| LINC01023 Promotes the Hepatoblastoma Tumorigenesis via miR-378a-5p/WNT3 Axis. | LINC01023 Promotes the Hepatoblastoma Tumorigenesis via miR-378a-5p/WNT3 Axis.
Bhandari R, Shaikh II, Bhandari R, Chapagain S. | 06/16/2023 |
| Transport and Secretion of the Wnt3 Ligand by Motor Neuron-like Cells and Developing Motor Neurons. | Transport and Secretion of the Wnt3 Ligand by Motor Neuron-like Cells and Developing Motor Neurons.
Pinto C, Pérez V, Mella J, Albistur M, Caprile T, Bronfman FC, Henríquez JP., Free PMC Article | 01/22/2022 |
| Paneth cell-derived growth factors support tumorigenesis in the small intestine. | Paneth cell-derived growth factors support tumorigenesis in the small intestine.
Chen Q, Suzuki K, Sifuentes-Dominguez L, Miyata N, Song J, Lopez A, Starokadomskyy P, Gopal P, Dozmorov I, Tan S, Ge B, Burstein E., Free PMC Article | 09/18/2021 |
| Expression of Wnt3, a morphogen of the Wnt/beta-catenin pathway, was higher in pubertal Sertoli cells relative to infant Sertoli cells. | Defective Wnt3 expression by testicular Sertoli cells compromise male fertility.
Basu S, Arya SP, Usmani A, Pradhan BS, Sarkar RK, Ganguli N, Shukla M, Mandal K, Singh S, Sarda K, Majumdar SS. | 04/6/2019 |
| Downregulation of Gata4 could restore the phenotype exhibited by Wnt3 downregulation in dorsal root ganglion neurons. | Wnt3 and Gata4 regulate axon regeneration in adult mouse DRG neurons.
Duan RS, Liu PP, Xi F, Wang WH, Tang GB, Wang RY, Saijilafu, Liu CM. | 10/13/2018 |
| Here, we describe the culture protocol using Wnt-3a for successful maintenance of skin epithelial stem cells . | Maintenance of Skin Epithelial Stem Cells by Wnt-3a In Vitro.
Ouji Y, Yoshikawa M. | 01/13/2018 |
| Study indicates essential roles for Wnt2 and Wnt3 in chronic restraint stress-induced depression-like behaviors and antidepressant. | The antidepressant roles of Wnt2 and Wnt3 in stress-induced depression-like behaviors.
Zhou WJ, Xu N, Kong L, Sun SC, Xu XF, Jia MZ, Wang Y, Chen ZY., Free PMC Article | 11/11/2017 |
| these results therefore highlight an unanticipated role for p53 family proteins in a regulatory network that integrates essential Wnt-Tcf and nodal-Smad inputs. | The p53 Family Coordinates Wnt and Nodal Inputs in Mesendodermal Differentiation of Embryonic Stem Cells.
Wang Q, Zou Y, Nowotschin S, Kim SY, Li QV, Soh CL, Su J, Zhang C, Shu W, Xi Q, Huangfu D, Hadjantonakis AK, Massagué J., Free PMC Article | 07/29/2017 |
| stem-cell membranes constitute a reservoir for Wnt proteins, while Frizzled receptor turnover and 'plasma membrane dilution' through cell division shape the epithelial Wnt3 gradient | Visualization of a short-range Wnt gradient in the intestinal stem-cell niche.
Farin HF, Jordens I, Mosa MH, Basak O, Korving J, Tauriello DV, de Punder K, Angers S, Peters PJ, Maurice MM, Clevers H. | 03/12/2016 |
| timed secretion of wnt3 by ingrowing axons from the thalamus regulates the combinatorial composition of ribosomal proteins in developing neocortex. WNT3 further regulates the specificity of mRNA translation and development of neurons and oligodendrocytes. | Thalamic WNT3 Secretion Spatiotemporally Regulates the Neocortical Ribosome Signature and mRNA Translation to Specify Neocortical Cell Subtypes.
Kraushar ML, Viljetic B, Wijeratne HR, Thompson K, Jiao X, Pike JW, Medvedeva V, Groszer M, Kiledjian M, Hart RP, Rasin MR., Free PMC Article | 11/7/2015 |
| this article shows that absence of Wnt3 in the posterior visceral endoderm leads to delayed formation of the primitive streak and that interplay between anterior and posterior visceral endoderm restricts the position of the primitive streak | Extra-embryonic Wnt3 regulates the establishment of the primitive streak in mice.
Yoon Y, Huang T, Tortelote GG, Wakamiya M, Hadjantonakis AK, Behringer RR, Rivera-Pérez JA., Free PMC Article | 09/12/2015 |
| Data indicate that functional Wnt3/beta-Catenin signaling is localized to the dorsal subventricular zone (SVZ) microdomain. | Persistent Wnt/β-catenin signaling determines dorsalization of the postnatal subventricular zone and neural stem cell specification into oligodendrocytes and glutamatergic neurons.
Azim K, Fischer B, Hurtado-Chong A, Draganova K, Cantù C, Zemke M, Sommer L, Butt A, Raineteau O. | 12/20/2014 |
| Wnt3 is part of a signaling loop that affects homeostasis of intestinal stem and Paneth cells in mice. | Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells.
Farin HF, Van Es JH, Clevers H. | 04/6/2013 |
| Wnt3 function in the epiblast is required for the maintenance but not the initiation of gastrulation in mice | Wnt3 function in the epiblast is required for the maintenance but not the initiation of gastrulation in mice.
Tortelote GG, Hernández-Hernández JM, Quaresma AJ, Nickerson JA, Imbalzano AN, Rivera-Pérez JA., Free PMC Article | 03/16/2013 |
| These results suggest that the regulation of paracrine factors plays a critical role in hippocampal aging and neurogenesis. | Reduction in paracrine Wnt3 factors during aging causes impaired adult neurogenesis.
Okamoto M, Inoue K, Iwamura H, Terashima K, Soya H, Asashima M, Kuwabara T. | 12/10/2011 |
| canonical Wnt signaling regulates CXCL12 gene expression at the transcriptional level | Regulation of CXCL12 expression by canonical Wnt signaling in bone marrow stromal cells.
Tamura M, Sato MM, Nashimoto M. | 08/6/2011 |
| Wnt-3a and Wnt-3 factors signal through the canonical Wnt/beta-catenin pathway to regulate different aspects of spinal cord neural progenitor development. | Wnt-3a and Wnt-3 differently stimulate proliferation and neurogenesis of spinal neural precursors and promote neurite outgrowth by canonical signaling.
David MD, Cantí C, Herreros J. | 06/25/2011 |
| The mRNA levels of Wnt3, 6, and 9a were significantly upregulated in the intestinal epithelial cells by Salmonella. | Salmonella regulation of intestinal stem cells through the Wnt/beta-catenin pathway.
Liu X, Lu R, Wu S, Sun J., Free PMC Article | 03/22/2010 |
| Different permissive Wnt3/beta-catenin signaling thresholds is required for the embryonic development of head structures and adult intestinal polyposis. | Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo.
Buchert M, Athineos D, Abud HE, Burke ZD, Faux MC, Samuel MS, Jarnicki AG, Winbanks CE, Newton IP, Meniel VS, Suzuki H, Stacker SA, Näthke IS, Tosh D, Huelsken J, Clarke AR, Heath JK, Sansom OJ, Ernst M., Free PMC Article | 03/15/2010 |
| Wnt3a stimulates Src docking to Dvl2 and activation of Src. | Dishevelled-2 docks and activates Src in a Wnt-dependent manner.
Yokoyama N, Malbon CC., Free PMC Article | 03/8/2010 |
| head development is sensitive to the level of WNT3 signalling and that DKK1 is the key antagonist that modulates WNT3 activity during anterior morphogenesis. | Dkk1 and Wnt3 interact to control head morphogenesis in the mouse.
Lewis SL, Khoo PL, De Young RA, Steiner K, Wilcock C, Mukhopadhyay M, Westphal H, Jamieson RV, Robb L, Tam PP. | 01/21/2010 |
| an internally truncated LRP5 receptor is strongly implicated in deregulated activation of the WNT/beta-catenin signaling pathway in hyperparathyroid tumors | An LRP5 receptor with internal deletion in hyperparathyroid tumors with implications for deregulated WNT/beta-catenin signaling.
Björklund P, Akerström G, Westin G., Free PMC Article | 01/21/2010 |
| Wnt3 expression in the epiblast is required for induction of the primitive streak and mesoderm whereas activity in the posterior visceral endoderm is dispensable. | Wnt3 signaling in the epiblast is required for proper orientation of the anteroposterior axis.
Barrow JR, Howell WD, Rule M, Hayashi S, Thomas KR, Capecchi MR, McMahon AP. | 01/21/2010 |
| This study findings reveal the rich contributions of the Wnt3a lineage to a variety of brain structures and show that functionally integrated nuclei can share a molecular identity. | The derivatives of the Wnt3a lineage in the central nervous system.
Louvi A, Yoshida M, Grove EA. | 01/21/2010 |
| Wnt3a and SB216763 promoted the proliferation of retinal stem cells, partly dependent on FGF2 signaling.A combination of Wnt and FGF signaling may provide a therapeutic strategy for in vitro expansion or in vivo activation of adult retinal stem cells. | Activation of canonical Wnt pathway promotes proliferation of retinal stem cells derived from adult mouse ciliary margin.
Inoue T, Kagawa T, Fukushima M, Shimizu T, Yoshinaga Y, Takada S, Tanihara H, Taga T. | 01/21/2010 |