| Structural and functional reorganization of inhibitory synapses by activity-dependent cleavage of neuroligin-2. | Structural and functional reorganization of inhibitory synapses by activity-dependent cleavage of neuroligin-2.
Xu N, Cao R, Chen SY, Gou XZ, Wang B, Luo HM, Gao F, Tang AH., Free PMC Article | 05/6/2024 |
| Neuroligin-2 shapes individual slow waves during slow-wave sleep and the response to sleep deprivation in mice. | Neuroligin-2 shapes individual slow waves during slow-wave sleep and the response to sleep deprivation in mice.
Leduc T, El Alami H, Bougadir K, Bélanger-Nelson E, Mongrain V., Free PMC Article | 04/8/2024 |
| Neuroligin-2 controls the establishment of fast GABAergic transmission in adult-born granule cells. | Neuroligin-2 controls the establishment of fast GABAergic transmission in adult-born granule cells.
Groisman AI, Aguilar-Arredondo A, Giacomini D, Schinder AF., Free PMC Article | 03/29/2023 |
| The gamma-Protocadherins Interact Physically and Functionally with Neuroligin-2 to Negatively Regulate Inhibitory Synapse Density and Are Required for Normal Social Interaction. | The γ-Protocadherins Interact Physically and Functionally with Neuroligin-2 to Negatively Regulate Inhibitory Synapse Density and Are Required for Normal Social Interaction.
Steffen DM, Ferri SL, Marcucci CG, Blocklinger KL, Molumby MJ, Abel T, Weiner JA., Free PMC Article | 11/27/2021 |
| Altered theta and beta oscillatory synchrony in a genetic mouse model of pathological anxiety. | Altered theta and beta oscillatory synchrony in a genetic mouse model of pathological anxiety.
Cruces-Solis H, Babaev O, Ali H, Piletti Chatain C, Mykytiuk V, Balekoglu N, Wenger S, Krueger-Burg D. | 07/24/2021 |
| Aberrant mPFC GABAergic synaptic transmission and fear behavior in neuroligin-2 R215H knock-in mice. | Aberrant mPFC GABAergic synaptic transmission and fear behavior in neuroligin-2 R215H knock-in mice.
Chen J, Dong B, Feng X, Jiang D, Chen G, Long C, Yang L. | 06/12/2021 |
| Neuroligin 2 regulates absence seizures and behavioral arrests through GABAergic transmission within the thalamocortical circuitry. | Neuroligin 2 regulates absence seizures and behavioral arrests through GABAergic transmission within the thalamocortical circuitry.
Cao F, Liu JJ, Zhou S, Cortez MA, Snead OC, Han J, Jia Z., Free PMC Article | 09/12/2020 |
| Neuroligin-2 Determines Inhibitory Synaptic Transmission in the Lateral Septum to Optimize Stress-Induced Neuronal Activation and Avoidance Behavior. | Neuroligin-2 Determines Inhibitory Synaptic Transmission in the Lateral Septum to Optimize Stress-Induced Neuronal Activation and Avoidance Behavior.
Troyano-Rodriguez E, Wirsig-Wiechmann CR, Ahmad M., Free PMC Article | 05/23/2020 |
| the essential role of LHFPL4/GARLH4 in brain functions by regulating inhibitory synapse formation as a major NL2 binding partner, is reported. | Impairment of Inhibitory Synapse Formation and Motor Behavior in Mice Lacking the NL2 Binding Partner LHFPL4/GARLH4.
Wu M, Tian HL, Liu X, Lai JHC, Du S, Xia J. | 12/14/2019 |
| This study provides a novel approach to understand the molecular basis of Fragile X syndrome by linking the dysregulated synaptic expression of NLGNs with FMRP | Neuroligin 1, 2, and 3 Regulation at the Synapse: FMRP-Dependent Translation and Activity-Induced Proteolytic Cleavage.
Chmielewska JJ, Kuzniewska B, Milek J, Urbanska K, Dziembowska M., Free PMC Article | 08/10/2019 |
| This review propose that shifts in NLGN1 and NLGN2 expression in specific excitatory and inhibitory neuronal subpopulations in response to experience regulate the dynamic processes of memory consolidation and strengthening. | NLGN1 and NLGN2 in the prefrontal cortex: their role in memory consolidation and strengthening.
Katzman A, Alberini CM., Free PMC Article | 02/16/2019 |
| NLGN2 participates in the regulation of sleep duration as well as electroencephalographic activity during wakefulness and sleep. | The effect of Neuroligin-2 absence on sleep architecture and electroencephalographic activity in mice.
Seok BS, Cao F, Bélanger-Nelson E, Provost C, Gibbs S, Jia Z, Mongrain V., Free PMC Article | 01/12/2019 |
| These results demonstrate a significant impact of a single point mutation NL2 R215H on brain functions. | GABAergic deficits and schizophrenia-like behaviors in a mouse model carrying patient-derived neuroligin-2 R215H mutation.
Jiang DY, Wu Z, Forsyth CT, Hu Y, Yee SP, Chen G., Free PMC Article | 10/27/2018 |
| At the molecular level NLGN2 colocalizes with its neuronal partner collibystin, a CDC42 guanine nucleotide exchange factor, which is also expressed by endothelial cells and in turn modulates Angiopoietin 2 release. | Modulation of Angiopoietin 2 release from endothelial cells and angiogenesis by the synaptic protein Neuroligin 2.
Pergolizzi M, Bizzozero L, Riccitelli E, Pascal D, Samarelli AV, Bussolino F, Arese M. | 10/13/2018 |
| nucleus accumbens neuroligin-2 has a role in depression and stress susceptibility | Cell-type-specific role for nucleus accumbens neuroligin-2 in depression and stress susceptibility.
Heshmati M, Aleyasin H, Menard C, Christoffel DJ, Flanigan ME, Pfau ML, Hodes GE, Lepack AE, Bicks LK, Takahashi A, Chandra R, Turecki G, Lobo MK, Maze I, Golden SA, Russo SJ., Free PMC Article | 07/28/2018 |
| The results of this study confirmed the importance of NL2 as organizer of the GABAergic PSD and unravel distinct roles for alpha1- and alpha2-GABAARs in the formation of GABAergic circuits in close interaction with the dystrophin-glycoprotein complex. | Differential role of GABA(A) receptors and neuroligin 2 for perisomatic GABAergic synapse formation in the hippocampus.
Panzanelli P, Früh S, Fritschy JM. | 06/30/2018 |
| SynCAM1, Neuroligin-1B and Neuroligin-2A were overexpressed in newborn neurons in the dentate gyrus of 7- to 9-week-old mice. SynCAM1 increased the morphological maturation of dendritic spines and mossy fiber terminals while Neuroligin-1B increased spine density. In contrast, Neuroligin-2A increased both spine density and size as well as GABAergic innervation and resulted in a drastic increase of neuronal survival. | Synaptic Adhesion Molecules Regulate the Integration of New Granule Neurons in the Postnatal Mouse Hippocampus and their Impact on Spatial Memory.
Krzisch M, Fülling C, Jabinet L, Armida J, Gebara E, Cassé F, Habbas S, Volterra A, Hornung JP, Toni N. | 05/5/2018 |
| findings reveal how unique postsynaptic Cell Adhesion Molecules neuroligin 2 and slitrk3 work in concert to control synaptogenesis and establish a general framework for GABAergic synapse development. | Molecular Dissection of Neuroligin 2 and Slitrk3 Reveals an Essential Framework for GABAergic Synapse Development.
Li J, Han W, Pelkey KA, Duan J, Mao X, Wang YX, Craig MT, Dong L, Petralia RS, McBain CJ, Lu W., Free PMC Article | 12/23/2017 |
| The alternatively spliced segment 4 (AS4) of NRX genes (Nrxn) is a critical element in selective trans-synaptic interactions. This study evaluated the synaptogenic receptor activity of NL1/2/3 isoforms in a neuron-fibroblast co-culture system, in which the Nrxn AS4 segments are manipulated using SLM2, a selective and dominant regulator of AS4 splicing. | Neuroligin-induced presynaptic differentiation through SLM2-mediated splicing modifications of neurexin in cerebellar cultures.
Sato Y, Suzuki S, Iijima Y, Iijima T. | 10/28/2017 |
| Neuroligin 2 deletion predominantly affects inhibitory synapses onto projection neurons in basal amygdala, resulting in decreased inhibitory drive onto these neurons and leading to their excessive activation under anxiogenic conditions. | Neuroligin 2 deletion alters inhibitory synapse function and anxiety-associated neuronal activation in the amygdala.
Babaev O, Botta P, Meyer E, Müller C, Ehrenreich H, Brose N, Lüthi A, Krueger-Burg D. | 07/16/2016 |
| Results indicate that Nlgn2 is required for continuous maintenance of inhibitory synapses in the adult medial prefrontal cortex | Conditional neuroligin-2 knockout in adult medial prefrontal cortex links chronic changes in synaptic inhibition to cognitive impairments.
Liang J, Xu W, Hsu YT, Yee AX, Chen L, Südhof TC. | 03/26/2016 |
| Results highlight the importance of neuroligin-2 in mediating early-life stress effects on social behavior and social cognition. | Hippocampal neuroligin-2 links early-life stress with impaired social recognition and increased aggression in adult mice.
Kohl C, Wang XD, Grosse J, Fournier C, Harbich D, Westerholz S, Li JT, Bacq A, Sippel C, Hausch F, Sandi C, Schmidt MV. | 01/2/2016 |
| Neuroligin-2 was essential for maintaining normal climbing-fiber synapse numbers in purkinje cell circuits. | Neuroligins Sculpt Cerebellar Purkinje-Cell Circuits by Differential Control of Distinct Classes of Synapses.
Zhang B, Chen LY, Liu X, Maxeiner S, Lee SJ, Gokce O, Südhof TC., Free PMC Article | 11/21/2015 |
| Endogenous NL2 undergoes proline-directed phosphorylation at its unique S714-P consensus site, leading to the recruitment of Pin1. This signaling cascade negatively regulates NL2's ability to interact with gephyrin at GABAergic post-synaptic sites. | Pin1-dependent signalling negatively affects GABAergic transmission by modulating neuroligin2/gephyrin interaction.
Antonelli R, Pizzarelli R, Pedroni A, Fritschy JM, Del Sal G, Cherubini E, Zacchi P., Free PMC Article | 07/25/2015 |
| analysis of neuroligin-2 trafficking and proteomics | A combined transgenic proteomic analysis and regulated trafficking of neuroligin-2.
Kang Y, Ge Y, Cassidy RM, Lam V, Luo L, Moon KM, Lewis R, Molday RS, Wong RO, Foster LJ, Craig AM., Free PMC Article | 12/27/2014 |