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    ALDH1A1 aldehyde dehydrogenase 1 family member A1 [ Homo sapiens (human) ]

    Gene ID: 216, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The role of ALDH1A1 in glioblastoma proliferation and invasion.

    The role of ALDH1A1 in glioblastoma proliferation and invasion.
    Huang YK, Wang TM, Chen CY, Li CY, Wang SC, Irshad K, Pan Y, Chang KC.

    11/1/2024
    Autism patient-derived SHANK2B[Y29X] mutation affects the development of ALDH1A1 negative dopamine neuron.

    Autism patient-derived SHANK2B(Y29X) mutation affects the development of ALDH1A1 negative dopamine neuron.
    Lai W, Zhao Y, Chen Y, Dai Z, Chen R, Niu Y, Chen X, Chen S, Huang G, Shan Z, Zheng J, Hu Y, Chen Q, Gong S, Kang S, Guo H, Ma X, Song Y, Xia K, Wang J, Zhou L, So KF, Wang K, Qiu S, Zhang L, Chen J, Shi L., Free PMC Article

    10/10/2024
    ALDH1A1 promotes immune escape of tumor cells through ZBTB7B-glycolysis pathway.

    ALDH1A1 promotes immune escape of tumor cells through ZBTB7B-glycolysis pathway.
    Wang M, Wang T, Wang J, Yang Y, Li X, Chen H, Liao J., Free PMC Article

    09/13/2024
    Associations of stem cell markers CD44, CD24 and ALDH1A1 with mammographic breast density in women with benign breast biopsies.

    Associations of stem cell markers CD44, CD24 and ALDH1A1 with mammographic breast density in women with benign breast biopsies.
    Yaghjyan L, Heng YJ, Baker GM, Murthy D, Mahoney MB, Rosner B, Tamimi RM.,

    08/22/2024
    METTL3-mediated ALDH m[6]A methylation regulates the malignant behavior of BMI1[+] HNSCC stem cells.

    METTL3-mediated ALDH m(6)A methylation regulates the malignant behavior of BMI1(+) HNSCC stem cells.
    Chen Z, Chen J, Xu X, Li Q, Zhang C, Li S, Liu L, Cao C, Chen D, He Q.

    06/11/2024
    Are embryonic stem cell markers and ALDH1A1 relevant in the context of breast cancer estrogen positivity?

    Are embryonic stem cell markers and ALDH1A1 relevant in the context of breast cancer estrogen positivity?
    Mousa NA, Hussein A, Elemam NM, Mohammed G, Elwany M, Basha T, AlHammadi AA, Majzob RS, Talaat IM., Free PMC Article

    02/29/2024
    ALDH1A1 drives prostate cancer metastases and radioresistance by interplay with AR- and RAR-dependent transcription.

    ALDH1A1 drives prostate cancer metastases and radioresistance by interplay with AR- and RAR-dependent transcription.
    Gorodetska I, Offermann A, Püschel J, Lukiyanchuk V, Gaete D, Kurzyukova A, Freytag V, Haider MT, Fjeldbo CS, Di Gaetano S, Schwarz FM, Patil S, Borkowetz A, Erb HHH, Baniahmad A, Mircetic J, Lyng H, Löck S, Linge A, Lange T, Knopf F, Wielockx B, Krause M, Perner S, Dubrovska A., Free PMC Article

    01/9/2024
    The Molecular Context of Oxidant Stress Response in Cancer Establishes ALDH1A1 as a Critical Target: What This Means for Acute Myeloid Leukemia.

    The Molecular Context of Oxidant Stress Response in Cancer Establishes ALDH1A1 as a Critical Target: What This Means for Acute Myeloid Leukemia.
    Dancik GM, Varisli L, Vlahopoulos SA., Free PMC Article

    06/13/2023
    The Prognostic Value of Cancer Stem Cell Markers (CSCs) Expression-ALDH1A1, CD133, CD44-For Survival and Long-Term Follow-Up of Ovarian Cancer Patients.

    The Prognostic Value of Cancer Stem Cell Markers (CSCs) Expression-ALDH1A1, CD133, CD44-For Survival and Long-Term Follow-Up of Ovarian Cancer Patients.
    Izycka N, Rucinski M, Andrzejewska M, Szubert S, Nowak-Markwitz E, Sterzynska K., Free PMC Article

    02/16/2023
    ALDH1-Mediated Autophagy Sensitizes Glioblastoma Cells to Ferroptosis.

    ALDH1-Mediated Autophagy Sensitizes Glioblastoma Cells to Ferroptosis.
    Wu Y, Kram H, Gempt J, Liesche-Starnecker F, Wu W, Schlegel J., Free PMC Article

    01/14/2023
    Chromium (VI)-induced ALDH1A1/EGF axis promotes lung cancer progression.

    Chromium (VI)-induced ALDH1A1/EGF axis promotes lung cancer progression.
    Ge X, Li M, Song GX, Zhang Z, Yin J, Ge Z, Shi Z, Liu LZ, Jiang BH, Qian X, Shen H., Free PMC Article

    01/11/2023
    Proteomic profiling reveals an association between ALDH and oxidative phosphorylation and DNA damage repair pathways in human colon adenocarcinoma stem cells.

    Proteomic profiling reveals an association between ALDH and oxidative phosphorylation and DNA damage repair pathways in human colon adenocarcinoma stem cells.
    Wang Y, Chen Y, Garcia-Milian R, Golla JP, Charkoftaki G, Lam TT, Thompson DC, Vasiliou V., Free PMC Article

    12/3/2022
    Lack of association of CYP2B6 pharmacogenetics with cyclophosphamide toxicity in patients with cancer.

    Lack of association of CYP2B6 pharmacogenetics with cyclophosphamide toxicity in patients with cancer.
    Hwang M, Medley S, Shakeel F, Vanderwerff B, Zawistowski M, Kidwell KM, Hertz DL.

    08/27/2022
    Loss of PBRM1 Alters Promoter Histone Modifications and Activates ALDH1A1 to Drive Renal Cell Carcinoma.

    Loss of PBRM1 Alters Promoter Histone Modifications and Activates ALDH1A1 to Drive Renal Cell Carcinoma.
    Schoenfeld DA, Zhou R, Zairis S, Su W, Steinbach N, Mathur D, Bansal A, Zachem AL, Tavarez B, Hasson D, Bernstein E, Rabadan R, Parsons R., Free PMC Article

    08/13/2022
    Aldehyde Dehydrogenase Isoform 1 Predicts a Poor Prognosis of Acute Cerebral Infarction.

    Aldehyde Dehydrogenase Isoform 1 Predicts a Poor Prognosis of Acute Cerebral Infarction.
    Yang J, Duan J, Li M, Sun H, Sun Y, Pan W, Xi H., Free PMC Article

    08/6/2022
    An antisense Alu transposon insertion/deletion polymorphism of ALDH1A1 may functionally associate with Parkinson's disease.

    An antisense Alu transposon insertion/deletion polymorphism of ALDH1A1 may functionally associate with Parkinson's disease.
    Fan HH, Zheng J, Huang XY, Wu KY, Cui L, Dong HJ, Wang Z, Zhang X, Zhu JH., Free PMC Article

    05/28/2022
    Association of ALDH1 with Response to Radiotherapy and Its Impact on Survival in Patients with Advanced Stage of Head and Neck Squamous Cell Carcinoma (HNSCC).

    Association of ALDH1 with Response to Radiotherapy and Its Impact on Survival in Patients with Advanced Stage of Head and Neck Squamous Cell Carcinoma (HNSCC).
    Dubey P, Kumar N, Gupta R, Mishra A, Bhadauriya S, Kumar V, Bhatt MB., Free PMC Article

    05/14/2022
    Effect of ALDH1A1 Gene Knockout on Drug Resistance in Paclitaxel and Topotecan Resistant Human Ovarian Cancer Cell Lines in 2D and 3D Model.

    Effect of ALDH1A1 Gene Knockout on Drug Resistance in Paclitaxel and Topotecan Resistant Human Ovarian Cancer Cell Lines in 2D and 3D Model.
    Nowacka M, Ginter-Matuszewska B, Świerczewska M, Sterzyńska K, Nowicki M, Januchowski R., Free PMC Article

    04/16/2022
    ITGA7, CD133, ALDH1 are inter-correlated, and linked with poor differentiation, lymph node metastasis as well as worse survival in surgical cervical cancer.

    ITGA7, CD133, ALDH1 are inter-correlated, and linked with poor differentiation, lymph node metastasis as well as worse survival in surgical cervical cancer.
    Yuan N, Wang L, Xi Q, Zou N, Zhang X, Lu X, Zhang Z., Free PMC Article

    04/16/2022
    Aldehyde dehydrogenase 1A1 and 1A3 isoforms - mechanism of activation and regulation in cancer.

    Aldehyde dehydrogenase 1A1 and 1A3 isoforms - mechanism of activation and regulation in cancer.
    Poturnajova M, Kozovska Z, Matuskova M., Free PMC Article

    04/9/2022
    Co-expression of cancer stem cell markers, SALL4/ALDH1A1, is associated with tumor aggressiveness and poor survival in patients with serous ovarian carcinoma.

    Co-expression of cancer stem cell markers, SALL4/ALDH1A1, is associated with tumor aggressiveness and poor survival in patients with serous ovarian carcinoma.
    Sharbatoghli M, Shamshiripour P, Fattahi F, Kalantari E, Habibi Shams Z, Panahi M, Totonchi M, Asadi-Lari Z, Madjd Z, Saeednejad Zanjani L., Free PMC Article

    03/19/2022
    Mesothelin Expression Is Not Associated with the Presence of Cancer Stem Cell Markers SOX2 and ALDH1 in Ovarian Cancer.

    Mesothelin Expression Is Not Associated with the Presence of Cancer Stem Cell Markers SOX2 and ALDH1 in Ovarian Cancer.
    Nunes M, Pacheco F, Coelho R, Leitão D, Ricardo S, David L., Free PMC Article

    03/12/2022
    EHMT1 promotes tumor progression and maintains stemness by regulating ALDH1A1 expression in alveolar rhabdomyosarcoma.

    EHMT1 promotes tumor progression and maintains stemness by regulating ALDH1A1 expression in alveolar rhabdomyosarcoma.
    Nachiyappan A, Soon JLJ, Lim HJ, Lee VK, Taneja R.

    03/5/2022
    High aldehyde dehydrogenase 1 activity is related to radiation resistance due to activation of AKT signaling after insulin stimulation in prostate cancer.

    High aldehyde dehydrogenase 1 activity is related to radiation resistance due to activation of AKT signaling after insulin stimulation in prostate cancer.
    Wakamiya T, Hirohashi Y, Murai A, Yanagawa J, Mizue Y, Kubo T, Hashimoto S, Murata K, Kanaseki T, Tsukahara T, Nishida S, Kohjimoto Y, Hara I, Torigoe T.

    02/12/2022
    ALDH1A1 Activity in Tumor-Initiating Cells Remodels Myeloid-Derived Suppressor Cells to Promote Breast Cancer Progression.

    ALDH1A1 Activity in Tumor-Initiating Cells Remodels Myeloid-Derived Suppressor Cells to Promote Breast Cancer Progression.
    Liu C, Qiang J, Deng Q, Xia J, Deng L, Zhou L, Wang D, He X, Liu Y, Zhao B, Lv J, Yu Z, Lei QY, Shao ZM, Zhang XY, Zhang L, Liu S.

    01/15/2022
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