| PAK2 is necessary for myelination in the peripheral nervous system. | PAK2 is necessary for myelination in the peripheral nervous system.
Hu B, Moiseev D, Schena I, Faezov B, Dunbrack R, Chernoff J, Li J., Free PMC Article | 05/7/2024 |
| PAK2 is essential for chromosome alignment in metaphase I oocytes. | PAK2 is essential for chromosome alignment in metaphase I oocytes.
Zeng J, Wang S, Gao M, Lu D, Song S, Chen D, Fan W, Xu Z, Zhang Z, Sun X., Free PMC Article | 02/24/2023 |
| Loss-of-Function of p21-Activated Kinase 2 Links BMP Signaling to Neural Tube Patterning Defects. | Loss-of-Function of p21-Activated Kinase 2 Links BMP Signaling to Neural Tube Patterning Defects.
Wang Y, Zhang K, Guo J, Yang S, Shi X, Pan J, Sun Z, Zou J, Li Y, Li Y, Fan T, Song W, Cheng F, Zeng C, Li J, Zhang T, Sun ZS., Free PMC Article | 02/10/2023 |
| Pak2-mediated phosphorylation promotes RORgammat ubiquitination and inhibits colonic inflammation. | Pak2-mediated phosphorylation promotes RORγt ubiquitination and inhibits colonic inflammation.
Kathania M, Kumar R, Lenou ET, Basrur V, Theiss AL, Chernoff J, Venuprasad K., Free PMC Article | 10/1/2022 |
| Inactivation of p21-Activated Kinase 2 (Pak2) Inhibits the Development of Nf2-Deficient Tumors by Restricting Downstream Hedgehog and Wnt Signaling. | Inactivation of p21-Activated Kinase 2 (Pak2) Inhibits the Development of Nf2-Deficient Tumors by Restricting Downstream Hedgehog and Wnt Signaling.
Sementino E, Kadariya Y, Cheung M, Menges CW, Tan Y, Kukuyan AM, Shrestha U, Karchugina S, Cai KQ, Peri S, Duncan JS, Chernoff J, Testa JR., Free PMC Article | 05/7/2022 |
| PAK1 inhibition reduces tumor size and extends the lifespan of mice in a genetically engineered mouse model of Neurofibromatosis Type 2 (NF2). | PAK1 inhibition reduces tumor size and extends the lifespan of mice in a genetically engineered mouse model of Neurofibromatosis Type 2 (NF2).
Hawley E, Gehlhausen J, Karchugina S, Chow HY, Araiza-Olivera D, Radu M, Smith A, Burks C, Jiang L, Li X, Bessler W, Masters A, Edwards D, Burgin C, Jones D, Yates C, Clapp DW, Chernoff J, Park SJ., Free PMC Article | 03/26/2022 |
| Pak2 reduction induces a failure of early embryonic development in mice. | Pak2 reduction induces a failure of early embryonic development in mice.
Zeng J, Liu N, Yang Y, Cheng Y, Li Y, Guo X, Luo Q, Zhu L, Guan H, Song B, Sun X., Free PMC Article | 03/12/2022 |
| The p21-activated kinase 2 (PAK2), but not PAK1, regulates contraction-stimulated skeletal muscle glucose transport. | The p21-activated kinase 2 (PAK2), but not PAK1, regulates contraction-stimulated skeletal muscle glucose transport.
Møller LLV, Nielsen IL, Knudsen JR, Andersen NR, Jensen TE, Sylow L, Richter EA., Free PMC Article | 07/3/2021 |
| The dynactin subunit DCTN1 controls osteoclastogenesis via the Cdc42/PAK2 pathway. | The dynactin subunit DCTN1 controls osteoclastogenesis via the Cdc42/PAK2 pathway.
Lee YD, Kim B, Jung S, Kim H, Kim MK, Kwon JO, Song MK, Lee ZH, Kim HH., Free PMC Article | 07/3/2021 |
| our results suggest that miR-455-3p promotes TGF-b/Smad signaling in chondrocytes and inhibits cartilage degeneration by directly suppressing PAK2. | MicroRNA-455-3p promotes TGF-β signaling and inhibits osteoarthritis development by directly targeting PAK2.
Hu S, Zhao X, Mao G, Zhang Z, Wen X, Zhang C, Liao W, Zhang Z., Free PMC Article | 06/13/2020 |
| PAK2 deficiency extensively perturbed functional networks associated with ASD by regulating actin cytoskeleton dynamics. | PAK2 Haploinsufficiency Results in Synaptic Cytoskeleton Impairment and Autism-Related Behavior.
Wang Y, Zeng C, Li J, Zhou Z, Ju X, Xia S, Li Y, Liu A, Teng H, Zhang K, Shi L, Bi C, Xie W, He X, Jia Z, Jiang Y, Cai T, Wu J, Xia K, Sun ZS. | 02/1/2020 |
| Pak2 promotes a protective endoplasmic reticulum stress response, protecting the heart from disease. | Pak2 as a Novel Therapeutic Target for Cardioprotective Endoplasmic Reticulum Stress Response.
Binder P, Wang S, Radu M, Zin M, Collins L, Khan S, Li Y, Sekeres K, Humphreys N, Swanton E, Reid A, Pu F, Oceandy D, Guan K, Hille SS, Frey N, Müller OJ, Cartwright EJ, Chernoff J, Wang X, Liu W., Free PMC Article | 12/21/2019 |
| Study showed that conditional loss of Pak1 and Pak2 in mice resulted in an age-dependent myopathy with similarity to mice and humans with CHKbeta deficiency. | Late-onset megaconial myopathy in mice lacking group I Paks.
Joseph GA, Hung M, Goel AJ, Hong M, Rieder MK, Beckmann ND, Serasinghe MN, Chipuk JE, Devarakonda PM, Goldhamer DJ, Aldana-Hernandez P, Curtis J, Jacobs RL, Krauss RS., Free PMC Article | 07/6/2019 |
| Pak2 is essential in maintaining the peripheral Treg cell pool by providing proliferation and maintenance signals to Foxp3(+) Treg cells. | P21-activated kinase 2 is essential in maintenance of peripheral Foxp3(+) regulatory T cells.
Choi J, Pease DR, Chen S, Zhang B, Phee H., Free PMC Article | 06/1/2019 |
| PAK2 acts as a Rac1-dependent negative regulator of neuronal glucose uptake and insulin sensitivity. | P21-activated kinase 2 (PAK2) regulates glucose uptake and insulin sensitivity in neuronal cells.
Varshney P, Dey CS. | 09/30/2017 |
| These results identify Pak1 and Pak2 as redundant regulators of myoblast differentiation in vitro and in vivo and as components of the promyogenic Ncad/Cdo/Cdc42 signaling pathway. | Group I Paks Promote Skeletal Myoblast Differentiation In Vivo and In Vitro.
Joseph GA, Lu M, Radu M, Lee JK, Burden SJ, Chernoff J, Krauss RS., Free PMC Article | 07/1/2017 |
| PAK-mediated phosphorylation of PKD1 at Ser203 triggers its membrane dissociation and subsequent entry into the nucleus, thereby regulating the phosphorylation of PKD1 nuclear targets, including class IIa histone deacetylases. | Protein kinase D1 (PKD1) phosphorylation on Ser(203) by type I p21-activated kinase (PAK) regulates PKD1 localization.
Chang JK, Ni Y, Han L, Sinnett-Smith J, Jacamo R, Rey O, Young SH, Rozengurt E., Free PMC Article | 06/24/2017 |
| Data indicate that resveratrol treatment inhibits neuronal glucose uptake via P21-activated kinase 2 (PAK2). | Resveratrol regulates neuronal glucose uptake and insulin sensitivity via P21-activated kinase 2 (PAK2).
Varshney P, Dey CS. | 06/24/2017 |
| Mechanistic insights into the role of Pak2 in hematopoietic stem cells migration and homing. | p21-activated kinase 2 regulates HSPC cytoskeleton, migration, and homing via CDC42 activation and interaction with β-Pix.
Reddy PN, Radu M, Xu K, Wood J, Harris CE, Chernoff J, Williams DA., Free PMC Article | 10/1/2016 |
| Pak2 disruption decreased the survival and proliferation of multicytokine stimulated immature progenitors. | Pak2 regulates hematopoietic progenitor cell proliferation, survival, and differentiation.
Zeng Y, Broxmeyer HE, Staser K, Chitteti BR, Park SJ, Hahn S, Cooper S, Sun Z, Jiang L, Yang X, Yuan J, Kosoff R, Sandusky G, Srour EF, Chernoff J, Clapp DW., Free PMC Article | 04/2/2016 |
| The data suggest that Pak2 controls thymic Natural Killer T-cell development by providing a signal that links Egr2 to induce PLZF, in part by regulating signaling lymphocyte activation molecule 6 expression. | Pak2 Controls Acquisition of NKT Cell Fate by Regulating Expression of the Transcription Factors PLZF and Egr2.
O'Hagan KL, Zhao J, Pryshchep O, Wang CR, Phee H., Free PMC Article | 03/19/2016 |
| In adult endothelial cells, Pak2 depletion leads to severe apoptosis and acute angiogenesis defects, and in adult mice, endothelial Pak2 deletion leads to increased vascular permeability. | p21-Activated Kinase 2 Regulates Endothelial Development and Function through the Bmk1/Erk5 Pathway.
Radu M, Lyle K, Hoeflich KP, Villamar-Cruz O, Koeppen H, Chernoff J., Free PMC Article | 02/20/2016 |
| Pak2 Links TCR Signaling Strength to the Development of Regulatory T Cells and Maintains Peripheral Tolerance | Pak2 Links TCR Signaling Strength to the Development of Regulatory T Cells and Maintains Peripheral Tolerance.
O'Hagan KL, Choi J, Pryshchep O, Chernoff J, Phee H., Free PMC Article | 11/28/2015 |
| Failure to induce proper actin cytoskeletal remodeling impaired PLCgamma1 and Erk1/2 signaling in the absence of Pak2, uncovering the critical function of Pak2 as an essential regulator that governs the actin cytoskeleton-dependent signaling | Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation.
Phee H, Au-Yeung BB, Pryshchep O, O'Hagan KL, Fairbairn SG, Radu M, Kosoff R, Mollenauer M, Cheng D, Chernoff J, Weiss A., Free PMC Article | 11/21/2015 |
| p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment. | The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment.
Dorrance AM, De Vita S, Radu M, Reddy PN, McGuinness MK, Harris CE, Mathieu R, Lane SW, Kosoff R, Milsom MD, Chernoff J, Williams DA., Free PMC Article | 06/8/2013 |