| LncRNA TSIX aggravates spinal cord injury by regulating the PI3K/AKT pathway via the miR-532-3p/DDOST axis. | LncRNA TSIX aggravates spinal cord injury by regulating the PI3K/AKT pathway via the miR-532-3p/DDOST axis.
Dong J, Wei Z, Zhu Z. | 08/22/2023 |
| Dynamics of transcription-mediated conversion from euchromatin to facultative heterochromatin at the Xist promoter by Tsix. | Dynamics of transcription-mediated conversion from euchromatin to facultative heterochromatin at the Xist promoter by Tsix.
Ohhata T, Yamazawa K, Miura-Kamio A, Takahashi S, Sakai S, Tamura Y, Uchida C, Kitagawa K, Niida H, Hiratani I, Kobayashi H, Kimura H, Wutz A, Kitagawa M. | 01/29/2022 |
| Inhibition of long non-coding RNA TSIX accelerates tibia fraction healing via binding and positively regulating the SOX6 expression. | Inhibition of long non-coding RNA TSIX accelerates tibia fraction healing via binding and positively regulating the SOX6 expression.
Xu WW, Xu Y, Ji F, Ji Y, Wang QG. | 04/3/2021 |
| TSIX played a pivotal role in particle-induced osteolysis development by negatively regulating miR-30a-5p. | LncRNA TSIX promotes osteoblast apoptosis in particle-induced osteolysis by down-regulating miR-30a-5p.
Bu Y, Zheng D, Wang L, Liu J. | 10/12/2019 |
| antagonistic roles for Tsix on Xist and vice versa and indicate the presence of semistable transcriptional states of the X inactivation cente locus predicting the outcome of X chromosome inactivation. | Xist and Tsix Transcription Dynamics Is Regulated by the X-to-Autosome Ratio and Semistable Transcriptional States.
Loos F, Maduro C, Loda A, Lehmann J, Kremers GJ, Ten Berge D, Grootegoed JA, Gribnau J., Free PMC Article | 06/24/2017 |
| In late preimplantation, Oct4 served as a chromatin opener to create transcriptional permissive states at Xm-Xist/Tsix genomic loci. In parthenogenetic embryos, Rnf12 overdose caused Xm-Xist derepression via Xm-Tsix repression; physiological Rnf12 levels were essential for Xm-Xist silencing maintenance in fertilized embryos. | Maintenance of Xist Imprinting Depends on Chromatin Condensation State and Rnf12 Dosage in Mice.
Fukuda A, Mitani A, Miyashita T, Sado T, Umezawa A, Akutsu H., Free PMC Article | 05/6/2017 |
| These unexpected transcriptional regulations of the Xist locus call for a re-evaluation of the early functioning of the maternal imprint on the X-chromosome and suggest that Xist/Tsix antagonist transcriptional activities may participate in imprinting | Antagonist Xist and Tsix co-transcription during mouse oogenesis and maternal Xist expression during pre-implantation development calls into question the nature of the maternal imprint on the X chromosome.
Deuve JL, Bonnet-Garnier A, Beaujean N, Avner P, Morey C., Free PMC Article | 08/6/2016 |
| the H3K27-specific demethylase Utx regulates the expression of the master regulators for XCI and XCR: Prdm14, Tsix, and Xist. | Histone demethylation maintains Prdm14 and Tsix expression and represses xIst in embryonic stem cells.
Kamikawa YF, Donohoe ME., Free PMC Article | 02/13/2016 |
| The study identified histone H3 lysine 36 trimethylation (H3K36me3) as a modification that is recruited by Tsix cotranscriptionally and extends over the Xist promoter. | Histone H3 Lysine 36 Trimethylation Is Established over the Xist Promoter by Antisense Tsix Transcription and Contributes to Repressing Xist Expression.
Ohhata T, Matsumoto M, Leeb M, Shibata S, Sakai S, Kitagawa K, Niida H, Kitagawa M, Wutz A., Free PMC Article | 02/6/2016 |
| Tsix is dispensable for inhibiting Xist and X-inactivation in the early embryo and in cultured stem cells. | Differentiation-dependent requirement of Tsix long non-coding RNA in imprinted X-chromosome inactivation.
Maclary E, Buttigieg E, Hinten M, Gayen S, Harris C, Sarkar MK, Purushothaman S, Kalantry S., Free PMC Article | 10/31/2015 |
| Tsix and PRDM14 directly link X-chromosome reactivation to stem cell pluripotency. | Tsix RNA and the germline factor, PRDM14, link X reactivation and stem cell reprogramming.
Payer B, Rosenberg M, Yamaji M, Yabuta Y, Koyanagi-Aoi M, Hayashi K, Yamanaka S, Saitou M, Lee JT., Free PMC Article | 02/22/2014 |
| Data show that a junction element between Tsix and Xist binds Ctcf and contributes to the initiation of X-chromosome inactivation. | A boundary element between Tsix and Xist binds the chromatin insulator Ctcf and contributes to initiation of X-chromosome inactivation.
Spencer RJ, del Rosario BC, Pinter SF, Lessing D, Sadreyev RI, Lee JT., Free PMC Article | 02/18/2012 |
| Data show that Tsix has a clear functional window in extraembryonic development, and within this window, Tsix can repress Xist, which is accompanied by DNA methylation of the Xist promoter. | Lineage-specific function of the noncoding Tsix RNA for Xist repression and Xi reactivation in mice.
Ohhata T, Senner CE, Hemberger M, Wutz A., Free PMC Article | 12/10/2011 |
| Tsix upregulation in embryonic stem cells depends on the recruitment of the pluripotent marker Rex1, and of the reprogramming-associated factors Klf4 and c-Myc, by the DXPas34 minisatellite associated with the Tsix promoter | Molecular coupling of Tsix regulation and pluripotency.
Navarro P, Oldfield A, Legoupi J, Festuccia N, Dubois A, Attia M, Schoorlemmer J, Rougeulle C, Chambers I, Avner P. | 01/8/2011 |
| Tsix gene is imprinted, with exclusive expression from the maternal allele. It encodes an antisense Xist transcript, which controls imprinted X chromosome inactivation in mouse. | Disruption of imprinted X inactivation by parent-of-origin effects at Tsix.
Lee JT. | 12/10/2010 |
| Study tests the idea that retinoic acid may affect Xist levels through Oct4 by studying one well-characterized Tsix mutation, TsixDeltaCpG, in male ES cells; results indicate that differentiation methods indeed influence Xist expression in these ES cells. | Retinoic acid accelerates downregulation of the Xist repressor, Oct4, and increases the likelihood of Xist activation when Tsix is deficient.
Ahn JY, Lee JT., Free PMC Article | 11/27/2010 |
| delayed reprogramming of Xist/reactivation of inactive X chromosome after cell fusion was accelerated by DNA methylation and | Enhanced reprogramming of Xist by induced upregulation of Tsix and Dnmt3a.
Do JT, Han DW, Gentile L, Sobek-Klocke I, Stehling M, Schöler HR. | 01/21/2010 |
| Tsix is Xist antisense partner gene and prevents Xist up-regulation in cis | Alteration of histone tail modifications in the Xist locus in wild-type and Tsix-mutant male embryonic stem cells during differentiation.
Shibata S, Yokota T. | 01/21/2010 |
| Male embryonic stem cells with Eed-null and Tsix mutations (X(Delta)Y Eed-/-) showed Xist hyperactivation upon differentiation, whereas cells with either mutation alone did not. | Synergy of Eed and Tsix in the repression of Xist gene and X-chromosome inactivation.
Shibata S, Yokota T, Wutz A., Free PMC Article | 01/21/2010 |
| study reports that Xist and Tsix form duplexes in vivo; during X-chromosome inactivation, the duplexes are processed to small RNAs (sRNAs), most likely on the active X (Xa) in a Dicer-dependent manner | Intersection of the RNA interference and X-inactivation pathways.
Ogawa Y, Sun BK, Lee JT., Free PMC Article | 01/21/2010 |
| These results suggest a crucial role for antisense transcription across the Xist promoter in Xist silencing. | Crucial role of antisense transcription across the Xist promoter in Tsix-mediated Xist chromatin modification.
Ohhata T, Hoki Y, Sasaki H, Sado T. | 01/21/2010 |
| It's proposed that Tsix and CTCF together establish a regulatable epigenetic switch for X-inactivation | CTCF, a candidate trans-acting factor for X-inactivation choice.
Chao W, Huynh KD, Spencer RJ, Davidow LS, Lee JT. | 01/21/2010 |
| The maternal Xist allele, which is normally silent in the extraembryonic lineages, is ectopically activated when Tsix is disrupted on the same chromosome. | Tsix-deficient X chromosome does not undergo inactivation in the embryonic lineage in males: implications for Tsix-independent silencing of Xist.
Ohhata T, Hoki Y, Sasaki H, Sado T. | 01/21/2010 |
| intergenic transcription element Xite is an enhancer of Tsix and the repeat element DXPas34 is a component of the bipartite enhancer | Identification of developmentally specific enhancers for Tsix in the regulation of X chromosome inactivation.
Stavropoulos N, Rowntree RK, Lee JT., Free PMC Article | 01/21/2010 |
| Disruption of Tsix impairs establishment of repressive epigenetic modifications and chromatin structure at the Xist locus. | Tsix silences Xist through modification of chromatin structure.
Sado T, Hoki Y, Sasaki H. | 01/21/2010 |