| Excess Transforming Growth Factor-alpha Changed the Cell Properties of Corneal Epithelium and Stroma. | Excess Transforming Growth Factor-α Changed the Cell Properties of Corneal Epithelium and Stroma.
Zhang L, Yuan Y, Yeh LK, Dong F, Zhang J, Okada Y, Kao WWY, Liu CY, Zhang Y., Free PMC Article | 01/9/2021 |
| TGFalpha preserves oligodendrocyte lineage cells and improves white matter integrity after cerebral ischemia. | TGFα preserves oligodendrocyte lineage cells and improves white matter integrity after cerebral ischemia.
Dai X, Chen J, Xu F, Zhao J, Cai W, Sun Z, Hitchens TK, Foley LM, Leak RK, Chen J, Hu X., Free PMC Article | 09/26/2020 |
| Tgfa null mice are equally susceptible to spontaneous osteoarthritis development during aging. | Context-specific protection of TGFα null mice from osteoarthritis.
Usmani SE, Ulici V, Pest MA, Hill TL, Welch ID, Beier F., Free PMC Article | 04/28/2018 |
| Here the authors show that the mammalian rhomboid protease RHBDL4 (also known as Rhbdd1) promotes trafficking of several membrane proteins, including the EGFR ligand TGFalpha, from the endoplasmic reticulum (ER) to the Golgi apparatus, thereby triggering their secretion by extracellular microvesicles. | Rhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGFα.
Wunderle L, Knopf JD, Kühnle N, Morlé A, Hehn B, Adrain C, Strisovsky K, Freeman M, Lemberg MK., Free PMC Article | 04/28/2018 |
| TGF-alpha contributes to the progression of diabetic kidney disease. | Role of TGF-alpha in the progression of diabetic kidney disease.
Heuer JG, Harlan SM, Yang DD, Jaqua DL, Boyles JS, Wilson JM, Heinz-Taheny KM, Sullivan JM, Wei T, Qian HR, Witcher DR, Breyer MD. | 08/12/2017 |
| Perturbed meibomian gland and tarsal plate morphogenesis by excess TGFalpha in eyelid stroma. | Perturbed meibomian gland and tarsal plate morphogenesis by excess TGFα in eyelid stroma.
Dong F, Liu CY, Yuan Y, Zhang Y, Li W, Call M, Zhang L, Chen Y, Liu Z, Kao WW., Free PMC Article | 02/20/2016 |
| c-Myc and transforming growth factor alpha enhance the development of hepatic lesions due to mutant beta-catenin in transgenic mice. | c-Myc and transforming growth factor α enhance the development of hepatic lesions due to mutant β-catenin in transgenic mice.
Jochem AS, Holmes KE, Stein TJ., Free PMC Article | 07/25/2015 |
| Reverse transcriptase polymerase chain reaction studies showed that three members, Tgfa, Hbegf,and Nrg1 of the EGF family were expressed in the epithelium cultured with FGF7 + LPA as well as in the epithelium freshly isolated from the rudiments. | FGF7 signals are relayed to autocrine EGF family growth factors to induce branching morphogenesis of mouse salivary epithelium.
Kera H, Yuki S, Nogawa H. | 11/22/2014 |
| findings suggest that elevated PHD4 levels disturb the angiogenic balance in osteosarcoma via induction of the TGF-alpha pathway and inhibit tumor growth by reducing the expression of HIF-2alpha | PHD4 stimulates tumor angiogenesis in osteosarcoma cells via TGF-α.
Klotzsche-von Ameln A, Prade I, Grosser M, Kettelhake A, Rezaei M, Chavakis T, Flamme I, Wielockx B, Breier G. | 06/14/2014 |
| Interaction between IRF6 and TGFA genes contribute to the risk of nonsyndromic cleft lip/palate. | Interaction between IRF6 and TGFA genes contribute to the risk of nonsyndromic cleft lip/palate.
Letra A, Fakhouri W, Fonseca RF, Menezes R, Kempa I, Prasad JL, McHenry TG, Lidral AC, Moreno L, Murray JC, Daack-Hirsch S, Marazita ML, Castilla EE, Lace B, Orioli IM, Granjeiro JM, Schutte BC, Vieira AR., Free PMC Article | 03/2/2013 |
| TGFalpha appears to be an important growth factor regulating the conversion of cartilage to bone during the process of endochondral ossification. | Transforming growth factor alpha controls the transition from hypertrophic cartilage to bone during endochondral bone growth.
Usmani SE, Pest MA, Kim G, Ohora SN, Qin L, Beier F. | 10/6/2012 |
| These results imply that TGFalpha stimulates proliferation of endometrial stromal cells through multiple mechanisms, including its regulation of Igfbp3 and Mmp3 transcription. | Transforming growth factor-α mRNA expression and its possible roles in mouse endometrial stromal cells.
Maekawa T, Sakuma A, Taniuchi S, Ogo Y, Iguchi T, Takeuchi S, Takahashi S. | 08/25/2012 |
| ADAM-17 and TGF-alpha are strongly and locally upregulated following adult mice cortical damage. | ADAM-17/tumor necrosis factor-α-converting enzyme inhibits neurogenesis and promotes gliogenesis from neural stem cells.
Romero-Grimaldi C, Murillo-Carretero M, López-Toledano MA, Carrasco M, Castro C, Estrada C. | 01/28/2012 |
| Different mechanisms regulate neurogenesis in neonatal and adult olfactory epithelium; fibroblast growth factor (FGF)2 and TGFalpha may have different roles throughout development. | ATP differentially upregulates fibroblast growth factor 2 and transforming growth factor α in neonatal and adult mice: effect on neuroproliferation.
Jia C, Cussen AR, Hegg CC., Free PMC Article | 01/21/2012 |
| beta-catenin controlled both cell-autonomous and non-cell-autonomous hepatocyte proliferation, through direct transcriptional and complex control of cyclin D1 gene expression and of the expression of a new target gene, Tgfalpha. | The transforming growth factor-α and cyclin D1 genes are direct targets of β-catenin signaling in hepatocyte proliferation.
Torre C, Benhamouche S, Mitchell C, Godard C, Veber P, Letourneur F, Cagnard N, Jacques S, Finzi L, Perret C, Colnot S. | 11/12/2011 |
| variable TGF-alpha expression may explain, in part, the genetic susceptibility to chronic kidney disease (CKD) progression. | TGF-alpha mediates genetic susceptibility to chronic kidney disease.
Laouari D, Burtin M, Phelep A, Martino C, Pillebout E, Montagutelli X, Friedlander G, Terzi F., Free PMC Article | 03/19/2011 |
| our results suggest that TGFalpha overexpression in mouse urogenital organs alone may not be responsible for tumor formation and epithelial hyperplasia, but is involved in bladder outlet obstruction | Effect of transforming growth factor α overexpression on urogenital organ development in mouse.
Yoshio Y, Ishii K, Arase S, Hori Y, Nishikawa K, Soga N, Kise H, Arima K, Sugimura Y. | 01/22/2011 |
| This may be the first report of the expression of carcinogenesis-related molecules such as EGFR, K-ras, Cox2 and TGFalpha during chronic pancreatitis. | Chronic pancreatitis in mice by treatment with choline-deficient ethionine-supplemented diet.
Ida S, Ohmuraya M, Hirota M, Ozaki N, Hiramatsu S, Uehara H, Takamori H, Araki K, Baba H, Yamamura K. | 11/13/2010 |
| EGFR-dependent increases in receptor ligands TGFa and PTGS2 likely drive diet-related tumor promotion | Epidermal growth factor receptor is required for colonic tumor promotion by dietary fat in the azoxymethane/dextran sulfate sodium model: roles of transforming growth factor-{alpha} and PTGS2.
Dougherty U, Cerasi D, Taylor I, Kocherginsky M, Tekin U, Badal S, Aluri L, Sehdev A, Cerda S, Mustafi R, Delgado J, Joseph L, Zhu H, Hart J, Threadgill D, Fichera A, Bissonnette M., Free PMC Article | 03/29/2010 |
| Widespread hyperplasia induced by transgenic TGFalpha in ApcMin mice is associated with regional effects on tumorigenesis | Widespread hyperplasia induced by transgenic TGFalpha in ApcMin mice is associated with only regional effects on tumorigenesis.
Bilger A, Sullivan R, Prunuske AJ, Clipson L, Drinkwater NR, Dove WF., Free PMC Article | 01/21/2010 |
| Expression of imprinted Igf2 and Peg1/Mest genes in postimplantation parthenogenetic mouse embryos treated with transforming growth factor alpha in vitro | [Expression of imprinted Igf2 and Peg1/Mest genes in postimplantation parthenogenetic mouse embryos treated with transforming growth factor alpha in vitro].
Penkov LI, Kondrakhina MS, Mironova OV, Platonov ES. | 01/21/2010 |
| TGFalpha has a novel suppressive function that contributes to decelerating distal lung cell proliferation synergistically with HB-EGF through EGFR in perinatal distal lung development | HB-EGF decelerates cell proliferation synergistically with TGFalpha in perinatal distal lung development.
Minami S, Iwamoto R, Mekada E. | 01/21/2010 |
| PRL expands the pool of cells susceptible to tumorigenesis, which is then facilitated by PRL and TGF-alpha cross talk | Prolactin drives estrogen receptor-alpha-dependent ductal expansion and synergizes with transforming growth factor-alpha to induce mammary tumors in males.
Arendt LM, Schuler LA., Free PMC Article | 01/21/2010 |
| Concomitant expression of TGFalpha and Kras(G12D) accelerates the progression of mPanIN lesions to metastatic pancreatic cancer and leads to the development of cystic papillary lesions resembling human intraductal papillary mucinous neoplasms (IPMN). | Concomitant pancreatic activation of Kras(G12D) and Tgfa results in cystic papillary neoplasms reminiscent of human IPMN.
Siveke JT, Einwächter H, Sipos B, Lubeseder-Martellato C, Klöppel G, Schmid RM. | 01/21/2010 |
| unregulated TGFalpha expression in the mammary gland leads to oncogenesis that is dependent on ovarian steroids early in tumorigenesis | Estrogen receptor-positive mammary tumorigenesis in TGFalpha transgenic mice progresses with progesterone receptor loss.
Rose-Hellekant TA, Schroeder MD, Brockman JL, Zhdankin O, Bolstad R, Chen KS, Gould MN, Schuler LA, Sandgren EP., Free PMC Article | 01/21/2010 |