| MCU inhibition protects against intestinal ischemia-reperfusion by inhibiting Drp1-dependent mitochondrial fission. | MCU inhibition protects against intestinal ischemia‒reperfusion by inhibiting Drp1-dependent mitochondrial fission.
Kadier T, Zhang YG, Jing YX, Weng ZY, Liao SS, Luo J, Ding K, Cao C, Chen R, Meng QT. | 06/27/2024 |
| Mitochondrial calcium uniporter deficiency in dentate granule cells remodels neuronal metabolism and impairs reversal learning. | Mitochondrial calcium uniporter deficiency in dentate granule cells remodels neuronal metabolism and impairs reversal learning.
Rose HM, Ferrán B, Ranjit R, Masingale AM, Owen DB, Hussong S, Kinter MT, Galvan V, Logan S, Díaz-García CM., | 05/21/2024 |
| Mitochondrial Calcium Uniporter (MCU) is Involved in an Ischemic Postconditioning Effect Against Ischemic Reperfusion Brain Injury in Mice. | Mitochondrial Calcium Uniporter (MCU) is Involved in an Ischemic Postconditioning Effect Against Ischemic Reperfusion Brain Injury in Mice.
Sasaki H, Nakagawa I, Furuta T, Yokoyama S, Morisaki Y, Saito Y, Nakase H., Free PMC Article | 04/8/2024 |
| MCU-independent Ca[2+] uptake mediates mitochondrial Ca[2+] overload and necrotic cell death in a mouse model of Duchenne muscular dystrophy. | MCU-independent Ca(2+) uptake mediates mitochondrial Ca(2+) overload and necrotic cell death in a mouse model of Duchenne muscular dystrophy.
Bround MJ, Abay E, Huo J, Havens JR, York AJ, Bers DM, Molkentin JD., Free PMC Article | 03/27/2024 |
| Deletion of the mitochondrial calcium uniporter in adipose tissue promotes energy expenditure and alleviates diet-induced obesity. | Deletion of the mitochondrial calcium uniporter in adipose tissue promotes energy expenditure and alleviates diet-induced obesity.
Jia M, Liu S, Xiao Y, Zhang Z, Li M, Qi X, Qi X, Yu L, Zhang C, Jiang T, Pan T, Sun Y, Yu J, Su S, Li Y, Damba T, Batchuluun K, Liang Y, Zhou L., Free PMC Article | 02/20/2024 |
| Negative modulation of mitochondrial calcium uniporter complex protects neurons against ferroptosis. | Negative modulation of mitochondrial calcium uniporter complex protects neurons against ferroptosis.
Marmolejo-Garza A, Krabbendam IE, Luu MDA, Brouwer F, Trombetta-Lima M, Unal O, O'Connor SJ, Majerníková N, Elzinga CRS, Mammucari C, Schmidt M, Madesh M, Boddeke E, Dolga AM., Free PMC Article | 11/29/2023 |
| SEPSIS LEADS TO IMPAIRED MITOCHONDRIAL CALCIUM UPTAKE AND SKELETAL MUSCLE WEAKNESS BY REDUCING THE MICU1:MCU PROTEIN RATIO. | SEPSIS LEADS TO IMPAIRED MITOCHONDRIAL CALCIUM UPTAKE AND SKELETAL MUSCLE WEAKNESS BY REDUCING THE MICU1:MCU PROTEIN RATIO.
Li X, Sun B, Li J, Ye W, Li M, Guan F, Wu S, Luo X, Feng J, Jia J, Liu X, Li T, Liu L., Free PMC Article | 11/13/2023 |
| Distinct effects of cardiac mitochondrial calcium uniporter inactivation via EMRE deletion in the short and long term. | Distinct effects of cardiac mitochondrial calcium uniporter inactivation via EMRE deletion in the short and long term.
Chapoy Villanueva H, Sung JH, Stevens JA, Zhang MJ, Nelson PM, Denduluri LS, Feng F, O'Connell TD, Townsend D, Liu JC., Free PMC Article | 10/20/2023 |
| Acute Downregulation but Not Genetic Ablation of Murine MCU Impairs Suppressive Capacity of Regulatory CD4 T Cells. | Acute Downregulation but Not Genetic Ablation of Murine MCU Impairs Suppressive Capacity of Regulatory CD4 T Cells.
Jost P, Klein F, Brand B, Wahl V, Wyatt A, Yildiz D, Boehm U, Niemeyer BA, Vaeth M, Alansary D., Free PMC Article | 05/19/2023 |
| MCU Upregulation Overactivates Mitophagy by Promoting VDAC1 Dimerization and Ubiquitination in the Hepatotoxicity of Cadmium. | MCU Upregulation Overactivates Mitophagy by Promoting VDAC1 Dimerization and Ubiquitination in the Hepatotoxicity of Cadmium.
Liu C, Li HJ, Duan WX, Duan Y, Yu Q, Zhang T, Sun YP, Li YY, Liu YS, Xu SC., Free PMC Article | 03/27/2023 |
| Mitochondrial Ca2+ uniporter haploinsufficiency enhances long-term potentiation at hippocampal mossy fibre synapses. | Mitochondrial Ca2+ uniporter haploinsufficiency enhances long-term potentiation at hippocampal mossy fibre synapses.
Devine MJ, Szulc BR, Howden JH, López-Doménech G, Ruiz A, Kittler JT., Free PMC Article | 01/28/2023 |
| MCU knockdown in hippocampal neurons improves memory performance of an Alzheimer's disease mouse model. | MCU knockdown in hippocampal neurons improves memory performance of an Alzheimer's disease mouse model.
Cai H, Qiao J, Chen S, Yang J, Hölscher C, Wang Z, Qi J, Wu M., Free PMC Article | 01/11/2023 |
| Mitochondrial calcium uniporter promotes phagocytosis-dependent activation of the NLRP3 inflammasome. | Mitochondrial calcium uniporter promotes phagocytosis-dependent activation of the NLRP3 inflammasome.
Dong H, Zhao B, Chen J, Liu Z, Li X, Li L, Wen H., Free PMC Article | 07/2/2022 |
| MCU-dependent mitochondrial calcium uptake-induced mitophagy contributes to apelin-13-stimulated VSMCs proliferation. | MCU-dependent mitochondrial calcium uptake-induced mitophagy contributes to apelin-13-stimulated VSMCs proliferation.
Chen Z, Zhou Q, Chen J, Yang Y, Chen W, Mao H, Ouyang X, Zhang K, Tang M, Yan J, Wang L, Chen L, Li L. | 06/25/2022 |
| Monitoring mitochondrial calcium and metabolism in the beating MCU-KO heart. | Monitoring mitochondrial calcium and metabolism in the beating MCU-KO heart.
Kosmach A, Roman B, Sun J, Femnou A, Zhang F, Liu C, Combs CA, Balaban RS, Murphy E., Free PMC Article | 02/19/2022 |
| The mitochondrial calcium uniporter promotes arrhythmias caused by high-fat diet. | The mitochondrial calcium uniporter promotes arrhythmias caused by high-fat diet.
Joseph LC, Reyes MV, Homan EA, Gowen B, Avula UMR, Goulbourne CN, Wan EY, Elrod JW, Morrow JP., Free PMC Article | 11/13/2021 |
| Mitochondrial pyruvate and fatty acid flux modulate MICU1-dependent control of MCU activity. | Mitochondrial pyruvate and fatty acid flux modulate MICU1-dependent control of MCU activity.
Nemani N, Dong Z, Daw CC, Madaris TR, Ramachandran K, Enslow BT, Rubannelsonkumar CS, Shanmughapriya S, Mallireddigari V, Maity S, SinghMalla P, Natarajanseenivasan K, Hooper R, Shannon CE, Tourtellotte WG, Singh BB, Reeves WB, Sharma K, Norton L, Srikantan S, Soboloff J, Madesh M., Free PMC Article | 11/6/2021 |
| Mitochondrial calcium uniporter is essential for hearing and hair cell preservation in congenic FVB/NJ mice. | Mitochondrial calcium uniporter is essential for hearing and hair cell preservation in congenic FVB/NJ mice.
Manikandan M, Walker S, Deshmukh AR, Perea E, Wang D, Alagramam KN, Stepanyan R., Free PMC Article | 10/23/2021 |
| The effect of mitochondrial calcium uniporter and cyclophilin D knockout on resistance of brain mitochondria to Ca(2+)-induced damage. | The effect of mitochondrial calcium uniporter and cyclophilin D knockout on resistance of brain mitochondria to Ca(2+)-induced damage.
Hamilton J, Brustovetsky T, Brustovetsky N., Free PMC Article | 08/7/2021 |
| Knockout of the Mitochondrial Calcium Uniporter Strongly Suppresses Stimulus-Metabolism Coupling in Pancreatic Acinar Cells but Does Not Reduce Severity of Experimental Acute Pancreatitis. | Knockout of the Mitochondrial Calcium Uniporter Strongly Suppresses Stimulus-Metabolism Coupling in Pancreatic Acinar Cells but Does Not Reduce Severity of Experimental Acute Pancreatitis.
Chvanov M, Voronina S, Zhang X, Telnova S, Chard R, Ouyang Y, Armstrong J, Tanton H, Awais M, Latawiec D, Sutton R, Criddle DN, Tepikin AV., Free PMC Article | 03/6/2021 |
| Neuronal mitochondrial calcium uniporter deficiency exacerbates axonal injury and suppresses remyelination in mice subjected to experimental autoimmune encephalomyelitis. | Neuronal mitochondrial calcium uniporter deficiency exacerbates axonal injury and suppresses remyelination in mice subjected to experimental autoimmune encephalomyelitis.
Holman SP, Lobo AS, Novorolsky RJ, Nichols M, Fiander MDJ, Konda P, Kennedy BE, Gujar S, Robertson GS. | 03/6/2021 |
| Cyclophilin D counterbalances mitochondrial calcium uniporter-mediated brain mitochondrial calcium uptake. | Cyclophilin D counterbalances mitochondrial calcium uniporter-mediated brain mitochondrial calcium uptake.
Zhang B, Jia K, Tian J, Du H., Free PMC Article | 02/13/2021 |
| MCU Up-regulation contributes to myocardial ischemia-reperfusion Injury through calpain/OPA-1-mediated mitochondrial fusion/mitophagy Inhibition. | MCU Up-regulation contributes to myocardial ischemia-reperfusion Injury through calpain/OPA-1-mediated mitochondrial fusion/mitophagy Inhibition.
Guan L, Che Z, Meng X, Yu Y, Li M, Yu Z, Shi H, Yang D, Yu M., Free PMC Article | 09/12/2020 |
| BAT-Mcu-KO mice lack uniporter-based calcium uptake in BAT mitochondria but exhibit unaffected cold tolerance, diet-induced obesity, and transcriptional response to cold in BAT. | Exploring the In Vivo Role of the Mitochondrial Calcium Uniporter in Brown Fat Bioenergetics.
Flicker D, Sancak Y, Mick E, Goldberger O, Mootha VK., Free PMC Article | 07/11/2020 |
| Data indicate a key function for the mitochondrial calcium uniporter (MCU) in mitochondrial adaptation to the metabolic demands during cell cycle progression. | Loss of MCU prevents mitochondrial fusion in G(1)-S phase and blocks cell cycle progression and proliferation.
Koval OM, Nguyen EK, Santhana V, Fidler TP, Sebag SC, Rasmussen TP, Mittauer DJ, Strack S, Goswami PC, Abel ED, Grumbach IM., Free PMC Article | 07/4/2020 |