| Increased extracellular matrix stiffness regulates myofibroblast transformation through induction of autophagy-mediated Kindlin-2 cytoplasmic translocation. | Increased extracellular matrix stiffness regulates myofibroblast transformation through induction of autophagy-mediated Kindlin-2 cytoplasmic translocation.
Zhao Z, Han W, Huang G, He Y, Zuo X, Hong L. | 03/26/2024 |
| Kindlin-2 maintains liver homeostasis by regulating GSTP1-OPN-mediated oxidative stress and inflammation in mice. | Kindlin-2 maintains liver homeostasis by regulating GSTP1-OPN-mediated oxidative stress and inflammation in mice.
Zhong Y, Zhou L, Wang H, Lin S, Liu T, Kong X, Xiao G, Gao H., Free PMC Article | 02/26/2024 |
| Kindlin-2 in myoepithelium controls luminal progenitor commitment to alveoli in mouse mammary gland. | Kindlin-2 in myoepithelium controls luminal progenitor commitment to alveoli in mouse mammary gland.
Wang Z, Zhang L, Li B, Song J, Yu M, Zhang J, Chen C, Zhan J, Zhang H., Free PMC Article | 10/24/2023 |
| Kindlin-2 enhances c-Myc translation through association with DDX3X to promote pancreatic ductal adenocarcinoma progression. | Kindlin-2 enhances c-Myc translation through association with DDX3X to promote pancreatic ductal adenocarcinoma progression.
Liu C, Jiang K, Ding Y, Yang A, Cai R, Bai P, Xiong M, Fu C, Quan M, Xiong Z, Deng Y, Tian R, Wu C, Sun Y., Free PMC Article | 09/22/2023 |
| Kindlin-2 preserves integrity of the articular cartilage to protect against osteoarthritis. | Kindlin-2 preserves integrity of the articular cartilage to protect against osteoarthritis.
Wu X, Lai Y, Chen S, Zhou C, Tao C, Fu X, Li J, Tong W, Tian H, Shao Z, Liu C, Chen D, Bai X, Cao H, Xiao G. | 05/3/2023 |
| Kindlin-2 inhibits TNF/NF-kappaB-Caspase 8 pathway in hepatocytes to maintain liver development and function. | Kindlin-2 inhibits TNF/NF-κB-Caspase 8 pathway in hepatocytes to maintain liver development and function.
Gao H, Zhong Y, Zhou L, Lin S, Hou X, Ding Z, Li Y, Yao Q, Cao H, Zou X, Chen D, Bai X, Xiao G., Free PMC Article | 03/1/2023 |
| [Kindlin-2 regulates endometrium development via mTOR and Hippo signaling pathways in mice]. | [Kindlin-2 regulates endometrium development via mTOR and Hippo signaling pathways in mice].
Zhang J, Song JG, Wang ZB, Gong YQ, Wang TZ, Zhou JY, Zhan J, Zhang HQ., Free PMC Article | 10/22/2022 |
| Kindlin-2 loss in condylar chondrocytes causes spontaneous osteoarthritic lesions in the temporomandibular joint in mice. | Kindlin-2 loss in condylar chondrocytes causes spontaneous osteoarthritic lesions in the temporomandibular joint in mice.
Lai Y, Zheng W, Qu M, Xiao CC, Chen S, Yao Q, Gong W, Tao C, Yan Q, Zhang P, Wu X, Xiao G., Free PMC Article | 07/16/2022 |
| Mechanosensors control skeletal muscle mass, molecular clocks, and metabolism. | Mechanosensors control skeletal muscle mass, molecular clocks, and metabolism.
Vanmunster M, Rojo Garcia AV, Pacolet A, Dalle S, Koppo K, Jonkers I, Lories R, Suhr F., Free PMC Article | 06/18/2022 |
| Kindlin-2 promotes Src-mediated tyrosine phosphorylation of androgen receptor and contributes to breast cancer progression. | Kindlin-2 promotes Src-mediated tyrosine phosphorylation of androgen receptor and contributes to breast cancer progression.
Ma L, Tian Y, Qian T, Li W, Liu C, Chu B, Kong Q, Cai R, Bai P, Ma L, Deng Y, Tian R, Wu C, Sun Y., Free PMC Article | 06/11/2022 |
| Kindlin-2 protects pancreatic beta cells through inhibiting NLRP3 inflammasome activation in diabetic mice. | Kindlin-2 protects pancreatic β cells through inhibiting NLRP3 inflammasome activation in diabetic mice.
Huang XT, Xiong DY, Xiao JN, Deng L, Liu W, Tang SY. | 06/11/2022 |
| Fermitin family homolog 2 (Kindlin-2) affects vascularization during the wound healing process by regulating the Wnt/beta-catenin signaling pathway in vascular endothelial cells. | Fermitin family homolog 2 (Kindlin-2) affects vascularization during the wound healing process by regulating the Wnt/β-catenin signaling pathway in vascular endothelial cells.
Ying J, Wang Q, Lu L, Liu J, Guo R, Hu H, Jiang H, Qi F., Free PMC Article | 12/18/2021 |
| Kindlin-2 in Sertoli cells is essential for testis development and male fertility in mice. | Kindlin-2 in Sertoli cells is essential for testis development and male fertility in mice.
Chi X, Luo W, Song J, Li B, Su T, Yu M, Wang T, Wang Z, Liu C, Li Z, He H, Zhan J, Zhang H., Free PMC Article | 11/6/2021 |
| Kindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice. | Kindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice.
Fu X, Zhou B, Yan Q, Tao C, Qin L, Wu X, Lin S, Chen S, Lai Y, Zou X, Shao Z, Wang M, Chen D, Jin W, Song Y, Cao H, Zhang G, Xiao G., Free PMC Article | 10/16/2021 |
| Kindlin-2 Acts as a Key Mediator of Lung Fibroblast Activation and Pulmonary Fibrosis Progression. | Kindlin-2 Acts as a Key Mediator of Lung Fibroblast Activation and Pulmonary Fibrosis Progression.
Zhang P, Wang J, Luo W, Yuan J, Cui C, Guo L, Wu C. | 09/18/2021 |
| Kindlin-2 mediates mechanotransduction in bone by regulating expression of Sclerostin in osteocytes. | Kindlin-2 mediates mechanotransduction in bone by regulating expression of Sclerostin in osteocytes.
Qin L, Fu X, Ma J, Lin M, Zhang P, Wang Y, Yan Q, Tao C, Liu W, Tang B, Chen D, Bai X, Cao H, Xiao G., Free PMC Article | 08/7/2021 |
| Involvement of kindlin-2 in irisin's protection against ischaemia reperfusion-induced liver injury in high-fat diet-fed mice. | Involvement of kindlin-2 in irisin's protection against ischaemia reperfusion-induced liver injury in high-fat diet-fed mice.
Zhang J, Ren Y, Bi J, Wang M, Zhang L, Wang T, Wei S, Mou X, Lv Y, Wu R., Free PMC Article | 06/19/2021 |
| Kindlin-2 deficiency induces fatal intestinal obstruction in mice. | Kindlin-2 deficiency induces fatal intestinal obstruction in mice.
He X, Song J, Cai Z, Chi X, Wang Z, Yang D, Xie S, Zhou J, Fu Y, Li W, Kong W, Zhan J, Zhang H., Free PMC Article | 05/22/2021 |
| Kindlin-2 Inhibits the Hippo Signaling Pathway by Promoting Degradation of MOB1. | Kindlin-2 Inhibits the Hippo Signaling Pathway by Promoting Degradation of MOB1.
Song J, Wang T, Chi X, Wei X, Xu S, Yu M, He H, Ma J, Li X, Du J, Sun X, Wang Y, Zhan J, Zhang H. | 09/26/2020 |
| Kindlin-2 suppresses transcription factor GATA4 through interaction with SUV39H1 to attenuate hypertrophy. | Kindlin-2 suppresses transcription factor GATA4 through interaction with SUV39H1 to attenuate hypertrophy.
Qi L, Chi X, Zhang X, Feng X, Chu W, Zhang S, Wu J, Song Y, Zhang Y, Kong W, Yu Y, Zhang H., Free PMC Article | 09/5/2020 |
| Effects of Kindlin-2 on proliferation and migration of VSMC and integrinbeta1 andbeta3 activity via FAK-PI3K signaling pathway. | Effects of Kindlin-2 on proliferation and migration of VSMC and integrinβ1 andβ3 activity via FAK-PI3K signaling pathway.
Wu X, Bian F, Hu H, Zhu T, Li C, Zhou Q., Free PMC Article | 08/29/2020 |
| Deleting kindlin-2 expression in adipocytes in mice caused a severe lipodystrophy with drastically reduced adipose tissue mass. Kindlin-2 ablation elevated the blood levels of nonesterified fatty acids and triglycerides, resulting in massive fatty livers in the mutant mice fed with high-fat diet establishing a critical role of kindlin-2 in control of adipogenesis and lipid metabolism as well as bone homeostasis. | Lipoatrophy and metabolic disturbance in mice with adipose-specific deletion of kindlin-2.
Gao H, Guo Y, Yan Q, Yang W, Li R, Lin S, Bai X, Liu C, Chen D, Cao H, Xiao G., Free PMC Article | 07/25/2020 |
| Kindlin-2 loss reduces the percentage of beta-cells and concomitantly increases that of alpha-cells during early pancreatic development. Genetic activation of beta-catenin in beta-cells restores the diabetes-like phenotypes induced by Kindlin-2 loss. | Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice.
Zhu K, Lai Y, Cao H, Bai X, Liu C, Yan Q, Ma L, Chen D, Kanaporis G, Wang J, Li L, Cheng T, Wang Y, Wu C, Xiao G., Free PMC Article | 04/18/2020 |
| Kindlin-2 regulation of epithelial-to-mesenchymal transition in breast cancer metastasis is mediated through miR-200b | The Kindlin-2 regulation of epithelial-to-mesenchymal transition in breast cancer metastasis is mediated through miR-200b.
Sossey-Alaoui K, Pluskota E, Szpak D, Schiemann WP, Plow EF., Free PMC Article | 10/12/2019 |
| Novel kindlin-2 signaling axis that senses the mechanical cues of cell microenvironment and controls mesenchymal stem cell fate decision through YAP1/TAZ. | Kindlin-2 regulates mesenchymal stem cell differentiation through control of YAP1/TAZ.
Guo L, Cai T, Chen K, Wang R, Wang J, Cui C, Yuan J, Zhang K, Liu Z, Deng Y, Xiao G, Wu C., Free PMC Article | 03/23/2019 |