez-Gómez HR, Esgleas M, Román MJ, Canals JM, Tole S, Vicario C., Free PMC Article | 08/27/2022 |
| Enhancing WNT Signaling Restores Cortical Neuronal Spine Maturation and Synaptogenesis in Tbr1 Mutants. | Enhancing WNT Signaling Restores Cortical Neuronal Spine Maturation and Synaptogenesis in Tbr1 Mutants.
Fazel Darbandi S, Robinson Schwartz SE, Pai EL, Everitt A, Turner ML, Cheyette BNR, Willsey AJ, State MW, Sohal VS, Rubenstein JLR., Free PMC Article | 05/1/2021 |
| Tbr1 is genetically ablated during retinal development, these two RGC groups cannot develop. Ectopically expressing Tbr1 in M4 ipRGCs during development alters dendritic branching and density but not the inner plexiform layer stratification level. | Essential Roles of Tbr1 in the Formation and Maintenance of the Orientation-Selective J-RGCs and a Group of OFF-Sustained RGCs in Mouse.
Kiyama T, Long Y, Chen CK, Whitaker CM, Shay A, Wu H, Badea TC, Mohsenin A, Parker-Thornburg J, Klein WH, Mills SL, Massey SC, Mao CA., Free PMC Article | 06/20/2020 |
| Tbr1 gene dosage regulates neocortex layer 6 connectivity. | Neonatal Tbr1 Dosage Controls Cortical Layer 6 Connectivity.
Fazel Darbandi S, Robinson Schwartz SE, Qi Q, Catta-Preta R, Pai EL, Mandell JD, Everitt A, Rubin A, Krasnoff RA, Katzman S, Tastad D, Nord AS, Willsey AJ, Chen B, State MW, Sohal VS, Rubenstein JLR., Free PMC Article | 08/17/2019 |
| Two transmembrane molecules, Sorcs3 and Cdh8, act as effectors of the Tbr1-controlled lamination program | Tbr1 instructs laminar patterning of retinal ganglion cell dendrites.
Liu J, Reggiani JDS, Laboulaye MA, Pandey S, Chen B, Rubenstein JLR, Krishnaswamy A, Sanes JR., Free PMC Article | 05/18/2019 |
| Tbr1 haploinsufficiency specifically impaired olfactory discrimination but not olfactory sensation. Tbr1+/- mice exhibited abnormal olfactory bulbs. | Haploinsufficiency of autism causative gene Tbr1 impairs olfactory discrimination and neuronal activation of the olfactory system in mice.
Huang TN, Yen TL, Qiu LR, Chuang HC, Lerch JP, Hsueh YP., Free PMC Article | 04/13/2019 |
| Study induced neuronal differentiation of mouse bone mesenchymal stem cells (bMSCs) into neuron-like cells in vitro. miR-122-5p was well complementary with the target site of Tbr1 mRNA3'UTR and could inhibit Tbr1 expression by binding to its 3'UTR. Expressions of Tbr1 mRNA and protein were decreased. Overexpression of miR-122-5p downregulated the expressions of Tbr1, NSE, and TAU. | The role of miR-122-5p in negatively regulating T-box brain 1 expression on the differentiation of mouse bone mesenchymal stem cells.
Yang Y, Shen Z, Sun W, Gao S, Li Y, Guo Y. | 01/20/2018 |
| CASK T740A mutation attenuated the interaction between CASK and TBR1 in the brain. However, CASK T740A mice were generally healthy, without obvious defects in brain morphology. The most dramatic defect among the mutant mice was in extinction of associative memory, though acquisition was normal. | Calcium/calmodulin-dependent serine protein kinase (CASK), a protein implicated in mental retardation and autism-spectrum disorders, interacts with T-Brain-1 (TBR1) to control extinction of associative memory in male mice.
Huang TN, Hsueh YP., Free PMC Article | 01/13/2018 |
| Mice lacking Tbr1 have Ca2+ waves in the cortex at normal frequencies and with normal neurotransmitter dependencies. | Distinct calcium signals in developing cortical interneurons persist despite disorganization of cortex by Tbr1 KO.
Easton CR, Dickey CW, Moen SP, Neuzil KE, Barger Z, Anderson TM, Moody WJ, Hevner RF. | 10/14/2017 |
| Our findings highlight a TBR1-regulated network of autism spectrum disorders genes in the developing neocortex that are relatively intolerant to loss-of-function mutations, indicating that these genes may play critical roles in normal cortical development. | TBR1 regulates autism risk genes in the developing neocortex.
Notwell JH, Heavner WE, Darbandi SF, Katzman S, McKenna WL, Ortiz-Londono CF, Tastad D, Eckler MJ, Rubenstein JL, McConnell SK, Chen B, Bejerano G., Free PMC Article | 03/25/2017 |
| T-Brain-1 (TBR1), a causative gene in autism spectrum disorders (ASDs), encodes a brain-specific T-box transcription factor. | T-Brain-1--A Potential Master Regulator in Autism Spectrum Disorders.
Chuang HC, Huang TN, Hsueh YP. | 06/4/2016 |
| trans-synaptic Zn mobilization by clioquinol, a Zn chelator and ionophore, rescues the social interaction deficits in Shank2-/- and Tbr1+/- mice | Trans-synaptic zinc mobilization improves social interaction in two mouse models of autism through NMDAR activation.
Lee EJ, Lee H, Huang TN, Chung C, Shin W, Kim K, Koh JY, Hsueh YP, Kim E., Free PMC Article | 03/26/2016 |
| Transgenic overexpression of Wnt7b decreased expression of Tbr1 in both progenitor cells and post-mitotic neurons. | Transgenic increase of Wnt7b in neural progenitor cells decreases expression of T-domain transcription factors and impairs neuronal differentiation.
Papachristou P, Dyberg C, Lindqvist M, Horn Z, Ringstedt T. | 04/4/2015 |
| This study demonistrated that Tbr1 haploinsufficiency impairs amygdalar axonal projections and results in cognitive abnormality. | Tbr1 haploinsufficiency impairs amygdalar axonal projections and results in cognitive abnormality.
Huang TN, Chuang HC, Chou WH, Chen CY, Wang HF, Chou SJ, Hsueh YP. | 03/29/2014 |
| Results show that the expression of Tbr1 in neural stem and progenitor cells prevents them from following an astrocyte fate during olfactory bulb development. | The T-box brain 1 (Tbr1) transcription factor inhibits astrocyte formation in the olfactory bulb and regulates neural stem cell fate.
Méndez-Gómez HR, Vergaño-Vera E, Abad JL, Bulfone A, Moratalla R, de Pablo F, Vicario-Abejón C. | 07/9/2011 |
| TBR1 is a direct transcriptional repressor of Fezf2 and a negative regulator of CS tract formation that restricts the laminar origin of CS axons specifically to L5. | TBR1 directly represses Fezf2 to control the laminar origin and development of the corticospinal tract.
Han W, Kwan KY, Shim S, Lam MM, Shin Y, Xu X, Zhu Y, Li M, Sestan N., Free PMC Article | 04/16/2011 |
| TBR1 promotes the identity of corticothalamic neurons and represses subcerebral fates through reducing expression of Fezf2 and CTIP2. | Tbr1 and Fezf2 regulate alternate corticofugal neuronal identities during neocortical development.
McKenna WL, Betancourt J, Larkin KA, Abrams B, Guo C, Rubenstein JL, Chen B., Free PMC Article | 02/26/2011 |
| Tbr1 coordinately regulates regional and laminar identity of postmitotic cortical neurons. | Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex.
Bedogni F, Hodge RD, Elsen GE, Nelson BR, Daza RA, Beyer RP, Bammler TK, Rubenstein JL, Hevner RF., Free PMC Article | 09/6/2010 |
| Af9/Mllt3 interferes with Tbr1 expression through epigenetic modification of histone H3K79 during development of the cerebral cortex | Af9/Mllt3 interferes with Tbr1 expression through epigenetic modification of histone H3K79 during development of the cerebral cortex.
Büttner N, Johnsen SA, Kügler S, Vogel T., Free PMC Article | 05/31/2010 |
| Taken together, our data illustrate that Ngn2, neuroD and Tbr transcription factors are involved in postnatal neurogenesis in the olfactory bulb. | Involvement of Ngn2, Tbr and NeuroD proteins during postnatal olfactory bulb neurogenesis.
Roybon L, Deierborg T, Brundin P, Li JY. | 01/21/2010 |
| These findings delineate the transcription factor sequence Pax6 --> Tbr2 --> Tbr1 in the differentiation of radial glia --> intermediate progenitor cell --> postmitotic projection neuron. | Pax6, Tbr2, and Tbr1 are expressed sequentially by radial glia, intermediate progenitor cells, and postmitotic neurons in developing neocortex.
Englund C, Fink A, Lau C, Pham D, Daza RA, Bulfone A, Kowalczyk T, Hevner RF., Free PMC Article | 01/21/2010 |
| While Tbr1 is expressed in postmitotic neurons, Tbr2 (which is also expressed during gastrulation) is also expressed in neural progenitors. | Developmental expression of the T-box transcription factor T-bet/Tbx21 during mouse embryogenesis.
Faedo A, Ficara F, Ghiani M, Aiuti A, Rubenstein JL, Bulfone A. | 01/21/2010 |
| Here, we provide a tool to illuminate a unique subset of SP and deep CP neurons: expression of a Tbrain-1 (Tbr1)-driven transgene. | A unique subpopulation of Tbr1-expressing deep layer neurons in the developing cerebral cortex.
Kolk SM, Whitman MC, Yun ME, Shete P, Donoghue MJ. | 01/21/2010 |
| Here, we provide a tool to illuminate a unique subset of SP and deep CP neurons: expression of a Tbrain-1 (Tbr1)-driven transgene. | A unique subpopulation of Tbr1-expressing deep layer neurons in the developing cerebral cortex.
Kolk SM, Whitman MC, Yun ME, Shete P, Donoghue MJ. | 01/21/2010 |
| Tbr1 gene is expressed in cells that interact with olfactory sensory neurons | Novel subdomains of the mouse olfactory bulb defined by molecular heterogeneity in the nascent external plexiform and glomerular layers.
Williams EO, Xiao Y, Sickles HM, Shafer P, Yona G, Yang JY, Lin DM., Free PMC Article | 01/21/2010 |