| PAR3 is essential in thrombin stimulated insulin secretion. | Thrombin stimulates insulin secretion via protease-activated receptor-3.
Hänzelmann S, Wang J, Güney E, Tang Y, Zhang E, Axelsson AS, Nenonen H, Salehi AS, Wollheim CB, Zetterberg E, Berntorp E, Costa IG, Castelo R, Rosengren AH., Free PMC Article | 11/12/2016 |
| TFRGAP, a PAR-3 mimicking peptide significantly induced the phosphorylation of eNOS-Thr-495 with minimal phosphorylation of eNOS-Ser-1177 with no change in nitric oxide production. | Featured Article: Differential regulation of endothelial nitric oxide synthase phosphorylation by protease-activated receptors in adult human endothelial cells.
Tillery LC, Epperson TA, Eguchi S, Motley ED., Free PMC Article | 08/6/2016 |
| These data provide intriguing novel insights into the diversification of functional selectivity of protease signaling achievable by canonical and noncanonical PAR activation, such as the activation of vascular-protective Tie2 by noncanonical PAR3 activation. | Noncanonical PAR3 activation by factor Xa identifies a novel pathway for Tie2 activation and stabilization of vascular integrity.
Stavenuiter F, Mosnier LO., Free PMC Article | 02/28/2015 |
| In pancreatic adenocarcinoma cells, PAR3 knockdown enhances cell adhesion. We propose this is due to increased expression of E-cadherin, leading to a greater adhesion of free-floating cells to cells bound to the surface via integrins, particularly ITGalphav. | PAR-3 knockdown enhances adhesion rate of PANC-1 cells via increased expression of integrinαv and E-cadherin.
Segal L, Katz LS, Shapira H, Sandbank J, Geras-Raaka E, Gershengorn MC, Oron Y., Free PMC Article | 01/31/2015 |
| Data indicate that knockdowns of all three PARs PAR-1, PAR-2, and PAR-3 exhibited changes in the expression of CDC42, which correlated with the changes in their invasion. | Proteinase-activated receptors differentially modulate in vitro invasion of human pancreatic adenocarcinoma PANC-1 cells in correlation with changes in the expression of CDC42 protein.
Segal L, Katz LS, Lupu-Meiri M, Shapira H, Sandbank J, Gershengorn MC, Oron Y., Free PMC Article | 08/16/2014 |
| Elevated expression of PAR-3, but not PAR-4, was detected in the lungs of idiopathic pulmonary fibrosis patients. | Protease-activated receptors (PAR)-1 and -3 drive epithelial-mesenchymal transition of alveolar epithelial cells - potential role in lung fibrosis.
Wygrecka M, Didiasova M, Berscheid S, Piskulak K, Taborski B, Zakrzewicz D, Kwapiszewska G, Preissner KT, Markart P. | 04/5/2014 |
| A unique contributory role for PAR3 in the complex mechanisms underlying Activated protein C cytoprotective effects. | Novel mechanisms for activated protein C cytoprotective activities involving noncanonical activation of protease-activated receptor 3.
Burnier L, Mosnier LO., Free PMC Article | 11/2/2013 |
| PAR-3 receptors interact with thrombin and increase heme oxygenase-1 expression in synovial fibroblasts. | Thrombin induces heme oxygenase-1 expression in human synovial fibroblasts through protease-activated receptor signaling pathways.
Liu JF, Hou SM, Tsai CH, Huang CY, Yang WH, Tang CH., Free PMC Article | 05/25/2013 |
| Human PAR-3 is regulated post-transcriptionally via the mRNA-stabilizing factor HuR, whereas transcriptional control involves nuclear factor of activated T cells (NFAT). | Regulation of human vascular protease-activated receptor-3 through mRNA stabilization and the transcription factor nuclear factor of activated T cells (NFAT).
Rosenkranz AC, Rauch BH, Doller A, Eberhardt W, Böhm A, Bretschneider E, Schrör K. | 09/17/2011 |
| FXa bound in a punctate manner to thrombi under shear, while thrombin and fibrin(ogen) distributed ubiquitously over platelet-fibrin thrombi | Spatial distribution of factor Xa, thrombin, and fibrin(ogen) on thrombi at venous shear.
Berny MA, Munnix IC, Auger JM, Schols SE, Cosemans JM, Panizzi P, Bock PE, Watson SP, McCarty OJ, Heemskerk JW., Free PMC Article | 06/18/2011 |
| genetic polymorphism is associated with peripheral arterial disease severity | Thrombophilic risk factors and peripheral arterial disease severity.
Sartori M, Favaretto E, Legnani C, Cini M, Conti E, Amato A, Palareti G. | 02/26/2011 |
| Low concentrations of alpha-thrombin accelerate tissue factor-induced thrombin generation on the surface of vascular smooth muscle cells, and this effect is mediated by PAR-3 and PAR-4. | Activation of protease-activated receptors 3 and 4 accelerates tissue factor-induced thrombin generation on the surface of vascular smooth muscle cells.
Vidwan P, Pathak A, Sheth S, Huang J, Monroe DM, Stouffer GA., Free PMC Article | 01/1/2011 |
| Human cytomegalovirus induces PARs expression through transcriptional activation in endothelial cells, increasing sensitivity to thrombin. | Human cytomegalovirus increases HUVEC sensitivity to thrombin and modulates expression of thrombin receptors.
Popović M, Paskas S, Zivković M, Burysek L, Laumonnier Y. | 11/13/2010 |
| A novel role is identified for PAR3 in thrombin signaling. | Thrombin regulates the metastatic potential of human rhabdomyosarcoma cells: distinct role of PAR1 and PAR3 signaling.
Wysoczynski M, Liu R, Kucia M, Drukala J, Ratajczak MZ., Free PMC Article | 11/6/2010 |
| Down-regulation of connexin and par-3 signals early anaplasia and malignant change in rectal cancer. | Expressions of connexin and par-3 in the distal margin of rectal cancer after ultra-low anterior resection.
Liu J, Zhang W, Liu J, Lu X, Long Y, Zhou Y, Liu S. | 10/23/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium., Free PMC Article | 09/15/2010 |
| upregulated thrombin generation and inhibition of fibrinolysis, occurred in one-third of the Stem cell transplant patients associating with the development of Graft versus host disease | Early thrombin generation and impaired fibrinolysis after SCT associate with acute GVHD.
Pinomäki A, Volin L, Joutsi-Korhonen L, Virtanen JO, Lemponen M, Ruutu T, Lassila R. | 08/9/2010 |
| Lower plasma levels of thrombin-antithrombin complex correlate to higher recanalisation rates after ischaemic stroke | Lower concentrations of thrombin-antithrombin complex (TAT) correlate to higher recanalisation rates among ischaemic stroke patients treated with t-PA.
Fernandez-Cadenas I, Mendioroz M, Munuera J, Alvarez-Sabin J, Rovira A, Quiroga A, Corbeto N, Rubiera M, Delgado P, Rosell A, Ribó M, Molina CA, Montaner J. | 05/3/2010 |
| Mechanism of the anticoagulant activity of thrombin mutant W215A/E217A. | Mechanism of the anticoagulant activity of thrombin mutant W215A/E217A.
Gandhi PS, Page MJ, Chen Z, Bush-Pelc L, Di Cera E., Free PMC Article | 01/21/2010 |
| This study demonstrates that the anticoagulant profile of thrombin often caused by a mutation of the thrombin scaffold finds its likely molecular origin in the stabilization of the inactive E* form. | Stabilization of the E* form turns thrombin into an anticoagulant.
Bah A, Carrell CJ, Chen Z, Gandhi PS, Di Cera E., Free PMC Article | 01/21/2010 |
| Thrombin-mediated increases in cytosolic [Ca2+] involve different mechanisms in human pulmonary artery smooth muscle and endothelial cells. | Thrombin-mediated increases in cytosolic [Ca2+] involve different mechanisms in human pulmonary artery smooth muscle and endothelial cells.
Sacks RS, Firth AL, Remillard CV, Agange N, Yau J, Ko EA, Yuan JX., Free PMC Article | 01/21/2010 |
| PAR-3 is able to signal autonomously to induce IL-8 release mediated by ERK1/2 phosphorylation, which contributes actively to inflammatory responses | The protease-activated receptor-3 (PAR-3) can signal autonomously to induce interleukin-8 release.
Ostrowska E, Reiser G., Free PMC Article | 01/21/2010 |
| PAR3 receptors and analogues can mediate cell signaling by interaction with PAR1-type thrombin receptors | Proteinase-activated receptors (PARs)--the PAR3 Neo-N-terminal peptide TFRGAP interacts with PAR1.
Kaufmann R, Schulze B, Krause G, Mayr LM, Settmacher U, Henklein P. | 01/21/2010 |
| a Na-independent Cl-/HCO3- exchange mechanism mediates the recovery of pHi from alkalosis in platelets and that thrombin activates this exchanger by a direct regulatory pathway | Thrombin stimulation of Cl-/HCO3- exchange in human platelets.
Gende OA. | 01/21/2010 |