| RAGE deficiency ameliorates autoimmune hepatitis involving inhibition of IL-6 production via suppressing protein Arid5a in mice. | RAGE deficiency ameliorates autoimmune hepatitis involving inhibition of IL-6 production via suppressing protein Arid5a in mice.
Li X, Hua S, Fang D, Fei X, Tan Z, Zheng F, Wang W, Fang M. | 10/5/2023 |
| Arid5a Mediates an IL-17-Dependent Pathway That Drives Autoimmunity but Not Antifungal Host Defense. | Arid5a Mediates an IL-17-Dependent Pathway That Drives Autoimmunity but Not Antifungal Host Defense.
Taylor TC, Li Y, Li DD, Majumder S, McGeachy MJ, Biswas PS, Gingras S, Gaffen SL., Free PMC Article | 10/8/2022 |
| The novel long noncoding RNA AU021063, induced by IL-6/Arid5a signaling, exacerbates breast cancer invasion and metastasis by stabilizing Trib3 and activating the Mek/Erk pathway. | The novel long noncoding RNA AU021063, induced by IL-6/Arid5a signaling, exacerbates breast cancer invasion and metastasis by stabilizing Trib3 and activating the Mek/Erk pathway.
Nyati KK, Hashimoto S, Singh SK, Tekguc M, Metwally H, Liu YC, Okuzaki D, Gemechu Y, Kang S, Kishimoto T. | 01/8/2022 |
| Feedback regulation of Arid5a and Ppar-gamma2 maintains adipose tissue homeostasis. | Feedback regulation of Arid5a and Ppar-γ2 maintains adipose tissue homeostasis.
Chalise JP, Hashimoto S, Parajuli G, Kang S, Singh SK, Gemechu Y, Metwally H, Nyati KK, Dubey PK, Zaman MM, Nagahama Y, Hamza H, Masuda K, Kishimoto T., Free PMC Article | 04/4/2020 |
| Arid5a orchestrates a feed-forward amplification loop, which promoted IL-17 signaling by controlling mRNA stability and translation | IL-17 integrates multiple self-reinforcing, feed-forward mechanisms through the RNA binding protein Arid5a.
Amatya N, Childs EE, Cruz JA, Aggor FEY, Garg AV, Berman AJ, Gudjonsson JE, Atasoy U, Gaffen SL., Free PMC Article | 11/2/2019 |
| Arid5a regulates the augmentation of OX40 in CD4+ T cells, and impairs destabilizing functions of Regnase-1 and Roquin-1 on OX40 alternative decay element-like stem-loop in the 3' untranslated region | Arid5a stabilizes OX40 mRNA in murine CD4(+) T cells by recognizing a stem-loop structure in its 3'UTR.
Hanieh H, Masuda K, Metwally H, Chalise JP, Mohamed M, Nyati KK, Standley DM, Li S, Higa M, Zaman MM, Kishimoto T. | 01/26/2019 |
| High Arid5a expression is associated with inflammation. | Regulation of inflammatory responses by dynamic subcellular localization of RNA-binding protein Arid5a.
Higa M, Oka M, Fujihara Y, Masuda K, Yoneda Y, Kishimoto T., Free PMC Article | 07/28/2018 |
| Arid5a deficiency resulted in decreased levels of IFN-gamma under Th1 cell conditions, in which T-box expressed in T cells (T-bet) mRNA expression was inhibited. | Arid5a exacerbates IFN-γ-mediated septic shock by stabilizing T-bet mRNA.
Zaman MM, Masuda K, Nyati KK, Dubey PK, Ripley B, Wang K, Chalise JP, Higa M, Hanieh H, Kishimoto T., Free PMC Article | 01/27/2018 |
| data showed that regulation of Arid5a by NF-kappaB and MAPK signaling is required to maintain the balance of IL-6 mRNA expression | TLR4-induced NF-κB and MAPK signaling regulate the IL-6 mRNA stabilizing protein Arid5a.
Nyati KK, Masuda K, Zaman MM, Dubey PK, Millrine D, Chalise JP, Higa M, Li S, Standley DM, Saito K, Hanieh H, Kishimoto T., Free PMC Article | 08/12/2017 |
| this study shows that Arid5a-deficient mice were highly refractory to bleomycin-induced lung injury | Arid5a-deficient mice are highly resistant to bleomycin-induced lung injury.
Dubey PK, Masuda K, Nyati KK, -Uz Zaman MM, Chalise JP, Millrine D, Kai W, Ripley B, Kishimoto T. | 05/7/2017 |
| T cell-intrinsic role of Arid5a on fate decisions of naive CD4(+)T cells through selective stabilization of Stat3 mRNA. | Arid5a regulates naive CD4+ T cell fate through selective stabilization of Stat3 mRNA.
Masuda K, Ripley B, Nyati KK, Dubey PK, Zaman MM, Hanieh H, Higa M, Yamashita K, Standley DM, Mashima T, Katahira M, Okamoto T, Matsuura Y, Takeuchi O, Kishimoto T., Free PMC Article | 08/20/2016 |
| Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo. | Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo.
Masuda K, Ripley B, Nishimura R, Mino T, Takeuchi O, Shioi G, Kiyonari H, Kishimoto T., Free PMC Article | 08/10/2013 |
| AT-rich interactive domain-containing protein 5a (Arid5a) cooperates with Sox9 to stimulate chondrocyte-specific transcription. | Arid5a cooperates with Sox9 to stimulate chondrocyte-specific transcription.
Amano K, Hata K, Muramatsu S, Wakabayashi M, Takigawa Y, Ono K, Nakanishi M, Takashima R, Kogo M, Matsuda A, Nishimura R, Yoneda T., Free PMC Article | 08/20/2011 |