| This study supports a role for Nr2c1 in defining the biphasic period of retinal development and specifically influencing the early phase of retinal cell fate. | The nuclear hormone receptor gene Nr2c1 (Tr2) is a critical regulator of early retina cell patterning.
Olivares AM, Han Y, Soto D, Flattery K, Marini J, Mollema N, Haider A, Escher P, DeAngelis MM, Haider NB. | 10/14/2017 |
| Nr2c1 may be a candidate for mediating parallel adaptive changes in cranial neural sensory specializations such as the olfactory epithelium, retina and mystacial vibrissae and in non-neural craniofacial features including teeth | Testicular receptor 2, Nr2c1, is associated with stem cells in the developing olfactory epithelium and other cranial sensory and skeletal structures.
Baker JL, Wood B, Karpinski BA, LaMantia AS, Maynard TM., Free PMC Article | 09/10/2016 |
| TR2/TR4 expression in sickle cell disease mice confers enhanced fetal hemoglobin synthesis and alleviated disease phenotypes | Forced TR2/TR4 expression in sickle cell disease mice confers enhanced fetal hemoglobin synthesis and alleviated disease phenotypes.
Campbell AD, Cui S, Shi L, Urbonya R, Mathias A, Bradley K, Bonsu KO, Douglas RR, Halford B, Schmidt L, Harro D, Giacherio D, Tanimoto K, Tanabe O, Engel JD., Free PMC Article | 01/28/2012 |
| in adult erythroid cells, TR2/TR4 bind to the embryonic beta-type globin promoters but not to the adult beta-globin promoter. | Nuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic β-type globin promoters in differentiated adult erythroid cells.
Cui S, Kolodziej KE, Obara N, Amaral-Psarris A, Demmers J, Shi L, Engel JD, Grosveld F, Strouboulis J, Tanabe O., Free PMC Article | 11/12/2011 |
| Possible roles for TR2 and TR4 in early embryonic development by regulating key genes involved in stem cell self-renewal, commitment, and differentiation. | Roles of testicular orphan nuclear receptors 2 and 4 in early embryonic development and embryonic stem cells.
Shyr CR, Kang HY, Tsai MY, Liu NC, Ku PY, Huang KE, Chang C. | 01/21/2010 |
| This is the first report identifying a deacetylase-independent function for HDAC3, which serves as a specific carrier molecule that targets a specifically phosphorylated protein to promyelocytic leukemia (PML) nuclear bodies. | HDAC3 as a molecular chaperone for shuttling phosphorylated TR2 to PML: a novel deacetylase activity-independent function of HDAC3.
Gupta P, Ho PC, Ha SG, Lin YW, Wei LN., Free PMC Article | 01/21/2010 |
| Retinoic acid-stimulated sequential phosphorylation, PML recruitment, and SUMOylation of nuclear receptor TR2 to suppress Oct4 expression | Retinoic acid-stimulated sequential phosphorylation, PML recruitment, and SUMOylation of nuclear receptor TR2 to suppress Oct4 expression.
Gupta P, Ho PC, Huq MM, Ha SG, Park SW, Khan AA, Tsai NP, Wei LN., Free PMC Article | 01/21/2010 |
| TR2 and TR4 orphan nuclear receptors repress Gata1 transcription. | The TR2 and TR4 orphan nuclear receptors repress Gata1 transcription.
Tanabe O, Shen Y, Liu Q, Campbell AD, Kuroha T, Yamamoto M, Engel JD., Free PMC Article | 01/21/2010 |
| These results suggest a SUMOylation-dependent partitioning and differential coregulator recruitment contribute to the maintenance of a homeostatic supply of activating, Tr2, thus fine-tuning Oct4 expression and regulating stem-cell proliferation. | SUMOylation of Tr2 orphan receptor involves Pml and fine-tunes Oct4 expression in stem cells.
Park SW, Hu X, Gupta P, Lin YP, Ha SG, Wei LN. | 01/21/2010 |
| Silencing of the embryonic and fetal beta globin genes is delayed in erythroid cells of Tr2 and Tr4 null mutant mice, whereas in transgenic mice expressing dominant-negative TR4 (dnTR4), human embryonic epsilon-globin is activated in erythroid cells. | Embryonic and fetal beta-globin gene repression by the orphan nuclear receptors, TR2 and TR4.
Tanabe O, McPhee D, Kobayashi S, Shen Y, Brandt W, Jiang X, Campbell AD, Chen YT, Chang Cs, Yamamoto M, Tanimoto K, Engel JD., Free PMC Article | 01/21/2010 |
| DRED is a 540 kDa complex containing the nuclear orphan receptors TR2 and TR4, which form a heterodimer that binds to the epsilon and gamma globin promoter DR1 sites. TR2 & 4 mRNAs are expressed at all stages of murine and human erythropoiesis. | An embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer.
Tanabe O, Katsuoka F, Campbell AD, Song W, Yamamoto M, Tanimoto K, Engel JD., Free PMC Article | 01/21/2010 |
| TR2 may not play essential roles in spermatogenesis and normal testis development, function, and maintenance. Alternatively, the roles of TR2 may be redundant and could be played by other close members of the nuclear receptor superfamily (TR2 receptor) | Spermatogenesis and testis development are normal in mice lacking testicular orphan nuclear receptor 2.
Shyr CR, Collins LL, Mu XM, Platt KA, Chang C., Free PMC Article | 01/21/2010 |