| USP4 regulates ribosome biogenesis and protein synthesis for hematopoietic stem cell regeneration and leukemia progression. | USP4 regulates ribosome biogenesis and protein synthesis for hematopoietic stem cell regeneration and leukemia progression.
Liu B, Zhang X, Zhou Y, Liu H, Wang Z, Fu Y, Gao Q, Cheng X, Sun Q, Ju Z. | 11/7/2024 |
| FBXO3 stabilizes USP4 and Twist1 to promote PI3K-mediated breast cancer metastasis. | FBXO3 stabilizes USP4 and Twist1 to promote PI3K-mediated breast cancer metastasis.
Xu J, Guo R, Wen N, Li L, Yi Y, Chen J, He Z, Yang J, Xiao ZJ, Niu M., Free PMC Article | 01/10/2024 |
| USP4 is pathogenic in allergic airway inflammation by inhibiting regulatory T cell response. | USP4 is pathogenic in allergic airway inflammation by inhibiting regulatory T cell response.
Hou X, Zhu F, Ni Y, Chen T, Du J, Liu X, Han Y, Liu Y, Du W, Li Y, Wang X, Li D, Liang R, Li B, Shi G. | 08/14/2021 |
| a novel H19/miR-148a/USP4 axis which promoted liver fibrosis via TGF-beta pathway in both hepatic stellate cells and hepatocytes, is reported. | H19/miR-148a/USP4 axis facilitates liver fibrosis by enhancing TGF-β signaling in both hepatic stellate cells and hepatocytes.
Zhu J, Luo Z, Pan Y, Zheng W, Li W, Zhang Z, Xiong P, Xu D, Du M, Wang B, Yu J, Zhang J, Liu J. | 04/18/2020 |
| Interference with or inhibition of USP4 prevented the activity of the TGFbeta/Smad pathway signaling and inhibited the formation of pathological scars. | Inhibition of USP4 attenuates pathological scarring by downregulation of the TGF‑β/Smad signaling pathway.
Zhang J, Na S, Pan S, Long S, Xin Y, Jiang Q, Lai Z, Yan J, Cao Z. | 01/11/2020 |
| functions as a pivotal suppressor in nonalcoholic fatty liver disease | Ubiquitin-Specific Protease 4 Is an Endogenous Negative Regulator of Metabolic Dysfunctions in Nonalcoholic Fatty Liver Disease in Mice.
Zhao Y, Wang F, Gao L, Xu L, Tong R, Lin N, Su Y, Yan Y, Gao Y, He J, Kong L, Yuan A, Zhuge Y, Pu J. | 12/28/2019 |
| USP4 is a key regulator of AQP2 deubiquitylation. | The Deubiquitylase USP4 Interacts with the Water Channel AQP2 to Modulate Its Apical Membrane Accumulation and Cellular Abundance.
Murali SK, Aroankins TS, Moeller HB, Fenton RA., Free PMC Article | 11/30/2019 |
| USP4 deficiency plays a detrimental role in hepatic I/R injury by promoting activation of the TAK1/JNK signalling pathways. | USP4 deficiency exacerbates hepatic ischaemia/reperfusion injury via TAK1 signalling.
Zhou J, Qiu T, Wang T, Chen Z, Ma X, Zhang L, Zou J. | 11/23/2019 |
| USP4 positively regulates RLR-induced NF-kappaB signalling while inhibiting EV71 replication, by targeting TRAF6 for K48-linked deubiquitination. | USP4 positively regulates RLR-induced NF-κB activation by targeting TRAF6 for K48-linked deubiquitination and inhibits enterovirus 71 replication.
Xu C, Peng Y, Zhang Q, Xu XP, Kong XM, Shi WF., Free PMC Article | 10/19/2019 |
| In this study, we identified ubiquitin-specific protease 4 (USP4), one of deubiquitinating enzymes, as a suppressor of MRFs by demonstrating that a knockdown of USP4 enhances myogenesis by controlling MyoD and the level of myogenesis marker proteins in C2C12 cells... we propose that USP4 is a key player in myogenic differentiation; it controls myogenic regulatory factors in a catalytic-independent manner | Ubiquitin-specific protease 4 (USP4) suppresses myoblast differentiation by down regulating MyoD activity in a catalytic-independent manner.
Yun SI, Kim KK. | 02/24/2018 |
| The authors demonstrated that ubiquitin-specific protease (USP) 4 strongly induces activin/BMP signaling by removing the inhibitory monoubiquitination from SMAD4. | USP4 inhibits SMAD4 monoubiquitination and promotes activin and BMP signaling.
Zhou F, Xie F, Jin K, Zhang Z, Clerici M, Gao R, van Dinther M, Sixma TK, Huang H, Zhang L, Ten Dijke P., Free PMC Article | 07/15/2017 |
| USP4 plays an essential role in negative regulation of the TLR/IL-1R signaling-mediated innate immune response | Ubiquitin-specific protease 4 mitigates Toll-like/interleukin-1 receptor signaling and regulates innate immune activation.
Zhou F, Zhang X, van Dam H, Ten Dijke P, Huang H, Zhang L., Free PMC Article | 09/22/2012 |
| Results uncover USP4 as an important determinant for crosstalk between TGF-beta/TGF-beta type I receptor and AKT signalling pathways. | USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor.
Zhang L, Zhou F, Drabsch Y, Gao R, Snaar-Jagalska BE, Mickanin C, Huang H, Sheppard KA, Porter JA, Lu CX, ten Dijke P. | 09/8/2012 |
| USP4 interacts directly with and deubiquitinates ARF-BP1, leading to the stabilization of ARF-BP1 and subsequent reduction of p53 levels. | USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1.
Zhang X, Berger FG, Yang J, Lu X., Free PMC Article | 08/6/2011 |
| the existence of a nuclear export signal ((133)VEVYLLELKL(142)) in Usp4;Usp4 is thus the first oncogenic deubiquitylating enzyme reported to have nucleocytoplasmic shuttling properties. | Nuclear-cytoplasmic shuttling of the oncogenic mouse UNP/USP4 deubiquitylating enzyme.
Soboleva TA, Jans DA, Johnson-Saliba M, Baker RT. | 01/21/2010 |