| TASK-3, two-pore potassium channels, contribute to circadian rhythms in the electrical properties of the suprachiasmatic nucleus and play a role in driving stable behavioural photic entrainment. | TASK-3, two-pore potassium channels, contribute to circadian rhythms in the electrical properties of the suprachiasmatic nucleus and play a role in driving stable behavioural photic entrainment.
Steponenaite A, Lalic T, Atkinson L, Tanday N, Brown L, Mathie A, Cader ZM, Lall GS. | 11/4/2024 |
| Biallelic non-productive enhancer-promoter interactions precede imprinted expression of Kcnk9 during mouse neural commitment. | Biallelic non-productive enhancer-promoter interactions precede imprinted expression of Kcnk9 during mouse neural commitment.
Rengifo Rojas C, Cercy J, Perillous S, Gonthier-Guéret C, Montibus B, Maupetit-Méhouas S, Espinadel A, Dupré M, Hong CC, Hata K, Nakabayashi K, Plagge A, Bouschet T, Arnaud P, Vaillant I, Court F., Free PMC Article | 04/18/2024 |
| TWIK-related acid-sensitive potassium channels TASK-1 and TASK-3 may participate in the process of the coexistence of asthma and OSA. | TWIK-related acid-sensitive potassium channels TASK-1 and TASK-3 may participate in the process of the coexistence of asthma and OSA.
Song HC, Zhang Y, Ma ZX, Yao QL, Ma XJ. | 03/21/2024 |
| Allelic chromatin structure precedes imprinted expression of Kcnk9 during neurogenesis. | Allelic chromatin structure precedes imprinted expression of Kcnk9 during neurogenesis.
Loftus D, Bae B, Whilden CM, Whipple AJ., Free PMC Article | 10/24/2023 |
| Deficiency of the Two-Pore Potassium Channel KCNK9 Impairs Intestinal Epithelial Cell Survival and Aggravates Dextran Sodium Sulfate-Induced Colitis. | Deficiency of the Two-Pore Potassium Channel KCNK9 Impairs Intestinal Epithelial Cell Survival and Aggravates Dextran Sodium Sulfate-Induced Colitis.
Pfeuffer S, Müntefering T, Rolfes L, Straeten FA, Eichler S, Gruchot J, Dobelmann V, Prozorovski T, Görg B, Vucur M, Berndt C, Küry P, Ruck T, Bittner S, Bettenworth D, Budde T, Lüdde T, Meuth SG., Free PMC Article | 11/26/2022 |
| Expression of p11 and heteromeric TASK channels in mouse adrenal cortical cells and H295R cells. | Expression of p11 and heteromeric TASK channels in mouse adrenal cortical cells and H295R cells.
Matsuoka H, Harada K, Sugawara A, Kim D, Inoue M. | 06/25/2022 |
| A 5' UTR GGN repeat controls localisation and translation of a potassium leak channel mRNA through G-quadruplex formation. | A 5' UTR GGN repeat controls localisation and translation of a potassium leak channel mRNA through G-quadruplex formation.
Maltby CJ, Schofield JPR, Houghton SD, O'Kelly I, Vargas-Caballero M, Deinhardt K, Coldwell MJ., Free PMC Article | 11/21/2020 |
| Selective activation of TWIK-related acid-sensitive K(+) 3 subunit-containing channels is analgesic in rodent models. | Selective activation of TWIK-related acid-sensitive K(+) 3 subunit-containing channels is analgesic in rodent models.
Liao P, Qiu Y, Mo Y, Fu J, Song Z, Huang L, Bai S, Wang Y, Zhu JJ, Tian F, Chen Z, Pan N, Sun EY, Yang L, Lan X, Chen Y, Huang D, Sun P, Zhao L, Yang D, Lu W, Yang T, Xiao J, Li WG, Gao Z, Shen B, Zhang Q, Liu J, Jiang H, Jiang R, Yang H. | 09/12/2020 |
| TASK-1 and TASK-3 strongly affect the development of pressure overload cardiomyopathies in genetic models of TASK-1 and TASK-3 loss of function. | TASK-1 and TASK-3 channels modulate pressure overload-induced cardiac remodeling and dysfunction.
Duan W, Hicks J, Makara MA, Ilkayeva O, Abraham DM., Free PMC Article | 05/23/2020 |
| Mutations in the actively expressed, maternal allele of the imprinted KCNK9 gene cause Birk-Barel intellectual disability syndrome (BBIDS). Using a BBIDS mouse model, we identify here a partial rescue of the BBIDS-like behavioral and neuronal phenotypes mediated via residual expression from the paternal Kcnk9 (Kcnk9(pat)) allele. | Inhibition of histone deacetylation rescues phenotype in a mouse model of Birk-Barel intellectual disability syndrome.
Cooper A, Butto T, Hammer N, Jagannath S, Fend-Guella DL, Akhtar J, Radyushkin K, Lesage F, Winter J, Strand S, Roeper J, Zechner U, Schweiger S., Free PMC Article | 04/18/2020 |
| deleted TASK-1 and TASK-3 channels selectively from zona glomerulosa cells and generated a model of mild aldosterone autonomy with attendant hypertension that is aldosterone-driven and Ang II (angiotensin II)-independent. | Adrenal Tissue-Specific Deletion of TASK Channels Causes Aldosterone-Driven Angiotensin II-Independent Hypertension.
Guagliardo NA, Yao J, Stipes EJ, Cechova S, Le TH, Bayliss DA, Breault DT, Barrett PQ., Free PMC Article | 11/23/2019 |
| TASK3 potassium channel knockdown in monoamine neurons induces antidepressant-like responses in mice. | Selective Knockdown of TASK3 Potassium Channel in Monoamine Neurons: a New Therapeutic Approach for Depression.
Fullana MN, Ferrés-Coy A, Ortega JE, Ruiz-Bronchal E, Paz V, Meana JJ, Artigas F, Bortolozzi A. | 08/10/2019 |
| Fluorescence-activated cell sorting (FACS) and subsequent microarray analysis of sensory neurons activated at 4 degrees C identified an enriched repertoire of ion channels, which include the Trp channel Trpm8 and potassium channel Kcnk9, that are potentially required for cold sensing above freezing temperatures in mouse DRG neurons. | Cold sensing by Na(V)1.8-positive and Na(V)1.8-negative sensory neurons.
Luiz AP, MacDonald DI, Santana-Varela S, Millet Q, Sikandar S, Wood JN, Emery EC., Free PMC Article | 05/11/2019 |
| impairment of the leak K(+) channel (Kcnk9) decreased sleep duration. Based on these results, we hypothesize that leak K(+) channels regulate sleep duration in mammals. | Leak potassium channels regulate sleep duration.
Yoshida K, Shi S, Ukai-Tadenuma M, Fujishima H, Ohno RI, Ueda HR., Free PMC Article | 10/20/2018 |
| Acute hypercapnia (5% CO2) stimulated ventilation in TASK-1/3(-/-) and wild-type mice to a similar extent; however, at higher CO2 concentrations the stimulation of ventilation was more pronounced in TASK-1/3(-/-) mice. At hyperoxia (100% O2), TASK-1(-/-), TASK-3(-/-) and wild-type mice showed the physiological small decrease of ventilation. TASK-1/3(-/-) mice exhibited an abnormal increase of ventilation under hyperoxia. | Abnormal respiration under hyperoxia in TASK-1/3 potassium channel double knockout mice.
Buehler PK, Bleiler D, Tegtmeier I, Heitzmann D, Both C, Georgieff M, Lesage F, Warth R, Thomas J. | 04/21/2018 |
| results demonstrate that neurotensin (NT) transiently increased the neuronal excitability of dentate gyrus granule cells (GCs) by inhibiting TASK-3 channels; NT-mediated increases in neuronal excitability facilitate long-term potentiation at the perforant path-GC synapses | Neurotensinergic Excitation of Dentate Gyrus Granule Cells via Gαq-Coupled Inhibition of TASK-3 Channels.
Zhang H, Dong H, Cilz NI, Kurada L, Hu B, Wada E, Bayliss DA, Porter JE, Lei S., Free PMC Article | 10/29/2016 |
| KCNK9 channels are not involved in hearing. | KCNK5 channels mostly expressed in cochlear outer sulcus cells are indispensable for hearing.
Cazals Y, Bévengut M, Zanella S, Brocard F, Barhanin J, Gestreau C., Free PMC Article | 05/14/2016 |
| THe results of this study suggested that dysfunction of KCNK9 causes a migration defect in the cortex via an activity-dependent mechanism. | Dysfunction of KCNK potassium channels impairs neuronal migration in the developing mouse cerebral cortex.
Bando Y, Hirano T, Tagawa Y. | 11/8/2014 |
| Oxygen and mitochondrial inhibitors modulate both monomeric and heteromeric TASK-1 and TASK-3 channels in mouse carotid body type-1 cells. | Oxygen and mitochondrial inhibitors modulate both monomeric and heteromeric TASK-1 and TASK-3 channels in mouse carotid body type-1 cells.
Turner PJ, Buckler KJ., Free PMC Article | 08/23/2014 |
| Data indicate that in 1-day-old Task3-/- mice, renal renin concentration was lower than in wild-type mice. | Severe hyperaldosteronism in neonatal Task3 potassium channel knockout mice is associated with activation of the intraadrenal renin-angiotensin system.
Bandulik S, Tauber P, Penton D, Schweda F, Tegtmeier I, Sterner C, Lalli E, Lesage F, Hartmann M, Barhanin J, Warth R. | 11/2/2013 |
| DPP6 co-expression with TASK-3 results in the formation of a protein complex that enhances resting membrane potassium conductance. | A new TASK for Dipeptidyl Peptidase-like Protein 6.
Nadin BM, Pfaffinger PJ., Free PMC Article | 10/26/2013 |
| An extracellular ion pathway plays a central role in the cooperative gating of a K(2P) K+ channel by extracellular pH | An extracellular ion pathway plays a central role in the cooperative gating of a K(2P) K+ channel by extracellular pH.
González W, Zúñiga L, Cid LP, Arévalo B, Niemeyer MI, Sepúlveda FV., Free PMC Article | 04/27/2013 |
| Task3 plays an important role in the adaptation of aldosterone secretion to dietary salt intake. | Task3 potassium channel gene invalidation causes low renin and salt-sensitive arterial hypertension.
Penton D, Bandulik S, Schweda F, Haubs S, Tauber P, Reichold M, Cong LD, El Wakil A, Budde T, Lesage F, Lalli E, Zennaro MC, Warth R, Barhanin J. | 12/22/2012 |
| This study demonistrated that kcnk9 gene expression in mouse dorsal raphe nucleus | Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.
Templin JS, Bang SJ, Soiza-Reilly M, Berde CB, Commons KG., Free PMC Article | 09/15/2012 |
| TASK3 channel genes may contribute to the development of low renin essential hypertension and idiopathic hyperaldosteronism in mice. | TASK-3 channel deletion in mice recapitulates low-renin essential hypertension.
Guagliardo NA, Yao J, Hu C, Schertz EM, Tyson DA, Carey RM, Bayliss DA, Barrett PQ., Free PMC Article | 06/16/2012 |