| HDAC1/2 control mesothelium/ovarian cancer adhesive interactions impacting on Talin-1-alpha5beta1-integrin-mediated actin cytoskeleton and extracellular matrix protein remodeling. | HDAC1/2 control mesothelium/ovarian cancer adhesive interactions impacting on Talin-1-α5β1-integrin-mediated actin cytoskeleton and extracellular matrix protein remodeling.
Terri M, Sandoval P, Bontempi G, Montaldo C, Tomero-Sanz H, de Turris V, Trionfetti F, Pascual-Antón L, Clares-Pedrero I, Battistelli C, Valente S, Zwergel C, Mai A, Rosanò L, Del Pozo MÁ, Sánchez-Álvarez M, Cabañas C, Tripodi M, López-Cabrera M, Strippoli R., Free PMC Article | 02/12/2024 |
| Myeloid deletion of talin-1 reduces mucosal macrophages and protects mice from colonic inflammation. | Myeloid deletion of talin-1 reduces mucosal macrophages and protects mice from colonic inflammation.
Latour YL, McNamara KM, Allaman MM, Barry DP, Smith TM, Asim M, Williams KJ, Hawkins CV, Jacobse J, Goettel JA, Delgado AG, Piazuelo MB, Washington MK, Gobert AP, Wilson KT., Free PMC Article | 12/26/2023 |
| Talin-1 inhibits Smurf1-mediated Stat3 degradation to modulate beta-cell proliferation and mass in mice. | Talin-1 inhibits Smurf1-mediated Stat3 degradation to modulate β-cell proliferation and mass in mice.
Hou X, Chen Y, Zhou B, Tang W, Ding Z, Chen L, Wu Y, Yang H, Du C, Yang D, Ma G, Cao H., Free PMC Article | 11/1/2023 |
| AGK Potentiates Arterial Thrombosis by Affecting Talin-1 and alphaIIbbeta3-Mediated Bidirectional Signaling Pathway. | AGK Potentiates Arterial Thrombosis by Affecting Talin-1 and αIIbβ3-Mediated Bidirectional Signaling Pathway.
Zhang P, Jiang H, Yang M, Bi C, Zhang K, Liu D, Wei M, Jiang Z, Lv K, Fang C, Liu J, Zhang T, Xu Y, Zhang J. | 05/28/2023 |
| Epithelial talin-1 protects mice from citrobacter rodentium-induced colitis by restricting bacterial crypt intrusion and enhancing t cell immunity. | Epithelial talin-1 protects mice from citrobacter rodentium-induced colitis by restricting bacterial crypt intrusion and enhancing t cell immunity.
Latour YL, Allaman MM, Barry DP, Smith TM, Williams KJ, McNamara KM, Jacobse J, Goettel JA, Delgado AG, Piazuelo MB, Zhao S, Gobert AP, Wilson KT., Free PMC Article | 03/28/2023 |
| Peptide-PAINT Enables Investigation of Endogenous Talin with Molecular Scale Resolution in Cells and Tissues. | Peptide-PAINT Enables Investigation of Endogenous Talin with Molecular Scale Resolution in Cells and Tissues.
Fischer LS, Schlichthaerle T, Chrostek-Grashoff A, Grashoff C., Free PMC Article | 02/26/2022 |
| Talin-dependent integrin activation is required for endothelial proliferation and postnatal angiogenesis. | Talin-dependent integrin activation is required for endothelial proliferation and postnatal angiogenesis.
Pulous FE, Carnevale JC, Al-Yafeai Z, Pearson BH, Hamilton JAG, Henry CJ, Orr AW, Petrich BG., Free PMC Article | 10/30/2021 |
| Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1. | Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1.
Gough RE, Jones MC, Zacharchenko T, Le S, Yu M, Jacquemet G, Muench SP, Yan J, Humphries JD, Jørgensen C, Humphries MJ, Goult BT., Free PMC Article | 08/28/2021 |
| Protective Role of Tangshen Formula on the Progression of Renal Damage in db/db Mice by TRPC6/Talin1 Pathway in Podocytes. | Protective Role of Tangshen Formula on the Progression of Renal Damage in db/db Mice by TRPC6/Talin1 Pathway in Podocytes.
Wang Q, Tian X, Zhou W, Wang Y, Zhao H, Li J, Zhou X, Zhang H, Zhao T, Li P., Free PMC Article | 08/28/2021 |
| Talin-1 is the principal platelet Rap1 effector of integrin activation. | Talin-1 is the principal platelet Rap1 effector of integrin activation.
Lagarrigue F, Paul DS, Gingras AR, Valadez AJ, Sun H, Lin J, Cuevas MN, Ablack JN, Lopez-Ramirez MA, Bergmeier W, Ginsberg MH., Free PMC Article | 03/27/2021 |
| Talin1 controls dendritic cell activation by regulating TLR complex assembly and signaling. | Talin1 controls dendritic cell activation by regulating TLR complex assembly and signaling.
Lim TJF, Bunjamin M, Ruedl C, Su IH., Free PMC Article | 03/6/2021 |
| Crystal structure of the FERM-folded talin head reveals the determinants for integrin binding. | Crystal structure of the FERM-folded talin head reveals the determinants for integrin binding.
Zhang P, Azizi L, Kukkurainen S, Gao T, Baikoghli M, Jacquier MC, Sun Y, Määttä JAE, Cheng RH, Wehrle-Haller B, Hytönen VP, Wu J., Free PMC Article | 02/13/2021 |
| Increased talin-vinculin spatial proximities in livers in response to spotted fever group rickettsial and Ebola virus infections. | Increased talin-vinculin spatial proximities in livers in response to spotted fever group rickettsial and Ebola virus infections.
Liu Y, Xiao J, Zhang B, Shelite TR, Su Z, Chang Q, Judy B, Li X, Drelich A, Bei J, Zhou Y, Zheng J, Jin Y, Rossi SL, Tang SJ, Wakamiya M, Saito T, Ksiazek T, Kaphalia B, Gong B., Free PMC Article | 11/21/2020 |
| Vinculins interaction with talin is essential for mammary epithelial differentiation. | Vinculins interaction with talin is essential for mammary epithelial differentiation.
Wang P, Wu J, Wood A, Jones M, Pedley R, Li W, Ross RS, Ballestrem C, Gilmore AP, Streuli CH., Free PMC Article | 11/21/2020 |
| Talin folding as the tuning fork of cellular mechanotransduction. | Talin folding as the tuning fork of cellular mechanotransduction.
Tapia-Rojo R, Alonso-Caballero Á, Fernández JM., Free PMC Article | 10/24/2020 |
| The study clarifies the division of roles between the force-regulated unfolding of a talin protein (talin 1) and its function as a physical linker between integrins and the cytoskeleton. | Talin-mediated force transmission and talin rod domain unfolding independently regulate adhesion signaling.
Rahikainen R, Öhman T, Turkki P, Varjosalo M, Hytönen VP. | 06/27/2020 |
| The focal molecular complex, which consists of integrin, talin, vinculin and actin, is known to form in response to a force applied via the extra-cellular matrix. These results demonstrated that talin was required to increase the stiffness of the nascent complex, which could be caused by the reinforced connection between the complex and actin filaments mediated by talin. | Talin is required to increase stiffness of focal molecular complex in its early formation process.
Nakao N, Maki K, Mofrad MRK, Adachi T. | 06/13/2020 |
| Talin promotes integrin activation accompanied by generation of tension in talin and an increase in osmotic pressure in neurite outgrowth. | Talin promotes integrin activation accompanied by generation of tension in talin and an increase in osmotic pressure in neurite outgrowth.
Wang Y, Zhang X, Tian J, Shan J, Hu Y, Zhai Y, Guo J. | 05/23/2020 |
| Taken together, our data suggest that the presence of embryos can affect expression of talin1 in the mouse endometrium, and a certain concentration of HCG can regulate its expression. | Regulation of Embryonic Signal on Talin1 in Mouse Endometrium.
Shen Y, Qin A. | 05/9/2020 |
| Macrophages use Syk tyrosine kinase signaling to build a mechanosensitive, talin- and vinculin- mediated, focal adhesion-like molecular clutch, which couples integrins to cytoskeletal forces to drive phagocytosis. | Coupling of β(2) integrins to actin by a mechanosensitive molecular clutch drives complement receptor-mediated phagocytosis.
Jaumouillé V, Cartagena-Rivera AX, Waterman CM., Free PMC Article | 02/22/2020 |
| Talin-dependent activation of EC beta1-integrin stabilizes VE-cadherin at endothelial junctions and promotes endothelial barrier function. | Talin-Dependent Integrin Activation Regulates VE-Cadherin Localization and Endothelial Cell Barrier Function.
Pulous FE, Grimsley-Myers CM, Kansal S, Kowalczyk AP, Petrich BG., Free PMC Article | 01/4/2020 |
| these results demonstrate that modulating talin function via autoinhibition is an important mechanism for regulating multiple aspects of integrin-mediated cell-extracellular matrix adhesion in vivo. | Talin Autoinhibition Regulates Cell-ECM Adhesion Dynamics and Wound Healing In Vivo.
Haage A, Goodwin K, Whitewood A, Camp D, Bogutz A, Turner CT, Granville DJ, Lefebvre L, Plotnikov S, Goult BT, Tanentzapf G. | 12/14/2019 |
| the Rap1-talin 1 F0 interaction has little effect on platelet GPIIb-IIIa activation and hemostasis and cannot account for the dramatic effects of loss of Rap1 activity on these platelet functions. | Rap1 binding to the talin 1 F0 domain makes a minimal contribution to murine platelet GPIIb-IIIa activation.
Lagarrigue F, Gingras AR, Paul DS, Valadez AJ, Cuevas MN, Sun H, Lopez-Ramirez MA, Goult BT, Shattil SJ, Bergmeier W, Ginsberg MH., Free PMC Article | 08/31/2019 |
| this study shows that Talin1 methylation is required for neutrophil infiltration during murine peritonitis | Talin1 Methylation Is Required for Neutrophil Infiltration and Lipopolysaccharide-Induced Lethality.
Lim TJF, Su IH. | 08/3/2019 |
| findings suggest that direct Rap1/Talin1 interaction is of particular importance in regulating the activity of different integrin classes expressed on platelets and neutrophils, which both depend on fast and dynamic integrin-mediated responses. | Direct Rap1/Talin1 interaction regulates platelet and neutrophil integrin activity in mice.
Bromberger T, Klapproth S, Rohwedder I, Zhu L, Mittmann L, Reichel CA, Sperandio M, Qin J, Moser M., Free PMC Article | 07/20/2019 |