| These results suggest that KLPH is required for lens-specific expression of Clic5 and that Clic5 has an important role in the machinery that controls lens fiber cell extension and organization. | The klotho-related protein KLPH (lctl) has preferred expression in lens and is essential for expression of clic5 and normal lens suture formation.
Fan J, Lerner J, Wyatt MK, Cai P, Peterson K, Dong L, Wistow G., Free PMC Article | 11/17/2018 |
| Results indicate CLICs-dependent chloride efflux as an essential and proximal upstream event for NLRP3 activation. | CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation.
Tang T, Lang X, Xu C, Wang X, Gong T, Yang Y, Cui J, Bai L, Wang J, Jiang W, Zhou R., Free PMC Article | 12/9/2017 |
| The findings indicate that CLIC4/CLIC5A-mediated ERM activation is required for maintenance of the glomerular capillary architecture. | Both CLIC4 and CLIC5A activate ERM proteins in glomerular endothelium.
Tavasoli M, Al-Momany A, Wang X, Li L, Edwards JC, Ballermann BJ. | 07/8/2017 |
| Augmented hypertension-induced glomerular capillary injury in mice lacking CLIC5 results from abrogation of Rac1-dependent Pak and ezrin activation, perhaps reducing the tensile strength of the podocyte actin cytoskeleton. | The chloride intracellular channel 5A stimulates podocyte Rac1, protecting against hypertension-induced glomerular injury.
Tavasoli M, Li L, Al-Momany A, Zhu LF, Adam BA, Wang Z, Ballermann BJ. | 02/4/2017 |
| The mechanism of CLIC5A action involves clustered plasma membrane phosphatidylinositol 4,5-bisphosphate accumulation, in turn facilitating ezrin activation and actin-dependent cell surface remodeling. | Clustered PI(4,5)P₂ accumulation and ezrin phosphorylation in response to CLIC5A.
Al-Momany A, Li L, Alexander RT, Ballermann BJ. | 11/21/2015 |
| Biochemical assays showed interaction of CLIC5 with ERM proteins, TPRN, and possibly myosin VI (MYO6). In addition, CLIC5 and RDX failed to localize normally in fused stereocilia of MYO6 mutant mice | CLIC5 stabilizes membrane-actin filament linkages at the base of hair cell stereocilia in a molecular complex with radixin, taperin, and myosin VI.
Salles FT, Andrade LR, Tanda S, Grati M, Plona KL, Gagnon LH, Johnson KR, Kachar B, Berryman MA., Free PMC Article | 11/8/2014 |
| miR-96 and miR-182 regulate the in vivo expression of CLIC5 in mouse inner ear hair cells | MiR-183 family regulates chloride intracellular channel 5 expression in inner ear hair cells.
Gu C, Li X, Tan Q, Wang Z, Chen L, Liu Y. | 09/21/2013 |
| Study identifies CLIC5 as a new component that is enriched in and necessary for foot process integrity and podocyte function in vivo. | Proteomic analysis of the slit diaphragm complex: CLIC5 is a protein critical for podocyte morphology and function.
Pierchala BA, Muñoz MR, Tsui CC., Free PMC Article | 02/26/2011 |
| CLIC5 disrupts proliferation of C2C12 cells and is involved in the differentiation of myoblasts by enhancing the protein expression level of MyHC, myogenin and desmin. | The CLIC5 (chloride intracellular channel 5) involved in C2C12 myoblasts proliferation and differentiation.
Li F, Yin J, Yue T, Liu L, Zhang H. | 06/28/2010 |
| Clic5 mutant mice are resistant to diet-induced obesity. | CLIC5 mutant mice are resistant to diet-induced obesity and exhibit gastric hemorrhaging and increased susceptibility to torpor.
Bradford EM, Miller ML, Prasad V, Nieman ML, Gawenis LR, Berryman M, Lorenz JN, Tso P, Shull GE., Free PMC Article | 06/28/2010 |
| CLIC5A colocalizes with ezrin and podocalyxin in podocytes and is required for the development/maintenance of the proper glomerular endothelial cell and podocyte architecture. | CLIC5A, a component of the ezrin-podocalyxin complex in glomeruli, is a determinant of podocyte integrity.
Wegner B, Al-Momany A, Kulak SC, Kozlowski K, Obeidat M, Jahroudi N, Paes J, Berryman M, Ballermann BJ., Free PMC Article | 06/28/2010 |
| CLIC5 associates with radixin in hair cell stereocilia and may help form or stabilize connections between the plasma membrane and the filamentous actin core. | The chloride intracellular channel protein CLIC5 is expressed at high levels in hair cell stereocilia and is essential for normal inner ear function.
Gagnon LH, Longo-Guess CM, Berryman M, Shin JB, Saylor KW, Yu H, Gillespie PG, Johnson KR., Free PMC Article | 01/21/2010 |