| Transcriptional programs of Pitx2 and Tfap2a/Tfap2b controlling lineage specification of mandibular epithelium during tooth initiation. | Transcriptional programs of Pitx2 and Tfap2a/Tfap2b controlling lineage specification of mandibular epithelium during tooth initiation.
Shao F, Phan AV, Yu W, Guo Y, Thompson J, Coppinger C, Venugopalan SR, Amendt BA, Van Otterloo E, Cao H., Free PMC Article | 09/13/2024 |
| TFAP2A is involved in neuropathic pain by regulating Grin1 expression in glial cells of the dorsal root ganglion. | TFAP2A is involved in neuropathic pain by regulating Grin1 expression in glial cells of the dorsal root ganglion.
Yuan BT, Li MN, Zhu LP, Xu ML, Gu J, Gao YJ, Ma LJ. | 08/22/2024 |
| TFAP2 paralogs regulate midfacial development in part through a conserved ALX genetic pathway. | TFAP2 paralogs regulate midfacial development in part through a conserved ALX genetic pathway.
Nguyen TT, Mitchell JM, Kiel MD, Kenny CP, Li H, Jones KL, Cornell RA, Williams TJ, Nichols JT, Van Otterloo E., Free PMC Article | 01/4/2024 |
| Overexpression of Tfap2a in Mouse Oocytes Impaired Spindle and Chromosome Organization. | Overexpression of Tfap2a in Mouse Oocytes Impaired Spindle and Chromosome Organization.
Lin J, Ji Z, Di Z, Zhang Y, Yan C, Zeng S., Free PMC Article | 12/17/2022 |
| The Ap-2alpha/Elk-1 axis regulates Sirpalpha-dependent tumor phagocytosis by tumor-associated macrophages in colorectal cancer. | The Ap-2α/Elk-1 axis regulates Sirpα-dependent tumor phagocytosis by tumor-associated macrophages in colorectal cancer.
Wang X, Luo X, Chen C, Tang Y, Li L, Mo B, Liang H, Yu S., Free PMC Article | 10/16/2021 |
| Functional Divergence of Mammalian TFAP2a and TFAP2b Transcription Factors for Bidirectional Sleep Control. | Functional Divergence of Mammalian TFAP2a and TFAP2b Transcription Factors for Bidirectional Sleep Control.
Hu Y, Korovaichuk A, Astiz M, Schroeder H, Islam R, Barrenetxea J, Fischer A, Oster H, Bringmann H., Free PMC Article | 07/17/2021 |
| Anomalous incisor morphology indicates tissue-specific roles for Tfap2a and Tfap2b in tooth development. | Anomalous incisor morphology indicates tissue-specific roles for Tfap2a and Tfap2b in tooth development.
Woodruff ED, Gutierrez GC, Van Otterloo E, Williams T, Cohn MJ., Free PMC Article | 06/26/2021 |
| KCTD1 promotes adipogenesis through the interaction with transcription factor AP2 alpha and by removing it from the nucleus. | KCTD1: A novel modulator of adipogenesis through the interaction with the transcription factor AP2α.
Pirone L, Smaldone G, Spinelli R, Barberisi M, Beguinot F, Vitagliano L, Miele C, Di Gaetano S, Raciti GA, Pedone E. | 02/29/2020 |
| these data suggest that the Tfap2a-Irf6-Grhl3 genetic pathway is shared by two embryologically distinct morphogenetic events that previously were considered independent during mammalian development | The TFAP2A-IRF6-GRHL3 genetic pathway is conserved in neurulation.
Kousa YA, Zhu H, Fakhouri WD, Lei Y, Kinoshita A, Roushangar RR, Patel NK, Agopian AJ, Yang W, Leslie EJ, Busch TD, Mansour TA, Li X, Smith AL, Li EB, Sharma DB, Williams TJ, Chai Y, Amendt BA, Liao EC, Mitchell LE, Bassuk AG, Gregory S, Ashley-Koch A, Shaw GM, Finnell RH, Schutte BC., Free PMC Article | 02/8/2020 |
| AMPKalpha/AP-2alpha/miR-124/P4Halpha1 axis plays a crucial role in the regulation of collagen synthesis in advanced atherosclerotic lesions. Targeting AMPKalpha/AP-2alpha/miRNA-124/P4Halpha1 signaling should be considered to increase the plaque stability in patients with atherosclerosis. | AMPKα inactivation destabilizes atherosclerotic plaque in streptozotocin-induced diabetic mice through AP-2α/miRNA-124 axis.
Liang WJ, Zhou SN, Shan MR, Wang XQ, Zhang M, Chen Y, Zhang Y, Wang SX, Guo T. | 10/19/2019 |
| Together these findings demonstrate the requirement for both AP-2alpha and AP-2beta in proper amacrine mosaic patterning and a normal functional light response in the retina. | Conditional Deletion of AP-2α and AP-2β in the Developing Murine Retina Leads to Altered Amacrine Cell Mosaics and Disrupted Visual Function.
Hicks EA, Zaveri M, Deschamps PA, Noseworthy MD, Ball A, Williams T, West-Mays JA., Free PMC Article | 02/16/2019 |
| AP2gamma is present in a sub-population of hippocampal transient amplifying progenitors. There, it is found to act as a positive regulator of the cell fate determinants Tbr2 and NeuroD, promoting proliferation and differentiation of new glutamatergic granular neurons. Conditional ablation of AP2gamma in adult brain reduced hippocampal neurogenesis and disrupted coherence between ventral hippocampus and medial prefronta... | AP2γ controls adult hippocampal neurogenesis and modulates cognitive, but not anxiety or depressive-like behavior.
Mateus-Pinheiro A, Alves ND, Patrício P, Machado-Santos AR, Loureiro-Campos E, Silva JM, Sardinha VM, Reis J, Schorle H, Oliveira JF, Ninkovic J, Sousa N, Pinto L. | 07/14/2018 |
| these findings reveal that the AP-2 genes have a major function in mammalian neural crest development, influencing patterning of the craniofacial skeleton | AP-2α and AP-2β cooperatively orchestrate homeobox gene expression during branchial arch patterning.
Van Otterloo E, Li H, Jones KL, Williams T., Free PMC Article | 03/31/2018 |
| RNA interference of transcriptional factor activator protein 2alpha (AP-2alpha) reversed the inhibitory effects of aspirin on atherosclerosis in Apoe-/- mice. | Activation of activator protein 2 alpha by aspirin alleviates atherosclerotic plaque growth and instability in vivo.
Yang JJ, Li P, Wang F, Liang WJ, Ma H, Chen Y, Ma ZM, Li QZ, Peng QS, Zhang Y, Wang SX., Free PMC Article | 02/3/2018 |
| Study systematically examined the expression profile of AP-2 family in the developing mouse and chick spinal cord and found that AP-2alpha and AP-2beta are specifically expressed in post-mitotic dorsal interneurons. Subsequent functional assessment in chick embryos demonstrated that AP-2alpha and AP-2beta have distinct functions in dorsal interneuron specification and differentiation. | AP-2α and AP-2β regulate dorsal interneuron specification in the spinal cord.
Xu X, Liu Z, Huang H, Zheng K, Hu X, Zhang Z, Qiu M. | 11/11/2017 |
| MEX3C associates with the endolysosomal compartment through an endocytosis-like process. siRNA-mediated inhibition of the MEX3C or AP-2 complex substantially decreased exosomal but not cellular microRNA miR-451a expression | MEX3C interacts with adaptor-related protein complex 2 and involves in miR-451a exosomal sorting.
Lu P, Li H, Li N, Singh RN, Bishop CE, Chen X, Lu B., Free PMC Article | 11/4/2017 |
| High AP-2 alpha phosphorylation is associated with abdominal aortic aneurysm. | Pravastatin activates activator protein 2 alpha to augment the angiotensin II-induced abdominal aortic aneurysms.
Ma H, Liang WJ, Shan MR, Wang XQ, Zhou SN, Chen Y, Guo T, Li P, Yu HY, Liu C, Yin YL, Wang YL, Dong B, Pang XY, Wang SX., Free PMC Article | 10/14/2017 |
| overexpression of Dnmt3a partially rescued the impairment of adipogenesis induced by AP2alpha knockdown. | Epigenetic programming of Dnmt3a mediated by AP2α is required for granting preadipocyte the ability to differentiate.
Guo W, Chen J, Yang Y, Zhu J, Wu J., Free PMC Article | 09/2/2017 |
| Data show that TFAP2A binds many of the same regulatory elements as MITF in melanocytes. | TFAP2 paralogs regulate melanocyte differentiation in parallel with MITF.
Seberg HE, Van Otterloo E, Loftus SK, Liu H, Bonde G, Sompallae R, Gildea DE, Santana JF, Manak JR, Pavan WJ, Williams T, Cornell RA., Free PMC Article | 06/24/2017 |
| TFAP2A is a conserved component of the core network that regulates EMT, acting as a repressor of many genes, including ZEB2. | TFAP2A is a component of the ZEB1/2 network that regulates TGFB1-induced epithelial to mesenchymal transition.
Dimitrova Y, Gruber AJ, Mittal N, Ghosh S, Dimitriades B, Mathow D, Grandy WA, Christofori G, Zavolan M., Free PMC Article | 04/29/2017 |
| The AP-2beta transcription factor is an important effector of PITX2 function during corneal development, required for differentiation of corneal endothelium and establishment of angiogenic privilege. | AP-2β Is a Downstream Effector of PITX2 Required to Specify Endothelium and Establish Angiogenic Privilege During Corneal Development.
Chen L, Martino V, Dombkowski A, Williams T, West-Mays J, Gage PJ., Free PMC Article | 07/30/2016 |
| the regulation of synaptic-vesicle (SV) recycling via early endosomes by the interdependent regulation of AP-2-mediated endocytosis and AP-1/sigma1B-mediated SV reformation, is reported. | AP-1/σ1B-Dependent SV Protein Recycling Is Regulated in Early Endosomes and Is Coupled to AP-2 Endocytosis.
Kratzke M, Candiello E, Schmidt B, Jahn O, Schu P. | 05/21/2016 |
| the Tfap2a and Tfap2b transcription factors were identified as two major downstream effectors of Ptf1a. | Tfap2a and 2b act downstream of Ptf1a to promote amacrine cell differentiation during retinogenesis.
Jin K, Jiang H, Xiao D, Zou M, Zhu J, Xiang M, Jin K, Jiang H, Xiao D, Zou M, Zhu J, Xiang M., Free PMC Articles: PMC4429372, PMC4429372 | 01/23/2016 |
| Tfap2a-dependent changes in mouse facial morphology result in clefting that can be ameliorated by a reduction in Fgf8 gene dosage | Tfap2a-dependent changes in mouse facial morphology result in clefting that can be ameliorated by a reduction in Fgf8 gene dosage.
Green RM, Feng W, Phang T, Fish JL, Li H, Spritz RA, Marcucio RS, Hooper J, Jamniczky H, Hallgrímsson B, Williams T., Free PMC Article | 10/3/2015 |
| By gain-of function and loss-of-function approaches, ap2a and 2b were identified to be the major downstream targets of Ptf1a to specify the amacrine cell fate. | Tfap2a and 2b act downstream of Ptf1a to promote amacrine cell differentiation during retinogenesis.
Jin K, Jiang H, Xiao D, Zou M, Zhu J, Xiang M, Jin K, Jiang H, Xiao D, Zou M, Zhu J, Xiang M., Free PMC Articles: PMC4429372, PMC4429372 | 06/12/2015 |