| Sidt2 is a key protein in the autophagy-lysosomal degradation pathway and is essential for the maintenance of kidney structure and filtration function. | Sidt2 is a key protein in the autophagy-lysosomal degradation pathway and is essential for the maintenance of kidney structure and filtration function.
Geng MY, Wang L, Song YY, Gu J, Hu X, Yuan C, Yang M, Pei WJ, Zhang Y, Gao JL., Free PMC Article | 03/26/2022 |
| Cytosolic domain of SIDT2 carries an arginine-rich motif that binds to RNA/DNA and is important for the direct transport of nucleic acids into lysosomes. | Cytosolic domain of SIDT2 carries an arginine-rich motif that binds to RNA/DNA and is important for the direct transport of nucleic acids into lysosomes.
Hase K, Contu VR, Kabuta C, Sakai R, Takahashi M, Kataoka N, Hakuno F, Takahashi SI, Fujiwara Y, Wada K, Kabuta T., Free PMC Article | 09/4/2021 |
| The lysosomal membrane protein Sidt2 is a vital regulator of mitochondrial quality control in skeletal muscle. | The lysosomal membrane protein Sidt2 is a vital regulator of mitochondrial quality control in skeletal muscle.
Wang L, Yu C, Pei W, Geng M, Zhang Y, Li Z, Liang F, Tan F, Du H, Gao J. | 07/24/2021 |
| The Effects of Sidt2 on the Inflammatory Pathway in Mouse Mesangial Cells. | The Effects of Sidt2 on the Inflammatory Pathway in Mouse Mesangial Cells.
Sun H, Ding JM, Zheng HH, Lv KJ, Hu YF, Luo YH, Wu X, Pei WJ, Wang LZ, Wu MC, Zhang Y, Gao JL., Free PMC Article | 07/10/2021 |
| The Sidt2 plays an important role in mouse hepatic lipid homeostasis by regulating autophagy at the terminal stage. | Sidt2 regulates hepatocellular lipid metabolism through autophagy.
Chen X, Gu X, Zhang H., Free PMC Article | 07/27/2019 |
| This study provides new insight into lysosomal targeting of proteins and intracellular RNA degradation, and further confirms the critical function of SIDT2 in RNautophagy. | Lysosomal targeting of SIDT2 via multiple YxxΦ motifs is required for SIDT2 function in the process of RNautophagy.
Contu VR, Hase K, Kozuka-Hata H, Oyama M, Fujiwara Y, Kabuta C, Takahashi M, Hakuno F, Takahashi SI, Wada K, Kabuta T. | 05/5/2018 |
| SIDT2 (SID1 transmembrane family, member 2), an ortholog of the Caenorhabditis elegans putative RNA transporter SID-1 (systemic RNA interference defective-1), mediates RNA translocation during RNautophagy | Lysosomal membrane protein SIDT2 mediates the direct uptake of DNA by lysosomes.
Aizawa S, Contu VR, Fujiwara Y, Hase K, Kikuchi H, Kabuta C, Wada K, Kabuta T., Free PMC Article | 12/9/2017 |
| We conclude that Sidt2 is involved in NAADP-mediated release of calcium from insulin secretory granules and thus regulates insulin secretion. | SIDT2 is involved in the NAADP-mediated release of calcium from insulin secretory granules.
Chang G, Yang R, Cao Y, Nie A, Gu X, Zhang H. | 10/28/2017 |
| SIDT2, is required to transport internalized extracellular dsRNA from endocytic compartments into the cytoplasm for immune activation. Sidt2-deficient mice exposed to extracellular dsRNA, encephalomyocarditis virus (EMCV), and herpes simplex virus 1 (HSV-1) show impaired production of antiviral cytokines and-in the case of EMCV and HSV-1-reduced survival. | SIDT2 Transports Extracellular dsRNA into the Cytoplasm for Innate Immune Recognition.
Nguyen TA, Smith BRC, Tate MD, Belz GT, Barrios MH, Elgass KD, Weisman AS, Baker PJ, Preston SP, Whitehead L, Garnham A, Lundie RJ, Smyth GK, Pellegrini M, O'Keeffe M, Wicks IP, Masters SL, Hunter CP, Pang KC., Free PMC Article | 10/21/2017 |
| Sidt2 plays an important role in the pathogenesis of spontaneous nonalcoholic fatty liver disease. | Spontaneous nonalcoholic fatty liver disease and ER stress in Sidt2 deficiency mice.
Gao J, Zhang Y, Yu C, Tan F, Wang L. | 05/27/2017 |
| Sidt2 is located on chromosome 11q23, a locus repeatedly found by chromosomal mapping of Alzheimer's disease-related genes. | Identification of Sidt2 as a lysosomal cation-conducting protein.
Beck A, Fecher-Trost C, Wolske K, Philipp SE, Flockerzi V, Wissenbach U. | 05/27/2017 |
| SIDT2 (SID1 transmembrane family, member 2), an ortholog of the Caenorhabditis elegans putative RNA transporter SID-1 (systemic RNA interference deficient-1), mediates RNA translocation during RNautophagy. | Lysosomal putative RNA transporter SIDT2 mediates direct uptake of RNA by lysosomes.
Aizawa S, Fujiwara Y, Contu VR, Hase K, Takahashi M, Kikuchi H, Kabuta C, Wada K, Kabuta T., Free PMC Article | 12/31/2016 |
| Sdit2 may play a vital role in the regulation of insulin secretion via two SNARE proteins synap1 and syanp3. | Lysosomal integral membrane protein Sidt2 plays a vital role in insulin secretion.
Gao J, Yu C, Xiong Q, Zhang Y, Wang L., Free PMC Article | 11/12/2016 |
| Sidt2 may play a critical role in the regulation of mouse insulin secretory granule secretion. | Impaired glucose tolerance in a mouse model of sidt2 deficiency.
Gao J, Gu X, Mahuran DJ, Wang Z, Zhang H., Free PMC Article | 01/18/2014 |
| Sidt2 is a highly glycosylated lysosomal integral membrane protein that shows tissue-specific expression. | SID1 transmembrane family, member 2 (Sidt2): a novel lysosomal membrane protein.
Jialin G, Xuefan G, Huiwen Z. | 01/15/2011 |