| Intracerebral hemorrhage-induced brain injury in mice: The role of peroxiredoxin 2-Toll-like receptor 4 inflammatory axis. | Intracerebral hemorrhage-induced brain injury in mice: The role of peroxiredoxin 2-Toll-like receptor 4 inflammatory axis.
Du Y, Wang J, Zhang J, Li N, Li G, Liu X, Lin Y, Wang D, Kang K, Bian L, Zhao X., Free PMC Article | 03/27/2024 |
| Correlation between PRDX2 and spermatogenesis under oxidative stress. | Correlation between PRDX2 and spermatogenesis under oxidative stress.
Xu GL, Ye XL, Vashisth MK, Zhao WZ. | 04/12/2023 |
| Peroxiredoxin 2 deficiency does not affect insulin resistance and oxidative stress in high-fat diet-fed obese mice. | Peroxiredoxin 2 deficiency does not affect insulin resistance and oxidative stress in high-fat diet-fed obese mice.
Kim JH, Cha HN, Kim YW, Park SY. | 08/6/2022 |
| Lgals9 deficiency ameliorates obesity by modulating redox state of PRDX2. | Lgals9 deficiency ameliorates obesity by modulating redox state of PRDX2.
Nunoue T, Yamaguchi S, Teshigawara S, Katayama A, Nakatsuka A, Eguchi J, Niki T, Wada J., Free PMC Article | 12/18/2021 |
| Active hematopoiesis triggers exosomal release of PRDX2 that promotes osteoclast formation. | Active hematopoiesis triggers exosomal release of PRDX2 that promotes osteoclast formation.
Sadvakassova G, Tiedemann K, Steer KJD, Mikolajewicz N, Stavnichuk M, In-Kyung Lee I, Sabirova Z, Schranzhofer M, Komarova SV., Free PMC Article | 12/11/2021 |
| Deficiency of peroxiredoxin 2 exacerbates angiotensin II-induced abdominal aortic aneurysm. | Deficiency of peroxiredoxin 2 exacerbates angiotensin II-induced abdominal aortic aneurysm.
Jeong SJ, Cho MJ, Ko NY, Kim S, Jung IH, Min JK, Lee SH, Park JG, Oh GT., Free PMC Article | 10/2/2021 |
| Peroxiredoxin 2 deficiency reduces white adipogenesis due to the excessive ROS generation. | Peroxiredoxin 2 deficiency reduces white adipogenesis due to the excessive ROS generation.
Kim MH, Kim JY, Kim JH, Lee HS, Huh JW, Lee DS. | 08/14/2021 |
| Peroxiredoxin II with dermal mesenchymal stem cells accelerates wound healing. | Peroxiredoxin II with dermal mesenchymal stem cells accelerates wound healing.
Jin MH, Yu NN, Jin YH, Mao YY, Feng L, Liu Y, Wang AG, Sun HN, Kwon T, Han YH., Free PMC Article | 07/24/2021 |
| Involvement of peroxiredoxin 2 in cumulus expansion and oocyte maturation in mice. | Involvement of peroxiredoxin 2 in cumulus expansion and oocyte maturation in mice.
Jang YJ, Kim JS, Yun PR, Seo YW, Lee TH, Park JI, Chun SY. | 02/20/2021 |
| BMP2-induced osteogenic gene expression and alkaline phosphatase activity were higher in Prx II knockout (KO) cells than they were in wild-type. | Peroxiredoxin II negatively regulates BMP2-induced osteoblast differentiation and bone formation via PP2A Cα-mediated Smad1/5/9 dephosphorylation.
Kim KM, Kim DY, Lee DS, Kim JW, Koh JT, Kim EJ, Jang WG., Free PMC Article | 06/27/2020 |
| These results showed that Prx2 expression declines in athero-prone aortic root before lesion formation, and this reduction in Prx2 expression correlates with lipid peroxidation, smooth muscle cells dedifferentiation, and macrophage recruitment | Temporal and spatial changes of peroxiredoxin 2 levels in aortic media at very early stages of atherosclerotic lesion formation in apoE-knockout mice.
Kato R, Hayashi M, Aiuchi T, Sawada N, Obama T, Itabe H. | 12/14/2019 |
| Deletion of Prdx2 increases age-related ovarian failure. | Peroxiredoxin 2 deficiency accelerates age-related ovarian failure through the reactive oxygen species-mediated JNK pathway in mice.
Park SJ, Kim JH, Lee DG, Kim JM, Lee DS. | 08/24/2019 |
| CDK2 depletion led to the reactivation of differentiation pathway translation, and the differentiation blockade function of CDK2 may be achieved directly by maintaining the activity of PRDX2. CDK2 depletion arrested tumor growth of acute myeloid leukemia (AML) cells in nude mice. | Ubiquitin-dependent degradation of CDK2 drives the therapeutic differentiation of AML by targeting PRDX2.
Ying M, Shao X, Jing H, Liu Y, Qi X, Cao J, Chen Y, Xiang S, Song H, Hu R, Wei G, Yang B, He Q. | 07/13/2019 |
| Data suggests that Prdx1 and Prdx2 in pronuclei of zygotes are involved in antioxidant mechanisms and epigenetic programming during maternal-to-zygotic transition (during ectogenesis following in vitro fertilization). PRDX1 and PRDX2 appear to be ninth and twenty-second highest expressed proteins, respectively, among 64 proteins identified in mouse zygotes. | Peroxiredoxin as a functional endogenous antioxidant enzyme in pronuclei of mouse zygotes.
Morita K, Tokoro M, Hatanaka Y, Higuchi C, Ikegami H, Nagai K, Anzai M, Kato H, Mitani T, Taguchi Y, Yamagata K, Hosoi Y, Miyamoto K, Matsumoto K., Free PMC Article | 09/29/2018 |
| our data highlight a novel role of Prx2 in iron homeostasis. Prx2 is a key cytoprotector against IO that is induced either by iron supplementation or due to chronic hemolysis as in beta-thalassemia. | Peroxiredoxin-2: A Novel Regulator of Iron Homeostasis in Ineffective Erythropoiesis.
Matte A, De Falco L, Federti E, Cozzi A, Iolascon A, Levi S, Mohandas N, Zamo A, Bruno M, Lebouef C, Janin A, Siciliano A, Ganz T, Federico G, Carlomagno F, Mueller S, Silva I, Carbone C, Melisi D, Kim DW, Choi SY, De Franceschi L. | 07/28/2018 |
| The data indicate that Prx2 is able to interrupt the hypoxia induced vicious cycle involving oxidation-inflammation-autophagy in the pathogenesis of pulmonary hypertension. | Peroxiredoxin-2 plays a pivotal role as multimodal cytoprotector in the early phase of pulmonary hypertension.
Federti E, Matté A, Ghigo A, Andolfo I, James C, Siciliano A, Leboeuf C, Janin A, Manna F, Choi SY, Iolascon A, Beneduce E, Melisi D, Kim DW, Levi S, De Franceschi L. | 06/2/2018 |
| one of the antioxidant enzymes, Prdx-2, was abundantly nitrosylated and temporarily reduced in antioxidant activity, causing transient endogenous hydrogen peroxide (H2O2) accumulation and subsequent X-box binding protein-1s/phosphatidylinositol 3-kinase pathway activation.Prdx-2 nitrosylation could be a potent strategy to affect the pluripotent stem cell-derived cardiomyogenesis. | Peroxiredoxin-2 nitrosylation facilitates cardiomyogenesis of mouse embryonic stem cells via XBP-1s/PI3K pathway.
Wu B, Yu H, Wang Y, Pan Z, Zhang Y, Li T, Li L, Zhang W, Ge L, Chen Y, Ho CK, Zhu D, Huang X, Lou Y. | 01/13/2018 |
| Oxidative stress promotes PRX2 and PRX3 hyperoxidation and attenuates pro-survival signaling in aging chondrocytes. | Oxidative Stress Promotes Peroxiredoxin Hyperoxidation and Attenuates Pro-survival Signaling in Aging Chondrocytes.
Collins JA, Wood ST, Nelson KJ, Rowe MA, Carlson CS, Chubinskaya S, Poole LB, Furdui CM, Loeser RF., Free PMC Article | 08/6/2016 |
| The ventral signal observed for Prdx2 from early stages colocalized with motor neuron markers Isl1/2 and FoxP1 and strong ventral signal colocalizing with Isl1/2 was observed in all rostrocaudal segments of the spinal cord. | Expression of peroxiredoxins and thioredoxins in the mouse spinal cord during embryonic development.
Pirson M, Knoops B. | 07/16/2016 |
| Prx2 glutathionylation is a favorable reaction that can occur in cells under oxidative stress and may have a role in redox signaling. GSH/Grx1 provide an alternative mechanism to thioredoxin and thioredoxin reductase for Prx2 recycling. | Glutathionylation of the Active Site Cysteines of Peroxiredoxin 2 and Recycling by Glutaredoxin.
Peskin AV, Pace PE, Behring JB, Paton LN, Soethoudt M, Bachschmid MM, Winterbourn CC., Free PMC Article | 06/28/2016 |
| elevation in hyperoxidized Prxs, notably Prx2 and Prx3, was observed in several organs from SOD1-deficient mice. However, a SOD1 deficiency had no impact on the wheel-running activity of the mice | SOD1 deficiency induces the systemic hyperoxidation of peroxiredoxin in the mouse.
Homma T, Okano S, Lee J, Ito J, Otsuki N, Kurahashi T, Kang ES, Nakajima O, Fujii J. | 11/7/2015 |
| PrxII functions as a protective antioxidant enzyme against collagen-stimulated platelet activation and platelet-dependent thrombosis | Peroxiredoxin II is an antioxidant enzyme that negatively regulates collagen-stimulated platelet function.
Jang JY, Wang SB, Min JH, Chae YH, Baek JY, Yu DY, Chang TS., Free PMC Article | 07/25/2015 |
| Prx I and Prx II appear to have a tight association with the mechanism underlying the protection of ESC stemness in developing teratomas. | Dominant role of peroxiredoxin/JNK axis in stemness regulation during neurogenesis from embryonic stem cells.
Kim SU, Park YH, Kim JM, Sun HN, Song IS, Huang SM, Lee SH, Chae JI, Hong S, Sik Choi S, Choi SC, Lee TH, Kang SW, Rhee SG, Chang KT, Lee SH, Yu DY, Lee DS. | 02/14/2015 |
| results suggest that inactivation of PrxII is important for the stability of FoxO1 protein, which subsequently mediates Foxp3( ) Treg cell development, thereby attenuating colonic inflammation | Ablation of peroxiredoxin II attenuates experimental colitis by increasing FoxO1-induced Foxp3+ regulatory T cells.
Won HY, Jang EJ, Lee K, Oh S, Kim HK, Woo HA, Kang SW, Yu DY, Rhee SG, Hwang ES. | 12/14/2013 |
| PRDX2 neutralizes hydrogen peroxide generated in vivo under the transient hypoxic conditions experienced as erythrocytes pass through the microcirculation. | Role of peroxiredoxin-2 in protecting RBCs from hydrogen peroxide-induced oxidative stress.
Nagababu E, Mohanty JG, Friedman JS, Rifkind JM., Free PMC Article | 07/20/2013 |