| DeltaNp73 and its effector targets promote colorectal peritoneal carcinosis and predict survival. | ΔNp73 and its effector targets promote colorectal peritoneal carcinosis and predict survival.
Pastor-Morate D, Amigo-Morán L, Garranzo-Asensio M, Rejas-González R, Carnicero P, Rodríguez N, Pérez-Robledo JP, Barderas R, Prieto-Nieto I, Domínguez G. | 11/5/2024 |
| Loss of p73 Expression Contributes to Chronic Obstructive Pulmonary Disease. | Loss of p73 Expression Contributes to Chronic Obstructive Pulmonary Disease.
Richmond BW, Marshall CB, Blackburn JB, Tufenkjian TS, Lehmann BD, Han W, Newcomb D, Gutor SS, Hunt RP, Michell DL, Vickers KC, Polosukhin VV, Blackwell TS, Pietenpol JA., | 01/17/2024 |
| Tumor suppressor p73 induces apoptosis of murine peritoneal cell after exposure to hydatid cyst antigens; a possibly survival mechanism of cystic echinococcosis in vivo mice model. | Tumor suppressor p73 induces apoptosis of murine peritoneal cell after exposure to hydatid cyst antigens; a possibly survival mechanism of cystic echinococcosis in vivo mice model.
Ahmadpour E, Spotin A, Moghimi A, Shahrivar F, Jadidi-Niaragh F, Hajizadeh F, Mehrani S, Mazhab-Jafari K., Free PMC Article | 10/10/2023 |
| Isoform-specific disruption of the TP73 gene reveals a critical role for TAp73gamma in tumorigenesis via leptin. | Isoform-specific disruption of the TP73 gene reveals a critical role for TAp73γ in tumorigenesis via leptin.
Kong X, Yan W, Sun W, Zhang Y, Yang HJ, Chen M, Chen H, de Vere White RW, Zhang J, Chen X., Free PMC Article | 09/22/2023 |
| Pulsed Electromagnetic Fields Combined With Adipose-Derived Stem Cells Protect Ischemic Myocardium by Regulating miR-20a-5p/E2F1/p73 Signaling. | Pulsed Electromagnetic Fields Combined With Adipose-Derived Stem Cells Protect Ischemic Myocardium by Regulating miR-20a-5p/E2F1/p73 Signaling.
Wang Y, Chen L, Wang L, Pei G, Cheng H, Zhang Q, Wang S, Hu D, He Y, He C, Fu C, Wei Q. | 09/11/2023 |
| TP73 Isoform-specific disruption reveals a critical role of TAp73beta in growth suppression and inflammatory response. | TP73 Isoform-specific disruption reveals a critical role of TAp73beta in growth suppression and inflammatory response.
Zhang J, Sun W, Yan W, Kong X, Shen T, Laubach K, Chen M, Chen X., Free PMC Article | 02/10/2023 |
| p73alpha1, a p73 C-terminal isoform, regulates tumor suppression and the inflammatory response via Notch1. | p73α1, a p73 C-terminal isoform, regulates tumor suppression and the inflammatory response via Notch1.
Laubach KN, Yan W, Kong X, Sun W, Chen M, Zhang J, Chen X., Free PMC Article | 06/11/2022 |
| P73 C-terminus is dispensable for multiciliogenesis. | P73 C-terminus is dispensable for multiciliogenesis.
Buckley N, Panatta E, Morone N, Noguchi M, Scorrano L, Knight RA, Amelio I, Melino G., Free PMC Article | 09/4/2021 |
| Molecular Mechanisms and Function of the p53 Protein Family Member - p73. | Molecular Mechanisms and Function of the p53 Protein Family Member - p73.
Melino G. | 03/20/2021 |
| p53-Related Transcription Targets of TAp73 in Cancer Cells-Bona Fide or Distorted Reality? | p53-Related Transcription Targets of TAp73 in Cancer Cells-Bona Fide or Distorted Reality?
Wang C, Teo CR, Sabapathy K., Free PMC Article | 12/12/2020 |
| Cajal-Retzius neurons are required for the development of the human hippocampal fissure. | Cajal-Retzius neurons are required for the development of the human hippocampal fissure.
Meyer G, González-Arnay E, Moll U, Nemajerova A, Tissir F, González-Gómez M., Free PMC Article | 09/12/2020 |
| The C terminus of p73 is essential for hippocampal development. | The C terminus of p73 is essential for hippocampal development.
Amelio I, Panatta E, Niklison-Chirou MV, Steinert JR, Agostini M, Morone N, Knight RA, Melino G., Free PMC Article | 09/5/2020 |
| These p73 dysregulation may contribute to susceptibility to autoimmune disease. | Transcription factor p73 regulates Th1 differentiation.
Ren M, Kazemian M, Zheng M, He J, Li P, Oh J, Liao W, Li J, Rajaseelan J, Kelsall BL, Peltz G, Leonard WJ., Free PMC Article | 07/18/2020 |
| Using human and murine in vitro systems, in vivo xenograft modeling as well as patient-derived brain tumor initiating cells, study demonstrates that tumor suppressor TAp73 is required for maintaining the growth and stemness features of stem-like cancer cells. TAp73 modifies the proline regulatory axis through regulation of enzymes GLS, OAT, and PYCR1 involved in the interconversion of proline-glutamine-ornithine. | TAp73 Modifies Metabolism and Positively Regulates Growth of Cancer Stem-Like Cells in a Redox-Sensitive Manner.
Sharif T, Dai C, Martell E, Ghassemi-Rad MS, Hanes MR, Murphy PJ, Kennedy BE, Venugopal C, Subapanditha M, Giacomantonio CA, Marcato P, Singh SK, Gujar S. | 05/30/2020 |
| P73 role and expression during tumor suppression.HES1 and ECM1 are transcriptionally repressed by p73. | Mutant p53 antagonizes p63/p73-mediated tumor suppression via Notch1.
Zhang J, Sun W, Kong X, Zhang Y, Yang HJ, Ren C, Jiang Y, Chen M, Chen X., Free PMC Article | 05/2/2020 |
| We identified a set of 44 genes directly or indirectly regulated by DeltaNp73 that are involved in skin development, cell junctions, cornification, proliferation, and wound healing. Our results establish a role for p73 in cutaneous wound healing through regulation of basal keratinocyte function. | p73 regulates epidermal wound healing and induced keratinocyte programming.
Beeler JS, Marshall CB, Gonzalez-Ericsson PI, Shaver TM, Santos Guasch GL, Lea ST, Johnson KN, Jin H, Venters BJ, Sanders ME, Pietenpol JA., Free PMC Article | 02/15/2020 |
| p73 regulates ependymal planar cell polarity by modulating actin and microtubule cytoskeleton. | p73 regulates ependymal planar cell polarity by modulating actin and microtubule cytoskeleton.
Fuertes-Alvarez S, Maeso-Alonso L, Villoch-Fernandez J, Wildung M, Martin-Lopez M, Marshall C, Villena-Cortes AJ, Diez-Prieto I, Pietenpol JA, Tissir F, Lizé M, Marques MM, Marin MC., Free PMC Article | 11/30/2019 |
| Results suggest that the loss of tumor suppressor protein p73 (p73) during the embryonic period is critical for hydrocephalus development. | Loss of p73 in ependymal cells during the perinatal period leads to aqueductal stenosis.
Fujitani M, Sato R, Yamashita T., Free PMC Article | 07/20/2019 |
| Current understanding indicates that various products from TP73 genes, originated by alternative gene promoter usage and differential splicing, might differentially participate in complex networks that regulate cell growth, differentiation and death. TAp73alpha is found as the exclusive, or major, expressed isoform in most of the biological system analyzed. [review] | p73 Alternative Splicing: Exploring a Biological Role for the C-Terminal Isoforms.
Vikhreva P, Melino G, Amelio I., Free PMC Article | 06/1/2019 |
| TAp73 deficiency results in a pronounced reduction in tumorigenic potential, which can be rescued by forced PFKL expression. | TAp73-induced phosphofructokinase-1 transcription promotes the Warburg effect and enhances cell proliferation.
Li L, Li L, Li W, Chen T, Bin Zou, Zhao L, Wang H, Wang X, Xu L, Liu X, Wang D, Li B, Mak TW, Du W, Yang X, Jiang P., Free PMC Article | 05/4/2019 |
| p73 exerts its functions in neuronal biology at least partially through the regulation of metabolic pathways. | p73 Regulates Primary Cortical Neuron Metabolism: a Global Metabolic Profile.
Agostini M, Niklison-Chirou MV, Annicchiarico-Petruzzelli MM, Grelli S, Di Daniele N, Pestlikis I, Knight RA, Melino G, Rufini A. | 02/9/2019 |
| Data (including data from studies in knockout/transgenic mice) suggest Ppp2ca supports cortical neuronal growth and cognitive function via regulating p73/Gls2 signal transduction in neurons of hippocampus. Ppp2ca gene knock-out results in embryonic cortical atrophy with learning/memory deficits. (Ppp2ca = protein phosphatase 2a catalytic subunit alpha isoform; p73 = transformation related protein 73; Gls2 = glutaminase-2) | Protein phosphatase 2ACα gene knock-out results in cortical atrophy through activating hippo cascade in neuronal progenitor cells.
Liu B, Sun LH, Huang YF, Guo LJ, Luo LS. | 11/3/2018 |
| p73 is required for appropriate BMP-induced mesenchymal-to-epithelial transition during somatic cell reprogramming. | p73 is required for appropriate BMP-induced mesenchymal-to-epithelial transition during somatic cell reprogramming.
Martin-Lopez M, Maeso-Alonso L, Fuertes-Alvarez S, Balboa D, Rodríguez-Cortez V, Weltner J, Diez-Prieto I, Davis A, Wu Y, Otonkoski T, Flores ER, Menéndez P, Marques MM, Marin MC., Free PMC Article | 06/9/2018 |
| P73 role in differentiating stem cells.RASSF1A promotes a YAP-p73 transcriptional programme that enables differentiation. | RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73.
Papaspyropoulos A, Bradley L, Thapa A, Leung CY, Toskas K, Koennig D, Pefani DE, Raso C, Grou C, Hamilton G, Vlahov N, Grawenda A, Haider S, Chauhan J, Buti L, Kanapin A, Lu X, Buffa F, Dianov G, von Kriegsheim A, Matallanas D, Samsonova A, Zernicka-Goetz M, O'Neill E., Free PMC Article | 03/17/2018 |
| Absence of TAp73 leads to activation of TGF-beta signaling through a Sma and Mad-related proteins-independent pathway, favoring oncogenic transforming growth factor-beta effects and epithelial-to-mesenchymal transition. | TAp73 loss favors Smad-independent TGF-β signaling that drives EMT in pancreatic ductal adenocarcinoma.
Thakur AK, Nigri J, Lac S, Leca J, Bressy C, Berthezene P, Bartholin L, Chan P, Calvo E, Iovanna JL, Vasseur S, Guillaumond F, Tomasini R., Free PMC Article | 01/13/2018 |